Auranofin_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Auranofin perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Auranofin_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAM13A family with sequence similarity 13, member A 0.0584944
HELZ helicase with zinc finger 0.0584917
NAMPT nicotinamide phosphoribosyltransferase 0.0568849
MEIS2 Meis homeobox 2 0.0562744
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0509722
MEF2A myocyte enhancer factor 2A 0.0495185
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0489216
ADGRG6 adhesion G protein-coupled receptor G6 0.0441219
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0436332
HMGB2 high mobility group box 2 0.0434118
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.040959
NPEPPS aminopeptidase puromycin sensitive 0.0403269
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0402085
FNBP1 formin binding protein 1 0.0388577
IGF2 insulin-like growth factor 2 0.0374229
PLAT plasminogen activator, tissue 0.0349609
SOS1 son of sevenless homolog 1 (Drosophila) 0.0313819
FNDC3B fibronectin type III domain containing 3B 0.0312806
ITPRID2 ITPR interacting domain containing 2 0.0312371
MARCHF6 membrane associated ring-CH-type finger 6 0.0307581
AKAP12 A kinase (PRKA) anchor protein 12 0.0298993
OGA O-GlcNAcase 0.0280862
MAP1B microtubule-associated protein 1B 0.0280852
SRP54 signal recognition particle 54kDa 0.0278085
WDR45B WD repeat domain 45B 0.0275648
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0268768
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0258122
SSBP2 single-stranded DNA binding protein 2 0.0252245
USP3 ubiquitin specific peptidase 3 0.0250678
GNA13 guanine nucleotide binding protein (G protein), alpha 13 0.0247203
DDIT4 DNA-damage-inducible transcript 4 0.0245915
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0245322
DSCAM Down syndrome cell adhesion molecule 0.0242456
FOXO3 forkhead box O3 0.0242408
GPC5 glypican 5 0.0241157
ZNF654 zinc finger protein 654 0.0239185
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.023597
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.023544
ZNF148 zinc finger protein 148 0.023473
CD36 CD36 molecule (thrombospondin receptor) 0.0233263
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0228183
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0226506
YME1L1 YME1-like 1 ATPase 0.0225201
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0223925
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0223783
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0220783
SETD2 SET domain containing 2 0.0219703
WAC WW domain containing adaptor with coiled-coil 0.021892
GOLGA4 golgin A4 0.0217014
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0214843
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0213879
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0208035
ETNK1 ethanolamine kinase 1 0.0207159
AOPEP aminopeptidase O (putative) 0.0207155
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0206438
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha 0.020447
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 0.0204369
PUM2 pumilio RNA-binding family member 2 0.0204014
KDM3A lysine (K)-specific demethylase 3A 0.0202938
ARRDC3 arrestin domain containing 3 0.0202509
MBD5 methyl-CpG binding domain protein 5 0.0200101
ZMYM2 zinc finger, MYM-type 2 0.0197799
WDR43 WD repeat domain 43 0.0197426
RBM25 RNA binding motif protein 25 0.0197175
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0195152
CD46 CD46 molecule, complement regulatory protein 0.0194305
CENPF centromere protein F, 350/400kDa 0.0194144
RAB18 RAB18, member RAS oncogene family 0.0193651
AKAP10 A kinase (PRKA) anchor protein 10 0.0190203
TPR translocated promoter region, nuclear basket protein 0.0184135
GARS1 glycyl-tRNA synthetase 1 0.0183917
RNF145 ring finger protein 145 0.0183916
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0183825
MSMO1 methylsterol monooxygenase 1 0.0183748
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0183201
RAB6A RAB6A, member RAS oncogene family 0.0179752
PAPOLA poly(A) polymerase alpha 0.0179583
MXI1 MAX interactor 1, dimerization protein 0.017758
CENPC centromere protein C 0.0176958
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0176683
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0175941
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0175467
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0175377
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.017451
PCNX1 pecanex 1 0.0174395
SUCO SUN domain containing ossification factor 0.0173929
NEK7 NIMA-related kinase 7 0.0173046
NUP58 nucleoporin 58 0.0171609
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0170029
SERINC1 serine incorporator 1 0.0169826
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0169615
SEC23A Sec23 homolog A (S. cerevisiae) 0.0169106
LCORL ligand dependent nuclear receptor corepressor-like 0.0167197
SLMAP sarcolemma associated protein 0.0165025
ADAM9 ADAM metallopeptidase domain 9 0.0164494
DENND4C DENN/MADD domain containing 4C 0.0163503
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0162341
TP53BP1 tumor protein p53 binding protein 1 0.0161843
NRIP1 nuclear receptor interacting protein 1 0.0161764
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0161222

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.268437
LSAMP limbic system-associated membrane protein -0.170928
VCL vinculin -0.170619
NALF1 NALCN channel auxiliary factor 1 -0.139385
ACTG1 actin gamma 1 -0.127736
VIM vimentin -0.117344
RPS6 ribosomal protein S6 -0.104806
RPL23 ribosomal protein L23 -0.104709
TPT1 tumor protein, translationally-controlled 1 -0.102829
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.100139
EXT1 exostosin glycosyltransferase 1 -0.0995097
TMSB10 thymosin beta 10 -0.0907857
RPL35A ribosomal protein L35a -0.0858696
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0857585
SYT1 synaptotagmin I -0.0853797
NRG1 neuregulin 1 -0.0826124
FMN1 formin 1 -0.0781733
PTMA prothymosin, alpha -0.0746568
RPL34 ribosomal protein L34 -0.069965
RPLP1 ribosomal protein, large, P1 -0.0694552
BPTF bromodomain PHD finger transcription factor -0.0692247
RPL31 ribosomal protein L31 -0.0677417
RPS24 ribosomal protein S24 -0.0658364
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0645552
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0628187
PTPRD protein tyrosine phosphatase, receptor type, D -0.0606815
RPS8 ribosomal protein S8 -0.0605481
RPL19 ribosomal protein L19 -0.060125
MCL1 myeloid cell leukemia 1 -0.0586509
NPAS2 neuronal PAS domain protein 2 -0.0575172
THSD4 thrombospondin, type I, domain containing 4 -0.0561924
FTL ferritin, light polypeptide -0.0561162
BCAS3 breast carcinoma amplified sequence 3 -0.0553606
RPS19 ribosomal protein S19 -0.0548894
TPM4 tropomyosin 4 -0.0539127
RPL9 ribosomal protein L9 -0.0529425
RPS3 ribosomal protein S3 -0.0526296
RPL37A ribosomal protein L37a -0.0511481
RPS12 ribosomal protein S12 -0.0507856
EGR1 early growth response 1 -0.0504667
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0495251
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0492362
RPS23 ribosomal protein S23 -0.0479442
RPL7A ribosomal protein L7a -0.0479395
PDE4D phosphodiesterase 4D, cAMP-specific -0.0471238
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0455373
ENO1 enolase 1, (alpha) -0.0452117
TPM1 tropomyosin 1 (alpha) -0.0450572
RPS14 ribosomal protein S14 -0.0447365
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0446298
AEBP2 AE binding protein 2 -0.044202
RPL11 ribosomal protein L11 -0.0438753
ZNF804A zinc finger protein 804A -0.0432303
NDRG1 N-myc downstream regulated 1 -0.0429344
SLC38A2 solute carrier family 38, member 2 -0.0427545
RPS17 ribosomal protein S17 -0.0427386
PRKCA protein kinase C, alpha -0.0421201
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0420077
GREM2 gremlin 2, DAN family BMP antagonist -0.0411747
MYO1E myosin IE -0.0407057
RPS16 ribosomal protein S16 -0.0402589
RPS29 ribosomal protein S29 -0.0395069
IER3 immediate early response 3 -0.0394775
SLIT2 slit homolog 2 (Drosophila) -0.0387394
LPP LIM domain containing preferred translocation partner in lipoma -0.0385456
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0385016
EFNA5 ephrin-A5 -0.0381064
RPS27A ribosomal protein S27a -0.0378444
RPS13 ribosomal protein S13 -0.0374882
RPL13A ribosomal protein L13a -0.0372849
GOLGB1 golgin B1 -0.0372128
RPL26 ribosomal protein L26 -0.0366326
RPLP2 ribosomal protein, large, P2 -0.0364712
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0364153
RPL7 ribosomal protein L7 -0.0364093
RPL27 ribosomal protein L27 -0.0359673
CUX1 cut-like homeobox 1 -0.0356886
COL1A1 collagen, type I, alpha 1 -0.0356573
RPL12 ribosomal protein L12 -0.0354407
RPS27 ribosomal protein S27 -0.0350514
VDAC1 voltage-dependent anion channel 1 -0.0348476
RPL37 ribosomal protein L37 -0.0344356
CADM2 cell adhesion molecule 2 -0.0341448
FRMD4A FERM domain containing 4A -0.033986
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0338584
SIK2 salt-inducible kinase 2 -0.0337864
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0337794
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0337416
FN1 fibronectin 1 -0.0330782
RNF213 ring finger protein 213 -0.0328299
ZFAND3 zinc finger, AN1-type domain 3 -0.0327759
RPS20 ribosomal protein S20 -0.0325246
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0322467
ATXN1 ataxin 1 -0.0320585
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0320472
S100A9 S100 calcium binding protein A9 -0.0318254
LOC102724023 ES1 protein homolog, mitochondrial -0.0316165
GPC6 glypican 6 -0.0315343
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0312684
IGFBP3 insulin-like growth factor binding protein 3 -0.0311653