| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ataluren perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ataluren_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.427247 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.207167 |
| CALR | calreticulin | 0.104956 |
| MT2A | metallothionein 2A | 0.0949912 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0938431 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0869159 |
| NDRG1 | N-myc downstream regulated 1 | 0.0758743 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0750883 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0647675 |
| CADM1 | cell adhesion molecule 1 | 0.0592245 |
| ATP13A3 | ATPase type 13A3 | 0.0531449 |
| LDHA | lactate dehydrogenase A | 0.0525315 |
| ENO1 | enolase 1, (alpha) | 0.0497379 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0424949 |
| ARRDC3 | arrestin domain containing 3 | 0.0417938 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0412798 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0410256 |
| ZNF292 | zinc finger protein 292 | 0.0400708 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0397254 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0386804 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0378271 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0358748 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0356672 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0352729 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0343289 |
| CD44 | CD44 molecule (Indian blood group) | 0.0340783 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0335254 |
| DST | dystonin | 0.0331483 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0331315 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0328074 |
| B2M | beta-2-microglobulin | 0.032122 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0316201 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0313032 |
| SFTPA2 | surfactant protein A2 | 0.0311691 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0311166 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0309369 |
| RPL3 | ribosomal protein L3 | 0.0308077 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.030292 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0300843 |
| RPS12 | ribosomal protein S12 | 0.0296816 |
| SMAD3 | SMAD family member 3 | 0.0288348 |
| SPAG9 | sperm associated antigen 9 | 0.0286161 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0282868 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0279664 |
| APP | amyloid beta (A4) precursor protein | 0.0278711 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0275263 |
| SPCS2 | signal peptidase complex subunit 2 homolog (S. cerevisiae) | 0.0273943 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.027305 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0270964 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0267714 |
| SET | SET nuclear proto-oncogene | 0.0266744 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0257493 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0256491 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0253152 |
| MLEC | malectin | 0.0252338 |
| NUP58 | nucleoporin 58 | 0.0249399 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0247084 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0246943 |
| ANXA5 | annexin A5 | 0.0243533 |
| PTMA | prothymosin, alpha | 0.0241106 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0239365 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0238094 |
| ANLN | anillin, actin binding protein | 0.0236686 |
| MKI67 | marker of proliferation Ki-67 | 0.0235317 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0234365 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0234089 |
| HYOU1 | hypoxia up-regulated 1 | 0.0233578 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.02329 |
| RNF145 | ring finger protein 145 | 0.0232808 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0232748 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0229864 |
| CCNL1 | cyclin L1 | 0.0229633 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0229311 |
| MATR3 | matrin 3 | 0.0228016 |
| MRTFA | myocardin related transcription factor A | 0.02271 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0225719 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0222398 |
| LOXL2 | lysyl oxidase-like 2 | 0.0219331 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0216494 |
| TFG | TRK-fused gene | 0.0212026 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0211744 |
| MTSS1 | metastasis suppressor 1 | 0.0211065 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0210119 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0209854 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0208184 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0206878 |
| GADD45B | growth arrest and DNA-damage-inducible, beta | 0.0206183 |
| CENPF | centromere protein F, 350/400kDa | 0.0205155 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0203266 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0202621 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0202511 |
| TMF1 | TATA element modulatory factor 1 | 0.0199459 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0198535 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0197569 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0197524 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0195435 |
| POSTN | periostin, osteoblast specific factor | 0.0194464 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0193502 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0192225 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0190142 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.349316 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.23576 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.160096 |
| FN1 | fibronectin 1 | -0.153964 |
| COL1A1 | collagen, type I, alpha 1 | -0.119432 |
| ACTG1 | actin gamma 1 | -0.0790719 |
| CDH13 | cadherin 13 | -0.0623339 |
| VIM | vimentin | -0.0614795 |
| IER3 | immediate early response 3 | -0.0578405 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0577167 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0559244 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0546308 |
| FBN1 | fibrillin 1 | -0.0506688 |
| AHNAK | AHNAK nucleoprotein | -0.050565 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0490382 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0460611 |
| UBC | ubiquitin C | -0.0442109 |
| RPS6 | ribosomal protein S6 | -0.0426677 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0387643 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0385972 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0372758 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0362502 |
| RPL28 | ribosomal protein L28 | -0.0362253 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0351541 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0348838 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0336438 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0320723 |
| SP100 | SP100 nuclear antigen | -0.0319614 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0314275 |
| POTEF | POTE ankyrin domain family, member F | -0.030596 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0305858 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0300101 |
| THY1 | Thy-1 cell surface antigen | -0.0289225 |
| PXDN | peroxidasin | -0.0288199 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0284888 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0280098 |
| IL6 | interleukin 6 | -0.0274083 |
| RPS8 | ribosomal protein S8 | -0.0272374 |
| GLIS3 | GLIS family zinc finger 3 | -0.0267086 |
| RPS24 | ribosomal protein S24 | -0.026626 |
| COL1A2 | collagen, type I, alpha 2 | -0.0264642 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0260119 |
| RPLP0 | ribosomal protein, large, P0 | -0.0256955 |
| MTDH | metadherin | -0.0256682 |
| ANXA2 | annexin A2 | -0.025508 |
| HLA-B | major histocompatibility complex, class I, B | -0.0254954 |
| RPS5 | ribosomal protein S5 | -0.0247018 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0237058 |
| NAV1 | neuron navigator 1 | -0.0236136 |
| RPS16 | ribosomal protein S16 | -0.0227585 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0227547 |
| OSMR | oncostatin M receptor | -0.022375 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.021864 |
| SQSTM1 | sequestosome 1 | -0.0217478 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0216396 |
| CLMP | CXADR-like membrane protein | -0.0215635 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0213845 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0213826 |
| GOLGB1 | golgin B1 | -0.0212765 |
| RPL8 | ribosomal protein L8 | -0.0212351 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.021204 |
| TUBB | tubulin, beta class I | -0.0211467 |
| CCND1 | cyclin D1 | -0.0211005 |
| ATXN1 | ataxin 1 | -0.0209343 |
| HMGA2 | high mobility group AT-hook 2 | -0.0207501 |
| NEK10 | NIMA-related kinase 10 | -0.0205856 |
| HDLBP | high density lipoprotein binding protein | -0.0205167 |
| RRBP1 | ribosome binding protein 1 | -0.0205068 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0204915 |
| TUBA1B | tubulin, alpha 1b | -0.0201614 |
| RPS15 | ribosomal protein S15 | -0.0200649 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0191287 |
| FOXP1 | forkhead box P1 | -0.019014 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0189922 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0188235 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0187073 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0185531 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0185527 |
| RPS11 | ribosomal protein S11 | -0.0185428 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0184423 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.018422 |
| CNTN5 | contactin 5 | -0.0181496 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0180537 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0176143 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0175199 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0173519 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0173353 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0173329 |
| GNAS | GNAS complex locus | -0.0172726 |
| CALD1 | caldesmon 1 | -0.0171789 |
| INHBA | inhibin, beta A | -0.0171254 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0168552 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0168376 |
| PRKCA | protein kinase C, alpha | -0.0167609 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0163169 |
| RTN3 | reticulon 3 | -0.0157825 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0157675 |
| TAPBP | TAP binding protein (tapasin) | -0.0156487 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0156242 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0154064 |
