| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ataluren perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ataluren_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.110846 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.103089 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.102711 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.101738 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0997774 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0917977 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0862436 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0822576 |
| MKI67 | marker of proliferation Ki-67 | 0.0773075 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0724508 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0719102 |
| CALR | calreticulin | 0.0712399 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0703189 |
| TPM3 | tropomyosin 3 | 0.0678505 |
| MT2A | metallothionein 2A | 0.0619352 |
| GRAMD1B | GRAM domain containing 1B | 0.0615113 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0609174 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0575227 |
| ASPH | aspartate beta-hydroxylase | 0.0555285 |
| IGF2 | insulin-like growth factor 2 | 0.0490524 |
| PFDN2 | prefoldin subunit 2 | 0.0489088 |
| KIF5B | kinesin family member 5B | 0.0477434 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0474477 |
| RPL23 | ribosomal protein L23 | 0.047139 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0469427 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0467173 |
| SFTPA2 | surfactant protein A2 | 0.0455982 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0454667 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.04489 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0445977 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0438315 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0436958 |
| FGB | fibrinogen beta chain | 0.0432654 |
| MCL1 | myeloid cell leukemia 1 | 0.042471 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0391402 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0377582 |
| SET | SET nuclear proto-oncogene | 0.0373251 |
| CANX | calnexin | 0.0367847 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0367047 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0359811 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0333265 |
| RPS12 | ribosomal protein S12 | 0.0332165 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0327371 |
| DST | dystonin | 0.0322487 |
| GOLGA4 | golgin A4 | 0.03223 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.030535 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.030064 |
| CENPF | centromere protein F, 350/400kDa | 0.0299959 |
| PSMD11 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 | 0.0281898 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0281554 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0281315 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0274767 |
| RPL3 | ribosomal protein L3 | 0.027148 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0270804 |
| ANLN | anillin, actin binding protein | 0.0269793 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0263209 |
| HNRNPUL2 | heterogeneous nuclear ribonucleoprotein U-like 2 | 0.0262137 |
| SERINC3 | serine incorporator 3 | 0.0257212 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0255763 |
| TMED2 | transmembrane emp24 domain trafficking protein 2 | 0.0253497 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0253172 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0252346 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0248895 |
| NUP58 | nucleoporin 58 | 0.0244448 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0242368 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0242234 |
| PSMC6 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 0.0240614 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0240152 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0239006 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0238693 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0232186 |
| TNPO1 | transportin 1 | 0.0231062 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0229709 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0228178 |
| SP3 | Sp3 transcription factor | 0.0224536 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0220811 |
| MORF4L2 | mortality factor 4 like 2 | 0.0220438 |
| HYOU1 | hypoxia up-regulated 1 | 0.0218385 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0218039 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0215706 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0214182 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0211949 |
| IER3 | immediate early response 3 | 0.0206832 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0204657 |
| DSE | dermatan sulfate epimerase | 0.0204284 |
| RPL30 | ribosomal protein L30 | 0.0204254 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0204071 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0203904 |
| RPS15A | ribosomal protein S15a | 0.0203078 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0201707 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | 0.0200476 |
| RPS7 | ribosomal protein S7 | 0.0199911 |
| CALU | calumenin | 0.0198973 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.019794 |
| WDR43 | WD repeat domain 43 | 0.0197752 |
| TFG | TRK-fused gene | 0.0196704 |
| PLEC | plectin | 0.0196354 |
| FGG | fibrinogen gamma chain | 0.0194736 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0194201 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0191158 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.36906 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.132667 |
| TMSB10 | thymosin beta 10 | -0.119525 |
| FTL | ferritin, light polypeptide | -0.0982797 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0604756 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0583632 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0577824 |
| ACTG1 | actin gamma 1 | -0.0557823 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0542822 |
| POTEF | POTE ankyrin domain family, member F | -0.0541627 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.052937 |
| RPL19 | ribosomal protein L19 | -0.0501168 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0492133 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0471592 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0465938 |
| PKM | pyruvate kinase, muscle | -0.0456927 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0453323 |
| PARD3 | par-3 family cell polarity regulator | -0.0445984 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0436767 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0428184 |
| SIK3 | SIK family kinase 3 | -0.0410567 |
| VIM | vimentin | -0.0408683 |
| HDAC9 | histone deacetylase 9 | -0.0408677 |
| FMNL2 | formin-like 2 | -0.0393564 |
| S100A6 | S100 calcium binding protein A6 | -0.0384833 |
| RNF145 | ring finger protein 145 | -0.0368492 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0367507 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0360565 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0358391 |
| RBM25 | RNA binding motif protein 25 | -0.0349826 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0348604 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0347846 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0345622 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0333466 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.032678 |
| RPS5 | ribosomal protein S5 | -0.0323184 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0319597 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0319106 |
| COPA | coatomer protein complex, subunit alpha | -0.0315592 |
| FNBP1L | formin binding protein 1-like | -0.0315252 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.031284 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0307002 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0305695 |
| USP3 | ubiquitin specific peptidase 3 | -0.0305569 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0302907 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0299615 |
| MYADM | myeloid-associated differentiation marker | -0.0299211 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0298282 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0292051 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0291513 |
| TXNRD1 | thioredoxin reductase 1 | -0.0283553 |
| TPD52 | tumor protein D52 | -0.0280822 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0278222 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0276856 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0275332 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0274228 |
| AHR | aryl hydrocarbon receptor | -0.0268601 |
| S100A10 | S100 calcium binding protein A10 | -0.0267989 |
| BMPR1B | bone morphogenetic protein receptor, type IB | -0.0267807 |
| RPS16 | ribosomal protein S16 | -0.0266922 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0265607 |
| HMGA1 | high mobility group AT-hook 1 | -0.0261687 |
| KYNU | kynureninase | -0.0260781 |
| SVIL | supervillin | -0.0260235 |
| TMEM131 | transmembrane protein 131 | -0.0258298 |
| EFNA5 | ephrin-A5 | -0.0257925 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0256982 |
| UTRN | utrophin | -0.0256439 |
| PFN1 | profilin 1 | -0.0254448 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0252337 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.024969 |
| RASAL2 | RAS protein activator like 2 | -0.0248921 |
| RYK | receptor-like tyrosine kinase | -0.0248152 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0247881 |
| RPL13A | ribosomal protein L13a | -0.024597 |
| JMJD1C | jumonji domain containing 1C | -0.0242784 |
| TPI1 | triosephosphate isomerase 1 | -0.0240017 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0238321 |
| VDAC1 | voltage-dependent anion channel 1 | -0.023633 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | -0.0235572 |
| RPL28 | ribosomal protein L28 | -0.0235405 |
| PTK2 | protein tyrosine kinase 2 | -0.0234321 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0234031 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0229859 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0228065 |
| RPS6 | ribosomal protein S6 | -0.022795 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0225222 |
| RPS15 | ribosomal protein S15 | -0.0220389 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0220103 |
| NEBL | nebulette | -0.0218879 |
| AK1 | adenylate kinase 1 | -0.0217523 |
| HLA-A | major histocompatibility complex, class I, A | -0.021752 |
| EGFR | epidermal growth factor receptor | -0.0215638 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0212745 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0211409 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0209611 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.020649 |
| SLC38A2 | solute carrier family 38, member 2 | -0.020381 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0203253 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0202403 |
