| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Auranofin perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Auranofin_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.116022 |
| PTMA | prothymosin, alpha | 0.111044 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0928783 |
| FLNB | filamin B, beta | 0.0880051 |
| CLU | clusterin | 0.0748338 |
| SQLE | squalene epoxidase | 0.0705594 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0690503 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0674243 |
| B2M | beta-2-microglobulin | 0.0633095 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0630307 |
| GOLGA4 | golgin A4 | 0.061568 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0581396 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0577041 |
| IGF2 | insulin-like growth factor 2 | 0.0548335 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0537627 |
| TMSB4X | thymosin beta 4, X-linked | 0.0536775 |
| ANXA2 | annexin A2 | 0.0535378 |
| MEF2A | myocyte enhancer factor 2A | 0.0530099 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0529173 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0491251 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0475364 |
| KRT17 | keratin 17, type I | 0.0471382 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0447833 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0443897 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0443317 |
| TMSB10 | thymosin beta 10 | 0.0439152 |
| CAVIN1 | caveolae associated protein 1 | 0.043386 |
| SRP54 | signal recognition particle 54kDa | 0.0404185 |
| ENO1 | enolase 1, (alpha) | 0.039838 |
| PGK1 | phosphoglycerate kinase 1 | 0.0398229 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0390723 |
| EPHA2 | EPH receptor A2 | 0.0390147 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0378832 |
| NDRG1 | N-myc downstream regulated 1 | 0.0378362 |
| OGA | O-GlcNAcase | 0.0376002 |
| EZR | ezrin | 0.0370623 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0366933 |
| DPM1 | dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit | 0.0357568 |
| LDHA | lactate dehydrogenase A | 0.0357466 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0355365 |
| TMEM41B | transmembrane protein 41B | 0.0350994 |
| EMP1 | epithelial membrane protein 1 | 0.0347506 |
| YBX3 | Y box binding protein 3 | 0.0344022 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.03402 |
| CD44 | CD44 molecule (Indian blood group) | 0.0338473 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.03383 |
| LMAN1 | lectin, mannose-binding, 1 | 0.033572 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0334549 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0328834 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0325873 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | 0.0324401 |
| YBX1 | Y box binding protein 1 | 0.0320182 |
| ARRDC3 | arrestin domain containing 3 | 0.0319985 |
| KRT6A | keratin 6A, type II | 0.0318798 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0317869 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0317597 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0315392 |
| COPB1 | coatomer protein complex, subunit beta 1 | 0.031452 |
| LMNA | lamin A/C | 0.0314219 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0312705 |
| TAGLN2 | transgelin 2 | 0.0312439 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | 0.0310848 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.0309678 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0306023 |
| RPL12 | ribosomal protein L12 | 0.0303193 |
| ANLN | anillin, actin binding protein | 0.0302465 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.029637 |
| TMF1 | TATA element modulatory factor 1 | 0.0296122 |
| CD99 | CD99 molecule | 0.0295989 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | 0.0294634 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0294064 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | 0.029122 |
| DSTN | destrin (actin depolymerizing factor) | 0.028964 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0288469 |
| ANKRD33B | ankyrin repeat domain 33B | 0.028511 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.028389 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0282075 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0281728 |
| GNAS | GNAS complex locus | 0.0281631 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0281497 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0281326 |
| COPA | coatomer protein complex, subunit alpha | 0.028122 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0279253 |
| RAB22A | RAB22A, member RAS oncogene family | 0.0277695 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0274483 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0271869 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0271855 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0270748 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0266 |
| FOSL1 | FOS-like antigen 1 | 0.0265953 |
| HLA-A | major histocompatibility complex, class I, A | 0.0265564 |
| CALU | calumenin | 0.0263481 |
| CUL4B | cullin 4B | 0.0262505 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0259736 |
| BCL2L1 | BCL2-like 1 | 0.0257877 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.025663 |
| TXNRD1 | thioredoxin reductase 1 | 0.0255251 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0255158 |
| TMEM165 | transmembrane protein 165 | 0.0255141 |
| RPL36A | ribosomal protein L36a | 0.0254372 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.216931 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.209262 |
| DPYD | dihydropyrimidine dehydrogenase | -0.161432 |
| LMO7 | LIM domain 7 | -0.144462 |
| INTS6 | integrator complex subunit 6 | -0.120788 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.118441 |
| PDLIM5 | PDZ and LIM domain 5 | -0.102402 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0958685 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0911678 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0768399 |
| SULF1 | sulfatase 1 | -0.0748951 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0744747 |
| MTSS1 | metastasis suppressor 1 | -0.073412 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.071459 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0687141 |
| SULF2 | sulfatase 2 | -0.0674329 |
| HMGA2 | high mobility group AT-hook 2 | -0.0607391 |
| MECOM | MDS1 and EVI1 complex locus | -0.0595046 |
| RIGI | RNA sensor RIG-I | -0.0586316 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0573527 |
| EFNA5 | ephrin-A5 | -0.0571678 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0567939 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0552659 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0548474 |
| PALLD | palladin, cytoskeletal associated protein | -0.0539219 |
| PRSS23 | protease, serine, 23 | -0.0537407 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0536111 |
| RAD51B | RAD51 paralog B | -0.0526831 |
| ANO1 | anoctamin 1, calcium activated chloride channel | -0.0514898 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0478633 |
| SMYD3 | SET and MYND domain containing 3 | -0.0472809 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0471919 |
| FOXP1 | forkhead box P1 | -0.0466021 |
| RASAL2 | RAS protein activator like 2 | -0.0463758 |
| UTRN | utrophin | -0.0458766 |
| AHNAK | AHNAK nucleoprotein | -0.0458161 |
| CDK6 | cyclin-dependent kinase 6 | -0.044968 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0448496 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0446859 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0442063 |
| RAI14 | retinoic acid induced 14 | -0.0426241 |
| CSMD2 | CUB and Sushi multiple domains 2 | -0.0417481 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0415325 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -0.0415126 |
| DGKH | diacylglycerol kinase, eta | -0.0411501 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0404805 |
| EXOC4 | exocyst complex component 4 | -0.0391915 |
| PLEC | plectin | -0.0379304 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0378748 |
| DOK5 | docking protein 5 | -0.03744 |
| KLF12 | Kruppel-like factor 12 | -0.0373599 |
| TENM4 | teneurin transmembrane protein 4 | -0.0372778 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0362366 |
| PLS3 | plastin 3 | -0.0352026 |
| ACTN4 | actinin, alpha 4 | -0.035109 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0349448 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0346011 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0345935 |
| KIAA1671 | KIAA1671 | -0.0337493 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0336505 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0333806 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0332054 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0330226 |
| DOCK9 | dedicator of cytokinesis 9 | -0.0330119 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0319806 |
| MTAP | methylthioadenosine phosphorylase | -0.031493 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0314021 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.031327 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0309542 |
| TNS3 | tensin 3 | -0.0306278 |
| RNF217 | ring finger protein 217 | -0.0305439 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0299757 |
| EGFR | epidermal growth factor receptor | -0.0298062 |
| FRMD4B | FERM domain containing 4B | -0.0292901 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0292813 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | -0.0291695 |
| MT1E | metallothionein 1E | -0.0286392 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0282776 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | -0.0282558 |
| PTK2 | protein tyrosine kinase 2 | -0.0280972 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0273767 |
| HDAC9 | histone deacetylase 9 | -0.0267988 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0267261 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0265822 |
| SVIL | supervillin | -0.0262567 |
| FOXO1 | forkhead box O1 | -0.0257337 |
| DST | dystonin | -0.0255052 |
| TJP1 | tight junction protein 1 | -0.0254272 |
| DENND1A | DENN/MADD domain containing 1A | -0.0252617 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0246614 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.024504 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | -0.0244654 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.024305 |
| CRACDL | CRACD like | -0.0241822 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0240427 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.024034 |
| CDK17 | cyclin-dependent kinase 17 | -0.0239779 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0238931 |
| ARHGEF7 | Rho guanine nucleotide exchange factor (GEF) 7 | -0.0238221 |
| VTI1A | vesicle transport through interaction with t-SNAREs 1A | -0.0237889 |
