| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ataluren perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ataluren_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.123659 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0957822 |
| RBM39 | RNA binding motif protein 39 | 0.0944464 |
| PGK1 | phosphoglycerate kinase 1 | 0.0852022 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0742918 |
| ZNF292 | zinc finger protein 292 | 0.0742305 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0675327 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0669707 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0658925 |
| NUP58 | nucleoporin 58 | 0.0644718 |
| CDC73 | cell division cycle 73 | 0.0634143 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0631105 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0623691 |
| CCNL1 | cyclin L1 | 0.060634 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0570006 |
| CERS6 | ceramide synthase 6 | 0.0567961 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0564528 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0552931 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0551167 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0548496 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0546549 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0543387 |
| ANKRD11 | ankyrin repeat domain 11 | 0.053898 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0538031 |
| FAM13A | family with sequence similarity 13, member A | 0.0514976 |
| PAPOLA | poly(A) polymerase alpha | 0.0512182 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0498842 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.0494891 |
| TCEA2 | transcription elongation factor A (SII), 2 | 0.0493226 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0489217 |
| LCORL | ligand dependent nuclear receptor corepressor-like | 0.0489018 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0487902 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0485341 |
| ACTN4 | actinin, alpha 4 | 0.0484787 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | 0.0476629 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0475817 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | 0.0473498 |
| DST | dystonin | 0.0461028 |
| HDLBP | high density lipoprotein binding protein | 0.0458939 |
| WDR43 | WD repeat domain 43 | 0.0450676 |
| GOLGA4 | golgin A4 | 0.0448614 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0443952 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.0439874 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0437076 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0433054 |
| NGLY1 | N-glycanase 1 | 0.0431518 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0429811 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0429445 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0429119 |
| HMBOX1 | homeobox containing 1 | 0.0427377 |
| KIF5B | kinesin family member 5B | 0.0425461 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0425375 |
| NF1 | neurofibromin 1 | 0.0425369 |
| SYT1 | synaptotagmin I | 0.042514 |
| GPC6 | glypican 6 | 0.0423838 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0422912 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0422214 |
| SCAF8 | SR-related CTD-associated factor 8 | 0.0421254 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0417963 |
| RLF | rearranged L-myc fusion | 0.0416961 |
| FMNL2 | formin-like 2 | 0.041241 |
| USP15 | ubiquitin specific peptidase 15 | 0.0410532 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0410435 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0405207 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0401164 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0400425 |
| PRRC2B | proline-rich coiled-coil 2B | 0.0397905 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0390058 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.038998 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.0385303 |
| PARD3 | par-3 family cell polarity regulator | 0.0385037 |
| TRA2B | transformer 2 beta homolog (Drosophila) | 0.0384642 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0382552 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0380793 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0379609 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0378354 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0378329 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0378093 |
| NCKAP1 | NCK-associated protein 1 | 0.0377834 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0377717 |
| TBL1X | transducin (beta)-like 1X-linked | 0.0377518 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0376405 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | 0.0375017 |
| ARRDC3 | arrestin domain containing 3 | 0.0373568 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0372582 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0371416 |
| SET | SET nuclear proto-oncogene | 0.0369338 |
| QKI | QKI, KH domain containing, RNA binding | 0.0368725 |
| ATP13A3 | ATPase type 13A3 | 0.0368663 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0368301 |
| NOP58 | NOP58 ribonucleoprotein | 0.036714 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0365764 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.036393 |
| RPS4X | ribosomal protein S4, X-linked | 0.0362772 |
| SPATA13 | spermatogenesis associated 13 | 0.036093 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0359764 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.035882 |
| TCF12 | transcription factor 12 | 0.0358383 |
| WDR26 | WD repeat domain 26 | 0.0356718 |
| PCM1 | pericentriolar material 1 | 0.0351182 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.187577 |
| TMSB10 | thymosin beta 10 | -0.155588 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.133998 |
| LMO7 | LIM domain 7 | -0.131511 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.113378 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.110429 |
| LAMB3 | laminin, beta 3 | -0.109096 |
| PRKCA | protein kinase C, alpha | -0.0978024 |
| ATOSA | atos homolog A | -0.0875086 |
| LAMC2 | laminin, gamma 2 | -0.0855664 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0855343 |
| B2M | beta-2-microglobulin | -0.0821958 |
| SMYD3 | SET and MYND domain containing 3 | -0.0767723 |
| FTL | ferritin, light polypeptide | -0.0743001 |
| RPS25 | ribosomal protein S25 | -0.0704392 |
| MT2A | metallothionein 2A | -0.0700405 |
| KATNBL1 | katanin p80 subunit B-like 1 | -0.0695135 |
| TXNRD1 | thioredoxin reductase 1 | -0.0692058 |
| VIM | vimentin | -0.0664357 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0659197 |
| MYO1E | myosin IE | -0.0649525 |
| AK1 | adenylate kinase 1 | -0.0624511 |
| HLA-A | major histocompatibility complex, class I, A | -0.0604515 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0586344 |
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced | -0.058362 |
| UBC | ubiquitin C | -0.0574659 |
| SVIL | supervillin | -0.0545873 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.054517 |
| RPL35A | ribosomal protein L35a | -0.0532404 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0528834 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0517131 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0513637 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.051272 |
| TPM4 | tropomyosin 4 | -0.0501304 |
| HLA-B | major histocompatibility complex, class I, B | -0.0500311 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0498698 |
| GLIS3 | GLIS family zinc finger 3 | -0.0493911 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0485552 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.047722 |
| KYNU | kynureninase | -0.0474496 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0470151 |
| KRT19 | keratin 19, type I | -0.0468169 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0467083 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0464161 |
| RPS21 | ribosomal protein S21 | -0.0448611 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0440891 |
| FN1 | fibronectin 1 | -0.0440875 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0438417 |
| S100A11 | S100 calcium binding protein A11 | -0.0437654 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0434336 |
| RAB22A | RAB22A, member RAS oncogene family | -0.0434021 |
| ANKLE2 | ankyrin repeat and LEM domain containing 2 | -0.0430024 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.042662 |
| GNAS | GNAS complex locus | -0.0420903 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0420863 |
| PKM | pyruvate kinase, muscle | -0.0419848 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.0411774 |
| RBM47 | RNA binding motif protein 47 | -0.0411058 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0410003 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0409966 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0409296 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0408929 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0406605 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0400856 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0400536 |
| S100A10 | S100 calcium binding protein A10 | -0.0400325 |
| TMCC3 | transmembrane and coiled-coil domain family 3 | -0.0397203 |
| CDCP1 | CUB domain containing protein 1 | -0.0396799 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0393803 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0389666 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0389635 |
| CD44 | CD44 molecule (Indian blood group) | -0.0388506 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0382565 |
| ANXA2 | annexin A2 | -0.0381858 |
| ERGIC1 | endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 | -0.0381824 |
| RPL15 | ribosomal protein L15 | -0.038037 |
| RPS11 | ribosomal protein S11 | -0.0379708 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0378848 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0378826 |
| RPS3 | ribosomal protein S3 | -0.0376014 |
| PRSS23 | protease, serine, 23 | -0.0375853 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0375623 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0374751 |
| RPS24 | ribosomal protein S24 | -0.0374361 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0373855 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0370496 |
| TJP1 | tight junction protein 1 | -0.036938 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0367993 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0366106 |
| CSTB | cystatin B (stefin B) | -0.0364578 |
| RPS23 | ribosomal protein S23 | -0.0364379 |
| JMJD1C | jumonji domain containing 1C | -0.0363807 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0363452 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0361653 |
| S100A6 | S100 calcium binding protein A6 | -0.0361452 |
| TMPRSS4 | transmembrane protease, serine 4 | -0.0361047 |
| GRB10 | growth factor receptor-bound protein 10 | -0.035684 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0356608 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0353825 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0353813 |
