Atazanavir (sulfate)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Atazanavir (sulfate) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Atazanavir (sulfate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NKD1 naked cuticle homolog 1 (Drosophila) 0.111867
PABPC1 poly(A) binding protein, cytoplasmic 1 0.107159
MYH9 myosin, heavy chain 9, non-muscle 0.0762592
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0730102
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0709699
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0708618
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0697516
PGK1 phosphoglycerate kinase 1 0.0695144
ESYT2 extended synaptotagmin-like protein 2 0.0693573
ITGA6 integrin, alpha 6 0.0683348
MACF1 microtubule-actin crosslinking factor 1 0.0677337
BCL2L1 BCL2-like 1 0.0674961
ETNK1 ethanolamine kinase 1 0.0673042
AKAP12 A kinase (PRKA) anchor protein 12 0.0652367
VMP1 vacuole membrane protein 1 0.0592676
PROX1 prospero homeobox 1 0.0572302
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0564194
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0559608
ERRFI1 ERBB receptor feedback inhibitor 1 0.0551479
ABHD2 abhydrolase domain containing 2 0.0541319
SNX9 sorting nexin 9 0.0541253
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0537118
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0527735
MED13 mediator complex subunit 13 0.0519641
ITPRID2 ITPR interacting domain containing 2 0.0518471
ANLN anillin, actin binding protein 0.050931
LMO7 LIM domain 7 0.0508369
CEMIP2 cell migration inducing hyaluronidase 2 0.0507526
USP34 ubiquitin specific peptidase 34 0.0492668
SETD5 SET domain containing 5 0.0491944
OXR1 oxidation resistance 1 0.0484675
GOLGA4 golgin A4 0.0480975
MACC1 metastasis associated in colon cancer 1 0.0478393
KMT2C lysine (K)-specific methyltransferase 2C 0.0477371
ZMYND8 zinc finger, MYND-type containing 8 0.0471577
MKI67 marker of proliferation Ki-67 0.0470902
AKAP9 A kinase (PRKA) anchor protein 9 0.0470767
EFNB2 ephrin-B2 0.0468339
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0461533
AFDN afadin, adherens junction formation factor 0.0453583
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0449945
NF1 neurofibromin 1 0.0445892
WDFY2 WD repeat and FYVE domain containing 2 0.0441177
PDGFA platelet-derived growth factor alpha polypeptide 0.044025
CANX calnexin 0.0439193
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0436808
DSPP dentin sialophosphoprotein 0.0435145
DST dystonin 0.0430105
PRRC2C proline-rich coiled-coil 2C 0.0427992
EEF2 eukaryotic translation elongation factor 2 0.0427187
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0420338
TMEM41B transmembrane protein 41B 0.0410325
TXNIP thioredoxin interacting protein 0.0409589
SPATA13 spermatogenesis associated 13 0.0395213
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0391493
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0389627
CTNND1 catenin (cadherin-associated protein), delta 1 0.0382505
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0378096
JAG1 jagged 1 0.0376227
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0374769
TTC3 tetratricopeptide repeat domain 3 0.036509
KDM3A lysine (K)-specific demethylase 3A 0.0364035
RAB6A RAB6A, member RAS oncogene family 0.0362358
JMJD1C jumonji domain containing 1C 0.0359079
ARHGAP9 Rho GTPase activating protein 9 0.035878
ZFAND3 zinc finger, AN1-type domain 3 0.0356107
THOC2 THO complex 2 0.0354337
NCEH1 neutral cholesterol ester hydrolase 1 0.0351185
OGA O-GlcNAcase 0.0348224
SEC31A SEC31 homolog A (S. cerevisiae) 0.0347947
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0344739
BRWD3 bromodomain and WD repeat domain containing 3 0.0343252
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0338924
MAML2 mastermind-like 2 (Drosophila) 0.0336802
UBA6 ubiquitin-like modifier activating enzyme 6 0.0336712
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0333874
YAP1 Yes-associated protein 1 0.0327869
H1-0 H1.0 linker histone 0.0327815
SBF2 SET binding factor 2 0.0327729
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0325271
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0322214
SRRM2 serine/arginine repetitive matrix 2 0.0320571
TMF1 TATA element modulatory factor 1 0.031936
MORF4L2 mortality factor 4 like 2 0.0315767
PICALM phosphatidylinositol binding clathrin assembly protein 0.0313923
CCDC82 coiled-coil domain containing 82 0.0311528
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0311512
LDHA lactate dehydrogenase A 0.031068
PDE8A phosphodiesterase 8A 0.0310463
USP9X ubiquitin specific peptidase 9, X-linked 0.030949
ZNF292 zinc finger protein 292 0.0308434
MON2 MON2 homolog (S. cerevisiae) 0.0307578
GCC2 GRIP and coiled-coil domain containing 2 0.0306805
GLG1 golgi glycoprotein 1 0.0306128
SCAF11 SR-related CTD-associated factor 11 0.0304319
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0303356
COPA coatomer protein complex, subunit alpha 0.0300749
SPRED2 sprouty-related, EVH1 domain containing 2 0.02987
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0298303
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0297893

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.165749
NAV2 neuron navigator 2 -0.0970189
TMSB10 thymosin beta 10 -0.0774697
SDK1 sidekick cell adhesion molecule 1 -0.0770729
CCND1 cyclin D1 -0.0731165
INTS6 integrator complex subunit 6 -0.0685204
WWOX WW domain containing oxidoreductase -0.062443
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0597504
CDH13 cadherin 13 -0.0592726
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0560202
RPLP1 ribosomal protein, large, P1 -0.053143
RPL23 ribosomal protein L23 -0.052628
RPL35A ribosomal protein L35a -0.0523007
RPS8 ribosomal protein S8 -0.0499196
RPS19 ribosomal protein S19 -0.0473162
ADGRL2 adhesion G protein-coupled receptor L2 -0.044927
RPS6 ribosomal protein S6 -0.0410273
RPL37A ribosomal protein L37a -0.0396883
RPL28 ribosomal protein L28 -0.0392869
TPT1 tumor protein, translationally-controlled 1 -0.0389778
RPL12 ribosomal protein L12 -0.038943
RPS24 ribosomal protein S24 -0.0368986
RPL35 ribosomal protein L35 -0.0365528
MT2A metallothionein 2A -0.0348737
HMGB1 high mobility group box 1 -0.0344488
RPL31 ribosomal protein L31 -0.0343422
VCL vinculin -0.0340848
RPL38 ribosomal protein L38 -0.0339891
RPS12 ribosomal protein S12 -0.0333013
RPL26 ribosomal protein L26 -0.0322421
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0315367
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0314068
RPS5 ribosomal protein S5 -0.0312513
GMDS GDP-mannose 4,6-dehydratase -0.030532
SYT1 synaptotagmin I -0.0301096
PTMA prothymosin, alpha -0.0297992
FTL ferritin, light polypeptide -0.0295288
RPL11 ribosomal protein L11 -0.0293649
RPLP2 ribosomal protein, large, P2 -0.028528
RBP1 retinol binding protein 1, cellular -0.0274579
LRMDA leucine rich melanocyte differentiation associated -0.0263397
RPS21 ribosomal protein S21 -0.0261607
RPS25 ribosomal protein S25 -0.0260735
FHIT fragile histidine triad -0.0260617
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0259376
RPS23 ribosomal protein S23 -0.0252521
HMGA1 high mobility group AT-hook 1 -0.0248486
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0247745
RPL32 ribosomal protein L32 -0.0244445
RPL18 ribosomal protein L18 -0.0243895
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0241369
RPL36 ribosomal protein L36 -0.0240816
EMP1 epithelial membrane protein 1 -0.0235834
CD44 CD44 molecule (Indian blood group) -0.0234752
RPS17 ribosomal protein S17 -0.0233375
RPS16 ribosomal protein S16 -0.0232964
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0229103
RPS20 ribosomal protein S20 -0.0226931
RPL19 ribosomal protein L19 -0.0225638
PCDH9 protocadherin 9 -0.0224324
S100A10 S100 calcium binding protein A10 -0.022425
MRPS6 mitochondrial ribosomal protein S6 -0.0220584
POTEF POTE ankyrin domain family, member F -0.0216966
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 -0.0216038
RAD51B RAD51 paralog B -0.0211041
RCC1 regulator of chromosome condensation 1 -0.0208962
EXOC4 exocyst complex component 4 -0.0208876
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0207166
RPS11 ribosomal protein S11 -0.0206701
FUS FUS RNA binding protein -0.0206228
HDAC4 histone deacetylase 4 -0.0204649
NOP56 NOP56 ribonucleoprotein -0.0204118
TAS2R14 taste receptor, type 2, member 14 -0.0202416
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0197721
SPIDR scaffolding protein involved in DNA repair -0.0197643
YBX1 Y box binding protein 1 -0.0196734
RPS15 ribosomal protein S15 -0.0196149
GPHN gephyrin -0.0194999
PDE4D phosphodiesterase 4D, cAMP-specific -0.0193895
RPS4X ribosomal protein S4, X-linked -0.0190543
RPS3 ribosomal protein S3 -0.0189351
NABP1 nucleic acid binding protein 1 -0.0189292
RPL9 ribosomal protein L9 -0.0187294
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0187214
UBAP2 ubiquitin associated protein 2 -0.018551
RPS14 ribosomal protein S14 -0.018493
RPL8 ribosomal protein L8 -0.0184224
SERBP1 SERPINE1 mRNA binding protein 1 -0.0181973
SKAP1 src kinase associated phosphoprotein 1 -0.01813
BACE2 beta-site APP-cleaving enzyme 2 -0.0179409
TFRC transferrin receptor -0.0179351
LMNA lamin A/C -0.017838
E2F3 E2F transcription factor 3 -0.017828
RPL27 ribosomal protein L27 -0.0178133
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0177647
SQSTM1 sequestosome 1 -0.0175459
RPS27A ribosomal protein S27a -0.0175239
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.017467
PA2G4 proliferation-associated 2G4, 38kDa -0.0172771
DNAH14 dynein, axonemal, heavy chain 14 -0.017257