Asthma Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description A chronic respiratory disease manifested as difficulty breathing due to the narrowing of bronchial passageways.|Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.|A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).|A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors resulting in recurring periods of wheezing (a whistling sound while breathing), chest tightness, shortness of breath, mucus production and coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, excercise, stress, reflux disease, medications, foods and emotional anxiety. (Experimental Factor Ontology, EFO_0000270)
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Genes

107 genes associated with the trait Asthma in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
NOTCH4 notch 4 1.49716
GSDMB gasdermin B 1.26538
IL33R interleukin 33 receptor 1.21571
PBX2 pre-B-cell leukemia homeobox 2 1.21571
C6ORF10 chromosome 6 open reading frame 10 1.20587
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 1.11353
SLC30A8 solute carrier family 30 (zinc transporter), member 8 1.09046
CDK2 cyclin-dependent kinase 2 0.944178
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.922056
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.922056
IL18R1 interleukin 18 receptor 1 0.820059
SMAD3 SMAD family member 3 0.807263
PYHIN1 pyrin and HIN domain family, member 1 0.807263
GSDMA gasdermin A 0.796965
IL2RB interleukin 2 receptor, beta 0.763999
IL6R interleukin 6 receptor 0.731179
PDE4D phosphodiesterase 4D, cAMP-specific 0.711358
TUSC3 tumor suppressor candidate 3 0.685324
GAB1 GRB2-associated binding protein 1 0.667558
IL13 interleukin 13 0.64828
RORA RAR-related orphan receptor A 0.64828
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 0.609816
RAD50 RAD50 homolog (S. cerevisiae) 0.585749
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.581148
PRKG1 protein kinase, cGMP-dependent, type I 0.552134
RPS28P1 ribosomal protein S28 pseudogene 1 0.539181
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 0.527821
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 0.50084
PCDH15 protocadherin-related 15 0.50084
AKAP6 A kinase (PRKA) anchor protein 6 0.446581
ATP11AUN ATP11A upstream neighbor 0.444195
PLXNA4 plexin A4 0.443956
NOS2 nitric oxide synthase 2, inducible 0.438439
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.406869
CCDC67 coiled-coil domain containing 67 0.378873
ANK1 ankyrin 1, erythrocytic 0.356676
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.33862
CDH23 cadherin-related 23 0.33862
PDE9A phosphodiesterase 9A 0.33862
C10ORF54 chromosome 10 open reading frame 54 0.33862
CTNND2 catenin (cadherin-associated protein), delta 2 0.33862
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.338563
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 0.323533
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.323533
PRKCE protein kinase C, epsilon 0.323533
MAVS mitochondrial antiviral signaling protein 0.310838
CSMD1 CUB and Sushi multiple domains 1 0.29992
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.29992
KANK1 KN motif and ankyrin repeat domains 1 0.29992
CNTLN centlein, centrosomal protein 0.29992
ZMYND8 zinc finger, MYND-type containing 8 0.295627
FAM196B family with sequence similarity 196, member B 0.281822
DOCK2 dedicator of cytokinesis 2 0.281822
NRDE2 NRDE-2, necessary for RNA interference, domain containing 0.275245
SYNPR synaptoporin 0.27422
IL36R interleukin 36 receptor 0.2597
GLIS3 GLIS family zinc finger 3 0.254293
PTPRD protein tyrosine phosphatase, receptor type, D 0.240131
TNIP1 TNFAIP3 interacting protein 1 0.239948
RAB39A RAB39A, member RAS oncogene family 0.237447
FSTL4 follistatin-like 4 0.201427
PARVB parvin, beta 0.188268
ZNF585B zinc finger protein 585B 0.187017
TMEM132D transmembrane protein 132D 0.185859
PAX3 paired box 3 0.184031
CPNE4 copine IV 0.178409
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.174347
LRRC4C leucine rich repeat containing 4C 0.166982
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.164001
FSIP1 fibrous sheath interacting protein 1 0.163714
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.16082
ADGRB3 adhesion G protein-coupled receptor B3 0.157919
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.154311
ZNF423 zinc finger protein 423 0.152972
ADORA1 adenosine A1 receptor 0.152895
POLI polymerase (DNA directed) iota 0.145438
NR1D1 nuclear receptor subfamily 1, group D, member 1 0.140051
NRG3 neuregulin 3 0.13128
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 0.128323
TMCO4 transmembrane and coiled-coil domains 4 0.123077
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.12113
BEST1 bestrophin 1 0.115367
MTUS2 microtubule associated tumor suppressor candidate 2 0.107545
CGN cingulin 0.104017
GSTA4 glutathione S-transferase alpha 4 0.10384
DPY19L1P1 DPY19L1 pseudogene 1 0.103132
LBH limb bud and heart development 0.101497
CACUL1 CDK2-associated, cullin domain 1 0.100621
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.099862
LAMA1 laminin, alpha 1 0.099379
PKP1 plakophilin 1 0.093803
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 0.090338
THBS4 thrombospondin 4 0.089726
EYA2 EYA transcriptional coactivator and phosphatase 2 0.087521
CREB5 cAMP responsive element binding protein 5 0.086983
ADCY2 adenylate cyclase 2 (brain) 0.086208
CCDC140 coiled-coil domain containing 140 0.08243
OR4K13 olfactory receptor, family 4, subfamily K, member 13 0.080809
TMEM161B transmembrane protein 161B 0.07697
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.07594
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.075029
TMEM62 transmembrane protein 62 0.074539
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 0.072962
NPAS3 neuronal PAS domain protein 3 0.070194
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.063346
NAV2 neuron navigator 2 0.061534
MAPK10 mitogen-activated protein kinase 10 0.060188