| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ataluren perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ataluren_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | 0.16248 |
| MCL1 | myeloid cell leukemia 1 | 0.130364 |
| LAMC2 | laminin, gamma 2 | 0.104332 |
| SLTM | SAFB-like, transcription modulator | 0.0815405 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0716018 |
| MKI67 | marker of proliferation Ki-67 | 0.0660417 |
| SPAG9 | sperm associated antigen 9 | 0.059017 |
| ARRDC3 | arrestin domain containing 3 | 0.0547023 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0539715 |
| FAM13A | family with sequence similarity 13, member A | 0.0539448 |
| CCNL1 | cyclin L1 | 0.0522271 |
| TSC22D2 | TSC22 domain family, member 2 | 0.050832 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0496378 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.047907 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.04749 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0471766 |
| GSK3B | glycogen synthase kinase 3 beta | 0.04656 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0425138 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0419021 |
| LAMB3 | laminin, beta 3 | 0.0417147 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.041701 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0415314 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0407027 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0394762 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0391829 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0386523 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0385718 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0384173 |
| PCBP2 | poly(rC) binding protein 2 | 0.03602 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0358531 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0357666 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0355343 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0352388 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.035154 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0349789 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0346293 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0343395 |
| NGLY1 | N-glycanase 1 | 0.0342865 |
| SPCS2 | signal peptidase complex subunit 2 homolog (S. cerevisiae) | 0.0339583 |
| TPM3 | tropomyosin 3 | 0.0334474 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0334063 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0319305 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0315158 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0310703 |
| LDHA | lactate dehydrogenase A | 0.030953 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0307923 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0307625 |
| TOP1 | topoisomerase (DNA) I | 0.030338 |
| JMJD1C | jumonji domain containing 1C | 0.0302339 |
| PGK1 | phosphoglycerate kinase 1 | 0.0297452 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0296288 |
| USP53 | ubiquitin specific peptidase 53 | 0.0295662 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0289951 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0287092 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0285339 |
| CES1 | carboxylesterase 1 | 0.0282605 |
| CPE | carboxypeptidase E | 0.0282139 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0281295 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0281288 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0279994 |
| OGA | O-GlcNAcase | 0.0278193 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0274052 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0272944 |
| IRS2 | insulin receptor substrate 2 | 0.0272368 |
| TMEM165 | transmembrane protein 165 | 0.0269568 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0268372 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0267254 |
| LAMA4 | laminin, alpha 4 | 0.0266238 |
| CUL3 | cullin 3 | 0.0265271 |
| FAT1 | FAT atypical cadherin 1 | 0.0262152 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0261794 |
| RTN4 | reticulon 4 | 0.0261544 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0261169 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0261108 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0260976 |
| SLMAP | sarcolemma associated protein | 0.0259357 |
| MSN | moesin | 0.0259222 |
| NUP58 | nucleoporin 58 | 0.0252869 |
| SNX9 | sorting nexin 9 | 0.025101 |
| KLC1 | kinesin light chain 1 | 0.0250576 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0250033 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0246203 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.0245803 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0245768 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0244244 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0243501 |
| RNF145 | ring finger protein 145 | 0.0241656 |
| DSPP | dentin sialophosphoprotein | 0.0241007 |
| PTEN | phosphatase and tensin homolog | 0.0240784 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0238504 |
| RPS12 | ribosomal protein S12 | 0.0237123 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0236219 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0232995 |
| ESCO1 | establishment of sister chromatid cohesion N-acetyltransferase 1 | 0.0232888 |
| ITSN2 | intersectin 2 | 0.0232831 |
| ANO6 | anoctamin 6 | 0.0232817 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.023269 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0231625 |
| TFG | TRK-fused gene | 0.0230079 |
| KMT5B | lysine methyltransferase 5B | 0.0227137 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.422665 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0817266 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0662591 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0573825 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0540543 |
| ACTG1 | actin gamma 1 | -0.0514476 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0458706 |
| TMSB10 | thymosin beta 10 | -0.0433852 |
| INTS6 | integrator complex subunit 6 | -0.0393566 |
| RPS24 | ribosomal protein S24 | -0.0379019 |
| AHNAK | AHNAK nucleoprotein | -0.0377784 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.035791 |
| GRAMD1B | GRAM domain containing 1B | -0.0348788 |
| EMP1 | epithelial membrane protein 1 | -0.0347367 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0347111 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.034314 |
| RPLP1 | ribosomal protein, large, P1 | -0.0330823 |
| CCND1 | cyclin D1 | -0.032369 |
| HDLBP | high density lipoprotein binding protein | -0.0323463 |
| S100A10 | S100 calcium binding protein A10 | -0.0308094 |
| FTL | ferritin, light polypeptide | -0.0303226 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.030115 |
| RPS25 | ribosomal protein S25 | -0.0284915 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0284552 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0274828 |
| PTMA | prothymosin, alpha | -0.0272365 |
| ANXA2 | annexin A2 | -0.0271998 |
| RPS8 | ribosomal protein S8 | -0.0264468 |
| PKM | pyruvate kinase, muscle | -0.026128 |
| RPLP0 | ribosomal protein, large, P0 | -0.025456 |
| IER3 | immediate early response 3 | -0.0251723 |
| ASPH | aspartate beta-hydroxylase | -0.0244791 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0236201 |
| EGFR | epidermal growth factor receptor | -0.0229038 |
| GM2A | GM2 ganglioside activator | -0.0226397 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0224828 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0222847 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0221217 |
| KRT7 | keratin 7, type II | -0.0214232 |
| RPL34 | ribosomal protein L34 | -0.0207054 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0200345 |
| RPS23 | ribosomal protein S23 | -0.0197796 |
| RPS29 | ribosomal protein S29 | -0.0196858 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0190916 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0188986 |
| SMYD3 | SET and MYND domain containing 3 | -0.0188551 |
| AGR2 | anterior gradient 2 | -0.0187841 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0187386 |
| HBP1 | HMG-box transcription factor 1 | -0.0187355 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0186092 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0185604 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0184173 |
| RPS27A | ribosomal protein S27a | -0.0182317 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0179004 |
| RACK1 | receptor for activated C kinase 1 | -0.0178591 |
| RPS16 | ribosomal protein S16 | -0.0178009 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.0173421 |
| RPL38 | ribosomal protein L38 | -0.0172886 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0167629 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0167403 |
| TKT | transketolase | -0.0166697 |
| SP100 | SP100 nuclear antigen | -0.0165672 |
| HOMER1 | homer scaffolding protein 1 | -0.0165454 |
| NBEAL1 | neurobeachin-like 1 | -0.0161024 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0160862 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0160159 |
| IRF1 | interferon regulatory factor 1 | -0.0159183 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0157936 |
| RPL19 | ribosomal protein L19 | -0.0157085 |
| RNF213 | ring finger protein 213 | -0.0156974 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0156114 |
| HLA-B | major histocompatibility complex, class I, B | -0.0154702 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0153434 |
| RPL8 | ribosomal protein L8 | -0.0151755 |
| RPS15 | ribosomal protein S15 | -0.0151254 |
| GNAS | GNAS complex locus | -0.0150504 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0148126 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0147666 |
| RPL39 | ribosomal protein L39 | -0.0147004 |
| ARF1 | ADP-ribosylation factor 1 | -0.0145694 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0145438 |
| RPS21 | ribosomal protein S21 | -0.0142199 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0141737 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0141683 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | -0.0141382 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0141071 |
| SMIM14 | small integral membrane protein 14 | -0.0139771 |
| GOLGB1 | golgin B1 | -0.0138784 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0138775 |
| CD99 | CD99 molecule | -0.0138054 |
| RPLP2 | ribosomal protein, large, P2 | -0.0137852 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | -0.0137224 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.013704 |
| ABLIM1 | actin binding LIM protein 1 | -0.0136893 |
| RPL6 | ribosomal protein L6 | -0.0136503 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0136424 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0135975 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0135708 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0134445 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0134171 |
