Atazanavir (sulfate)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Atazanavir (sulfate) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Atazanavir (sulfate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VMP1 vacuole membrane protein 1 0.0889668
IGFBP5 insulin-like growth factor binding protein 5 0.0679425
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0532762
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0522298
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0510511
NDRG1 N-myc downstream regulated 1 0.0508778
FTH1 ferritin, heavy polypeptide 1 0.043958
CEP250 centrosomal protein 250kDa 0.0437295
ACSS2 acyl-CoA synthetase short-chain family member 2 0.0367662
MCL1 myeloid cell leukemia 1 0.0353155
UBE2H ubiquitin-conjugating enzyme E2H 0.0309015
PDLIM5 PDZ and LIM domain 5 0.0302177
MYH9 myosin, heavy chain 9, non-muscle 0.0299087
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0286979
TSC22D2 TSC22 domain family, member 2 0.0282924
GRB7 growth factor receptor-bound protein 7 0.0281433
FBXL20 F-box and leucine-rich repeat protein 20 0.0271278
CCNL1 cyclin L1 0.0265212
NCOA3 nuclear receptor coactivator 3 0.0263768
SLC38A1 solute carrier family 38, member 1 0.0261934
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0231092
ITCH itchy E3 ubiquitin protein ligase 0.0230476
ZFP36L1 ZFP36 ring finger protein-like 1 0.0229795
SRRM2 serine/arginine repetitive matrix 2 0.0225474
NIBAN2 niban apoptosis regulator 2 0.0224667
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0222659
ANKRD12 ankyrin repeat domain 12 0.0222474
RAB6A RAB6A, member RAS oncogene family 0.0218357
ANKRD36C ankyrin repeat domain 36C 0.0215424
EZR ezrin 0.0210021
LASP1 LIM and SH3 protein 1 0.0208071
PRRC2C proline-rich coiled-coil 2C 0.0207991
TOM1L1 target of myb1 (chicken)-like 1 0.0207014
CTNND1 catenin (cadherin-associated protein), delta 1 0.0205827
TPD52 tumor protein D52 0.0205678
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0203117
YAP1 Yes-associated protein 1 0.0198112
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.019599
HOOK2 hook microtubule-tethering protein 2 0.0194551
VEGFA vascular endothelial growth factor A 0.0190796
NRIP1 nuclear receptor interacting protein 1 0.0190658
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0190621
CEMIP cell migration inducing protein, hyaluronan binding 0.0188859
UBC ubiquitin C 0.0185459
KIF16B kinesin family member 16B 0.0181759
GOLGA2 golgin A2 0.0180237
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0175737
RAB22A RAB22A, member RAS oncogene family 0.0171465
MYO9B myosin IXB 0.0169216
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0167424
PKM pyruvate kinase, muscle 0.0165026
SETD5 SET domain containing 5 0.0163231
SLC22A23 solute carrier family 22, member 23 0.0162705
CDH15 cadherin 15, type 1, M-cadherin (myotubule) 0.0160999
CAB39 calcium binding protein 39 0.0160279
B2M beta-2-microglobulin 0.0158096
ACTN4 actinin, alpha 4 0.0155679
CCNI cyclin I 0.0154713
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0154334
TMEM41B transmembrane protein 41B 0.0153599
TOP6BL TOP6B like initiator of meiotic double strand breaks 0.0153412
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0153235
UGCG UDP-glucose ceramide glucosyltransferase 0.0152845
WASF2 WAS protein family, member 2 0.0152583
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0151956
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0151686
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae) 0.0151226
LRRC59 leucine rich repeat containing 59 0.0151106
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0150298
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0149926
KMT2E lysine (K)-specific methyltransferase 2E 0.0149562
GSE1 Gse1 coiled-coil protein 0.0148623
ZNF292 zinc finger protein 292 0.0148616
SMAD3 SMAD family member 3 0.0148263
SEC23A Sec23 homolog A (S. cerevisiae) 0.0147896
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0147061
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0145697
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0145053
HILPDA hypoxia inducible lipid droplet-associated 0.0144479
RIOK3 RIO kinase 3 0.0143473
WSB1 WD repeat and SOCS box containing 1 0.01425
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 0.0139958
LCOR ligand dependent nuclear receptor corepressor 0.0139785
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta 0.0136472
SBF2 SET binding factor 2 0.0135739
CD46 CD46 molecule, complement regulatory protein 0.013505
TMEM165 transmembrane protein 165 0.0133076
DSPP dentin sialophosphoprotein 0.0132705
SOD2 superoxide dismutase 2, mitochondrial 0.0132165
BRD4 bromodomain containing 4 0.0130604
SEC16A SEC16 homolog A (S. cerevisiae) 0.0130348
SERINC3 serine incorporator 3 0.0129927
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0129011
LPP LIM domain containing preferred translocation partner in lipoma 0.0128694
APLP2 amyloid beta (A4) precursor-like protein 2 0.0128441
FOXO3 forkhead box O3 0.0128077
JUN jun proto-oncogene 0.0127845
MLPH melanophilin 0.0127603
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0126924
EGFR epidermal growth factor receptor 0.0126668

decreased expression

Symbol Name Standardized Value
ACACA acetyl-CoA carboxylase alpha -0.0950591
CATSPERB catsper channel auxiliary subunit beta -0.0938242
TRPS1 trichorhinophalangeal syndrome I -0.0559127
THSD4 thrombospondin, type I, domain containing 4 -0.0534489
CDK12 cyclin-dependent kinase 12 -0.0487493
RPL19 ribosomal protein L19 -0.0366098
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0338395
RIMS2 regulating synaptic membrane exocytosis 2 -0.0287502
CCND1 cyclin D1 -0.0280802
GMDS GDP-mannose 4,6-dehydratase -0.0265641
ASPH aspartate beta-hydroxylase -0.0264576
DNAH14 dynein, axonemal, heavy chain 14 -0.0263142
DTNA dystrobrevin, alpha -0.0258927
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0251279
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0248477
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 -0.024805
TTC6 tetratricopeptide repeat domain 6 -0.0247095
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0233939
PTPRK protein tyrosine phosphatase, receptor type, K -0.0227373
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0203457
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0196504
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0195252
DPYD dihydropyrimidine dehydrogenase -0.0192684
PTK2 protein tyrosine kinase 2 -0.0190401
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0187431
NIPBL Nipped-B homolog (Drosophila) -0.0184777
ZNFX1 zinc finger, NFX1-type containing 1 -0.0183456
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -0.017223
RPL23 ribosomal protein L23 -0.0171682
SP100 SP100 nuclear antigen -0.0170681
IFIH1 interferon induced with helicase C domain 1 -0.0165863
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.016424
FAF1 Fas (TNFRSF6) associated factor 1 -0.0162723
STAT1 signal transducer and activator of transcription 1, 91kDa -0.016131
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0158677
RAD21 RAD21 homolog (S. pombe) -0.0156423
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0150864
PLSCR1 phospholipid scramblase 1 -0.0150153
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) -0.0148233
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0148157
TCF12 transcription factor 12 -0.0147912
ARF1 ADP-ribosylation factor 1 -0.0147225
SPIDR scaffolding protein involved in DNA repair -0.0146753
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0146159
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0145734
RABGAP1 RAB GTPase activating protein 1 -0.0144524
KMT5B lysine methyltransferase 5B -0.0143638
PMP22 peripheral myelin protein 22 -0.0141735
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0141143
ARHGAP26 Rho GTPase activating protein 26 -0.0139747
GRHL2 grainyhead-like 2 (Drosophila) -0.0136293
ENAH enabled homolog (Drosophila) -0.0134857
EXOC4 exocyst complex component 4 -0.0134066
LGALS12 lectin, galactoside-binding, soluble, 12 -0.013323
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0131283
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.0130414
TENM4 teneurin transmembrane protein 4 -0.0129239
MBNL2 muscleblind-like splicing regulator 2 -0.0127184
EFNA5 ephrin-A5 -0.0124017
COMMD10 COMM domain containing 10 -0.0124014
TAS2R14 taste receptor, type 2, member 14 -0.012363
MBD4 methyl-CpG binding domain protein 4 -0.0123515
TFRC transferrin receptor -0.0122091
PAWR PRKC, apoptosis, WT1, regulator -0.0120808
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0120429
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0120005
MTDH metadherin -0.0119444
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0119091
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -0.0118921
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0117754
NFIA nuclear factor I/A -0.0116844
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0116232
PRH1 proline-rich protein HaeIII subfamily 1 -0.0116134
AHNAK AHNAK nucleoprotein -0.011513
RRM2 ribonucleotide reductase M2 -0.0114361
PTPRG protein tyrosine phosphatase, receptor type, G -0.0114119
ATP5F1B ATP synthase F1 subunit beta -0.0113652
CLIP1 CAP-GLY domain containing linker protein 1 -0.0113549
STAU1 staufen double-stranded RNA binding protein 1 -0.0112885
ARHGAP32 Rho GTPase activating protein 32 -0.011269
MIPOL1 mirror-image polydactyly 1 -0.0112182
TENM2 teneurin transmembrane protein 2 -0.0111253
SIDT1 SID1 transmembrane family, member 1 -0.0110624
MACROD2 MACRO domain containing 2 -0.0110452
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0110383
STRBP spermatid perinuclear RNA binding protein -0.0109982
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0109314
UBAC2 UBA domain containing 2 -0.0109187
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0108961
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.0108138
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0107139
TRIO trio Rho guanine nucleotide exchange factor -0.0105267
RPS24 ribosomal protein S24 -0.0105028
TUBA1B tubulin, alpha 1b -0.0104783
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0104658
GNAS GNAS complex locus -0.0104148
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0104008
NRG3 neuregulin 3 -0.0103672
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L -0.0103627
WARS1 tryptophanyl-tRNA synthetase 1 -0.010285