Atazanavir (sulfate)_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Atazanavir (sulfate) perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Atazanavir (sulfate)_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.193834
AKAP12 A kinase (PRKA) anchor protein 12 0.169867
FAM20C family with sequence similarity 20, member C 0.12194
LOX lysyl oxidase 0.118288
EIF1 eukaryotic translation initiation factor 1 0.0884792
USP34 ubiquitin specific peptidase 34 0.0866802
DSCAM Down syndrome cell adhesion molecule 0.0821793
GOLGA4 golgin A4 0.0812112
CXCL8 chemokine (C-X-C motif) ligand 8 0.0751608
DOCK5 dedicator of cytokinesis 5 0.0733278
EFNA5 ephrin-A5 0.069042
SOD2 superoxide dismutase 2, mitochondrial 0.0684966
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0676507
FN1 fibronectin 1 0.0638083
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0633168
SMAD3 SMAD family member 3 0.0628839
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0623435
TRIO trio Rho guanine nucleotide exchange factor 0.0578479
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0573845
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0570246
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0531754
STC1 stanniocalcin 1 0.0514896
FAM107B family with sequence similarity 107, member B 0.0503928
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0499565
YEATS2 YEATS domain containing 2 0.0498778
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0486118
AKAP9 A kinase (PRKA) anchor protein 9 0.0477508
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.046858
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0452477
TTC3 tetratricopeptide repeat domain 3 0.0447874
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.043424
EXT1 exostosin glycosyltransferase 1 0.0433646
CLTC clathrin, heavy chain (Hc) 0.0429216
JARID2 jumonji, AT rich interactive domain 2 0.0427276
MYH9 myosin, heavy chain 9, non-muscle 0.0419792
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0405985
CALU calumenin 0.0399121
MCL1 myeloid cell leukemia 1 0.0392157
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0384686
SUN1 Sad1 and UNC84 domain containing 1 0.0381851
ANKRD17 ankyrin repeat domain 17 0.0369542
MINDY2 MINDY lysine 48 deubiquitinase 2 0.035991
GOLGA3 golgin A3 0.0357035
EGFR epidermal growth factor receptor 0.0354656
ZEB2 zinc finger E-box binding homeobox 2 0.0350057
PRELID2 PRELI domain containing 2 0.0350035
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0348829
PYGL phosphorylase, glycogen, liver 0.0347286
KDM3A lysine (K)-specific demethylase 3A 0.034212
TFPI2 tissue factor pathway inhibitor 2 0.0340714
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.034016
SEC31A SEC31 homolog A (S. cerevisiae) 0.033499
RBM39 RNA binding motif protein 39 0.0330988
NAV2 neuron navigator 2 0.0330956
CTNND1 catenin (cadherin-associated protein), delta 1 0.0329209
ZC3H12C zinc finger CCCH-type containing 12C 0.032728
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0327072
ARHGAP5 Rho GTPase activating protein 5 0.032336
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0318061
LMAN1 lectin, mannose-binding, 1 0.0313517
CEP250 centrosomal protein 250kDa 0.0311796
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0302068
ZCCHC7 zinc finger, CCHC domain containing 7 0.0301923
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0300888
SAMD4A sterile alpha motif domain containing 4A 0.0299942
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0288927
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0288485
ZBTB20 zinc finger and BTB domain containing 20 0.0288303
RAB1A RAB1A, member RAS oncogene family 0.0287595
SKAP2 src kinase associated phosphoprotein 2 0.0285689
LOXL2 lysyl oxidase-like 2 0.0284887
ANKRD36 ankyrin repeat domain 36 0.0284514
CANX calnexin 0.0281758
ADM adrenomedullin 0.0281669
SDK1 sidekick cell adhesion molecule 1 0.0280898
GOLT1B golgi transport 1B 0.0280675
LAMB3 laminin, beta 3 0.028064
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0280459
UBC ubiquitin C 0.0279716
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0277963
COG5 component of oligomeric golgi complex 5 0.0275601
ESYT2 extended synaptotagmin-like protein 2 0.027432
FNBP1 formin binding protein 1 0.0274042
IQGAP1 IQ motif containing GTPase activating protein 1 0.0274025
NPC1 Niemann-Pick disease, type C1 0.0273858
IGF1R insulin-like growth factor 1 receptor 0.0270874
OXR1 oxidation resistance 1 0.0270622
FAM114A1 family with sequence similarity 114, member A1 0.0269787
BACE2 beta-site APP-cleaving enzyme 2 0.0269265
SIK3 SIK family kinase 3 0.0267826
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0266874
MARS1 methionyl-tRNA synthetase 1 0.0266527
DAAM1 dishevelled associated activator of morphogenesis 1 0.0261575
HDLBP high density lipoprotein binding protein 0.0260004
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0259739
OFD1 oral-facial-digital syndrome 1 0.0258078
RAP1B RAP1B, member of RAS oncogene family 0.0256387
KMT2C lysine (K)-specific methyltransferase 2C 0.0253983
DENND4A DENN/MADD domain containing 4A 0.0253862
GOLGA2 golgin A2 0.0253358

decreased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 -0.0839747
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0814933
PCBP2 poly(rC) binding protein 2 -0.0710144
PDIA3 protein disulfide isomerase family A, member 3 -0.0705619
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0611557
FTL ferritin, light polypeptide -0.058364
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0556459
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0550602
MAP1B microtubule-associated protein 1B -0.049433
POTEF POTE ankyrin domain family, member F -0.0452095
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.0448978
EGR1 early growth response 1 -0.0423082
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0405533
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0394206
HMGA1 high mobility group AT-hook 1 -0.0375028
TXNRD1 thioredoxin reductase 1 -0.0372839
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0364914
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0358644
USP3 ubiquitin specific peptidase 3 -0.0352803
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0348402
ELL2 elongation factor, RNA polymerase II, 2 -0.0348032
GPC6 glypican 6 -0.0334242
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.033341
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0329898
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0316226
CDCP1 CUB domain containing protein 1 -0.0306004
PLIN2 perilipin 2 -0.0304924
DDIT3 DNA-damage-inducible transcript 3 -0.0300648
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0286096
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0273014
ASPH aspartate beta-hydroxylase -0.0272306
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0267763
NDRG1 N-myc downstream regulated 1 -0.0261951
YBX1 Y box binding protein 1 -0.02537
ADAM9 ADAM metallopeptidase domain 9 -0.0248605
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0247471
PHIP pleckstrin homology domain interacting protein -0.0242298
UGCG UDP-glucose ceramide glucosyltransferase -0.0242129
PTBP2 polypyrimidine tract binding protein 2 -0.023396
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0233141
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0232711
CD44 CD44 molecule (Indian blood group) -0.0232278
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0229924
CDK17 cyclin-dependent kinase 17 -0.022792
PDE4D phosphodiesterase 4D, cAMP-specific -0.0226862
RPL35A ribosomal protein L35a -0.021753
TBC1D5 TBC1 domain family, member 5 -0.0216608
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0216336
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0211895
NRG1 neuregulin 1 -0.0206153
PDIA4 protein disulfide isomerase family A, member 4 -0.0204599
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0204419
QKI QKI, KH domain containing, RNA binding -0.0202156
SYT1 synaptotagmin I -0.0202012
TMEM123 transmembrane protein 123 -0.0200805
IFI44 interferon-induced protein 44 -0.0200522
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) -0.0199651
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0193223
SOS1 son of sevenless homolog 1 (Drosophila) -0.0190622
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0189655
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0184414
BZW2 basic leucine zipper and W2 domains 2 -0.0183575
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0181104
NPEPPS aminopeptidase puromycin sensitive -0.0180962
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0180587
BSG basigin (Ok blood group) -0.0178217
KLHL24 kelch-like family member 24 -0.0177257
FAM13A family with sequence similarity 13, member A -0.0177212
CHD1L chromodomain helicase DNA binding protein 1-like -0.0177154
MGST1 microsomal glutathione S-transferase 1 -0.0176603
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.017578
GCLC glutamate-cysteine ligase, catalytic subunit -0.0175551
PFN1 profilin 1 -0.0175458
PTPRK protein tyrosine phosphatase, receptor type, K -0.0175433
CLEC1B C-type lectin domain family 1, member B -0.0175066
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0172973
ZMYM2 zinc finger, MYM-type 2 -0.0171498
UGDH UDP-glucose 6-dehydrogenase -0.0171027
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0170627
TXNIP thioredoxin interacting protein -0.0170416
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0170416
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0170244
LRMDA leucine rich melanocyte differentiation associated -0.016851
FBXO11 F-box protein 11 -0.0165447
STAU1 staufen double-stranded RNA binding protein 1 -0.0164233
EPS8 epidermal growth factor receptor pathway substrate 8 -0.01642
RNASEH2A ribonuclease H2, subunit A -0.0164186
FOSL1 FOS-like antigen 1 -0.0164006
IFI44L interferon-induced protein 44-like -0.0163824
GTF2B general transcription factor IIB -0.0163234
CCNL1 cyclin L1 -0.0162311
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0162109
RTN4 reticulon 4 -0.0160297
IFI6 interferon, alpha-inducible protein 6 -0.0159966
NUP58 nucleoporin 58 -0.0159818
TSC22D2 TSC22 domain family, member 2 -0.0157948
ECPAS Ecm29 proteasome adaptor and scaffold -0.0157195
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha -0.0153492
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0153071
GPHN gephyrin -0.0152281