| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ataluren perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Ataluren_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.21613 |
| ANXA1 | annexin A1 | 0.136444 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.110522 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.102952 |
| DST | dystonin | 0.0968059 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0917907 |
| ASPH | aspartate beta-hydroxylase | 0.0883001 |
| AREG | amphiregulin | 0.0748112 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0711589 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0704265 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0690469 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0615679 |
| ENO1 | enolase 1, (alpha) | 0.0611834 |
| PGK1 | phosphoglycerate kinase 1 | 0.0603623 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | 0.0586121 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0585948 |
| KIF5B | kinesin family member 5B | 0.0575865 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0566106 |
| SET | SET nuclear proto-oncogene | 0.0565404 |
| TPM3 | tropomyosin 3 | 0.0562753 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0556799 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.055665 |
| PCBP2 | poly(rC) binding protein 2 | 0.054671 |
| SFTPA2 | surfactant protein A2 | 0.0533547 |
| TXNRD1 | thioredoxin reductase 1 | 0.0494622 |
| EHBP1 | EH domain binding protein 1 | 0.0489025 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0475203 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0474085 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0466002 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0457775 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0454469 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0451765 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.044359 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0433469 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.042934 |
| XPO1 | exportin 1 | 0.0422785 |
| CALR | calreticulin | 0.0412945 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0407316 |
| SMYD3 | SET and MYND domain containing 3 | 0.0403805 |
| MCL1 | myeloid cell leukemia 1 | 0.0399143 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0398998 |
| MMP12 | matrix metallopeptidase 12 | 0.0388318 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0386974 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0382485 |
| USP34 | ubiquitin specific peptidase 34 | 0.0378817 |
| CPOX | coproporphyrinogen oxidase | 0.037414 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0368297 |
| YEATS2 | YEATS domain containing 2 | 0.0355518 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0355043 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0351305 |
| RPL3 | ribosomal protein L3 | 0.0345955 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0344438 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0337429 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0337142 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0337035 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0335779 |
| LDHA | lactate dehydrogenase A | 0.033441 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0332803 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.0331959 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0330549 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0330117 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0328213 |
| DSPP | dentin sialophosphoprotein | 0.0325621 |
| VIM | vimentin | 0.0322221 |
| XPOT | exportin, tRNA | 0.0319147 |
| TNPO1 | transportin 1 | 0.0317813 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0317745 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0316831 |
| MED13L | mediator complex subunit 13-like | 0.0312109 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.031158 |
| IPO7 | importin 7 | 0.0311044 |
| NEBL | nebulette | 0.030259 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.0301988 |
| TPR | translocated promoter region, nuclear basket protein | 0.0301916 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.030133 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0299606 |
| FBXO11 | F-box protein 11 | 0.0299568 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0295708 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0292485 |
| CLDND1 | claudin domain containing 1 | 0.0292098 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0292074 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0290682 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0289633 |
| IL6ST | interleukin 6 signal transducer | 0.0289497 |
| USP53 | ubiquitin specific peptidase 53 | 0.0287929 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.028458 |
| RRM2 | ribonucleotide reductase M2 | 0.0283849 |
| SPAG9 | sperm associated antigen 9 | 0.0282703 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | 0.0281518 |
| CEP350 | centrosomal protein 350kDa | 0.0281147 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0280525 |
| NUP58 | nucleoporin 58 | 0.0280256 |
| NCKAP1 | NCK-associated protein 1 | 0.0280011 |
| YME1L1 | YME1-like 1 ATPase | 0.0279326 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0278868 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0277482 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0275584 |
| CCNL1 | cyclin L1 | 0.0272964 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0272804 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0271449 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.329069 |
| TMSB10 | thymosin beta 10 | -0.191019 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0825229 |
| ACTG1 | actin gamma 1 | -0.0673553 |
| RPS6 | ribosomal protein S6 | -0.0635462 |
| FTL | ferritin, light polypeptide | -0.0599942 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.059389 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0589539 |
| POTEF | POTE ankyrin domain family, member F | -0.0534869 |
| RPL19 | ribosomal protein L19 | -0.045466 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.04271 |
| CCND1 | cyclin D1 | -0.0397934 |
| RPL28 | ribosomal protein L28 | -0.0397318 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0390669 |
| RPS23 | ribosomal protein S23 | -0.0378579 |
| RPS15 | ribosomal protein S15 | -0.0376809 |
| RPLP1 | ribosomal protein, large, P1 | -0.0375263 |
| TUBA1B | tubulin, alpha 1b | -0.0373997 |
| CCN2 | cellular communication network factor 2 | -0.0373278 |
| RPLP0 | ribosomal protein, large, P0 | -0.0358211 |
| RPS19 | ribosomal protein S19 | -0.0351723 |
| RPLP2 | ribosomal protein, large, P2 | -0.0333058 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0330283 |
| ZNF804A | zinc finger protein 804A | -0.0326825 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0320644 |
| AHNAK | AHNAK nucleoprotein | -0.0318043 |
| RPL9 | ribosomal protein L9 | -0.0313493 |
| RPS16 | ribosomal protein S16 | -0.0313209 |
| RPL35A | ribosomal protein L35a | -0.030981 |
| HMGA1 | high mobility group AT-hook 1 | -0.0309473 |
| RPS21 | ribosomal protein S21 | -0.0307362 |
| RPS29 | ribosomal protein S29 | -0.0304747 |
| KLF6 | Kruppel-like factor 6 | -0.0302017 |
| RPS5 | ribosomal protein S5 | -0.0300214 |
| RPS24 | ribosomal protein S24 | -0.0289547 |
| NLGN1 | neuroligin 1 | -0.0286615 |
| CENPE | centromere protein E, 312kDa | -0.0270367 |
| RPS20 | ribosomal protein S20 | -0.0263214 |
| TBCA | tubulin folding cofactor A | -0.025782 |
| RPS14 | ribosomal protein S14 | -0.0250263 |
| RPL27 | ribosomal protein L27 | -0.0247577 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0245125 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0243388 |
| RPS8 | ribosomal protein S8 | -0.0243121 |
| RPL5 | ribosomal protein L5 | -0.0242411 |
| RPL12 | ribosomal protein L12 | -0.0241506 |
| TUBB | tubulin, beta class I | -0.0240516 |
| HMGB1 | high mobility group box 1 | -0.0236715 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0236543 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0231048 |
| RPL34 | ribosomal protein L34 | -0.02281 |
| RPS10 | ribosomal protein S10 | -0.0227839 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0227649 |
| DHX36 | DEAH (Asp-Glu-Ala-His) box polypeptide 36 | -0.0220273 |
| RPS4X | ribosomal protein S4, X-linked | -0.0217118 |
| RPL38 | ribosomal protein L38 | -0.0216829 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0216782 |
| RTN4 | reticulon 4 | -0.0216117 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0215754 |
| PCDH7 | protocadherin 7 | -0.0211631 |
| RPS13 | ribosomal protein S13 | -0.0204796 |
| CDK6 | cyclin-dependent kinase 6 | -0.0203688 |
| SYT1 | synaptotagmin I | -0.020355 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0202864 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0198513 |
| RPS11 | ribosomal protein S11 | -0.0198198 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0197351 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0192042 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0190401 |
| UQCRQ | ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa | -0.0189288 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0187396 |
| RPL36 | ribosomal protein L36 | -0.0186488 |
| FUS | FUS RNA binding protein | -0.0186301 |
| RASAL2 | RAS protein activator like 2 | -0.0183608 |
| EGR1 | early growth response 1 | -0.0182904 |
| GNAS | GNAS complex locus | -0.0182394 |
| S100A10 | S100 calcium binding protein A10 | -0.0180703 |
| MAP1B | microtubule-associated protein 1B | -0.0179237 |
| VDAC1 | voltage-dependent anion channel 1 | -0.017766 |
| RPL35 | ribosomal protein L35 | -0.0176815 |
| YAP1 | Yes-associated protein 1 | -0.0176051 |
| WDR45B | WD repeat domain 45B | -0.0173558 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0172075 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0170921 |
| DIAPH3 | diaphanous-related formin 3 | -0.0169239 |
| RPL13A | ribosomal protein L13a | -0.0169078 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0166526 |
| TGM2 | transglutaminase 2 | -0.0165976 |
| MYPN | myopalladin | -0.0165944 |
| BTG3 | BTG family, member 3 | -0.0165249 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0165239 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0164371 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0163949 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0162692 |
| TUBB6 | tubulin, beta 6 class V | -0.0161242 |
| CBX3 | chromobox homolog 3 | -0.0160097 |
| CEP112 | centrosomal protein 112kDa | -0.0159832 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0159814 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0158203 |
| RAN | RAN, member RAS oncogene family | -0.0157416 |
