Atazanavir (sulfate)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Atazanavir (sulfate) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Atazanavir (sulfate)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.213964
MYH9 myosin, heavy chain 9, non-muscle 0.0951791
TRIO trio Rho guanine nucleotide exchange factor 0.0736052
PDE10A phosphodiesterase 10A 0.0731529
NAMPT nicotinamide phosphoribosyltransferase 0.0703084
JMJD1C jumonji domain containing 1C 0.0661895
FN1 fibronectin 1 0.0649528
ELL2 elongation factor, RNA polymerase II, 2 0.0614881
MSN moesin 0.0602421
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.059
UGCG UDP-glucose ceramide glucosyltransferase 0.0569301
IGFBP3 insulin-like growth factor binding protein 3 0.0547294
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0533992
FNDC3B fibronectin type III domain containing 3B 0.0533313
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.050057
GOLGA4 golgin A4 0.04841
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.047852
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.046031
ATP13A3 ATPase type 13A3 0.0458396
AKAP12 A kinase (PRKA) anchor protein 12 0.0441659
CADM1 cell adhesion molecule 1 0.0439844
RND3 Rho family GTPase 3 0.0428345
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0425365
DST dystonin 0.0423422
RB1CC1 RB1-inducible coiled-coil 1 0.0418
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0412136
NAV2 neuron navigator 2 0.0402585
HDAC9 histone deacetylase 9 0.0389739
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.038364
OGA O-GlcNAcase 0.0381046
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0379233
ADM adrenomedullin 0.0378566
ARRDC3 arrestin domain containing 3 0.0376904
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0375771
USP9X ubiquitin specific peptidase 9, X-linked 0.0374432
FMNL2 formin-like 2 0.0371695
FNIP1 folliculin interacting protein 1 0.0369846
SPTBN1 spectrin, beta, non-erythrocytic 1 0.035789
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0357496
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0342031
UBA6 ubiquitin-like modifier activating enzyme 6 0.033869
MACF1 microtubule-actin crosslinking factor 1 0.0330078
CDK19 cyclin-dependent kinase 19 0.0328096
SPAG9 sperm associated antigen 9 0.0327599
FLNB filamin B, beta 0.0324623
ZFAND3 zinc finger, AN1-type domain 3 0.0321879
MYOF myoferlin 0.0320401
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0318752
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0316619
FOXO3 forkhead box O3 0.0316128
ESYT2 extended synaptotagmin-like protein 2 0.0312161
WDFY1 WD repeat and FYVE domain containing 1 0.0304082
YEATS2 YEATS domain containing 2 0.0300378
SETD5 SET domain containing 5 0.0295267
RAB7A RAB7A, member RAS oncogene family 0.0287042
STC1 stanniocalcin 1 0.0284904
DSCAM Down syndrome cell adhesion molecule 0.0277252
AFF4 AF4/FMR2 family, member 4 0.0274941
RICTOR RPTOR independent companion of MTOR, complex 2 0.0272908
MMP12 matrix metallopeptidase 12 0.0270677
TENT5A terminal nucleotidyltransferase 5A 0.0270205
STAG2 stromal antigen 2 0.0269595
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.02683
VMP1 vacuole membrane protein 1 0.0262732
ZNF292 zinc finger protein 292 0.0262243
KMT2E lysine (K)-specific methyltransferase 2E 0.0258157
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.025444
KYNU kynureninase 0.025444
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0253712
OPTN optineurin 0.025166
PRRC2C proline-rich coiled-coil 2C 0.025151
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0249664
SNX9 sorting nexin 9 0.0246204
KDM2A lysine (K)-specific demethylase 2A 0.0245615
MCL1 myeloid cell leukemia 1 0.0245308
RAB6A RAB6A, member RAS oncogene family 0.0243401
ARFGEF3 ARFGEF family member 3 0.024112
PPARD peroxisome proliferator-activated receptor delta 0.0234808
DLG1 discs, large homolog 1 (Drosophila) 0.0233844
NDRG1 N-myc downstream regulated 1 0.0232536
RBM39 RNA binding motif protein 39 0.0228713
HELZ helicase with zinc finger 0.0226984
CEP250 centrosomal protein 250kDa 0.0226384
ERRFI1 ERBB receptor feedback inhibitor 1 0.0226353
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0224849
SERINC1 serine incorporator 1 0.0222581
SFTPA2 surfactant protein A2 0.0221827
AKAP13 A kinase (PRKA) anchor protein 13 0.0220914
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0218628
CLTC clathrin, heavy chain (Hc) 0.0216976
AFF3 AF4/FMR2 family, member 3 0.0216802
SBF2 SET binding factor 2 0.0216749
COL6A3 collagen, type VI, alpha 3 0.0215574
CSNK1A1 casein kinase 1, alpha 1 0.0210784
KMT2C lysine (K)-specific methyltransferase 2C 0.0207619
LPP LIM domain containing preferred translocation partner in lipoma 0.0206388
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0205215
PRELID2 PRELI domain containing 2 0.0205054
LOXL2 lysyl oxidase-like 2 0.0204423
KDM6A lysine (K)-specific demethylase 6A 0.0203464

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0835152
IER3 immediate early response 3 -0.0801259
FTL ferritin, light polypeptide -0.0781274
TMSB10 thymosin beta 10 -0.076067
VIM vimentin -0.0608855
RPS24 ribosomal protein S24 -0.0482282
HLA-B major histocompatibility complex, class I, B -0.0433299
TPT1 tumor protein, translationally-controlled 1 -0.0424805
RPL35A ribosomal protein L35a -0.0396375
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0394436
RPLP2 ribosomal protein, large, P2 -0.039023
BICC1 BicC family RNA binding protein 1 -0.0358377
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0334375
TPM4 tropomyosin 4 -0.0332871
RPS3 ribosomal protein S3 -0.0326423
MT2A metallothionein 2A -0.0322994
RPS12 ribosomal protein S12 -0.0318433
ENO1 enolase 1, (alpha) -0.0308064
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0304898
RPLP1 ribosomal protein, large, P1 -0.0303964
RPL23 ribosomal protein L23 -0.0301256
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0299889
THBS1 thrombospondin 1 -0.029504
RPS8 ribosomal protein S8 -0.0290808
GLIS3 GLIS family zinc finger 3 -0.0273871
RPS4X ribosomal protein S4, X-linked -0.0273815
RPL19 ribosomal protein L19 -0.0270011
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0264015
IFITM3 interferon induced transmembrane protein 3 -0.0252432
RPL36 ribosomal protein L36 -0.0249079
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0247855
RPL12 ribosomal protein L12 -0.0246013
POTEF POTE ankyrin domain family, member F -0.0246005
RPS23 ribosomal protein S23 -0.0245487
RPS6 ribosomal protein S6 -0.0241424
PTMA prothymosin, alpha -0.0235005
RPL37A ribosomal protein L37a -0.0232647
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0229639
RPL11 ribosomal protein L11 -0.0229437
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0228378
RPL5 ribosomal protein L5 -0.0226455
RPL31 ribosomal protein L31 -0.0217217
STAT1 signal transducer and activator of transcription 1, 91kDa -0.021513
RPL38 ribosomal protein L38 -0.0213044
RPS10 ribosomal protein S10 -0.0206236
RPS21 ribosomal protein S21 -0.0204714
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0203192
TPM1 tropomyosin 1 (alpha) -0.0200747
GNAS GNAS complex locus -0.019999
HLA-A major histocompatibility complex, class I, A -0.0196877
RPS14 ribosomal protein S14 -0.0195912
RPL28 ribosomal protein L28 -0.0195394
RPS20 ribosomal protein S20 -0.019539
TUBB tubulin, beta class I -0.0190671
VDAC1 voltage-dependent anion channel 1 -0.0189371
RPS25 ribosomal protein S25 -0.0188131
LOC112694756 uncharaterized LOC112694756 -0.0187807
RRBP1 ribosome binding protein 1 -0.018611
VCL vinculin -0.0181794
RPS19 ribosomal protein S19 -0.0181107
FTH1 ferritin, heavy polypeptide 1 -0.017968
ACTG1 actin gamma 1 -0.0178789
CENPF centromere protein F, 350/400kDa -0.0177754
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0175861
RPL27A ribosomal protein L27a -0.0173731
RPL26 ribosomal protein L26 -0.0172752
HMGB1 high mobility group box 1 -0.0169567
RPS29 ribosomal protein S29 -0.0169265
RPL8 ribosomal protein L8 -0.0167994
EGR1 early growth response 1 -0.0165313
HMGA2 high mobility group AT-hook 2 -0.0164759
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0162425
UBB ubiquitin B -0.0162037
RIGI RNA sensor RIG-I -0.0160844
RPS2 ribosomal protein S2 -0.01589
RPS15 ribosomal protein S15 -0.0158326
CTSD cathepsin D -0.0156456
ANXA2 annexin A2 -0.0155151
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0154483
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0152792
RPL34 ribosomal protein L34 -0.015234
RPL27 ribosomal protein L27 -0.0150039
TKT transketolase -0.014944
RPS27A ribosomal protein S27a -0.0148039
IFIH1 interferon induced with helicase C domain 1 -0.0147661
RPL30 ribosomal protein L30 -0.0145726
SRGN serglycin -0.0143234
RPLP0 ribosomal protein, large, P0 -0.0141443
EXT1 exostosin glycosyltransferase 1 -0.0141177
HLA-C major histocompatibility complex, class I, C -0.0140744
RPL35 ribosomal protein L35 -0.0140372
GLIPR1 GLI pathogenesis-related 1 -0.0140171
RPS13 ribosomal protein S13 -0.0139854
COL1A2 collagen, type I, alpha 2 -0.0139389
RPL7A ribosomal protein L7a -0.0139349
LMNA lamin A/C -0.0139148
RPS16 ribosomal protein S16 -0.0138401
RPL32 ribosomal protein L32 -0.0137774
SAMD9 sterile alpha motif domain containing 9 -0.0135678
IFITM1 interferon induced transmembrane protein 1 -0.0134113