Auranofin_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Auranofin perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Auranofin_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.181625
PTMA prothymosin, alpha 0.165807
TMSB10 thymosin beta 10 0.103748
FTL ferritin, light polypeptide 0.0984946
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0786479
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.076507
FTH1 ferritin, heavy polypeptide 1 0.0691673
EIF1 eukaryotic translation initiation factor 1 0.0691518
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0616491
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0510654
POTEF POTE ankyrin domain family, member F 0.0493079
GARS1 glycyl-tRNA synthetase 1 0.049065
RPL23 ribosomal protein L23 0.0479742
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0454496
KLF6 Kruppel-like factor 6 0.0432071
DDIT4 DNA-damage-inducible transcript 4 0.0414883
CALR calreticulin 0.0376792
LDHA lactate dehydrogenase A 0.037543
DLG1 discs, large homolog 1 (Drosophila) 0.0372207
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0366957
TMSB4X thymosin beta 4, X-linked 0.0325633
RACK1 receptor for activated C kinase 1 0.0317498
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0313553
EEF2 eukaryotic translation elongation factor 2 0.030775
ZFP36L1 ZFP36 ring finger protein-like 1 0.0297012
RAB7A RAB7A, member RAS oncogene family 0.0289208
NAMPT nicotinamide phosphoribosyltransferase 0.0281832
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0281361
RPL35A ribosomal protein L35a 0.0278896
ENO2 enolase 2 (gamma, neuronal) 0.0277845
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0277409
GOLGA4 golgin A4 0.0276767
WDR45B WD repeat domain 45B 0.0270335
RAI1 retinoic acid induced 1 0.0267954
YBX1 Y box binding protein 1 0.0259863
RPS8 ribosomal protein S8 0.0257958
PCBP2 poly(rC) binding protein 2 0.0255499
TXNIP thioredoxin interacting protein 0.0253462
MATR3 matrin 3 0.025238
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0250834
WDR43 WD repeat domain 43 0.0243032
WSB1 WD repeat and SOCS box containing 1 0.0241518
RAB6A RAB6A, member RAS oncogene family 0.0240542
PLIN2 perilipin 2 0.0235939
RPS3 ribosomal protein S3 0.0229892
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0227858
JUN jun proto-oncogene 0.0219229
HILPDA hypoxia inducible lipid droplet-associated 0.0218742
RNF145 ring finger protein 145 0.021781
HDGF hepatoma-derived growth factor 0.0215967
SRP54 signal recognition particle 54kDa 0.02152
LMAN1 lectin, mannose-binding, 1 0.021378
RPL12 ribosomal protein L12 0.0206064
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0205587
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0205457
PIAS2 protein inhibitor of activated STAT, 2 0.0203274
RPLP0 ribosomal protein, large, P0 0.0198939
WASF2 WAS protein family, member 2 0.0194498
RPS19 ribosomal protein S19 0.019405
HMOX1 heme oxygenase 1 0.0193715
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0190375
RHOA ras homolog family member A 0.0189684
NAP1L1 nucleosome assembly protein 1-like 1 0.0189339
RIOK3 RIO kinase 3 0.018876
PDIA6 protein disulfide isomerase family A, member 6 0.0188438
TOP1 topoisomerase (DNA) I 0.0187776
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0186954
ALKBH5 AlkB family member 5, RNA demethylase 0.0181968
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0181686
HMGB2 high mobility group box 2 0.0175191
RPL10A ribosomal protein L10a 0.0173949
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0173852
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0171569
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0171249
PER1 period circadian clock 1 0.0169569
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.0169086
CAVIN1 caveolae associated protein 1 0.0166396
CLIP2 CAP-GLY domain containing linker protein 2 0.0165598
UBE2B ubiquitin-conjugating enzyme E2B 0.0164887
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0164178
WAC WW domain containing adaptor with coiled-coil 0.0163976
RPS14 ribosomal protein S14 0.0163973
SFTPA2 surfactant protein A2 0.0163734
RPL18 ribosomal protein L18 0.0163165
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0160989
FAM162A family with sequence similarity 162, member A 0.0160474
SQSTM1 sequestosome 1 0.0158336
EZR ezrin 0.0157771
VEGFA vascular endothelial growth factor A 0.0157758
SLK STE20-like kinase 0.0157694
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0157268
FXR1 fragile X mental retardation, autosomal homolog 1 0.0157232
ANXA2 annexin A2 0.0156955
RPLP1 ribosomal protein, large, P1 0.015633
RPL36 ribosomal protein L36 0.0154358
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 0.0153317
UBE2C ubiquitin-conjugating enzyme E2C 0.0153143
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0151969
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0151815
NUP58 nucleoporin 58 0.0151209

decreased expression

Symbol Name Standardized Value
PSD3 pleckstrin and Sec7 domain containing 3 -0.232525
TP63 tumor protein p63 -0.181967
DST dystonin -0.142509
ERRFI1 ERBB receptor feedback inhibitor 1 -0.119915
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.117497
CD44 CD44 molecule (Indian blood group) -0.117036
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.112365
TM4SF1 transmembrane 4 L six family member 1 -0.0987824
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0984601
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0829658
BCAR3 breast cancer anti-estrogen resistance 3 -0.0745963
DPYD dihydropyrimidine dehydrogenase -0.0702451
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0674285
MACF1 microtubule-actin crosslinking factor 1 -0.0661306
CAPRIN2 caprin family member 2 -0.0629739
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.062732
RIGI RNA sensor RIG-I -0.0620989
WARS1 tryptophanyl-tRNA synthetase 1 -0.0594367
USP34 ubiquitin specific peptidase 34 -0.058659
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0578004
RUNX1 runt-related transcription factor 1 -0.0572536
APP amyloid beta (A4) precursor protein -0.056855
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0564106
PDE10A phosphodiesterase 10A -0.0557297
CADM2 cell adhesion molecule 2 -0.0545769
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0542684
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0531448
NPAS2 neuronal PAS domain protein 2 -0.0527023
TXNRD1 thioredoxin reductase 1 -0.0521762
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0520319
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0509613
EHBP1 EH domain binding protein 1 -0.0508179
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0500451
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.049057
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0482677
ARHGAP5 Rho GTPase activating protein 5 -0.0475565
CFAP299 cilia and flagella associated protein 299 -0.0472885
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0471517
EXOC4 exocyst complex component 4 -0.0465221
WWTR1 WW domain containing transcription regulator 1 -0.0458852
HLA-B major histocompatibility complex, class I, B -0.0457199
KMT2E lysine (K)-specific methyltransferase 2E -0.0454683
CMIP c-Maf inducing protein -0.0453109
RAB27B RAB27B, member RAS oncogene family -0.0449878
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0446229
FMNL2 formin-like 2 -0.0437932
ZMYND8 zinc finger, MYND-type containing 8 -0.0437728
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0435724
RAD51B RAD51 paralog B -0.0428936
GCLM glutamate-cysteine ligase, modifier subunit -0.0426735
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0424457
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0414258
SDCCAG8 serologically defined colon cancer antigen 8 -0.0411783
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0402541
SPIDR scaffolding protein involved in DNA repair -0.039568
FAF1 Fas (TNFRSF6) associated factor 1 -0.0395392
SP100 SP100 nuclear antigen -0.0392993
SMYD3 SET and MYND domain containing 3 -0.0390143
RNF213 ring finger protein 213 -0.0389873
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0383815
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0380455
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0379336
BICD1 bicaudal D homolog 1 (Drosophila) -0.0376644
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0372847
ZBTB38 zinc finger and BTB domain containing 38 -0.0371508
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0366809
RERE arginine-glutamic acid dipeptide (RE) repeats -0.036311
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0355908
PTK2 protein tyrosine kinase 2 -0.0354844
VMP1 vacuole membrane protein 1 -0.0352595
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0352593
MT2A metallothionein 2A -0.0351502
ADGRG6 adhesion G protein-coupled receptor G6 -0.0349587
BIRC2 baculoviral IAP repeat containing 2 -0.0349097
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.034618
TAS2R14 taste receptor, type 2, member 14 -0.0343856
PLSCR1 phospholipid scramblase 1 -0.0342952
TRIO trio Rho guanine nucleotide exchange factor -0.0342304
TRIP12 thyroid hormone receptor interactor 12 -0.0337945
HSPA8 heat shock 70kDa protein 8 -0.0332955
IFIH1 interferon induced with helicase C domain 1 -0.0324168
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.032382
ADAR adenosine deaminase, RNA-specific -0.0323197
BIRC3 baculoviral IAP repeat containing 3 -0.0322102
EMP1 epithelial membrane protein 1 -0.0321826
CFLAR CASP8 and FADD-like apoptosis regulator -0.032036
NT5E 5'-nucleotidase, ecto (CD73) -0.0316021
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.030682
BPTF bromodomain PHD finger transcription factor -0.0303595
AHNAK AHNAK nucleoprotein -0.0302738
CDK6 cyclin-dependent kinase 6 -0.0300006
WNK1 WNK lysine deficient protein kinase 1 -0.0299003
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.029687
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0295043
SPRY4 sprouty homolog 4 (Drosophila) -0.0294669
PRELID2 PRELI domain containing 2 -0.0293327
MT1E metallothionein 1E -0.0291122
TSC22D1 TSC22 domain family, member 1 -0.0288908
PRRC2B proline-rich coiled-coil 2B -0.0286224
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0279748