| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Auranofin perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Auranofin_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.168726 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.142782 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.11071 |
| FTL | ferritin, light polypeptide | 0.0769385 |
| B2M | beta-2-microglobulin | 0.0684618 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.066232 |
| MCL1 | myeloid cell leukemia 1 | 0.0588825 |
| CPE | carboxypeptidase E | 0.0588739 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0575018 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0566086 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0562165 |
| RPS3 | ribosomal protein S3 | 0.0522607 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0519473 |
| RPS6 | ribosomal protein S6 | 0.0496405 |
| TMEM165 | transmembrane protein 165 | 0.0487474 |
| NDRG1 | N-myc downstream regulated 1 | 0.0449815 |
| TMSB10 | thymosin beta 10 | 0.0438919 |
| AGO2 | argonaute RISC catalytic component 2 | 0.0436293 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.043211 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0427702 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0416663 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0410364 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0409243 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0408266 |
| MT2A | metallothionein 2A | 0.0407473 |
| TXNRD1 | thioredoxin reductase 1 | 0.0402784 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0402396 |
| SPAG9 | sperm associated antigen 9 | 0.0386493 |
| RPS12 | ribosomal protein S12 | 0.0380351 |
| RPL35A | ribosomal protein L35a | 0.0379567 |
| ARRDC3 | arrestin domain containing 3 | 0.0376797 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0374349 |
| PCBP2 | poly(rC) binding protein 2 | 0.0363998 |
| RUNX1 | runt-related transcription factor 1 | 0.035758 |
| JMJD1C | jumonji domain containing 1C | 0.0352231 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0351954 |
| DSCAM | Down syndrome cell adhesion molecule | 0.035053 |
| FAM13A | family with sequence similarity 13, member A | 0.0345087 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0344503 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0341016 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0336089 |
| KIAA1217 | KIAA1217 | 0.0335465 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0334459 |
| CCNL1 | cyclin L1 | 0.0329091 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0326402 |
| GPHN | gephyrin | 0.032365 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0323354 |
| MSN | moesin | 0.0321648 |
| RPLP1 | ribosomal protein, large, P1 | 0.032123 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0314944 |
| PRRC2C | proline-rich coiled-coil 2C | 0.031391 |
| DENND4A | DENN/MADD domain containing 4A | 0.0308197 |
| PKM | pyruvate kinase, muscle | 0.0305007 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.030451 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0302949 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.029794 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0292112 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0289879 |
| SLMAP | sarcolemma associated protein | 0.0285784 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0285021 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0285006 |
| PDE8A | phosphodiesterase 8A | 0.028474 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0277062 |
| ZNF292 | zinc finger protein 292 | 0.0273075 |
| RPS27 | ribosomal protein S27 | 0.0269813 |
| HLA-A | major histocompatibility complex, class I, A | 0.0268566 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0267816 |
| UBC | ubiquitin C | 0.0267206 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0263701 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.026234 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0261256 |
| RNF145 | ring finger protein 145 | 0.0257182 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0254961 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0250053 |
| VEGFA | vascular endothelial growth factor A | 0.0249058 |
| VMP1 | vacuole membrane protein 1 | 0.0248776 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0246974 |
| RPS25 | ribosomal protein S25 | 0.0246254 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0245059 |
| SQSTM1 | sequestosome 1 | 0.0245045 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0244147 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0240631 |
| RPLP0 | ribosomal protein, large, P0 | 0.0240199 |
| EGR1 | early growth response 1 | 0.0238606 |
| CST3 | cystatin C | 0.0235126 |
| RPS23 | ribosomal protein S23 | 0.0234781 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0233917 |
| KCMF1 | potassium channel modulatory factor 1 | 0.0233623 |
| PTEN | phosphatase and tensin homolog | 0.0232096 |
| NGLY1 | N-glycanase 1 | 0.0230811 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0230505 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0230065 |
| RPL31 | ribosomal protein L31 | 0.0229022 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0228169 |
| RPS17 | ribosomal protein S17 | 0.022761 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0223533 |
| SETD5 | SET domain containing 5 | 0.0222556 |
| RPS29 | ribosomal protein S29 | 0.0222208 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0221851 |
| VEZT | vezatin, adherens junctions transmembrane protein | 0.0221398 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | -0.297755 |
| LMO7 | LIM domain 7 | -0.151389 |
| ASPH | aspartate beta-hydroxylase | -0.147531 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0937315 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0872312 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0724193 |
| SCEL | sciellin | -0.0666722 |
| H1-0 | H1.0 linker histone | -0.0655271 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0607254 |
| AHNAK | AHNAK nucleoprotein | -0.0593062 |
| ACTG1 | actin gamma 1 | -0.0564927 |
| HDLBP | high density lipoprotein binding protein | -0.0518505 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0514848 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0496092 |
| MYOF | myoferlin | -0.0475579 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0471725 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0415408 |
| INTS6 | integrator complex subunit 6 | -0.0409653 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0407408 |
| CANX | calnexin | -0.0383329 |
| LDHA | lactate dehydrogenase A | -0.038175 |
| KRT18 | keratin 18, type I | -0.0369832 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0365641 |
| LAMA4 | laminin, alpha 4 | -0.0357997 |
| NABP1 | nucleic acid binding protein 1 | -0.0349415 |
| DSPP | dentin sialophosphoprotein | -0.0342616 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0341621 |
| GOLGB1 | golgin B1 | -0.0334116 |
| GM2A | GM2 ganglioside activator | -0.0329591 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0325588 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0302654 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0296166 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0286677 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0285858 |
| STC1 | stanniocalcin 1 | -0.0285364 |
| GRAMD1B | GRAM domain containing 1B | -0.0284063 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0280691 |
| CCND1 | cyclin D1 | -0.0271167 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0255447 |
| ARCN1 | archain 1 | -0.0237118 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.023471 |
| MORF4L2 | mortality factor 4 like 2 | -0.0228144 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0227722 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0226559 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0226298 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.0224183 |
| MCU | mitochondrial calcium uniporter | -0.0224087 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0222765 |
| EHBP1 | EH domain binding protein 1 | -0.0220076 |
| SUMF1 | sulfatase modifying factor 1 | -0.0218386 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0217972 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | -0.0215181 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0215009 |
| RAB27B | RAB27B, member RAS oncogene family | -0.021282 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.020913 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0208298 |
| S100A10 | S100 calcium binding protein A10 | -0.0207508 |
| LRP12 | low density lipoprotein receptor-related protein 12 | -0.0206096 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0199472 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0198891 |
| DSG2 | desmoglein 2 | -0.0196604 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0195957 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0195317 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0194907 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0194631 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0193366 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0192747 |
| GOLGA3 | golgin A3 | -0.0191232 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0191118 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0189424 |
| KRT8 | keratin 8, type II | -0.0188896 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | -0.0188397 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | -0.0187887 |
| TPTEP2-CSNK1E | TPTEP2-CSNK1E readthrough | -0.0187112 |
| DOCK9 | dedicator of cytokinesis 9 | -0.0183908 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0183128 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0182055 |
| MKI67 | marker of proliferation Ki-67 | -0.0179919 |
| ATP11A | ATPase, class VI, type 11A | -0.0179356 |
| OSMR | oncostatin M receptor | -0.0178263 |
| IER3 | immediate early response 3 | -0.0176577 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0175473 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0172091 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0169903 |
| KRT7 | keratin 7, type II | -0.0169819 |
| TPM4 | tropomyosin 4 | -0.0168485 |
| AGR2 | anterior gradient 2 | -0.0165011 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0163628 |
| SEC24D | SEC24 family member D | -0.0162348 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0161787 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0161231 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0161139 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0159472 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0158651 |
| EMP1 | epithelial membrane protein 1 | -0.015725 |
| ITFG1 | integrin alpha FG-GAP repeat containing 1 | -0.0156275 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0155875 |
| STAU2 | staufen double-stranded RNA binding protein 2 | -0.0153906 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0151663 |
| RASAL2 | RAS protein activator like 2 | -0.0151629 |
