| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ataluren perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ataluren_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | 0.216408 |
| IGF2 | insulin-like growth factor 2 | 0.182359 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.129579 |
| TF | transferrin | 0.116359 |
| CFB | complement factor B | 0.108552 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0813935 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0713787 |
| DSPP | dentin sialophosphoprotein | 0.0683649 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0666157 |
| AFDN | afadin, adherens junction formation factor | 0.0649 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0574974 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0571492 |
| SFTPA2 | surfactant protein A2 | 0.0502412 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0490658 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0481416 |
| C3 | complement component 3 | 0.0469783 |
| KIF5B | kinesin family member 5B | 0.0442465 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | 0.0433766 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0430249 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0417731 |
| RBM39 | RNA binding motif protein 39 | 0.0404778 |
| MATR3 | matrin 3 | 0.0401535 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0399782 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0393378 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0388356 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0381283 |
| SERPINA5 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 | 0.0364274 |
| CPE | carboxypeptidase E | 0.0355777 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0351192 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.033855 |
| A2M | alpha-2-macroglobulin | 0.033681 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.0326863 |
| SET | SET nuclear proto-oncogene | 0.0326015 |
| LDHA | lactate dehydrogenase A | 0.032039 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0313658 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0304412 |
| RPS12 | ribosomal protein S12 | 0.0302568 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0301653 |
| SPAG9 | sperm associated antigen 9 | 0.0285712 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0285237 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0277827 |
| SETD2 | SET domain containing 2 | 0.0275766 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0274391 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0273854 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0270765 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0268907 |
| CALR | calreticulin | 0.0267672 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0265735 |
| CCNL1 | cyclin L1 | 0.0257587 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0254936 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0253725 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0253707 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0253338 |
| RBM33 | RNA binding motif protein 33 | 0.025224 |
| PEG3 | paternally expressed 3 | 0.0251742 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0251307 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0248068 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0246992 |
| RAPGEF1 | Rap guanine nucleotide exchange factor (GEF) 1 | 0.0245713 |
| CCNY | cyclin Y | 0.0242253 |
| ICAM1 | intercellular adhesion molecule 1 | 0.0241899 |
| OLA1 | Obg-like ATPase 1 | 0.0240715 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.023826 |
| INSIG2 | insulin induced gene 2 | 0.023518 |
| VEGFA | vascular endothelial growth factor A | 0.0234831 |
| SLK | STE20-like kinase | 0.0230183 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0230113 |
| ZNF148 | zinc finger protein 148 | 0.0229671 |
| HLF | hepatic leukemia factor | 0.0228326 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0227466 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0225991 |
| RPS7 | ribosomal protein S7 | 0.0225218 |
| WAPL | WAPL cohesin release factor | 0.022358 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0220977 |
| CD109 | CD109 molecule | 0.0219765 |
| DENND5A | DENN/MADD domain containing 5A | 0.0219641 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0219007 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0218225 |
| OPTN | optineurin | 0.0218192 |
| ZNF292 | zinc finger protein 292 | 0.021431 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.021343 |
| RPL3 | ribosomal protein L3 | 0.0212818 |
| PHYHIPL | phytanoyl-CoA 2-hydroxylase interacting protein-like | 0.0212444 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0211868 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.021173 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0211193 |
| TNS1 | tensin 1 | 0.0210144 |
| CUL3 | cullin 3 | 0.0207183 |
| FBXO42 | F-box protein 42 | 0.0206912 |
| PEG10 | paternally expressed 10 | 0.0205643 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | 0.0204286 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0204194 |
| FGG | fibrinogen gamma chain | 0.0203452 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.020136 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0201157 |
| JMJD1C | jumonji domain containing 1C | 0.0199254 |
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | 0.019864 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | 0.0197702 |
| TPM3 | tropomyosin 3 | 0.0197541 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0197118 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.29182 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.21576 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.210871 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.133888 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.112876 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0950644 |
| UBC | ubiquitin C | -0.0916197 |
| APOA2 | apolipoprotein A-II | -0.0736505 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0731875 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0705954 |
| RPS27A | ribosomal protein S27a | -0.0698762 |
| FRMD5 | FERM domain containing 5 | -0.0685763 |
| RPS24 | ribosomal protein S24 | -0.0669194 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0662341 |
| ATXN1 | ataxin 1 | -0.0652447 |
| TMSB10 | thymosin beta 10 | -0.0646576 |
| SVIL | supervillin | -0.0636985 |
| FN1 | fibronectin 1 | -0.0635614 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0630013 |
| RPS6 | ribosomal protein S6 | -0.0625422 |
| EHBP1 | EH domain binding protein 1 | -0.0611022 |
| GPC6 | glypican 6 | -0.0605676 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0573623 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0553025 |
| FOXP1 | forkhead box P1 | -0.0534709 |
| ASPH | aspartate beta-hydroxylase | -0.0534671 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.0516715 |
| PLIN2 | perilipin 2 | -0.0496937 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0483441 |
| PARD3 | par-3 family cell polarity regulator | -0.0443864 |
| RPS8 | ribosomal protein S8 | -0.0437616 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0431847 |
| FAM107B | family with sequence similarity 107, member B | -0.0426796 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0425986 |
| AHNAK | AHNAK nucleoprotein | -0.0423249 |
| HMGA1 | high mobility group AT-hook 1 | -0.0418989 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.041696 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0416071 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0415317 |
| GK | glycerol kinase | -0.0414544 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0414482 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.039017 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0382584 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0379182 |
| AHSG | alpha-2-HS-glycoprotein | -0.037848 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0375221 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0365818 |
| ACTG1 | actin gamma 1 | -0.036567 |
| POTEF | POTE ankyrin domain family, member F | -0.0365002 |
| VCL | vinculin | -0.0364652 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0362442 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0361516 |
| RPS5 | ribosomal protein S5 | -0.0359407 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0356264 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0349226 |
| RPL5 | ribosomal protein L5 | -0.0343752 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0341212 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0336787 |
| PKM | pyruvate kinase, muscle | -0.0336774 |
| TPM4 | tropomyosin 4 | -0.0334853 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0329046 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0325269 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0324817 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0322284 |
| RRBP1 | ribosome binding protein 1 | -0.0313955 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0311556 |
| RPL9 | ribosomal protein L9 | -0.0310816 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.031066 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | -0.030981 |
| JUN | jun proto-oncogene | -0.0308445 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0303921 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0303187 |
| RPS25 | ribosomal protein S25 | -0.0302033 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.029665 |
| STK17A | serine/threonine kinase 17a | -0.029646 |
| PLXDC2 | plexin domain containing 2 | -0.0296376 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0293457 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0290466 |
| ENO1 | enolase 1, (alpha) | -0.0289151 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0283823 |
| RPLP0 | ribosomal protein, large, P0 | -0.0281437 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0280407 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0280232 |
| RPL28 | ribosomal protein L28 | -0.0275111 |
| VMP1 | vacuole membrane protein 1 | -0.0274012 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.027289 |
| RPLP2 | ribosomal protein, large, P2 | -0.0271863 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0271791 |
| RPL38 | ribosomal protein L38 | -0.0271486 |
| PTCHD4 | patched domain containing 4 | -0.0271041 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0261925 |
| RPS29 | ribosomal protein S29 | -0.0261063 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0258033 |
| TXNRD1 | thioredoxin reductase 1 | -0.0256144 |
| DSTN | destrin (actin depolymerizing factor) | -0.0252947 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0252836 |
| BCL2L1 | BCL2-like 1 | -0.0252681 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0249056 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0248353 |
| KYNU | kynureninase | -0.0246888 |
