| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Ataluren perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Ataluren_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.176639 |
| TXNRD1 | thioredoxin reductase 1 | 0.149809 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.112719 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0985081 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0965023 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0783832 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0764323 |
| MCL1 | myeloid cell leukemia 1 | 0.0599216 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.059877 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0596324 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0582988 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0580497 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0578625 |
| PCBP2 | poly(rC) binding protein 2 | 0.0538435 |
| OGA | O-GlcNAcase | 0.053124 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0489163 |
| XPO1 | exportin 1 | 0.0488529 |
| TPM3 | tropomyosin 3 | 0.0485274 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0484866 |
| MORF4L2 | mortality factor 4 like 2 | 0.0481838 |
| PGK1 | phosphoglycerate kinase 1 | 0.0475748 |
| KRT18 | keratin 18, type I | 0.0473975 |
| RAD51B | RAD51 paralog B | 0.0446935 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0441663 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0440462 |
| ANO6 | anoctamin 6 | 0.0437834 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0422406 |
| CLTC | clathrin, heavy chain (Hc) | 0.0420446 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0401289 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.039368 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0389555 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0377013 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0371109 |
| IPO7 | importin 7 | 0.0364314 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0362523 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.0359601 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0358271 |
| STK4 | serine/threonine kinase 4 | 0.0355849 |
| YBX3 | Y box binding protein 3 | 0.0353402 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.034771 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0340424 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0339722 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0337869 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0331462 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0329828 |
| LDHA | lactate dehydrogenase A | 0.0316607 |
| KDM7A | lysine (K)-specific demethylase 7A | 0.0316119 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0315032 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0312467 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.0312053 |
| DST | dystonin | 0.03109 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0310147 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0309668 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0307816 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0307631 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0301599 |
| MKI67 | marker of proliferation Ki-67 | 0.02997 |
| SMAP1 | small ArfGAP 1 | 0.0293027 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0291305 |
| RTN4 | reticulon 4 | 0.0290421 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | 0.0288657 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | 0.0287985 |
| GRAMD1B | GRAM domain containing 1B | 0.028766 |
| JMJD1C | jumonji domain containing 1C | 0.0287363 |
| ZNF638 | zinc finger protein 638 | 0.028627 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0281738 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0278658 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0277144 |
| MYO6 | myosin VI | 0.0276763 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0276637 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0276186 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0275125 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.027256 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.027028 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0269136 |
| PFDN2 | prefoldin subunit 2 | 0.0268882 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.026761 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0267423 |
| CCNL1 | cyclin L1 | 0.0265819 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | 0.026348 |
| SERINC3 | serine incorporator 3 | 0.0261092 |
| EPN2 | epsin 2 | 0.0259956 |
| PREPL | prolyl endopeptidase-like | 0.0256576 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0255839 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0253275 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0251674 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0250854 |
| BBX | bobby sox homolog (Drosophila) | 0.0250555 |
| UBC | ubiquitin C | 0.0250024 |
| RLIM | ring finger protein, LIM domain interacting | 0.0247557 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0246675 |
| MSH2 | mutS homolog 2 | 0.0246031 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0242183 |
| SMAD3 | SMAD family member 3 | 0.0241857 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0241032 |
| RPL3 | ribosomal protein L3 | 0.0239474 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0239158 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0238803 |
| MSH6 | mutS homolog 6 | 0.0238549 |
| NUP58 | nucleoporin 58 | 0.0236973 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.279189 |
| TMSB10 | thymosin beta 10 | -0.113589 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0677047 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0631296 |
| PTMA | prothymosin, alpha | -0.0560753 |
| POTEF | POTE ankyrin domain family, member F | -0.0555449 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0532765 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0468076 |
| PDE10A | phosphodiesterase 10A | -0.046263 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0456969 |
| RPLP1 | ribosomal protein, large, P1 | -0.0391587 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0387725 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0383811 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0381643 |
| RPL35A | ribosomal protein L35a | -0.0371857 |
| RPL5 | ribosomal protein L5 | -0.0348091 |
| ACTG1 | actin gamma 1 | -0.0342109 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0331052 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0316816 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0314594 |
| RPS15 | ribosomal protein S15 | -0.0314365 |
| RPS21 | ribosomal protein S21 | -0.0296855 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0296308 |
| OSMR | oncostatin M receptor | -0.0294657 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0290183 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0289859 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0287863 |
| HLA-B | major histocompatibility complex, class I, B | -0.0283196 |
| RPS27 | ribosomal protein S27 | -0.0282453 |
| DENND5B | DENN/MADD domain containing 5B | -0.0277888 |
| HMGA2 | high mobility group AT-hook 2 | -0.0273099 |
| TPM4 | tropomyosin 4 | -0.0271866 |
| RPL19 | ribosomal protein L19 | -0.0270119 |
| RPL28 | ribosomal protein L28 | -0.026663 |
| GNAS | GNAS complex locus | -0.0266469 |
| PFN1 | profilin 1 | -0.0262594 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0255204 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0253461 |
| FTL | ferritin, light polypeptide | -0.025109 |
| RYR3 | ryanodine receptor 3 | -0.0250979 |
| RPS19 | ribosomal protein S19 | -0.0249762 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0249359 |
| RPL12 | ribosomal protein L12 | -0.024379 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0241059 |
| EGR1 | early growth response 1 | -0.0239234 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0234388 |
| RPL38 | ribosomal protein L38 | -0.0232816 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0229105 |
| RBM25 | RNA binding motif protein 25 | -0.0228449 |
| PKM | pyruvate kinase, muscle | -0.0226336 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0223146 |
| ATG7 | autophagy related 7 | -0.0222321 |
| ATXN1 | ataxin 1 | -0.0221884 |
| RPL37A | ribosomal protein L37a | -0.0221668 |
| NEMF | nuclear export mediator factor | -0.021373 |
| SMIM44 | small integral membrane protein 44 | -0.0212514 |
| TAPBP | TAP binding protein (tapasin) | -0.0210433 |
| ITSN1 | intersectin 1 (SH3 domain protein) | -0.0209687 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0206442 |
| RPS8 | ribosomal protein S8 | -0.0206017 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0197073 |
| ETV6 | ets variant 6 | -0.0192681 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0191087 |
| CCND1 | cyclin D1 | -0.0187455 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.0186494 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | -0.018565 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0183491 |
| AP1S3 | adaptor-related protein complex 1, sigma 3 subunit | -0.0182816 |
| DEK | DEK proto-oncogene | -0.0181527 |
| TUBA1B | tubulin, alpha 1b | -0.0181525 |
| VCL | vinculin | -0.0181344 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.017999 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0177801 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0177184 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0174808 |
| EXOC4 | exocyst complex component 4 | -0.0173338 |
| CACNA2D1 | calcium channel, voltage-dependent, alpha 2/delta subunit 1 | -0.0172202 |
| RPL9 | ribosomal protein L9 | -0.0171851 |
| RPS6 | ribosomal protein S6 | -0.0171222 |
| CLDN1 | claudin 1 | -0.0169889 |
| BMP5 | bone morphogenetic protein 5 | -0.0167996 |
| PMP22 | peripheral myelin protein 22 | -0.0166769 |
| CBX3 | chromobox homolog 3 | -0.0166309 |
| RPL18 | ribosomal protein L18 | -0.0166206 |
| NME2 | NME/NM23 nucleoside diphosphate kinase 2 | -0.016476 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0163257 |
| RPLP2 | ribosomal protein, large, P2 | -0.016299 |
| EFNA5 | ephrin-A5 | -0.0161175 |
| RPS10 | ribosomal protein S10 | -0.0160319 |
| CD2AP | CD2-associated protein | -0.0159806 |
| PHF14 | PHD finger protein 14 | -0.015836 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0155706 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0154625 |
| RPS27A | ribosomal protein S27a | -0.0154363 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | -0.0154144 |
| CALD1 | caldesmon 1 | -0.0153855 |
| RPL27 | ribosomal protein L27 | -0.0153637 |
| COMMD10 | COMM domain containing 10 | -0.0153509 |
| RPS29 | ribosomal protein S29 | -0.0153435 |
| DDX27 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 | -0.0151847 |
