Astrocytoma Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A glial tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, and glioblastoma.|Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation (MeSH).|Neoplasms of the brain and spinal cord derived from glial cells which vary from histologically benign forms to highly anaplastic and malignant tumors. Fibrillary astrocytomas are the most common type and may be classified in order of increasing malignancy (grades I through IV). In the first two decades of life, astrocytomas tend to originate in the cerebellar hemispheres; in adults, they most frequently arise in the cerebrum and frequently undergo malignant transformation. (From Devita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2013-7; Holland et al., Cancer Medicine, 3d ed, p1082) (Experimental Factor Ontology, EFO_0000272)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D001254
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Genes

24 genes/proteins associated with the disease Astrocytoma from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
PTPN11 protein tyrosine phosphatase, non-receptor type 11 2.88009
TP53 tumor protein p53 2.88009
LATS2 large tumor suppressor kinase 2 2.88009
LATS1 large tumor suppressor kinase 1 2.88009
FGFR1 fibroblast growth factor receptor 1 2.88009
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 2.88009
NF1 neurofibromin 1 2.88009
NDRG1 N-myc downstream regulated 1 2.88009
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.88009
HEY2 hes-related family bHLH transcription factor with YRPW motif 2 2.88009
BRAF B-Raf proto-oncogene, serine/threonine kinase 2.88009
MMP3 matrix metallopeptidase 3 2.88009
NOTCH1 notch 1 2.88009
NOTCH2 notch 2 2.88009
KRAS Kirsten rat sarcoma viral oncogene homolog 2.88009
ACVR1 activin A receptor, type I 2.88009
DLL3 delta-like 3 (Drosophila) 2.88009
KIAA1549 KIAA1549 2.88009
MMP9 matrix metallopeptidase 9 2.88009
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 2.88009
MGMT O-6-methylguanine-DNA methyltransferase 1.26236
FOXF2 forkhead box F2 1.13997
INA internexin neuronal intermediate filament protein, alpha 1.03864
GOLGA8B golgin A8 family, member B 1.03678