Auranofin_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Auranofin perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Auranofin_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EIF1 eukaryotic translation initiation factor 1 0.0599255
PTMA prothymosin, alpha 0.0598573
FTL ferritin, light polypeptide 0.0593392
GOLGA4 golgin A4 0.0590462
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0586172
RPS6 ribosomal protein S6 0.0549505
FAM13A family with sequence similarity 13, member A 0.0526225
AREG amphiregulin 0.0516632
EREG epiregulin 0.0510803
VEGFA vascular endothelial growth factor A 0.0467092
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0458577
TXNIP thioredoxin interacting protein 0.044273
FTH1 ferritin, heavy polypeptide 1 0.0406734
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0398773
GDF15 growth differentiation factor 15 0.0396862
RNF145 ring finger protein 145 0.0378027
S100P S100 calcium binding protein P 0.0376803
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0375175
DDIT4 DNA-damage-inducible transcript 4 0.0371185
RPS19 ribosomal protein S19 0.0367935
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0363212
RPS12 ribosomal protein S12 0.0362596
ESYT2 extended synaptotagmin-like protein 2 0.0356541
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0355801
MED13L mediator complex subunit 13-like 0.033555
RPS3 ribosomal protein S3 0.0333687
LDHA lactate dehydrogenase A 0.0332284
RPL23 ribosomal protein L23 0.0323352
RPL12 ribosomal protein L12 0.0319001
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.030744
UBA6 ubiquitin-like modifier activating enzyme 6 0.0303244
KIF5B kinesin family member 5B 0.028061
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0279997
NDRG1 N-myc downstream regulated 1 0.0276758
WAC WW domain containing adaptor with coiled-coil 0.0276371
B2M beta-2-microglobulin 0.0262833
RAB6A RAB6A, member RAS oncogene family 0.0257433
RPL36 ribosomal protein L36 0.025482
RPLP1 ribosomal protein, large, P1 0.0253925
ZFAND3 zinc finger, AN1-type domain 3 0.0252366
EPCAM epithelial cell adhesion molecule 0.0244325
PRRC2C proline-rich coiled-coil 2C 0.0242016
PNISR PNN-interacting serine/arginine-rich protein 0.0241382
WDR45B WD repeat domain 45B 0.0241255
RPLP2 ribosomal protein, large, P2 0.0234901
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0233896
EEF2 eukaryotic translation elongation factor 2 0.0231238
RPL11 ribosomal protein L11 0.0229681
SETD5 SET domain containing 5 0.0229124
RPL18 ribosomal protein L18 0.0227169
RBM39 RNA binding motif protein 39 0.0226451
RPL37A ribosomal protein L37a 0.0225632
TMSB10 thymosin beta 10 0.0222741
OGA O-GlcNAcase 0.0221711
ZNF292 zinc finger protein 292 0.0219534
SRP54 signal recognition particle 54kDa 0.0218239
KDM3A lysine (K)-specific demethylase 3A 0.0208402
STRN3 striatin, calmodulin binding protein 3 0.0207578
ZMYM2 zinc finger, MYM-type 2 0.0207179
GARS1 glycyl-tRNA synthetase 1 0.0204718
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0203526
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0201085
PCBP2 poly(rC) binding protein 2 0.0196554
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0195725
TXNRD1 thioredoxin reductase 1 0.0194947
EZR ezrin 0.0194126
KMT2E lysine (K)-specific methyltransferase 2E 0.0192312
DSCAM Down syndrome cell adhesion molecule 0.019171
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0191372
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0191165
RAB1A RAB1A, member RAS oncogene family 0.0189206
NAMPT nicotinamide phosphoribosyltransferase 0.0188785
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0188723
RPS27 ribosomal protein S27 0.0188323
MATR3 matrin 3 0.0187008
TMF1 TATA element modulatory factor 1 0.0185932
RSRC2 arginine/serine-rich coiled-coil 2 0.0181874
MXI1 MAX interactor 1, dimerization protein 0.018042
KDM6A lysine (K)-specific demethylase 6A 0.0179323
ATF4 activating transcription factor 4 0.0178155
NUP58 nucleoporin 58 0.0177687
ZFC3H1 zinc finger, C3H1-type containing 0.0177373
ITPRID2 ITPR interacting domain containing 2 0.0176826
DERA deoxyribose-phosphate aldolase (putative) 0.0176395
GADD45A growth arrest and DNA-damage-inducible, alpha 0.0175747
RLF rearranged L-myc fusion 0.0174558
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0174226
USP3 ubiquitin specific peptidase 3 0.0174185
RPL10A ribosomal protein L10a 0.0174142
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0173725
PTBP3 polypyrimidine tract binding protein 3 0.0171963
PERP PERP, TP53 apoptosis effector 0.0171296
GCLC glutamate-cysteine ligase, catalytic subunit 0.0171209
SEC23A Sec23 homolog A (S. cerevisiae) 0.0170742
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0169115
HELZ helicase with zinc finger 0.0168984
COPA coatomer protein complex, subunit alpha 0.0168845
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0168677
GSK3B glycogen synthase kinase 3 beta 0.0168407
PLAUR plasminogen activator, urokinase receptor 0.0166917

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.107375
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0875408
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0800913
NALF1 NALCN channel auxiliary factor 1 -0.0777987
VCL vinculin -0.0745065
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0690973
GMDS GDP-mannose 4,6-dehydratase -0.0683928
CEMIP cell migration inducing protein, hyaluronan binding -0.0645408
ALCAM activated leukocyte cell adhesion molecule -0.0596116
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0579266
MYO1E myosin IE -0.0568396
EXT1 exostosin glycosyltransferase 1 -0.0566688
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0532871
PTPRK protein tyrosine phosphatase, receptor type, K -0.0511815
ANTXR2 anthrax toxin receptor 2 -0.0495081
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0483423
PDE4D phosphodiesterase 4D, cAMP-specific -0.0454019
FHIT fragile histidine triad -0.0437521
CADPS Ca++-dependent secretion activator -0.0415041
CCSER1 coiled-coil serine-rich protein 1 -0.0410577
AHNAK AHNAK nucleoprotein -0.0388444
GREB1L growth regulation by estrogen in breast cancer-like -0.0384795
SLC35F3 solute carrier family 35, member F3 -0.0378181
LPP LIM domain containing preferred translocation partner in lipoma -0.0365612
PDLIM5 PDZ and LIM domain 5 -0.0365527
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0357011
SAMD5 sterile alpha motif domain containing 5 -0.0353985
PATJ PATJ crumbs cell polarity complex component -0.0348224
SMYD3 SET and MYND domain containing 3 -0.0342971
RAD51B RAD51 paralog B -0.03371
MAML3 mastermind-like 3 (Drosophila) -0.0312588
FAT1 FAT atypical cadherin 1 -0.0311845
PIGR polymeric immunoglobulin receptor -0.0302834
ACTN4 actinin, alpha 4 -0.030118
ACTG1 actin gamma 1 -0.0296841
DIAPH2 diaphanous-related formin 2 -0.0290624
ONECUT3 one cut homeobox 3 -0.0279098
GPHN gephyrin -0.0272341
ZBTB20 zinc finger and BTB domain containing 20 -0.0270517
PSD3 pleckstrin and Sec7 domain containing 3 -0.0269325
EGFR epidermal growth factor receptor -0.0267137
POF1B premature ovarian failure, 1B -0.026179
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0260199
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0257564
PALLD palladin, cytoskeletal associated protein -0.0255538
FOXP1 forkhead box P1 -0.0250134
PARD3B par-3 family cell polarity regulator beta -0.0241051
EXOC4 exocyst complex component 4 -0.0240309
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0237695
MAML2 mastermind-like 2 (Drosophila) -0.0234055
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0228512
TRAPPC9 trafficking protein particle complex 9 -0.0218462
CCND1 cyclin D1 -0.0218199
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0217402
MECOM MDS1 and EVI1 complex locus -0.0216811
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0215765
TAS2R14 taste receptor, type 2, member 14 -0.021408
NRXN3 neurexin 3 -0.0213857
PTPRB protein tyrosine phosphatase, receptor type, B -0.0212455
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0211856
FRMD5 FERM domain containing 5 -0.0211381
DENND1A DENN/MADD domain containing 1A -0.020881
PTPRG protein tyrosine phosphatase, receptor type, G -0.0205987
ABR active BCR-related -0.0204349
TPM4 tropomyosin 4 -0.020167
MBNL1 muscleblind-like splicing regulator 1 -0.0201321
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0201116
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0200457
SH3D19 SH3 domain containing 19 -0.0198414
RNF217 ring finger protein 217 -0.0194472
LAMA4 laminin, alpha 4 -0.0192472
CUX1 cut-like homeobox 1 -0.0189705
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0188896
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0187444
MYO1D myosin ID -0.0186617
RABGAP1L RAB GTPase activating protein 1-like -0.0186222
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0185842
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.018578
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0184275
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0184068
GPR39 G protein-coupled receptor 39 -0.0183381
ATXN1 ataxin 1 -0.0181236
TPM1 tropomyosin 1 (alpha) -0.0178903
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.0178464
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0177819
TPT1 tumor protein, translationally-controlled 1 -0.0176406
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0176104
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0175842
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0172723
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0169593
SLC38A2 solute carrier family 38, member 2 -0.0169172
PKP2 plakophilin 2 -0.0161552
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.015991
MTAP methylthioadenosine phosphorylase -0.015905
PCDH9 protocadherin 9 -0.0158933
EHBP1 EH domain binding protein 1 -0.0158047
KANK1 KN motif and ankyrin repeat domains 1 -0.0155186
MSI2 musashi RNA-binding protein 2 -0.015508
TNS4 tensin 4 -0.0154824
ETV6 ets variant 6 -0.0154817