Atazanavir (sulfate)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Atazanavir (sulfate) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Atazanavir (sulfate)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.17844
RPS4Y1 ribosomal protein S4, Y-linked 1 0.133244
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.104912
WDR43 WD repeat domain 43 0.102596
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0889062
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0885624
PTK2 protein tyrosine kinase 2 0.086832
MCL1 myeloid cell leukemia 1 0.0835024
ZFAND3 zinc finger, AN1-type domain 3 0.0803362
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0790721
ERBIN erbb2 interacting protein 0.0763145
ERRFI1 ERBB receptor feedback inhibitor 1 0.0734458
COPA coatomer protein complex, subunit alpha 0.0666544
FMNL2 formin-like 2 0.0660989
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0641535
DSCAM Down syndrome cell adhesion molecule 0.0633526
TRA2A transformer 2 alpha homolog (Drosophila) 0.0622121
BHLHE40 basic helix-loop-helix family, member e40 0.0617892
VMP1 vacuole membrane protein 1 0.061716
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0615641
UBASH3B ubiquitin associated and SH3 domain containing B 0.0614722
TPD52 tumor protein D52 0.0599189
SETD5 SET domain containing 5 0.0595979
YME1L1 YME1-like 1 ATPase 0.0587529
SLC38A2 solute carrier family 38, member 2 0.0578185
HDAC9 histone deacetylase 9 0.0565524
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.056497
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0562318
RBM25 RNA binding motif protein 25 0.0555792
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0545855
RAB1A RAB1A, member RAS oncogene family 0.0544528
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0537848
PUM1 pumilio RNA-binding family member 1 0.0535828
WAC WW domain containing adaptor with coiled-coil 0.0534119
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0520258
CNOT1 CCR4-NOT transcription complex, subunit 1 0.051762
VIM vimentin 0.0517232
DENND4A DENN/MADD domain containing 4A 0.0516818
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0515113
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0511355
NUP58 nucleoporin 58 0.0507543
KLF6 Kruppel-like factor 6 0.0494784
RBM39 RNA binding motif protein 39 0.0493658
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0489454
USP36 ubiquitin specific peptidase 36 0.0489372
NOP58 NOP58 ribonucleoprotein 0.0481766
NOL10 nucleolar protein 10 0.0476212
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.0469711
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0469383
PAWR PRKC, apoptosis, WT1, regulator 0.0461609
FAM168A family with sequence similarity 168, member A 0.0454571
TMEM87A transmembrane protein 87A 0.0448376
COG5 component of oligomeric golgi complex 5 0.0440678
APP amyloid beta (A4) precursor protein 0.0439828
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0439126
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0439062
FLNB filamin B, beta 0.0438964
MARCHF6 membrane associated ring-CH-type finger 6 0.0437236
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0432096
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.043195
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.04308
CALU calumenin 0.0424971
SPAG9 sperm associated antigen 9 0.042464
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0418572
KDM3A lysine (K)-specific demethylase 3A 0.0414714
AKAP13 A kinase (PRKA) anchor protein 13 0.0407017
CCNL1 cyclin L1 0.0402932
CHN1 chimerin 1 0.0402219
TRIO trio Rho guanine nucleotide exchange factor 0.0401575
KMT2E lysine (K)-specific methyltransferase 2E 0.0398191
IGF2 insulin-like growth factor 2 0.0396878
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0394606
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.039354
RICTOR RPTOR independent companion of MTOR, complex 2 0.0393325
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0391966
MRTFA myocardin related transcription factor A 0.0390645
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0387116
EIF1 eukaryotic translation initiation factor 1 0.0386776
LOC102724023 ES1 protein homolog, mitochondrial 0.0385863
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0384472
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0379195
MORF4L1 mortality factor 4 like 1 0.0375044
ACTN1 actinin, alpha 1 0.0372488
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0370246
ACTG1 actin gamma 1 0.0364758
RASAL2 RAS protein activator like 2 0.0362818
GOLT1B golgi transport 1B 0.0362261
WIPF2 WAS/WASL interacting protein family, member 2 0.0360645
INO80 INO80 complex subunit 0.0360073
MSN moesin 0.0358254
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0357109
ANKRD11 ankyrin repeat domain 11 0.0355615
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0355282
IGFBP3 insulin-like growth factor binding protein 3 0.0353954
MYH9 myosin, heavy chain 9, non-muscle 0.0351281
ZNF292 zinc finger protein 292 0.0349193
MTMR3 myotubularin related protein 3 0.0348378
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0346826
EWSR1 EWS RNA-binding protein 1 0.034623
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0346

decreased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific -0.207846
PM20D1 peptidase M20 domain containing 1 -0.168602
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.125977
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.125515
GRAMD1B GRAM domain containing 1B -0.107834
POTEF POTE ankyrin domain family, member F -0.0881293
RPS2 ribosomal protein S2 -0.0858573
RPL19 ribosomal protein L19 -0.0740089
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0618856
RPLP1 ribosomal protein, large, P1 -0.052189
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial) -0.0487892
AKAP12 A kinase (PRKA) anchor protein 12 -0.0485183
WWOX WW domain containing oxidoreductase -0.0473555
IER3 immediate early response 3 -0.0459515
RPS6 ribosomal protein S6 -0.0449847
RPS8 ribosomal protein S8 -0.0425969
RPS12 ribosomal protein S12 -0.0425265
TMSB10 thymosin beta 10 -0.0404445
TXNRD1 thioredoxin reductase 1 -0.0397672
RPL4 ribosomal protein L4 -0.0395993
FTH1 ferritin, heavy polypeptide 1 -0.0364106
PDIA3 protein disulfide isomerase family A, member 3 -0.0358475
ENO1 enolase 1, (alpha) -0.0333005
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0331542
CDCP1 CUB domain containing protein 1 -0.0326055
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0325985
TPM3 tropomyosin 3 -0.0316669
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0301592
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0301039
RPL12 ribosomal protein L12 -0.0286264
NNMT nicotinamide N-methyltransferase -0.0282925
CCL5 chemokine (C-C motif) ligand 5 -0.028195
RSPO3 R-spondin 3 -0.0272824
UBB ubiquitin B -0.0270994
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0270894
RPL38 ribosomal protein L38 -0.026837
DST dystonin -0.0267394
MAP1B microtubule-associated protein 1B -0.0266507
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0251861
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0248643
EGR1 early growth response 1 -0.0248321
KANSL1L KAT8 regulatory NSL complex subunit 1-like -0.0243865
TM4SF1 transmembrane 4 L six family member 1 -0.0224325
HMGB1 high mobility group box 1 -0.022284
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0219725
SQSTM1 sequestosome 1 -0.0218962
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0209503
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0209385
ASPH aspartate beta-hydroxylase -0.0205078
PFN1 profilin 1 -0.0202891
GOLGB1 golgin B1 -0.0202054
GSTP1 glutathione S-transferase pi 1 -0.0200646
YBX1 Y box binding protein 1 -0.020064
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0200337
KIF5B kinesin family member 5B -0.0200012
RPL6 ribosomal protein L6 -0.0194099
CENPF centromere protein F, 350/400kDa -0.0193424
RPS20 ribosomal protein S20 -0.019243
PDE10A phosphodiesterase 10A -0.0190879
RPS17 ribosomal protein S17 -0.0189763
EXOC6B exocyst complex component 6B -0.0187848
DOCK3 dedicator of cytokinesis 3 -0.0187063
PRDX1 peroxiredoxin 1 -0.0186276
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0186126
EHBP1 EH domain binding protein 1 -0.018316
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0182382
TAS2R14 taste receptor, type 2, member 14 -0.0180256
MATR3 matrin 3 -0.0178465
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0177507
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0176175
RABGAP1L RAB GTPase activating protein 1-like -0.0174515
FGG fibrinogen gamma chain -0.0173468
ZBTB20 zinc finger and BTB domain containing 20 -0.017285
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) -0.0172529
TPM1 tropomyosin 1 (alpha) -0.0168873
TMOD3 tropomodulin 3 (ubiquitous) -0.0168558
S100A11 S100 calcium binding protein A11 -0.0168537
RPL9 ribosomal protein L9 -0.0166808
ADAR adenosine deaminase, RNA-specific -0.016679
EXOC4 exocyst complex component 4 -0.0166106
ANXA2 annexin A2 -0.0165844
TMEM123 transmembrane protein 123 -0.016253
TUBA1B tubulin, alpha 1b -0.016174
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0161664
HDGFL3 HDGF like 3 -0.0161249
SMYD3 SET and MYND domain containing 3 -0.0159504
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0159213
GPHN gephyrin -0.0157819
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.0157041
RACK1 receptor for activated C kinase 1 -0.0154021
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0153866
MYO9A myosin IXA -0.015335
RPS27A ribosomal protein S27a -0.0153098
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 -0.0152437
TDP2 tyrosyl-DNA phosphodiesterase 2 -0.015211
TUBB4B tubulin, beta 4B class IVb -0.0150671
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.014954
TCEAL4 transcription elongation factor A (SII)-like 4 -0.0149436
BCAS3 breast carcinoma amplified sequence 3 -0.014939
EPGN epithelial mitogen -0.0148914