Atosiban Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/5311010
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Genes

199 proteins with high or low expression in Atosiban relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
CCDC73 coiled-coil domain containing 73 3.68
IER2 immediate early response 2 3.24
ZNF175 zinc finger protein 175 2.53
NR1D2 nuclear receptor subfamily 1, group D, member 2 2.22
DIPK1B divergent protein kinase domain 1B 1.58
ANKRD20A4 ankyrin repeat domain 20 family, member A4 0.88
HMCES 5-hydroxymethylcytosine (hmC) binding, ES cell-specific 0.84
MINDY4 MINDY lysine 48 deubiquitinase 4 0.82
GREB1 growth regulation by estrogen in breast cancer 1 0.75
C7 complement component 7 0.73
ZSWIM9 zinc finger SWIM-type containing 9 0.72
KMT2B lysine (K)-specific methyltransferase 2B 0.7
CDPF1 cysteine-rich, DPF motif domain containing 1 0.69
ERCC6 excision repair cross-complementation group 6 0.62
TAZ tafazzin 0.62
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 0.61
DNAH6 dynein, axonemal, heavy chain 6 0.61
EXO1 exonuclease 1 0.6
CAMK4 calcium/calmodulin-dependent protein kinase IV 0.6
FAN1 FANCD2/FANCI-associated nuclease 1 0.58
HYLS1 hydrolethalus syndrome 1 0.54
SYTL3 synaptotagmin-like 3 0.54
PECR peroxisomal trans-2-enoyl-CoA reductase 0.54
APOE apolipoprotein E 0.52
RRM2 ribonucleotide reductase M2 0.49
MAPKBP1 mitogen-activated protein kinase binding protein 1 0.48
TCEA2 transcription elongation factor A (SII), 2 0.46
TOX2 TOX high mobility group box family member 2 0.46
CDC25B cell division cycle 25B 0.46
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae) 0.45
BRD8 bromodomain containing 8 0.44
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.44
HELLS helicase, lymphoid-specific 0.44
TBP TATA box binding protein 0.44
LAMA5 laminin, alpha 5 0.44
CADPS Ca++-dependent secretion activator 0.43
E2F8 E2F transcription factor 8 0.43
IVNS1ABP influenza virus NS1A binding protein 0.42
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.42
GEN1 GEN1 Holliday junction 5' flap endonuclease 0.42
ENC1 ectodermal-neural cortex 1 (with BTB domain) 0.42
ZNF689 zinc finger protein 689 0.42
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39 0.42
DMTF1 cyclin D binding myb-like transcription factor 1 0.42
LPIN2 lipin 2 0.42
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.42
DES desmin 0.41
ZNF496 zinc finger protein 496 0.41
ZNF320 zinc finger protein 320 0.41
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 0.41
VPS37C vacuolar protein sorting 37 homolog C (S. cerevisiae) 0.41
CCNF cyclin F 0.41
CDCA7 cell division cycle associated 7 0.4
COL11A1 collagen, type XI, alpha 1 0.4
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) 0.39
KIAA0586 KIAA0586 0.39
CAPN6 calpain 6 0.39
OBI1 ORC ubiquitin ligase 1 0.38
TP73 tumor protein p73 0.38
FAM53B family with sequence similarity 53, member B 0.38
C5ORF34 chromosome 5 open reading frame 34 0.38
PLA2G6 phospholipase A2, group VI (cytosolic, calcium-independent) 0.38
KMT2C lysine (K)-specific methyltransferase 2C 0.38
CCDC43 coiled-coil domain containing 43 0.37
PCLAF PCNA clamp associated factor 0.37
ERVMER34-1 endogenous retrovirus group MER34, member 1 0.37
ZNF267 zinc finger protein 267 0.36
PARPBP PARP1 binding protein 0.36
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 0.36
COBLL1 cordon-bleu WH2 repeat protein-like 1 0.36
H3C1 H3 clustered histone 1 0.36
DVL3 dishevelled segment polarity protein 3 0.36
ALMS1 Alstrom syndrome protein 1 0.36
CDC25C cell division cycle 25C 0.36
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 0.36
ZNF91 zinc finger protein 91 0.36
RPL37 ribosomal protein L37 0.35
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 0.35
IFFO2 intermediate filament family orphan 2 0.35
FBXO5 F-box protein 5 0.35
PTTG1 pituitary tumor-transforming 1 0.34
BCOR BCL6 corepressor 0.34
METRN meteorin, glial cell differentiation regulator 0.33
BARD1 BRCA1 associated RING domain 1 0.33
PEMT phosphatidylethanolamine N-methyltransferase 0.33
SIK3 SIK family kinase 3 0.33
ASNSD1 asparagine synthetase domain containing 1 0.33
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha 0.33
SS18L1 synovial sarcoma translocation gene on chromosome 18-like 1 0.33
NOVA1 neuro-oncological ventral antigen 1 0.32
BRCA2 breast cancer 2, early onset 0.32
RYK receptor-like tyrosine kinase 0.32
PLIN2 perilipin 2 0.32
DNA2 DNA replication helicase/nuclease 2 0.32
BCAM basal cell adhesion molecule (Lutheran blood group) 0.32
E2F2 E2F transcription factor 2 0.32
TPGS2 tubulin polyglutamylase complex subunit 2 0.32
NFE2L1 nuclear factor, erythroid 2-like 1 0.32
CBX7 chromobox homolog 7 0.32

low expression

Symbol Name Standardized Value
NGFR nerve growth factor receptor -0.89
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -0.85
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.74
PIP prolactin-induced protein -0.61
JAK3 Janus kinase 3 -0.57
CCDC158 coiled-coil domain containing 158 -0.55
CCND3 cyclin D3 -0.54
FTL ferritin, light polypeptide -0.51
COL14A1 collagen, type XIV, alpha 1 -0.5
TP53 tumor protein p53 -0.5
C18ORF32 chromosome 18 open reading frame 32 -0.46
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.45
TSKU tsukushi, small leucine rich proteoglycan -0.44
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.43
FAM219B family with sequence similarity 219, member B -0.43
SLC22A18 solute carrier family 22, member 18 -0.43
CALU calumenin -0.43
CES2 carboxylesterase 2 -0.43
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.41
HID1 HID1 domain containing -0.41
NDFIP1 Nedd4 family interacting protein 1 -0.41
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 -0.41
ZNF513 zinc finger protein 513 -0.41
ADIRF adipogenesis regulatory factor -0.41
S100A6 S100 calcium binding protein A6 -0.41
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.41
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 -0.4
GJB3 gap junction protein, beta 3, 31kDa -0.4
RABAC1 Rab acceptor 1 (prenylated) -0.4
TRIM7 tripartite motif containing 7 -0.4
ZFP37 ZFP37 zinc finger protein -0.4
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 -0.4
CLCN2 chloride channel, voltage-sensitive 2 -0.39
ZNF282 zinc finger protein 282 -0.39
CDK18 cyclin-dependent kinase 18 -0.39
TBX3 T-box 3 -0.38
HIST2H2AA3 histone cluster 2, H2aa3 -0.38
INPP5J inositol polyphosphate-5-phosphatase J -0.36
PRICKLE3 prickle homolog 3 (Drosophila) -0.36
TMC4 transmembrane channel-like 4 -0.36
CALHM2 calcium homeostasis modulator 2 -0.35
F5 coagulation factor V (proaccelerin, labile factor) -0.35
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -0.34
SESN1 sestrin 1 -0.34
ATE1 arginyltransferase 1 -0.34
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 -0.34
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit -0.34
CLCN6 chloride channel, voltage-sensitive 6 -0.33
UGDH UDP-glucose 6-dehydrogenase -0.33
MCFD2 multiple coagulation factor deficiency 2 -0.32
EMP3 epithelial membrane protein 3 -0.32
MYDGF myeloid-derived growth factor -0.32
GDF15 growth differentiation factor 15 -0.32
NAV2 neuron navigator 2 -0.32
FTH1 ferritin, heavy polypeptide 1 -0.31
ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) -0.31
GLRX glutaredoxin (thioltransferase) -0.31
ABHD2 abhydrolase domain containing 2 -0.31
TACSTD2 tumor-associated calcium signal transducer 2 -0.31
PHKB phosphorylase kinase, beta -0.31
BTBD7 BTB (POZ) domain containing 7 -0.31
UROC1 urocanate hydratase 1 -0.31
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.31
GVINP1 GTPase, very large interferon inducible pseudogene 1 -0.31
TMEM183B transmembrane protein 183B -0.3
IGSF8 immunoglobulin superfamily, member 8 -0.3
GPN2 GPN-loop GTPase 2 -0.3
TIMP1 TIMP metallopeptidase inhibitor 1 -0.3
DEDD death effector domain containing -0.3
RNF185 ring finger protein 185 -0.3
YIPF1 Yip1 domain family, member 1 -0.3
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2 -0.3
RCN1 reticulocalbin 1, EF-hand calcium binding domain -0.3
TDG thymine-DNA glycosylase -0.3
ACTB actin, beta -0.3
TMEM263 transmembrane protein 263 -0.29
PARD6G par-6 family cell polarity regulator gamma -0.29
SSR1 signal sequence receptor, alpha -0.29
HSP90AA4P heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene -0.29
HIPK2 homeodomain interacting protein kinase 2 -0.29
SDHAF4 succinate dehydrogenase complex assembly factor 4 -0.29
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 -0.29
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.29
FAT1 FAT atypical cadherin 1 -0.29
PDLIM3 PDZ and LIM domain 3 -0.29
PLEKHA3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 -0.28
TMEM40 transmembrane protein 40 -0.28
GPATCH3 G patch domain containing 3 -0.28
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 -0.28
TM7SF2 transmembrane 7 superfamily member 2 -0.28
SYVN1 synovial apoptosis inhibitor 1, synoviolin -0.28
KSR2 kinase suppressor of ras 2 -0.28
RAB30 RAB30, member RAS oncogene family -0.28
TSPAN3 tetraspanin 3 -0.28
MYBPC1 myosin binding protein C, slow type -0.28
HSBP1 heat shock factor binding protein 1 -0.28
C1ORF52 chromosome 1 open reading frame 52 -0.28
DENND3 DENN/MADD domain containing 3 -0.28
TREX1 three prime repair exonuclease 1 -0.28
NECTIN3 nectin cell adhesion molecule 3 -0.28