Atazanavir (sulfate)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Atazanavir (sulfate) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Atazanavir (sulfate)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 0.126538
COL6A3 collagen, type VI, alpha 3 0.118254
TRIO trio Rho guanine nucleotide exchange factor 0.115233
IGFBP3 insulin-like growth factor binding protein 3 0.11496
ERRFI1 ERBB receptor feedback inhibitor 1 0.108252
VIM vimentin 0.10347
UBC ubiquitin C 0.0796108
MYH9 myosin, heavy chain 9, non-muscle 0.0778123
TM4SF1 transmembrane 4 L six family member 1 0.0768245
AKAP9 A kinase (PRKA) anchor protein 9 0.0741338
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0738954
ATP13A3 ATPase type 13A3 0.0720374
SOD2 superoxide dismutase 2, mitochondrial 0.0711378
RAB1A RAB1A, member RAS oncogene family 0.0709953
CDH13 cadherin 13 0.0705252
FMNL2 formin-like 2 0.0698799
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0651709
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0647199
HELZ helicase with zinc finger 0.0613936
SDC4 syndecan 4 0.0604727
LOX lysyl oxidase 0.0597108
TMSB10 thymosin beta 10 0.0587514
PLAUR plasminogen activator, urokinase receptor 0.056857
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0561474
FNDC3B fibronectin type III domain containing 3B 0.0527236
PRRC2C proline-rich coiled-coil 2C 0.0516949
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.051592
MAP2K1 mitogen-activated protein kinase kinase 1 0.0500039
IL6 interleukin 6 0.0498091
STC1 stanniocalcin 1 0.0488525
EIF1 eukaryotic translation initiation factor 1 0.0482309
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0469418
WSB1 WD repeat and SOCS box containing 1 0.0456014
S100A9 S100 calcium binding protein A9 0.0443934
UGCG UDP-glucose ceramide glucosyltransferase 0.0439534
ANXA5 annexin A5 0.0422621
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0420322
YME1L1 YME1-like 1 ATPase 0.0419076
JARID2 jumonji, AT rich interactive domain 2 0.0409885
LOXL2 lysyl oxidase-like 2 0.0408857
SBF2 SET binding factor 2 0.0402825
COPA coatomer protein complex, subunit alpha 0.0397524
HOOK2 hook microtubule-tethering protein 2 0.0395065
WASF2 WAS protein family, member 2 0.0394727
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0392625
SEC31A SEC31 homolog A (S. cerevisiae) 0.0392349
WDFY2 WD repeat and FYVE domain containing 2 0.0389773
MSN moesin 0.0389459
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0386801
SPAG9 sperm associated antigen 9 0.0381905
RICTOR RPTOR independent companion of MTOR, complex 2 0.0380214
HILPDA hypoxia inducible lipid droplet-associated 0.0380152
CLASP1 cytoplasmic linker associated protein 1 0.0375083
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0370579
RAP1B RAP1B, member of RAS oncogene family 0.0369279
SAMD4A sterile alpha motif domain containing 4A 0.0369229
SND1 staphylococcal nuclease and tudor domain containing 1 0.0363889
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0362602
LMAN1 lectin, mannose-binding, 1 0.0362496
MARCHF6 membrane associated ring-CH-type finger 6 0.0357844
MORF4L2 mortality factor 4 like 2 0.0355449
MACF1 microtubule-actin crosslinking factor 1 0.0354663
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.035221
TFPI2 tissue factor pathway inhibitor 2 0.034697
ESYT2 extended synaptotagmin-like protein 2 0.0343852
OPTN optineurin 0.0340379
GOLGA2 golgin A2 0.0339751
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0337973
MANF mesencephalic astrocyte-derived neurotrophic factor 0.0336262
FNBP1L formin binding protein 1-like 0.0333714
SCARB2 scavenger receptor class B, member 2 0.0330654
CALU calumenin 0.0328703
MMP12 matrix metallopeptidase 12 0.0328444
EEF2 eukaryotic translation elongation factor 2 0.0326947
RPS6 ribosomal protein S6 0.0322953
EMP1 epithelial membrane protein 1 0.0320996
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0319802
FNBP4 formin binding protein 4 0.031876
USP9X ubiquitin specific peptidase 9, X-linked 0.0316155
HM13 histocompatibility (minor) 13 0.0315834
CALR calreticulin 0.0315042
RPS13 ribosomal protein S13 0.0313238
NCOR1 nuclear receptor corepressor 1 0.0312952
HMGA2 high mobility group AT-hook 2 0.0312081
WTAP Wilms tumor 1 associated protein 0.0307395
LDHA lactate dehydrogenase A 0.030674
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0305281
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0303894
SEPTIN9 septin 9 0.0300089
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0299942
AFAP1 actin filament associated protein 1 0.0298654
OGA O-GlcNAcase 0.0298511
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0298441
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0297587
USO1 USO1 vesicle transport factor 0.0296603
MIS18BP1 MIS18 binding protein 1 0.0293733
DTNA dystrobrevin, alpha 0.0292311
SRRM2 serine/arginine repetitive matrix 2 0.0288354
NDEL1 nudE neurodevelopment protein 1-like 1 0.0286195
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase 0.0283962

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.125111
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0846622
CD44 CD44 molecule (Indian blood group) -0.0767877
CALD1 caldesmon 1 -0.0745483
MEF2A myocyte enhancer factor 2A -0.0565114
MAP1B microtubule-associated protein 1B -0.0553972
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0519281
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0499483
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0485578
MT1X metallothionein 1X -0.0456444
TGFBI transforming growth factor, beta-induced, 68kDa -0.0448798
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0433621
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0414579
CAV1 caveolin 1, caveolae protein, 22kDa -0.0413744
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0399167
PRELID2 PRELI domain containing 2 -0.0396783
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0386242
FBXL7 F-box and leucine-rich repeat protein 7 -0.0384405
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0383461
PDLIM5 PDZ and LIM domain 5 -0.0379784
MTPN myotrophin -0.0370772
DPYD dihydropyrimidine dehydrogenase -0.0370606
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0368248
EXT1 exostosin glycosyltransferase 1 -0.0362963
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0359214
TBC1D5 TBC1 domain family, member 5 -0.0357641
KMT2E lysine (K)-specific methyltransferase 2E -0.0355792
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0352968
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0340375
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0338893
RRBP1 ribosome binding protein 1 -0.033699
ZNF395 zinc finger protein 395 -0.0331142
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0329515
IGFBP7 insulin-like growth factor binding protein 7 -0.0327083
SMYD3 SET and MYND domain containing 3 -0.0322935
GSE1 Gse1 coiled-coil protein -0.0319748
POTEF POTE ankyrin domain family, member F -0.0319447
SMAD3 SMAD family member 3 -0.0312367
JAG1 jagged 1 -0.0310648
TPM4 tropomyosin 4 -0.0308951
ARB2A ARB2 cotranscriptional regulator A -0.0308291
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0306921
RNF24 ring finger protein 24 -0.0304406
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase -0.030368
PTPN1 protein tyrosine phosphatase, non-receptor type 1 -0.0300118
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 -0.0298316
RAD51B RAD51 paralog B -0.0295534
RPL37 ribosomal protein L37 -0.0293403
LPP LIM domain containing preferred translocation partner in lipoma -0.0293338
LCORL ligand dependent nuclear receptor corepressor-like -0.0291094
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -0.0287913
WNT5A wingless-type MMTV integration site family, member 5A -0.0287503
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0286588
ANKRD12 ankyrin repeat domain 12 -0.0285604
PDIA3 protein disulfide isomerase family A, member 3 -0.028528
TANK TRAF family member-associated NFKB activator -0.0283429
SIL1 SIL1 nucleotide exchange factor -0.0281817
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.028037
EGFR epidermal growth factor receptor -0.0275433
MTERF1 mitochondrial transcription termination factor 1 -0.0274901
SNAP25 synaptosomal-associated protein, 25kDa -0.0274864
IARS1 isoleucyl-tRNA synthetase 1 -0.0273794
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.027376
BSG basigin (Ok blood group) -0.0273558
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0268661
ENO1 enolase 1, (alpha) -0.0268361
FAT1 FAT atypical cadherin 1 -0.0268139
SPDYA speedy/RINGO cell cycle regulator family member A -0.0265258
MRTFA myocardin related transcription factor A -0.0262761
GLIS3 GLIS family zinc finger 3 -0.0260669
MBNL1 muscleblind-like splicing regulator 1 -0.0256487
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.0254364
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0253275
ZNF736 zinc finger protein 736 -0.02527
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -0.0251522
PRIM2 primase, DNA, polypeptide 2 (58kDa) -0.0249384
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0248955
SUGCT succinyl-CoA:glutarate-CoA transferase -0.0248391
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0248291
WDPCP WD repeat containing planar cell polarity effector -0.0246393
ZMYND8 zinc finger, MYND-type containing 8 -0.0246311
ANKRD33B ankyrin repeat domain 33B -0.0246199
PALLD palladin, cytoskeletal associated protein -0.0245008
HMGB1 high mobility group box 1 -0.0244449
FER fer (fps/fes related) tyrosine kinase -0.0243344
AFF3 AF4/FMR2 family, member 3 -0.0243153
RNF130 ring finger protein 130 -0.0242846
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0242605
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0242002
TFG TRK-fused gene -0.0241524
SKAP2 src kinase associated phosphoprotein 2 -0.024034
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0240306
DOCK7 dedicator of cytokinesis 7 -0.0239533
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0238261
ZEB1 zinc finger E-box binding homeobox 1 -0.0237548
FAF1 Fas (TNFRSF6) associated factor 1 -0.023695
IFRD1 interferon-related developmental regulator 1 -0.0236936
MXD1 MAX dimerization protein 1 -0.0236848
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0235725
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 -0.0235415