Atazanavir (sulfate)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Atazanavir (sulfate) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Atazanavir (sulfate)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MTSS1 metastasis suppressor 1 0.0558475
NRIP1 nuclear receptor interacting protein 1 0.0458537
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0442712
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0401566
BLCAP bladder cancer associated protein 0.0338646
MYH9 myosin, heavy chain 9, non-muscle 0.0321955
INTS6 integrator complex subunit 6 0.0319025
MCL1 myeloid cell leukemia 1 0.0291999
KIAA1217 KIAA1217 0.0279827
ZMYND8 zinc finger, MYND-type containing 8 0.0268803
RAD51B RAD51 paralog B 0.0256228
SLC35F3 solute carrier family 35, member F3 0.025622
LUZP1 leucine zipper protein 1 0.0253839
CEMIP cell migration inducing protein, hyaluronan binding 0.025319
BCAR3 breast cancer anti-estrogen resistance 3 0.0248048
HLA-B major histocompatibility complex, class I, B 0.0247723
LAMC2 laminin, gamma 2 0.0242666
FNIP1 folliculin interacting protein 1 0.0237265
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0230293
RAI14 retinoic acid induced 14 0.0215311
N4BP2L2 NEDD4 binding protein 2-like 2 0.0214383
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0212128
VCL vinculin 0.0208493
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0207078
DOCK5 dedicator of cytokinesis 5 0.0206099
NCOR2 nuclear receptor corepressor 2 0.0205496
AKAP13 A kinase (PRKA) anchor protein 13 0.0204826
CTNND1 catenin (cadherin-associated protein), delta 1 0.0195045
OSMR oncostatin M receptor 0.0183541
IGF2 insulin-like growth factor 2 0.0181797
PDLIM5 PDZ and LIM domain 5 0.0176201
KIF16B kinesin family member 16B 0.0167714
MEGF6 multiple EGF-like-domains 6 0.0165519
PRELID2 PRELI domain containing 2 0.0162076
CLIC4 chloride intracellular channel 4 0.0159447
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0158685
BMAL2 basic helix-loop-helix ARNT like 2 0.0155304
LOXL2 lysyl oxidase-like 2 0.0153787
ANTXR2 anthrax toxin receptor 2 0.015254
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0151295
NCOA3 nuclear receptor coactivator 3 0.0150827
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0148764
NLRP1 NLR family, pyrin domain containing 1 0.0148298
TNIP1 TNFAIP3 interacting protein 1 0.0143262
ADAM19 ADAM metallopeptidase domain 19 0.0142636
FOXO1 forkhead box O1 0.0141904
AMOTL1 angiomotin like 1 0.0140472
SEC31A SEC31 homolog A (S. cerevisiae) 0.0140402
PYGL phosphorylase, glycogen, liver 0.013897
RIN2 Ras and Rab interactor 2 0.0137042
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0136834
ATXN1 ataxin 1 0.0132431
HMGA2 high mobility group AT-hook 2 0.0130677
PDE4D phosphodiesterase 4D, cAMP-specific 0.0128204
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0127794
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0127503
CAPRIN2 caprin family member 2 0.0127299
ITGAV integrin, alpha V 0.012681
ARHGAP21 Rho GTPase activating protein 21 0.012439
EGFR epidermal growth factor receptor 0.0122582
KDM4C lysine (K)-specific demethylase 4C 0.012244
EXT1 exostosin glycosyltransferase 1 0.0121103
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0120579
VMP1 vacuole membrane protein 1 0.0120545
NTSR1 neurotensin receptor 1 (high affinity) 0.0119889
HDAC9 histone deacetylase 9 0.0119871
PLEC plectin 0.0118267
SETX senataxin 0.0116309
NAV2 neuron navigator 2 0.0115271
TBC1D22A TBC1 domain family, member 22A 0.0114987
RASA3 RAS p21 protein activator 3 0.0114509
FLNB filamin B, beta 0.0113434
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough 0.0112591
SOX13 SRY (sex determining region Y)-box 13 0.011203
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0111889
SMAD3 SMAD family member 3 0.0111209
YOD1 YOD1 deubiquitinase 0.0110285
SYNJ2 synaptojanin 2 0.0109969
COL17A1 collagen, type XVII, alpha 1 0.0109781
EFNA5 ephrin-A5 0.0109689
HM13 histocompatibility (minor) 13 0.0108631
NPC1 Niemann-Pick disease, type C1 0.0108379
SPATS2 spermatogenesis associated, serine-rich 2 0.0108031
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0108025
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.010673
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1 0.0106292
SPINK5 serine peptidase inhibitor, Kazal type 5 0.0105592
NUMB numb homolog (Drosophila) 0.0104975
TNS3 tensin 3 0.010445
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0103649
PMM2 phosphomannomutase 2 0.010039
USP34 ubiquitin specific peptidase 34 0.00990767
ADAM10 ADAM metallopeptidase domain 10 0.0098978
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.00986197
RUNX1 runt-related transcription factor 1 0.00980946
CDK19 cyclin-dependent kinase 19 0.00978987
EIF4A2 eukaryotic translation initiation factor 4A2 0.00969256
SH3PXD2A SH3 and PX domains 2A 0.00965683
MYO9A myosin IXA 0.00963114
F3 coagulation factor III (thromboplastin, tissue factor) 0.00950153

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.177886
POTEF POTE ankyrin domain family, member F -0.076918
ANXA1 annexin A1 -0.0758351
TMSB10 thymosin beta 10 -0.062081
ENO1 enolase 1, (alpha) -0.0619375
KRT17 keratin 17, type I -0.060349
LOC112694756 uncharaterized LOC112694756 -0.0589137
S100A10 S100 calcium binding protein A10 -0.0558592
CLU clusterin -0.0552801
IFITM3 interferon induced transmembrane protein 3 -0.0541328
RPS6 ribosomal protein S6 -0.0531826
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0477852
LMNA lamin A/C -0.047763
SULF1 sulfatase 1 -0.0439088
DSTN destrin (actin depolymerizing factor) -0.0435447
ANXA2 annexin A2 -0.0432894
CAV1 caveolin 1, caveolae protein, 22kDa -0.0427826
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0404749
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0401445
DPYD dihydropyrimidine dehydrogenase -0.0400975
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0388585
RPS8 ribosomal protein S8 -0.0381215
EZR ezrin -0.0380951
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0370355
RPL8 ribosomal protein L8 -0.0368462
LDHA lactate dehydrogenase A -0.0365158
TAGLN2 transgelin 2 -0.0362836
NDRG1 N-myc downstream regulated 1 -0.0362169
YBX1 Y box binding protein 1 -0.0350397
HSPG2 heparan sulfate proteoglycan 2 -0.034978
MEF2A myocyte enhancer factor 2A -0.0349014
RPS21 ribosomal protein S21 -0.0346943
NAMPT nicotinamide phosphoribosyltransferase -0.0344878
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0340893
GNAS GNAS complex locus -0.0338178
CD44 CD44 molecule (Indian blood group) -0.0336836
SAMD9 sterile alpha motif domain containing 9 -0.0336032
PKM pyruvate kinase, muscle -0.0325175
RPL11 ribosomal protein L11 -0.0319846
EMP1 epithelial membrane protein 1 -0.0316888
RPS19 ribosomal protein S19 -0.0313167
MYOF myoferlin -0.0311852
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0305485
S100A2 S100 calcium binding protein A2 -0.0303238
FOXP1 forkhead box P1 -0.0302338
MT2A metallothionein 2A -0.0294869
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0292538
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0291918
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0288546
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0287137
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0281797
PFN1 profilin 1 -0.0281455
KRT14 keratin 14, type I -0.028079
MORF4L2 mortality factor 4 like 2 -0.0275831
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0274247
PGK1 phosphoglycerate kinase 1 -0.0270958
RBM39 RNA binding motif protein 39 -0.0270422
CNRIP1 cannabinoid receptor interacting protein 1 -0.0266217
RPS3 ribosomal protein S3 -0.0263888
RPLP2 ribosomal protein, large, P2 -0.0260569
PDIA3 protein disulfide isomerase family A, member 3 -0.0260266
RPL35 ribosomal protein L35 -0.0258146
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0245861
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0244578
RPLP0 ribosomal protein, large, P0 -0.0243443
RPL37 ribosomal protein L37 -0.0242806
RPL32 ribosomal protein L32 -0.0242727
RPL19 ribosomal protein L19 -0.0242222
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0241266
KRT6A keratin 6A, type II -0.0239762
FTL ferritin, light polypeptide -0.0238228
RPL5 ribosomal protein L5 -0.0234895
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0233578
SULF2 sulfatase 2 -0.0232908
IFITM1 interferon induced transmembrane protein 1 -0.023235
TXNRD1 thioredoxin reductase 1 -0.0232169
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0227429
FTH1 ferritin, heavy polypeptide 1 -0.0227343
RPS2 ribosomal protein S2 -0.0226289
S100A9 S100 calcium binding protein A9 -0.0225323
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0223901
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0223154
RPS13 ribosomal protein S13 -0.0222937
BSG basigin (Ok blood group) -0.0222343
RACK1 receptor for activated C kinase 1 -0.0221536
RPL23 ribosomal protein L23 -0.0221486
RPL28 ribosomal protein L28 -0.0221408
MT1X metallothionein 1X -0.0220256
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0219121
RPS4X ribosomal protein S4, X-linked -0.021808
RPS14 ribosomal protein S14 -0.0216308
RPL36 ribosomal protein L36 -0.0214249
S100A11 S100 calcium binding protein A11 -0.0212788
S100A6 S100 calcium binding protein A6 -0.0207837
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0205421
MYO10 myosin X -0.0203131
GOLGA4 golgin A4 -0.0203102
MBNL2 muscleblind-like splicing regulator 2 -0.0202117
TKT transketolase -0.0200979
NEK7 NIMA-related kinase 7 -0.0199277