Atazanavir (sulfate)_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Atazanavir (sulfate) perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Atazanavir (sulfate)_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AREG amphiregulin 0.151386
PABPC1 poly(A) binding protein, cytoplasmic 1 0.108231
ANXA1 annexin A1 0.0758032
ERRFI1 ERBB receptor feedback inhibitor 1 0.0745649
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0652881
PCBP2 poly(rC) binding protein 2 0.0629298
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0586172
VMP1 vacuole membrane protein 1 0.0495936
CCNL1 cyclin L1 0.0471127
FXR1 fragile X mental retardation, autosomal homolog 1 0.0440194
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0398433
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0392271
PCNP PEST proteolytic signal containing nuclear protein 0.036493
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0359784
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0352958
SETD5 SET domain containing 5 0.0344404
MED13L mediator complex subunit 13-like 0.0334714
CPOX coproporphyrinogen oxidase 0.0328033
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.032299
TBK1 TANK-binding kinase 1 0.031799
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0309594
EEF2 eukaryotic translation elongation factor 2 0.0296021
USP34 ubiquitin specific peptidase 34 0.0285762
LDHA lactate dehydrogenase A 0.0282101
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0280047
PLK2 polo-like kinase 2 0.0276921
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0273763
GSK3B glycogen synthase kinase 3 beta 0.0269491
SRRM2 serine/arginine repetitive matrix 2 0.0268152
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0266324
UBC ubiquitin C 0.0259941
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0259312
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0253597
PNN pinin, desmosome associated protein 0.0250708
LDHB lactate dehydrogenase B 0.02496
EPHA6 EPH receptor A6 0.0249548
BIRC6 baculoviral IAP repeat containing 6 0.0245034
PRKCI protein kinase C, iota 0.024324
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0240249
AKAP9 A kinase (PRKA) anchor protein 9 0.0239888
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0239389
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0238833
CSNK1A1 casein kinase 1, alpha 1 0.0237989
ECT2 epithelial cell transforming 2 0.0235393
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0234504
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.023357
PCM1 pericentriolar material 1 0.0233047
DSCAM Down syndrome cell adhesion molecule 0.0230554
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0229302
RPL3 ribosomal protein L3 0.0227166
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.0226517
KLHL24 kelch-like family member 24 0.022497
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0223421
HDAC9 histone deacetylase 9 0.0222117
DST dystonin 0.0221354
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0220297
CLTC clathrin, heavy chain (Hc) 0.0220055
CDK19 cyclin-dependent kinase 19 0.0219833
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0216386
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0214772
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0213061
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0210991
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0207393
KMT2C lysine (K)-specific methyltransferase 2C 0.0207374
TPM3 tropomyosin 3 0.0206803
EEF1G eukaryotic translation elongation factor 1 gamma 0.0206725
SSRP1 structure specific recognition protein 1 0.0206167
ZNF292 zinc finger protein 292 0.0197679
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0196161
NUP58 nucleoporin 58 0.0195497
YAP1 Yes-associated protein 1 0.019516
BRD2 bromodomain containing 2 0.0193939
SET SET nuclear proto-oncogene 0.0192654
HDGF hepatoma-derived growth factor 0.0189984
NBAS neuroblastoma amplified sequence 0.0188297
YEATS2 YEATS domain containing 2 0.0187582
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0187265
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0187199
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0187107
ARRDC3 arrestin domain containing 3 0.0183878
KMT2E lysine (K)-specific methyltransferase 2E 0.0182354
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0181857
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.0181827
ARL5B ADP-ribosylation factor-like 5B 0.0181755
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0180402
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0178603
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0177841
ZBTB20 zinc finger and BTB domain containing 20 0.0177474
CLDND1 claudin domain containing 1 0.0176209
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0176038
PDIA6 protein disulfide isomerase family A, member 6 0.0175292
RPS7 ribosomal protein S7 0.0174181
ARHGAP12 Rho GTPase activating protein 12 0.0173395
TCP1 t-complex 1 0.0172556
WNK1 WNK lysine deficient protein kinase 1 0.0171886
RICTOR RPTOR independent companion of MTOR, complex 2 0.0171831
RB1CC1 RB1-inducible coiled-coil 1 0.0171076
PREPL prolyl endopeptidase-like 0.0171068
HMGA1 high mobility group AT-hook 1 0.0171009
KDM5A lysine (K)-specific demethylase 5A 0.0170857

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.206668
VIM vimentin -0.16066
NLGN1 neuroligin 1 -0.133473
RPL35A ribosomal protein L35a -0.0934145
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0859229
TPT1 tumor protein, translationally-controlled 1 -0.0836379
PTMA prothymosin, alpha -0.0772212
MYL12B myosin, light chain 12B, regulatory -0.0733387
RPLP1 ribosomal protein, large, P1 -0.0719293
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.0688941
ACTG1 actin gamma 1 -0.0604877
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0586823
PDE4D phosphodiesterase 4D, cAMP-specific -0.0496635
RPL23 ribosomal protein L23 -0.0484173
RPL38 ribosomal protein L38 -0.0467339
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0453863
RPS24 ribosomal protein S24 -0.041491
RPL26 ribosomal protein L26 -0.041443
RPL12 ribosomal protein L12 -0.0386195
RPL19 ribosomal protein L19 -0.0381585
RPLP2 ribosomal protein, large, P2 -0.0379001
RPL34 ribosomal protein L34 -0.037807
RPS8 ribosomal protein S8 -0.0359627
KPNB1 karyopherin (importin) beta 1 -0.0358563
RPS12 ribosomal protein S12 -0.0350568
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0350282
FTL ferritin, light polypeptide -0.0345052
IFIH1 interferon induced with helicase C domain 1 -0.033043
HMGB1 high mobility group box 1 -0.0324916
CAVIN1 caveolae associated protein 1 -0.0316861
CCND1 cyclin D1 -0.0306014
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.030597
RPS21 ribosomal protein S21 -0.0301859
RPS27A ribosomal protein S27a -0.0298951
DLC1 DLC1 Rho GTPase activating protein -0.0290733
PCDH7 protocadherin 7 -0.028843
RPL27 ribosomal protein L27 -0.0270616
RPS29 ribosomal protein S29 -0.0267421
HMGA2 high mobility group AT-hook 2 -0.0266542
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0258551
GNAS GNAS complex locus -0.0256613
ZNF804A zinc finger protein 804A -0.0256032
RPL37A ribosomal protein L37a -0.0255057
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0249051
RPS23 ribosomal protein S23 -0.0244824
CANX calnexin -0.0243853
RPL37 ribosomal protein L37 -0.0243224
RPL11 ribosomal protein L11 -0.0240198
RIMS2 regulating synaptic membrane exocytosis 2 -0.0229969
TAS2R14 taste receptor, type 2, member 14 -0.0219551
CALR calreticulin -0.021861
RPL5 ribosomal protein L5 -0.021689
KLF6 Kruppel-like factor 6 -0.0211072
RPLP0 ribosomal protein, large, P0 -0.0209328
RPS13 ribosomal protein S13 -0.0208499
RPS3 ribosomal protein S3 -0.0207967
VDAC1 voltage-dependent anion channel 1 -0.0205092
TM4SF1 transmembrane 4 L six family member 1 -0.0205049
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0204975
RASAL2 RAS protein activator like 2 -0.0200504
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0198657
RPL36 ribosomal protein L36 -0.0196236
RPL31 ribosomal protein L31 -0.0195487
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0195246
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.019513
CLDN1 claudin 1 -0.0190878
MTAP methylthioadenosine phosphorylase -0.019039
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0190118
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0187402
RPS20 ribosomal protein S20 -0.0186016
ANKRD12 ankyrin repeat domain 12 -0.0178976
BRI3BP BRI3 binding protein -0.0178904
OSMR oncostatin M receptor -0.0175314
RPS16 ribosomal protein S16 -0.017342
RPS19 ribosomal protein S19 -0.0172446
NFE2L2 nuclear factor, erythroid 2-like 2 -0.017211
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0171496
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0170881
RPL6 ribosomal protein L6 -0.0170795
TUBB tubulin, beta class I -0.0168266
CDK12 cyclin-dependent kinase 12 -0.016379
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0163516
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0162121
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0160398
RPS27 ribosomal protein S27 -0.0160034
COMMD10 COMM domain containing 10 -0.0159692
MYPN myopalladin -0.01579
UBTF upstream binding transcription factor, RNA polymerase I -0.0156872
RPS15 ribosomal protein S15 -0.0156521
RPL9 ribosomal protein L9 -0.015649
FUS FUS RNA binding protein -0.0155363
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0153095
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.01523
RPL28 ribosomal protein L28 -0.0151604
EDARADD EDAR-associated death domain -0.0151235
DNAH14 dynein, axonemal, heavy chain 14 -0.0151162
CNRIP1 cannabinoid receptor interacting protein 1 -0.015113
ATP5F1E ATP synthase F1 subunit epsilon -0.0149507
MARCHF4 membrane associated ring-CH-type finger 4 -0.0148643
ROMO1 reactive oxygen species modulator 1 -0.0144063