Ataluren_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Ataluren perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Ataluren_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.123614
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.112498
NAMPT nicotinamide phosphoribosyltransferase 0.104642
AKAP12 A kinase (PRKA) anchor protein 12 0.0942263
MYH9 myosin, heavy chain 9, non-muscle 0.0930917
NPC1 Niemann-Pick disease, type C1 0.0803638
USP34 ubiquitin specific peptidase 34 0.0761809
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0667185
EFNA5 ephrin-A5 0.0662419
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0647783
PRRC2C proline-rich coiled-coil 2C 0.0613535
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0605027
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0596575
KMT2C lysine (K)-specific methyltransferase 2C 0.058775
ELL2 elongation factor, RNA polymerase II, 2 0.0555865
CTNND1 catenin (cadherin-associated protein), delta 1 0.054778
SMAD3 SMAD family member 3 0.054691
PCBP2 poly(rC) binding protein 2 0.0533293
OGA O-GlcNAcase 0.0527987
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0517894
FLNB filamin B, beta 0.0496191
ARHGAP5 Rho GTPase activating protein 5 0.0495772
PRELID2 PRELI domain containing 2 0.0495512
PDIA6 protein disulfide isomerase family A, member 6 0.0470238
KDM3A lysine (K)-specific demethylase 3A 0.0456866
NAV2 neuron navigator 2 0.0456712
ESYT2 extended synaptotagmin-like protein 2 0.0454904
UBA6 ubiquitin-like modifier activating enzyme 6 0.0437934
SFTPA2 surfactant protein A2 0.0429256
UGCG UDP-glucose ceramide glucosyltransferase 0.0424432
FAM13A family with sequence similarity 13, member A 0.042231
SPAG9 sperm associated antigen 9 0.0421424
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0413996
GOLGA4 golgin A4 0.0408682
TRIO trio Rho guanine nucleotide exchange factor 0.0401121
RBM39 RNA binding motif protein 39 0.0396934
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0387189
PELI1 pellino E3 ubiquitin protein ligase 1 0.0385177
EEF2 eukaryotic translation elongation factor 2 0.0382813
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0380896
RAB8B RAB8B, member RAS oncogene family 0.0378366
NGLY1 N-glycanase 1 0.0376055
ATP13A3 ATPase type 13A3 0.0375721
ADD3 adducin 3 (gamma) 0.0366784
SOD2 superoxide dismutase 2, mitochondrial 0.0360826
SRRM2 serine/arginine repetitive matrix 2 0.0360107
DSCAM Down syndrome cell adhesion molecule 0.0359827
KIF5B kinesin family member 5B 0.0359532
IL6ST interleukin 6 signal transducer 0.035196
FAM3C family with sequence similarity 3, member C 0.0350062
ANKRD11 ankyrin repeat domain 11 0.0348583
ITGAV integrin, alpha V 0.0344075
APP amyloid beta (A4) precursor protein 0.0343553
RAB6A RAB6A, member RAS oncogene family 0.0342499
ITCH itchy E3 ubiquitin protein ligase 0.0337019
RICTOR RPTOR independent companion of MTOR, complex 2 0.0321332
BMAL2 basic helix-loop-helix ARNT like 2 0.0319982
BIRC6 baculoviral IAP repeat containing 6 0.0317217
JMJD1C jumonji domain containing 1C 0.0316364
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0313095
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0312814
CALR calreticulin 0.0311702
KTN1 kinectin 1 (kinesin receptor) 0.0311301
FMNL2 formin-like 2 0.0309864
MYO1B myosin IB 0.0305574
SET SET nuclear proto-oncogene 0.0304391
AMPD3 adenosine monophosphate deaminase 3 0.0304374
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.030388
SAMD4A sterile alpha motif domain containing 4A 0.0302
CSDE1 cold shock domain containing E1, RNA-binding 0.0301625
NBAS neuroblastoma amplified sequence 0.0300919
SPRED1 sprouty-related, EVH1 domain containing 1 0.0300671
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.02989
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0297544
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0296284
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0293711
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0291562
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0286825
SREBF2 sterol regulatory element binding transcription factor 2 0.0284332
ZEB2 zinc finger E-box binding homeobox 2 0.0282365
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0281197
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0281075
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.028093
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0280923
TPM3 tropomyosin 3 0.0280912
ZFC3H1 zinc finger, C3H1-type containing 0.0279715
AGFG1 ArfGAP with FG repeats 1 0.0278864
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0274904
TPR translocated promoter region, nuclear basket protein 0.027227
SMAD4 SMAD family member 4 0.0271225
KLC1 kinesin light chain 1 0.0270014
PFKP phosphofructokinase, platelet 0.0269392
USP9X ubiquitin specific peptidase 9, X-linked 0.0268504
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0267858
SLTM SAFB-like, transcription modulator 0.026785
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0265361
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0264843
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0264816
ANKRD36 ankyrin repeat domain 36 0.0262378
NDRG1 N-myc downstream regulated 1 0.0260542

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.425826
FTL ferritin, light polypeptide -0.105019
VIM vimentin -0.101711
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0855709
TMSB10 thymosin beta 10 -0.0735156
RPLP1 ribosomal protein, large, P1 -0.0697873
ANKRD28 ankyrin repeat domain 28 -0.0652661
CD44 CD44 molecule (Indian blood group) -0.0643495
FTH1 ferritin, heavy polypeptide 1 -0.0638234
FN1 fibronectin 1 -0.0567769
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0516195
EGR1 early growth response 1 -0.0510349
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0488627
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0450564
RPLP0 ribosomal protein, large, P0 -0.0446171
RPS24 ribosomal protein S24 -0.0431815
NRG1 neuregulin 1 -0.0428007
PTMA prothymosin, alpha -0.042719
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0422876
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0412092
PDE4D phosphodiesterase 4D, cAMP-specific -0.040988
RPS6 ribosomal protein S6 -0.0406927
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0395701
RPL28 ribosomal protein L28 -0.0384639
AADAC arylacetamide deacetylase -0.0382553
IER3 immediate early response 3 -0.0377374
LOC102724023 ES1 protein homolog, mitochondrial -0.0375586
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0374549
MAP1B microtubule-associated protein 1B -0.0374146
PKM pyruvate kinase, muscle -0.03728
NTN4 netrin 4 -0.036148
RAB1A RAB1A, member RAS oncogene family -0.0353309
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0340693
S100A10 S100 calcium binding protein A10 -0.0338079
TPT1 tumor protein, translationally-controlled 1 -0.0337947
TNNC1 troponin C type 1 (slow) -0.0331022
IGFBP3 insulin-like growth factor binding protein 3 -0.0329029
POTEF POTE ankyrin domain family, member F -0.0325046
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.032493
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.032245
RPL19 ribosomal protein L19 -0.0317385
RPL34 ribosomal protein L34 -0.031433
GLIS3 GLIS family zinc finger 3 -0.0307706
RPS29 ribosomal protein S29 -0.0306215
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0300738
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0293811
RPLP2 ribosomal protein, large, P2 -0.0292827
S100A6 S100 calcium binding protein A6 -0.0289347
HMGA1 high mobility group AT-hook 1 -0.0284734
HILPDA hypoxia inducible lipid droplet-associated -0.0283839
RAB7A RAB7A, member RAS oncogene family -0.0280944
RPL12 ribosomal protein L12 -0.0280596
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0280436
RAD51B RAD51 paralog B -0.027946
VDAC1 voltage-dependent anion channel 1 -0.0278718
RPS8 ribosomal protein S8 -0.0276207
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0272573
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0272566
SEC31A SEC31 homolog A (S. cerevisiae) -0.0271314
AHNAK AHNAK nucleoprotein -0.0269763
RPL35A ribosomal protein L35a -0.0259687
MAML3 mastermind-like 3 (Drosophila) -0.0255455
RPS16 ribosomal protein S16 -0.0253862
MYADM myeloid-associated differentiation marker -0.0249003
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0248936
RPS21 ribosomal protein S21 -0.0243141
CDH13 cadherin 13 -0.0242679
RPL5 ribosomal protein L5 -0.0239506
RPS5 ribosomal protein S5 -0.0234642
RPS23 ribosomal protein S23 -0.0234163
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0233811
TGFB1 transforming growth factor, beta 1 -0.0231638
MX2 MX dynamin-like GTPase 2 -0.0226945
LOC112694756 uncharaterized LOC112694756 -0.0224744
TFPI2 tissue factor pathway inhibitor 2 -0.0221597
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0221567
EXT1 exostosin glycosyltransferase 1 -0.0219924
SUMF1 sulfatase modifying factor 1 -0.0216599
GPC6 glypican 6 -0.0207667
PTPRB protein tyrosine phosphatase, receptor type, B -0.0207167
SYAP1 synapse associated protein 1 -0.0207002
UBC ubiquitin C -0.0205726
C15ORF48 chromosome 15 open reading frame 48 -0.0205355
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0204062
ACTG1 actin gamma 1 -0.0203115
LMNA lamin A/C -0.0202492
TKT transketolase -0.0201449
GNAS GNAS complex locus -0.0201181
RPS25 ribosomal protein S25 -0.020058
EMP1 epithelial membrane protein 1 -0.0199359
SYT1 synaptotagmin I -0.0198887
RPL32 ribosomal protein L32 -0.0198732
CLIC4 chloride intracellular channel 4 -0.0198285
DPYD dihydropyrimidine dehydrogenase -0.0197955
RPS11 ribosomal protein S11 -0.0195512
TMEM263 transmembrane protein 263 -0.0194849
RPL38 ribosomal protein L38 -0.0193969
RPS20 ribosomal protein S20 -0.0193369
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0189791
BTG1 B-cell translocation gene 1, anti-proliferative -0.0187916