Atazanavir (sulfate)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Atazanavir (sulfate) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Atazanavir (sulfate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0864358
MYH9 myosin, heavy chain 9, non-muscle 0.0721518
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.066403
FNDC3B fibronectin type III domain containing 3B 0.0652308
ASPH aspartate beta-hydroxylase 0.0581603
NRIP1 nuclear receptor interacting protein 1 0.0547242
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.042007
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.041841
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0372478
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0369171
NPC1 Niemann-Pick disease, type C1 0.0345673
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0334316
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0333103
CAB39 calcium binding protein 39 0.0332545
MT2A metallothionein 2A 0.0331525
OGA O-GlcNAcase 0.0329352
WDR26 WD repeat domain 26 0.0324759
SMAD3 SMAD family member 3 0.0316304
ETNK1 ethanolamine kinase 1 0.0304675
ITGA1 integrin, alpha 1 0.0302668
NAP1L1 nucleosome assembly protein 1-like 1 0.0300927
SPRED2 sprouty-related, EVH1 domain containing 2 0.0289149
FOXO3 forkhead box O3 0.0285447
EREG epiregulin 0.0285414
ERRFI1 ERBB receptor feedback inhibitor 1 0.0282007
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0281782
DOCK5 dedicator of cytokinesis 5 0.0281451
MCTP2 multiple C2 domains, transmembrane 2 0.0280089
MKI67 marker of proliferation Ki-67 0.0273843
APP amyloid beta (A4) precursor protein 0.0271773
VCL vinculin 0.026721
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0265263
NAMPT nicotinamide phosphoribosyltransferase 0.0259178
PELO pelota homolog (Drosophila) 0.0258948
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0253164
TMEM156 transmembrane protein 156 0.02494
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0249179
ARRDC3 arrestin domain containing 3 0.0248526
SOD2 superoxide dismutase 2, mitochondrial 0.0248443
ITGB5 integrin, beta 5 0.0245988
IL6ST interleukin 6 signal transducer 0.0245775
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0244236
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0242634
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0237059
MACF1 microtubule-actin crosslinking factor 1 0.0233655
SPRED1 sprouty-related, EVH1 domain containing 1 0.023032
MAP3K9 mitogen-activated protein kinase kinase kinase 9 0.0224633
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0221436
PRELID2 PRELI domain containing 2 0.0219627
PTK2 protein tyrosine kinase 2 0.0218524
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0216721
FAM13A family with sequence similarity 13, member A 0.0214988
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0213512
SLTM SAFB-like, transcription modulator 0.0212881
WWTR1 WW domain containing transcription regulator 1 0.021173
RANBP2 RAN binding protein 2 0.0208373
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0205262
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0205012
ANXA5 annexin A5 0.0202894
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0199859
OSMR oncostatin M receptor 0.0199745
SMOX spermine oxidase 0.0197913
CAPN2 calpain 2, (m/II) large subunit 0.0192702
KDM3A lysine (K)-specific demethylase 3A 0.0192555
ADD3 adducin 3 (gamma) 0.0192065
NIPBL Nipped-B homolog (Drosophila) 0.0191625
SP3 Sp3 transcription factor 0.0191342
ACTN4 actinin, alpha 4 0.0190515
H1-0 H1.0 linker histone 0.0188918
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0186855
FAT1 FAT atypical cadherin 1 0.0186651
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0184558
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0182937
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0180412
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0178988
HSPA8 heat shock 70kDa protein 8 0.0177865
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0177151
IRAK3 interleukin-1 receptor-associated kinase 3 0.0177124
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0177073
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0176026
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0174815
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0173376
LTBP1 latent transforming growth factor beta binding protein 1 0.0170899
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0170369
ZFAND6 zinc finger, AN1-type domain 6 0.0170307
YAP1 Yes-associated protein 1 0.0169716
DNMBP dynamin binding protein 0.0161877
SHB Src homology 2 domain containing adaptor protein B 0.0161677
EPS8 epidermal growth factor receptor pathway substrate 8 0.0161134
MARCHF6 membrane associated ring-CH-type finger 6 0.0160124
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0159979
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0159619
ANLN anillin, actin binding protein 0.0159401
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0159346
USP12 ubiquitin specific peptidase 12 0.0158589
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0157545
FBXO28 F-box protein 28 0.0157054
SEPTIN9 septin 9 0.0156519
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0155287
TM9SF3 transmembrane 9 superfamily member 3 0.015514

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.134865
NRG1 neuregulin 1 -0.129761
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.127724
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.113462
FN1 fibronectin 1 -0.090714
GLIS3 GLIS family zinc finger 3 -0.0761405
TMSB10 thymosin beta 10 -0.0711865
FTL ferritin, light polypeptide -0.0699033
P4HB prolyl 4-hydroxylase, beta polypeptide -0.062722
SQSTM1 sequestosome 1 -0.061567
SYT1 synaptotagmin I -0.0562126
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.054489
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0534379
FTH1 ferritin, heavy polypeptide 1 -0.0522073
MRPS6 mitochondrial ribosomal protein S6 -0.0513575
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0512217
LMNA lamin A/C -0.0503246
HLA-B major histocompatibility complex, class I, B -0.0501957
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0490222
FOS FBJ murine osteosarcoma viral oncogene homolog -0.04784
VIM vimentin -0.0461933
LOC102724023 ES1 protein homolog, mitochondrial -0.0451879
IFI27 interferon, alpha-inducible protein 27 -0.0416544
STC2 stanniocalcin 2 -0.0379286
TXNIP thioredoxin interacting protein -0.0371223
PTMA prothymosin, alpha -0.0323774
NDRG1 N-myc downstream regulated 1 -0.0314586
PDIA3 protein disulfide isomerase family A, member 3 -0.0307325
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0297157
VEGFA vascular endothelial growth factor A -0.0289529
TXNRD1 thioredoxin reductase 1 -0.0280021
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.027343
RAI14 retinoic acid induced 14 -0.0262548
RANBP17 RAN binding protein 17 -0.0262306
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.026003
ENO2 enolase 2 (gamma, neuronal) -0.0257964
BIRC6 baculoviral IAP repeat containing 6 -0.0257598
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0256598
ENO1 enolase 1, (alpha) -0.0253838
S100A6 S100 calcium binding protein A6 -0.0251909
RPS25 ribosomal protein S25 -0.0248411
EGR1 early growth response 1 -0.0247053
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0243752
SPDYA speedy/RINGO cell cycle regulator family member A -0.0243467
PDIA6 protein disulfide isomerase family A, member 6 -0.0234225
GRB10 growth factor receptor-bound protein 10 -0.0223229
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0222592
MYADM myeloid-associated differentiation marker -0.0220614
HDLBP high density lipoprotein binding protein -0.0218671
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0218312
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0217581
HMGA2 high mobility group AT-hook 2 -0.0215601
SUCO SUN domain containing ossification factor -0.0215317
LY6E lymphocyte antigen 6 complex, locus E -0.0215079
MBD5 methyl-CpG binding domain protein 5 -0.0213296
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0212853
CALR calreticulin -0.0207336
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0199855
DPYD dihydropyrimidine dehydrogenase -0.0198078
IL6 interleukin 6 -0.0196691
RPL35A ribosomal protein L35a -0.0195914
FBN1 fibrillin 1 -0.019498
WASF2 WAS protein family, member 2 -0.0194049
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) -0.0193394
RPS16 ribosomal protein S16 -0.0192101
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0189993
RPL32 ribosomal protein L32 -0.0189037
PLIN2 perilipin 2 -0.0188791
RACK1 receptor for activated C kinase 1 -0.0188646
BRWD1 bromodomain and WD repeat domain containing 1 -0.0188113
MTDH metadherin -0.0184306
SOX4 SRY (sex determining region Y)-box 4 -0.0183138
TTC3 tetratricopeptide repeat domain 3 -0.0182705
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.0182667
ATN1 atrophin 1 -0.018263
HMGA1 high mobility group AT-hook 1 -0.0181657
GNAS GNAS complex locus -0.0173289
PFN1 profilin 1 -0.017149
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.017075
USP34 ubiquitin specific peptidase 34 -0.0167156
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0162191
TKT transketolase -0.0160765
HMGB3 high mobility group box 3 -0.0160742
DENND5B DENN/MADD domain containing 5B -0.0158799
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0157906
ALKBH5 AlkB family member 5, RNA demethylase -0.0157261
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0156532
NBEA neurobeachin -0.0156239
INTS6 integrator complex subunit 6 -0.0155099
RNF213 ring finger protein 213 -0.015393
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -0.0153884
UGDH UDP-glucose 6-dehydrogenase -0.0153576
CDK13 cyclin-dependent kinase 13 -0.0153484
ETV1 ets variant 1 -0.0153473
DSTN destrin (actin depolymerizing factor) -0.0152791
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0152122
CTSD cathepsin D -0.01516
IER3 immediate early response 3 -0.015148
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0150967
HIPK2 homeodomain interacting protein kinase 2 -0.015096