| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Auranofin perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Auranofin_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | 0.211315 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.191403 |
| TF | transferrin | 0.141369 |
| C3 | complement component 3 | 0.11759 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0986807 |
| VEGFA | vascular endothelial growth factor A | 0.0926537 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0919605 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0842397 |
| MT2A | metallothionein 2A | 0.0768049 |
| CPE | carboxypeptidase E | 0.0765981 |
| RPS12 | ribosomal protein S12 | 0.0557293 |
| ID2 | inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | 0.0438517 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0415723 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | 0.0414451 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0396345 |
| TMEM41B | transmembrane protein 41B | 0.0345558 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0337616 |
| FAM107B | family with sequence similarity 107, member B | 0.0331147 |
| SFTPA2 | surfactant protein A2 | 0.0328393 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0319597 |
| B2M | beta-2-microglobulin | 0.0314115 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.029675 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0294062 |
| AFDN | afadin, adherens junction formation factor | 0.0286849 |
| FNIP1 | folliculin interacting protein 1 | 0.0276866 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0276407 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0275501 |
| CRY1 | cryptochrome circadian clock 1 | 0.0275361 |
| PCBP2 | poly(rC) binding protein 2 | 0.0270137 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0267303 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 0.0265999 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0265434 |
| TNS1 | tensin 1 | 0.0261486 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0261206 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0257904 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.025152 |
| WDR43 | WD repeat domain 43 | 0.0245393 |
| SERINC1 | serine incorporator 1 | 0.0244633 |
| VCL | vinculin | 0.0243304 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.023697 |
| RACK1 | receptor for activated C kinase 1 | 0.0230471 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0228 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0227306 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0226908 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0225119 |
| SDC2 | syndecan 2 | 0.022431 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.0221027 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0220289 |
| SLC11A2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 | 0.0218145 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0215837 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0211907 |
| EFNA1 | ephrin-A1 | 0.0211801 |
| YTHDC1 | YTH domain containing 1 | 0.0210332 |
| FOXO1 | forkhead box O1 | 0.0208425 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0208307 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0207524 |
| INSIG2 | insulin induced gene 2 | 0.0205352 |
| RPL10A | ribosomal protein L10a | 0.0204499 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | 0.020043 |
| PDGFB | platelet-derived growth factor beta polypeptide | 0.0199515 |
| ATP1A4 | ATPase, Na+/K+ transporting, alpha 4 polypeptide | 0.0198663 |
| HLA-A | major histocompatibility complex, class I, A | 0.0197162 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0195405 |
| MTSS1 | metastasis suppressor 1 | 0.0195366 |
| MYO1E | myosin IE | 0.0193128 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0190914 |
| MRTFA | myocardin related transcription factor A | 0.0187196 |
| CORO1C | coronin, actin binding protein, 1C | 0.0185625 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0184972 |
| JAG1 | jagged 1 | 0.0184944 |
| RPL3 | ribosomal protein L3 | 0.0182877 |
| GDF15 | growth differentiation factor 15 | 0.018283 |
| CXXC5 | CXXC finger protein 5 | 0.0182089 |
| RANBP9 | RAN binding protein 9 | 0.0181981 |
| WASL | Wiskott-Aldrich syndrome-like | 0.0181941 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0180731 |
| ANGPTL8 | angiopoietin like 8 | 0.0179972 |
| HMGN1 | high mobility group nucleosome binding domain 1 | 0.017883 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.01755 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0175033 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0174539 |
| NPTN | neuroplastin | 0.0173434 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0173254 |
| TRIM26 | tripartite motif containing 26 | 0.0172755 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.017262 |
| CALD1 | caldesmon 1 | 0.0171219 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.017069 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.0169939 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0164274 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0164193 |
| FRA10AC1 | fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1 | 0.0164118 |
| ELP3 | elongator acetyltransferase complex subunit 3 | 0.0161622 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.0160483 |
| MT1E | metallothionein 1E | 0.0159927 |
| RHOF | ras homolog family member F (in filopodia) | 0.0158382 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0157923 |
| VEZF1 | vascular endothelial zinc finger 1 | 0.015692 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0156864 |
| MT1X | metallothionein 1X | 0.0156308 |
| C1D | C1D nuclear receptor corepressor | 0.0155853 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TPT1 | tumor protein, translationally-controlled 1 | -0.144243 |
| APOB | apolipoprotein B | -0.132764 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.109866 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.107826 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.10036 |
| FRMD5 | FERM domain containing 5 | -0.0893561 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0849671 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0847371 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0840483 |
| GPC6 | glypican 6 | -0.0836292 |
| DST | dystonin | -0.0828479 |
| FMNL2 | formin-like 2 | -0.0816552 |
| H1-0 | H1.0 linker histone | -0.0794194 |
| FN1 | fibronectin 1 | -0.0793614 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0758782 |
| RPS24 | ribosomal protein S24 | -0.0705214 |
| GPC3 | glypican 3 | -0.0686773 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0678903 |
| EHBP1 | EH domain binding protein 1 | -0.0654831 |
| PARD3 | par-3 family cell polarity regulator | -0.0635478 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0624093 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0605753 |
| PEG3 | paternally expressed 3 | -0.0601085 |
| RPL34 | ribosomal protein L34 | -0.05988 |
| ATXN1 | ataxin 1 | -0.0597829 |
| DOCK4 | dedicator of cytokinesis 4 | -0.058696 |
| APOA2 | apolipoprotein A-II | -0.0586162 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0584528 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0580783 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.055287 |
| MSI2 | musashi RNA-binding protein 2 | -0.0541842 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0529094 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0528589 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0527687 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0526134 |
| RPS8 | ribosomal protein S8 | -0.051967 |
| RPLP0 | ribosomal protein, large, P0 | -0.051495 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0513339 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0510782 |
| RPL35A | ribosomal protein L35a | -0.0505189 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0503641 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0498309 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.049828 |
| TMEM123 | transmembrane protein 123 | -0.0498069 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0489913 |
| RPLP1 | ribosomal protein, large, P1 | -0.048065 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.046273 |
| RBM39 | RNA binding motif protein 39 | -0.0453191 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0451583 |
| RRBP1 | ribosome binding protein 1 | -0.0451368 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0451352 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0445764 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0440579 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0439844 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0423659 |
| PTK2 | protein tyrosine kinase 2 | -0.0423373 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0421643 |
| RPS6 | ribosomal protein S6 | -0.0419492 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0409865 |
| CP | ceruloplasmin (ferroxidase) | -0.0405549 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0405333 |
| KRT18 | keratin 18, type I | -0.0399231 |
| ZNF292 | zinc finger protein 292 | -0.0390578 |
| DTNA | dystrobrevin, alpha | -0.0389976 |
| RPL19 | ribosomal protein L19 | -0.0387742 |
| SBF2 | SET binding factor 2 | -0.0384248 |
| RPL12 | ribosomal protein L12 | -0.0383037 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0380612 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0378258 |
| KIAA1217 | KIAA1217 | -0.0369475 |
| FUS | FUS RNA binding protein | -0.0365776 |
| NFIA | nuclear factor I/A | -0.0362275 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0362013 |
| ZFHX3 | zinc finger homeobox 3 | -0.0360189 |
| RPS21 | ribosomal protein S21 | -0.035902 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0358474 |
| RPL32 | ribosomal protein L32 | -0.0355999 |
| LMO7 | LIM domain 7 | -0.0353358 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0346105 |
| TOP1 | topoisomerase (DNA) I | -0.0345686 |
| CANX | calnexin | -0.0340805 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0336397 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0334997 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0329513 |
| CNKSR3 | CNKSR family member 3 | -0.0328382 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0327079 |
| TMSB10 | thymosin beta 10 | -0.032595 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.0325782 |
| WWC2 | WW and C2 domain containing 2 | -0.0325258 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0324552 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0321157 |
| RNF213 | ring finger protein 213 | -0.031775 |
| ACTN4 | actinin, alpha 4 | -0.0316463 |
| PHKB | phosphorylase kinase, beta | -0.0316097 |
| USP34 | ubiquitin specific peptidase 34 | -0.0314933 |
| AHSG | alpha-2-HS-glycoprotein | -0.0312754 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0312597 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0310978 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0310863 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0309605 |
