Atazanavir (sulfate)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Atazanavir (sulfate) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Atazanavir (sulfate)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
INHBA inhibin, beta A 0.131982
TRIO trio Rho guanine nucleotide exchange factor 0.08859
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0874908
SOD2 superoxide dismutase 2, mitochondrial 0.0822048
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0778297
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0761741
HIPK2 homeodomain interacting protein kinase 2 0.0680054
GOLGA4 golgin A4 0.0605093
ELL2 elongation factor, RNA polymerase II, 2 0.0579954
FAM13A family with sequence similarity 13, member A 0.0565229
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0549457
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0524964
COL1A2 collagen, type I, alpha 2 0.0520919
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0475306
TMEM165 transmembrane protein 165 0.0467391
RTN4 reticulon 4 0.0466301
DSCAM Down syndrome cell adhesion molecule 0.0464352
NAMPT nicotinamide phosphoribosyltransferase 0.044834
RUNX1 runt-related transcription factor 1 0.043096
MMP1 matrix metallopeptidase 1 0.0428545
MMP12 matrix metallopeptidase 12 0.040795
PGK1 phosphoglycerate kinase 1 0.0407746
WDR26 WD repeat domain 26 0.0406249
ABI3BP ABI family, member 3 (NESH) binding protein 0.0390056
WSB1 WD repeat and SOCS box containing 1 0.0387819
CALU calumenin 0.0385745
JARID2 jumonji, AT rich interactive domain 2 0.0377873
LIMS1 LIM and senescent cell antigen-like domains 1 0.0376776
FMNL2 formin-like 2 0.0372032
CENPF centromere protein F, 350/400kDa 0.036796
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0365516
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0360592
FNIP1 folliculin interacting protein 1 0.0358498
TAS2R14 taste receptor, type 2, member 14 0.0357013
ERRFI1 ERBB receptor feedback inhibitor 1 0.0349736
CAVIN1 caveolae associated protein 1 0.0340455
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.0340075
MYH9 myosin, heavy chain 9, non-muscle 0.033691
TGFBI transforming growth factor, beta-induced, 68kDa 0.0333839
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0327105
BIRC6 baculoviral IAP repeat containing 6 0.0326733
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0326642
SEC24D SEC24 family member D 0.0325967
PLPP3 phospholipid phosphatase 3 0.0323575
DUSP10 dual specificity phosphatase 10 0.0315475
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0314954
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0314326
SUCO SUN domain containing ossification factor 0.0312999
ZNF292 zinc finger protein 292 0.0312706
NGLY1 N-glycanase 1 0.0303649
AFF4 AF4/FMR2 family, member 4 0.0301401
RAD51B RAD51 paralog B 0.029798
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0297297
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.02935
ARHGAP21 Rho GTPase activating protein 21 0.0291853
BHLHE40 basic helix-loop-helix family, member e40 0.0285113
LTBP1 latent transforming growth factor beta binding protein 1 0.0283945
NAV2 neuron navigator 2 0.0282908
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0280907
OGA O-GlcNAcase 0.02783
ANKRD12 ankyrin repeat domain 12 0.0276988
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0275909
FNDC3B fibronectin type III domain containing 3B 0.0274943
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0273685
GREM1 gremlin 1, DAN family BMP antagonist 0.0273598
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0273384
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.027049
RABGAP1 RAB GTPase activating protein 1 0.0269924
UGCG UDP-glucose ceramide glucosyltransferase 0.0266125
CXCL8 chemokine (C-X-C motif) ligand 8 0.0264535
TTC3 tetratricopeptide repeat domain 3 0.0264526
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0263539
MON2 MON2 homolog (S. cerevisiae) 0.0263133
MSN moesin 0.0262675
LDHA lactate dehydrogenase A 0.0260488
SOCS5 suppressor of cytokine signaling 5 0.0260199
RBM39 RNA binding motif protein 39 0.0259727
RNF150 ring finger protein 150 0.0258562
LOXL2 lysyl oxidase-like 2 0.0254886
GPHN gephyrin 0.0254672
SPAG9 sperm associated antigen 9 0.0252788
CHD9 chromodomain helicase DNA binding protein 9 0.025131
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0251179
CCNL1 cyclin L1 0.0249648
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0249564
RAB1A RAB1A, member RAS oncogene family 0.0248149
VEGFC vascular endothelial growth factor C 0.024497
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0244696
USP9Y ubiquitin specific peptidase 9, Y-linked 0.0243716
YEATS2 YEATS domain containing 2 0.0243611
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0242414
FN1 fibronectin 1 0.0239472
ESYT2 extended synaptotagmin-like protein 2 0.0236899
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0236225
PRELID2 PRELI domain containing 2 0.0234276
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0231931
SP3 Sp3 transcription factor 0.0231808
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.023154
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0231122
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0231047

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.187849
TMSB10 thymosin beta 10 -0.0893171
HLA-B major histocompatibility complex, class I, B -0.063364
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0632363
VCL vinculin -0.0623497
CALD1 caldesmon 1 -0.0597582
FTL ferritin, light polypeptide -0.0563711
EXT1 exostosin glycosyltransferase 1 -0.0545767
COL6A1 collagen, type VI, alpha 1 -0.0519734
COL5A3 collagen, type V, alpha 3 -0.0519116
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0484475
SLIT2 slit homolog 2 (Drosophila) -0.0475973
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0436671
MT2A metallothionein 2A -0.0434704
LOC112694756 uncharaterized LOC112694756 -0.0431034
B2M beta-2-microglobulin -0.0417822
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.041398
COL4A1 collagen, type IV, alpha 1 -0.0411546
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0406929
RPLP1 ribosomal protein, large, P1 -0.0385826
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0378831
MAP1B microtubule-associated protein 1B -0.0357135
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0354605
LOX lysyl oxidase -0.034518
ARHGAP22 Rho GTPase activating protein 22 -0.0332215
ARHGAP24 Rho GTPase activating protein 24 -0.0332201
RPS6 ribosomal protein S6 -0.0324049
P4HB prolyl 4-hydroxylase, beta polypeptide -0.031822
CYTH3 cytohesin 3 -0.0318213
DIAPH2 diaphanous-related formin 2 -0.031349
LMNA lamin A/C -0.0310168
CLIC4 chloride intracellular channel 4 -0.0306872
WNT2B wingless-type MMTV integration site family, member 2B -0.0305393
SASH1 SAM and SH3 domain containing 1 -0.0296264
ADGRB3 adhesion G protein-coupled receptor B3 -0.0289791
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0281521
COL4A2 collagen, type IV, alpha 2 -0.0277735
PDLIM5 PDZ and LIM domain 5 -0.027405
EMP1 epithelial membrane protein 1 -0.0273017
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0270569
ACTN1 actinin, alpha 1 -0.0270076
VMP1 vacuole membrane protein 1 -0.0269261
ARHGAP31 Rho GTPase activating protein 31 -0.0265062
COL8A1 collagen, type VIII, alpha 1 -0.0262066
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0261838
RAB31 RAB31, member RAS oncogene family -0.0261267
MAML3 mastermind-like 3 (Drosophila) -0.0257876
RPS29 ribosomal protein S29 -0.0253522
RSU1 Ras suppressor protein 1 -0.0244309
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0244121
PALLD palladin, cytoskeletal associated protein -0.0243007
FBN1 fibrillin 1 -0.0242517
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0241435
GLIS3 GLIS family zinc finger 3 -0.0239187
FNDC3A fibronectin type III domain containing 3A -0.0236554
ZEB2 zinc finger E-box binding homeobox 2 -0.0236403
FRMD4A FERM domain containing 4A -0.0236073
SIK2 salt-inducible kinase 2 -0.0234239
CCDC102B coiled-coil domain containing 102B -0.0234047
ANXA2 annexin A2 -0.0233179
COL27A1 collagen, type XXVII, alpha 1 -0.023206
WNT5A wingless-type MMTV integration site family, member 5A -0.0230782
CCL5 chemokine (C-C motif) ligand 5 -0.0230499
PRRX1 paired related homeobox 1 -0.0227892
PCBP2 poly(rC) binding protein 2 -0.022697
PTPRG protein tyrosine phosphatase, receptor type, G -0.0226268
SERF2 small EDRK-rich factor 2 -0.0226257
CDPF1 cysteine-rich, DPF motif domain containing 1 -0.0225903
FERMT2 fermitin family member 2 -0.0225849
DGKH diacylglycerol kinase, eta -0.022495
RPL19 ribosomal protein L19 -0.0221625
RPL31 ribosomal protein L31 -0.0221588
NABP1 nucleic acid binding protein 1 -0.0220353
EGFR epidermal growth factor receptor -0.0219948
AHRR aryl-hydrocarbon receptor repressor -0.0218772
NALF1 NALCN channel auxiliary factor 1 -0.0215222
ZEB1 zinc finger E-box binding homeobox 1 -0.0212494
CALR calreticulin -0.0208901
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0205096
TPM4 tropomyosin 4 -0.0202688
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0201682
TGFB1 transforming growth factor, beta 1 -0.0201375
RPS23 ribosomal protein S23 -0.0199066
MYO10 myosin X -0.0198908
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0198299
ZNF207 zinc finger protein 207 -0.0197914
S100A6 S100 calcium binding protein A6 -0.0193041
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0192364
TAOK1 TAO kinase 1 -0.0192052
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -0.0191526
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0190701
RPLP2 ribosomal protein, large, P2 -0.0190101
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0190091
CDK14 cyclin-dependent kinase 14 -0.0187291
CDH13 cadherin 13 -0.0186873
USP15 ubiquitin specific peptidase 15 -0.0184862
ETV6 ets variant 6 -0.0183238
RPL5 ribosomal protein L5 -0.0183071
NCOR2 nuclear receptor corepressor 2 -0.0183009
RPL8 ribosomal protein L8 -0.0181952