Atazanavir (sulfate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Atazanavir (sulfate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Atazanavir (sulfate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.35352
IGFBP3 insulin-like growth factor binding protein 3 0.279901
MCL1 myeloid cell leukemia 1 0.196566
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.135374
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.124341
VIM vimentin 0.120514
EFNA5 ephrin-A5 0.118166
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.115273
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.111687
COL5A2 collagen, type V, alpha 2 0.107009
LIMCH1 LIM and calponin homology domains 1 0.0971295
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.089734
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.083223
S100A6 S100 calcium binding protein A6 0.0819001
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0795694
DNER delta/notch-like EGF repeat containing 0.078284
NPAS2 neuronal PAS domain protein 2 0.0735724
ESYT2 extended synaptotagmin-like protein 2 0.071899
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0700154
FNDC3B fibronectin type III domain containing 3B 0.0695709
STC1 stanniocalcin 1 0.0692585
PGK1 phosphoglycerate kinase 1 0.0689867
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0655191
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0643652
ZEB2 zinc finger E-box binding homeobox 2 0.0584031
PYGL phosphorylase, glycogen, liver 0.058157
CANX calnexin 0.057383
WARS1 tryptophanyl-tRNA synthetase 1 0.0571022
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0568784
SOD2 superoxide dismutase 2, mitochondrial 0.0563089
KMT2C lysine (K)-specific methyltransferase 2C 0.0557853
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0553276
BMERB1 bMERB domain containing 1 0.052854
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0522751
NBEAL1 neurobeachin-like 1 0.0521885
PTEN phosphatase and tensin homolog 0.0519441
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.050757
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0490325
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0488751
OGA O-GlcNAcase 0.0485314
PCBP3 poly(rC) binding protein 3 0.0473477
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0469488
ITPRID2 ITPR interacting domain containing 2 0.0462835
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0453557
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0452877
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0450518
SAMD4A sterile alpha motif domain containing 4A 0.0448021
COPA coatomer protein complex, subunit alpha 0.0443185
RAI1 retinoic acid induced 1 0.0442903
INHBA inhibin, beta A 0.0439229
CDH13 cadherin 13 0.0420806
CD109 CD109 molecule 0.0420008
SLC38A2 solute carrier family 38, member 2 0.0418134
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0405513
MON2 MON2 homolog (S. cerevisiae) 0.0398912
FNDC3A fibronectin type III domain containing 3A 0.0395718
USP34 ubiquitin specific peptidase 34 0.0393939
COL4A6 collagen, type IV, alpha 6 0.0389962
SPAG9 sperm associated antigen 9 0.0385134
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0384065
AKAP13 A kinase (PRKA) anchor protein 13 0.0381696
SOX4 SRY (sex determining region Y)-box 4 0.0367056
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0366892
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0362536
PRSS23 protease, serine, 23 0.0359185
HLA-A major histocompatibility complex, class I, A 0.0358169
WSB1 WD repeat and SOCS box containing 1 0.0354786
PDGFA platelet-derived growth factor alpha polypeptide 0.0353707
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0349321
GRB10 growth factor receptor-bound protein 10 0.034826
TRIO trio Rho guanine nucleotide exchange factor 0.0342216
JMJD1C jumonji domain containing 1C 0.033898
ZFHX3 zinc finger homeobox 3 0.0331525
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0330339
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0329411
BIRC6 baculoviral IAP repeat containing 6 0.0328325
FTH1 ferritin, heavy polypeptide 1 0.0328083
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0324873
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0323382
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0319907
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0306732
BTG1 B-cell translocation gene 1, anti-proliferative 0.0306313
SDK1 sidekick cell adhesion molecule 1 0.030596
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0301025
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0298566
DHRSX dehydrogenase/reductase (SDR family) X-linked 0.0296961
AVL9 AVL9 homolog (S. cerevisiase) 0.0295631
LMNA lamin A/C 0.0294521
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0292621
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0290596
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0290101
MSN moesin 0.0288688
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.028605
MYOF myoferlin 0.0283315
NF1 neurofibromin 1 0.0282417
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0279189
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0278933
EIF1 eukaryotic translation initiation factor 1 0.0277408
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0276217
GOLGA4 golgin A4 0.027388

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.131811
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0987599
GRAMD1B GRAM domain containing 1B -0.0848044
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.083485
RPS2 ribosomal protein S2 -0.0783673
COL8A1 collagen, type VIII, alpha 1 -0.0645841
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0638904
FTL ferritin, light polypeptide -0.0626448
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0586952
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0579288
NAMPT nicotinamide phosphoribosyltransferase -0.0569686
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0493082
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0452558
PDE4D phosphodiesterase 4D, cAMP-specific -0.04311
ANTXR1 anthrax toxin receptor 1 -0.0421082
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0419226
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0415796
RPS6 ribosomal protein S6 -0.0379839
RPL38 ribosomal protein L38 -0.0374718
CENPF centromere protein F, 350/400kDa -0.0370989
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0354777
ASPH aspartate beta-hydroxylase -0.0350432
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0348295
PDE10A phosphodiesterase 10A -0.0341862
RPL23 ribosomal protein L23 -0.0340844
RGS2 regulator of G-protein signaling 2 -0.0330038
EIF3A eukaryotic translation initiation factor 3, subunit A -0.032965
CADM2 cell adhesion molecule 2 -0.0329472
RPL12 ribosomal protein L12 -0.0323723
HSPA8 heat shock 70kDa protein 8 -0.0303988
POTEF POTE ankyrin domain family, member F -0.0296346
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0295676
RPLP1 ribosomal protein, large, P1 -0.0293783
PRDX1 peroxiredoxin 1 -0.0293593
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0289984
MATR3 matrin 3 -0.0282043
PRKN parkin RBR E3 ubiquitin protein ligase -0.0279121
TKT transketolase -0.0275281
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0272744
ATP5F1B ATP synthase F1 subunit beta -0.0268553
PTPRM protein tyrosine phosphatase, receptor type, M -0.0267681
RPL26 ribosomal protein L26 -0.0265864
RPL19 ribosomal protein L19 -0.0264523
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0261351
RPL4 ribosomal protein L4 -0.0259504
AKR1C1 aldo-keto reductase family 1, member C1 -0.025811
YBX1 Y box binding protein 1 -0.0256026
IPO7 importin 7 -0.025596
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0253134
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0251708
RPL37A ribosomal protein L37a -0.0243878
RPS8 ribosomal protein S8 -0.0242372
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0241331
RPS16 ribosomal protein S16 -0.0240883
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0240447
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0238019
RPL36 ribosomal protein L36 -0.0231037
RPS12 ribosomal protein S12 -0.023019
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0228541
RPL5 ribosomal protein L5 -0.0226852
RPL3 ribosomal protein L3 -0.0226144
RAB3B RAB3B, member RAS oncogene family -0.0225987
ANLN anillin, actin binding protein -0.0225281
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -0.0224944
PDE7B phosphodiesterase 7B -0.0222667
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0220376
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0218618
EPHA5 EPH receptor A5 -0.0212307
TUSC3 tumor suppressor candidate 3 -0.02096
NCKAP1 NCK-associated protein 1 -0.0209007
RPL35 ribosomal protein L35 -0.0207542
ALPK2 alpha-kinase 2 -0.0207455
MAML3 mastermind-like 3 (Drosophila) -0.0203062
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0200661
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.020017
RPS24 ribosomal protein S24 -0.0199715
LSAMP limbic system-associated membrane protein -0.0197839
MT2A metallothionein 2A -0.0197836
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0197333
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0196781
RPLP2 ribosomal protein, large, P2 -0.0194275
DNAH14 dynein, axonemal, heavy chain 14 -0.0193439
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0193391
SERBP1 SERPINE1 mRNA binding protein 1 -0.0190198
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) -0.0188348
RPS19 ribosomal protein S19 -0.0188248
NT5C2 5'-nucleotidase, cytosolic II -0.0187892
GREM2 gremlin 2, DAN family BMP antagonist -0.0187136
TUBA1B tubulin, alpha 1b -0.0183157
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.018045
RPS29 ribosomal protein S29 -0.0179402
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0178824
PCNX2 pecanex 2 -0.0178116
RPS21 ribosomal protein S21 -0.0175014
HSPE1 heat shock 10kDa protein 1 -0.0174158
RPS23 ribosomal protein S23 -0.0171743
RPL18 ribosomal protein L18 -0.0170675
RPL6 ribosomal protein L6 -0.0169389
RPL31 ribosomal protein L31 -0.0168719
TPM3 tropomyosin 3 -0.0168363