Atazanavir (sulfate)_A549 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Atazanavir (sulfate) perturbation in A549 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Atazanavir (sulfate)_A549 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.0648988
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0603256
MCL1 myeloid cell leukemia 1 0.0352657
TRIO trio Rho guanine nucleotide exchange factor 0.0340819
SOD2 superoxide dismutase 2, mitochondrial 0.0338199
MYH9 myosin, heavy chain 9, non-muscle 0.0330469
USP34 ubiquitin specific peptidase 34 0.0322633
FMNL2 formin-like 2 0.0320345
AKAP13 A kinase (PRKA) anchor protein 13 0.031726
CLTC clathrin, heavy chain (Hc) 0.0308324
NRIP1 nuclear receptor interacting protein 1 0.0298227
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0274316
ZCCHC7 zinc finger, CCHC domain containing 7 0.0269974
GOLGA4 golgin A4 0.0264958
ADAM17 ADAM metallopeptidase domain 17 0.0258074
BIRC6 baculoviral IAP repeat containing 6 0.0245133
SPAG9 sperm associated antigen 9 0.0243036
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0242543
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0241779
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0240121
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0224672
DSCAM Down syndrome cell adhesion molecule 0.0223633
FLNB filamin B, beta 0.0221286
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.021756
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0216975
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0216736
RB1CC1 RB1-inducible coiled-coil 1 0.0212827
SEC31A SEC31 homolog A (S. cerevisiae) 0.0204381
NAV2 neuron navigator 2 0.0200666
TTC3 tetratricopeptide repeat domain 3 0.0198035
OGA O-GlcNAcase 0.0196851
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0193224
MSN moesin 0.019303
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0192357
SBF2 SET binding factor 2 0.0191344
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0188855
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0188029
CTNND1 catenin (cadherin-associated protein), delta 1 0.0187946
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0187077
SETD5 SET domain containing 5 0.0185174
ARHGAP5 Rho GTPase activating protein 5 0.0184241
USP9X ubiquitin specific peptidase 9, X-linked 0.0184232
IQGAP1 IQ motif containing GTPase activating protein 1 0.0182106
MACF1 microtubule-actin crosslinking factor 1 0.0181083
KMT2C lysine (K)-specific methyltransferase 2C 0.018087
DGKD diacylglycerol kinase, delta 130kDa 0.0173551
ERRFI1 ERBB receptor feedback inhibitor 1 0.0173035
NBAS neuroblastoma amplified sequence 0.0171242
TNIP1 TNFAIP3 interacting protein 1 0.0170824
MON2 MON2 homolog (S. cerevisiae) 0.0170681
MAP2K1 mitogen-activated protein kinase kinase 1 0.0169724
CALU calumenin 0.016878
MED13 mediator complex subunit 13 0.0167675
LAMC2 laminin, gamma 2 0.01676
VCL vinculin 0.0167178
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0166104
AHNAK AHNAK nucleoprotein 0.0165295
ESYT2 extended synaptotagmin-like protein 2 0.0164478
VMP1 vacuole membrane protein 1 0.0163244
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.015887
KDM3A lysine (K)-specific demethylase 3A 0.0157728
AKAP9 A kinase (PRKA) anchor protein 9 0.0157497
ZNF146 zinc finger protein 146 0.0157135
CSNK1A1 casein kinase 1, alpha 1 0.0156031
YEATS2 YEATS domain containing 2 0.0154489
PRRC2C proline-rich coiled-coil 2C 0.0154275
ITSN2 intersectin 2 0.0153076
TBC1D22A TBC1 domain family, member 22A 0.0151535
USP47 ubiquitin specific peptidase 47 0.0151504
KIF16B kinesin family member 16B 0.0151347
ATXN2 ataxin 2 0.0151119
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0149338
PLEC plectin 0.0149312
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0148895
JMJD1C jumonji domain containing 1C 0.0147531
NDEL1 nudE neurodevelopment protein 1-like 1 0.0147277
NGLY1 N-glycanase 1 0.0146876
CLINT1 clathrin interactor 1 0.0145504
MKI67 marker of proliferation Ki-67 0.0144691
LAMB3 laminin, beta 3 0.0144036
ZFC3H1 zinc finger, C3H1-type containing 0.0143543
GOLGA2 golgin A2 0.0143117
COPA coatomer protein complex, subunit alpha 0.0142791
PTPRJ protein tyrosine phosphatase, receptor type, J 0.014115
PICALM phosphatidylinositol binding clathrin assembly protein 0.0141041
ITCH itchy E3 ubiquitin protein ligase 0.0140195
PMM2 phosphomannomutase 2 0.0138368
GOLGB1 golgin B1 0.0138076
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0137097
ETNK1 ethanolamine kinase 1 0.0137024
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0136814
BMAL2 basic helix-loop-helix ARNT like 2 0.0136509
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0136376
SEPTIN9 septin 9 0.0136258
VEZT vezatin, adherens junctions transmembrane protein 0.0135901
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0135014
TPD52 tumor protein D52 0.0134774
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.0133951
RAB1A RAB1A, member RAS oncogene family 0.0133594
RASA2 RAS p21 protein activator 2 0.013354

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.204222
FTL ferritin, light polypeptide -0.141432
TMSB10 thymosin beta 10 -0.126727
RPS19 ribosomal protein S19 -0.0820832
MT2A metallothionein 2A -0.0805963
RPS6 ribosomal protein S6 -0.0670118
RPS16 ribosomal protein S16 -0.0611096
VIM vimentin -0.060454
RPLP1 ribosomal protein, large, P1 -0.0596699
FTH1 ferritin, heavy polypeptide 1 -0.0521634
RPL23 ribosomal protein L23 -0.0501581
PDE4D phosphodiesterase 4D, cAMP-specific -0.0479694
RPL19 ribosomal protein L19 -0.0468604
KRT81 keratin 81, type II -0.0454565
RPS8 ribosomal protein S8 -0.043803
ACTG1 actin gamma 1 -0.0412049
RPL12 ribosomal protein L12 -0.0409299
IGFBP4 insulin-like growth factor binding protein 4 -0.0397958
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0394094
RPL26 ribosomal protein L26 -0.0390767
POTEF POTE ankyrin domain family, member F -0.0388164
KYNU kynureninase -0.0356014
KRT7 keratin 7, type II -0.0355158
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0339246
RPL28 ribosomal protein L28 -0.0335774
RPL37A ribosomal protein L37a -0.0333866
PKM pyruvate kinase, muscle -0.033146
RPL8 ribosomal protein L8 -0.032755
TPT1 tumor protein, translationally-controlled 1 -0.032616
RPS27A ribosomal protein S27a -0.0325278
RPS13 ribosomal protein S13 -0.0321877
RPL31 ribosomal protein L31 -0.0321528
RPLP2 ribosomal protein, large, P2 -0.0316739
RPLP0 ribosomal protein, large, P0 -0.0313612
RPS24 ribosomal protein S24 -0.0313082
RPS29 ribosomal protein S29 -0.0312467
RPS3 ribosomal protein S3 -0.0302958
PFN1 profilin 1 -0.0294184
RPL35A ribosomal protein L35a -0.0292369
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0292114
PTMA prothymosin, alpha -0.0289847
RACK1 receptor for activated C kinase 1 -0.0286913
AKR1C2 aldo-keto reductase family 1, member C2 -0.0279383
S100A10 S100 calcium binding protein A10 -0.0278806
MT1X metallothionein 1X -0.0273172
RPS23 ribosomal protein S23 -0.0268476
RPS5 ribosomal protein S5 -0.0267442
RPL18 ribosomal protein L18 -0.0259021
EIF1 eukaryotic translation initiation factor 1 -0.0255899
RPL32 ribosomal protein L32 -0.0255289
RPL13A ribosomal protein L13a -0.0247776
NAMPT nicotinamide phosphoribosyltransferase -0.0238611
ASPH aspartate beta-hydroxylase -0.0237699
RPS11 ribosomal protein S11 -0.0236105
EGR1 early growth response 1 -0.0232969
RPS4X ribosomal protein S4, X-linked -0.0230384
RPS25 ribosomal protein S25 -0.022785
RPL11 ribosomal protein L11 -0.022601
RPS21 ribosomal protein S21 -0.0222198
RPL7A ribosomal protein L7a -0.0221687
MAML3 mastermind-like 3 (Drosophila) -0.021956
TPI1 triosephosphate isomerase 1 -0.0218083
IER3 immediate early response 3 -0.021435
RPS17 ribosomal protein S17 -0.0211972
ANXA2 annexin A2 -0.0207047
HMGA1 high mobility group AT-hook 1 -0.0202144
RPL9 ribosomal protein L9 -0.0200476
TPM1 tropomyosin 1 (alpha) -0.0199089
UBC ubiquitin C -0.0192534
RPS14 ribosomal protein S14 -0.019245
RPL37 ribosomal protein L37 -0.019219
ASTN2 astrotactin 2 -0.0191229
TKT transketolase -0.0190106
RPS27 ribosomal protein S27 -0.0189332
KRT18 keratin 18, type I -0.018745
RPL34 ribosomal protein L34 -0.0185802
RPS2 ribosomal protein S2 -0.0182308
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0181589
RPL35 ribosomal protein L35 -0.0180832
LOC112694756 uncharaterized LOC112694756 -0.0175132
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0173439
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) -0.017011
EEF1G eukaryotic translation elongation factor 1 gamma -0.0168171
IFI6 interferon, alpha-inducible protein 6 -0.0163076
GSTP1 glutathione S-transferase pi 1 -0.0162909
ENO1 enolase 1, (alpha) -0.0162815
RPL36 ribosomal protein L36 -0.0162786
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.016136
C15ORF48 chromosome 15 open reading frame 48 -0.0161277
ALCAM activated leukocyte cell adhesion molecule -0.0160867
RPL27 ribosomal protein L27 -0.0158556
RPS20 ribosomal protein S20 -0.0156213
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0156093
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0154499
ZBTB20 zinc finger and BTB domain containing 20 -0.0150866
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 -0.0147915
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0144186
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0141442
RPS12 ribosomal protein S12 -0.0140871
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0139818