| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Auranofin perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Auranofin_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.171257 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.113864 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0460742 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0433718 |
| STC1 | stanniocalcin 1 | 0.0394218 |
| KLF6 | Kruppel-like factor 6 | 0.0377734 |
| WDR43 | WD repeat domain 43 | 0.0343431 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0335111 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0332264 |
| HDGF | hepatoma-derived growth factor | 0.0320924 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0306529 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.030366 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0295684 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0274405 |
| GRAMD1B | GRAM domain containing 1B | 0.0262015 |
| MSN | moesin | 0.0258808 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0257578 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0252788 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0249152 |
| RCOR1 | REST corepressor 1 | 0.0248089 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0247031 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0245665 |
| AREG | amphiregulin | 0.0244343 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0244061 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0240588 |
| RPS12 | ribosomal protein S12 | 0.0228344 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0226746 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0218436 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0215648 |
| RPL37A | ribosomal protein L37a | 0.0215566 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0215219 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0215137 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0212663 |
| ITGB5 | integrin, beta 5 | 0.0208855 |
| PCBP2 | poly(rC) binding protein 2 | 0.0198257 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0197679 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0195933 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0189836 |
| MEMO1 | mediator of cell motility 1 | 0.0188 |
| RPS26 | ribosomal protein S26 | 0.018768 |
| OSMR | oncostatin M receptor | 0.0185626 |
| PYGL | phosphorylase, glycogen, liver | 0.0183521 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0182509 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0180588 |
| RPS29 | ribosomal protein S29 | 0.0179872 |
| CFDP1 | craniofacial development protein 1 | 0.0178296 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0177186 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0173007 |
| NUP58 | nucleoporin 58 | 0.0172873 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0170685 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0168677 |
| NPC1 | Niemann-Pick disease, type C1 | 0.0168487 |
| PHIP | pleckstrin homology domain interacting protein | 0.0165146 |
| COPA | coatomer protein complex, subunit alpha | 0.0163731 |
| FLNB | filamin B, beta | 0.0163421 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.0162375 |
| PNN | pinin, desmosome associated protein | 0.0160665 |
| RPL10A | ribosomal protein L10a | 0.0160467 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0159895 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0158862 |
| CBX3 | chromobox homolog 3 | 0.015865 |
| HLA-A | major histocompatibility complex, class I, A | 0.0158614 |
| SP3 | Sp3 transcription factor | 0.015851 |
| RPL21 | ribosomal protein L21 | 0.015532 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | 0.0154732 |
| ESCO1 | establishment of sister chromatid cohesion N-acetyltransferase 1 | 0.015423 |
| TERF2IP | telomeric repeat binding factor 2, interacting protein | 0.0152983 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.0149755 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0148915 |
| RBM25 | RNA binding motif protein 25 | 0.0148209 |
| ANGPTL4 | angiopoietin-like 4 | 0.0148133 |
| THOC2 | THO complex 2 | 0.0148028 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0147678 |
| AXL | AXL receptor tyrosine kinase | 0.0146804 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0143857 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | 0.0143766 |
| DIAPH1 | diaphanous-related formin 1 | 0.0143075 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0142995 |
| VMP1 | vacuole membrane protein 1 | 0.0142937 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0142909 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.0142818 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0142521 |
| EGR1 | early growth response 1 | 0.0142495 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | 0.0141297 |
| ITGA6 | integrin, alpha 6 | 0.0140445 |
| ATXN3 | ataxin 3 | 0.0140326 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.013964 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0138995 |
| ANKRD12 | ankyrin repeat domain 12 | 0.013857 |
| RBMS2 | RNA binding motif, single stranded interacting protein 2 | 0.0138513 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | 0.0138165 |
| HJURP | Holliday junction recognition protein | 0.013794 |
| RBM26 | RNA binding motif protein 26 | 0.0136978 |
| NKTR | natural killer cell triggering receptor | 0.0136569 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | 0.0136549 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0135162 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0135069 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.013503 |
| PLS3 | plastin 3 | 0.0131452 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0129918 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.408735 |
| FTL | ferritin, light polypeptide | -0.268167 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.215476 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.105931 |
| TXNRD1 | thioredoxin reductase 1 | -0.0915959 |
| RPL19 | ribosomal protein L19 | -0.08427 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0781691 |
| ACTG1 | actin gamma 1 | -0.0769928 |
| TMSB10 | thymosin beta 10 | -0.0754381 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0734775 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0686757 |
| S100A6 | S100 calcium binding protein A6 | -0.0668829 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0649944 |
| APP | amyloid beta (A4) precursor protein | -0.0637412 |
| PTK2 | protein tyrosine kinase 2 | -0.0597159 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.0593184 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.057864 |
| S100A10 | S100 calcium binding protein A10 | -0.0565152 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0550304 |
| ANXA2 | annexin A2 | -0.0530983 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0506303 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0482149 |
| UBC | ubiquitin C | -0.0480072 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0475857 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0457466 |
| ASPH | aspartate beta-hydroxylase | -0.0450401 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0445371 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0427473 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0417201 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0409995 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0402659 |
| RPLP0 | ribosomal protein, large, P0 | -0.0369983 |
| RPL4 | ribosomal protein L4 | -0.0363943 |
| AHNAK | AHNAK nucleoprotein | -0.0361664 |
| IER3 | immediate early response 3 | -0.0361593 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0353017 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0349836 |
| IGF2 | insulin-like growth factor 2 | -0.0347866 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0347663 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0346746 |
| GNAS | GNAS complex locus | -0.0331938 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0328648 |
| KYNU | kynureninase | -0.0326741 |
| DENND4A | DENN/MADD domain containing 4A | -0.0323966 |
| YBX1 | Y box binding protein 1 | -0.0323008 |
| RPL8 | ribosomal protein L8 | -0.0322848 |
| CANX | calnexin | -0.0319646 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0319311 |
| RAB7A | RAB7A, member RAS oncogene family | -0.031694 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0309626 |
| TPD52 | tumor protein D52 | -0.0308388 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0308362 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0308198 |
| CAVIN1 | caveolae associated protein 1 | -0.0307871 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0301959 |
| RPL34 | ribosomal protein L34 | -0.0298264 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0294515 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.029328 |
| RPS2 | ribosomal protein S2 | -0.0292983 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -0.0292646 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0292462 |
| SVIL | supervillin | -0.0291909 |
| HMGA1 | high mobility group AT-hook 1 | -0.0291821 |
| ENO1 | enolase 1, (alpha) | -0.0288805 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0283401 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0282885 |
| RPLP1 | ribosomal protein, large, P1 | -0.0279374 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0278817 |
| TPI1 | triosephosphate isomerase 1 | -0.0276852 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0273414 |
| BTBD7 | BTB (POZ) domain containing 7 | -0.0271519 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0270235 |
| FAM168A | family with sequence similarity 168, member A | -0.0269976 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0268306 |
| SRGN | serglycin | -0.0267854 |
| HBP1 | HMG-box transcription factor 1 | -0.0266978 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0266533 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0266491 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.026473 |
| CUX1 | cut-like homeobox 1 | -0.0264133 |
| RPS5 | ribosomal protein S5 | -0.0263129 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0262327 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0262152 |
| BZW2 | basic leucine zipper and W2 domains 2 | -0.0257974 |
| OSBPL9 | oxysterol binding protein-like 9 | -0.0257815 |
| SETD5 | SET domain containing 5 | -0.0257045 |
| EIF4A3 | eukaryotic translation initiation factor 4A3 | -0.0255849 |
| PARD3 | par-3 family cell polarity regulator | -0.025491 |
| CDK12 | cyclin-dependent kinase 12 | -0.0253631 |
| BMPR1B | bone morphogenetic protein receptor, type IB | -0.0252555 |
| WIPF2 | WAS/WASL interacting protein family, member 2 | -0.0250077 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0248258 |
| DST | dystonin | -0.0248174 |
| TMEM131 | transmembrane protein 131 | -0.0245065 |
| RPL26 | ribosomal protein L26 | -0.0244211 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0240561 |
| RPTOR | regulatory associated protein of MTOR, complex 1 | -0.0240516 |
| RPS25 | ribosomal protein S25 | -0.0239584 |
| SDC4 | syndecan 4 | -0.0239492 |
| DENND5B | DENN/MADD domain containing 5B | -0.0239053 |
