| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Auranofin perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Auranofin_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.139064 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.114936 |
| VIM | vimentin | 0.0992028 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0915351 |
| KRT17 | keratin 17, type I | 0.086152 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0854534 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0849145 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0842486 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0841232 |
| FAM13A | family with sequence similarity 13, member A | 0.0813754 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0812795 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0807897 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0792116 |
| RPS16 | ribosomal protein S16 | 0.0760465 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0735627 |
| CD44 | CD44 molecule (Indian blood group) | 0.0729477 |
| RNF145 | ring finger protein 145 | 0.0718568 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0665355 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0647216 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | 0.0638086 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0635516 |
| ZNF292 | zinc finger protein 292 | 0.0625559 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0621988 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.0605979 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.0605019 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0602357 |
| LDHA | lactate dehydrogenase A | 0.0594158 |
| RUNX1 | runt-related transcription factor 1 | 0.0589027 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0588946 |
| NOP58 | NOP58 ribonucleoprotein | 0.0584896 |
| SQSTM1 | sequestosome 1 | 0.0582873 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0577309 |
| QKI | QKI, KH domain containing, RNA binding | 0.0576879 |
| TXNRD1 | thioredoxin reductase 1 | 0.0564888 |
| USP3 | ubiquitin specific peptidase 3 | 0.0561964 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0557961 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0549791 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.054889 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0540052 |
| FDPS | farnesyl diphosphate synthase | 0.0539369 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0534158 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0532762 |
| ARL6IP5 | ADP-ribosylation factor-like 6 interacting protein 5 | 0.0528413 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0528233 |
| RPLP2 | ribosomal protein, large, P2 | 0.0526844 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0523307 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0522498 |
| PLAU | plasminogen activator, urokinase | 0.0522255 |
| LAMB3 | laminin, beta 3 | 0.0517822 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0507073 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0504254 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0503882 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0498816 |
| CALR | calreticulin | 0.0498277 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.048063 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0476844 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0475009 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0472129 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0456943 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0451177 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | 0.0449161 |
| TCERG1 | transcription elongation regulator 1 | 0.0448125 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0447403 |
| CDC73 | cell division cycle 73 | 0.0444767 |
| ERBIN | erbb2 interacting protein | 0.0442064 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0438792 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0432876 |
| TBK1 | TANK-binding kinase 1 | 0.0432429 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0429525 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0429463 |
| UQCRB | ubiquinol-cytochrome c reductase binding protein | 0.0425146 |
| RPL12 | ribosomal protein L12 | 0.0420295 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | 0.0413556 |
| ATP11A | ATPase, class VI, type 11A | 0.0413296 |
| HMGA2 | high mobility group AT-hook 2 | 0.0411557 |
| MEF2A | myocyte enhancer factor 2A | 0.0402904 |
| ATP13A3 | ATPase type 13A3 | 0.0400238 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0399989 |
| PCBP2 | poly(rC) binding protein 2 | 0.0399897 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0393234 |
| MXD1 | MAX dimerization protein 1 | 0.0391542 |
| TPM3 | tropomyosin 3 | 0.0389346 |
| POU2F1 | POU class 2 homeobox 1 | 0.0388625 |
| RPS25 | ribosomal protein S25 | 0.0387323 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0384032 |
| NCKAP1 | NCK-associated protein 1 | 0.0383605 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0380648 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0380373 |
| FAM168A | family with sequence similarity 168, member A | 0.0380043 |
| CCNL1 | cyclin L1 | 0.0378838 |
| FRYL | FRY-like | 0.0377034 |
| JAK1 | Janus kinase 1 | 0.0372629 |
| FNBP1L | formin binding protein 1-like | 0.0364659 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0364645 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0364242 |
| RPL23 | ribosomal protein L23 | 0.0363175 |
| EGFR | epidermal growth factor receptor | 0.0361998 |
| RND3 | Rho family GTPase 3 | 0.0361734 |
| MORF4L2 | mortality factor 4 like 2 | 0.0358741 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0357973 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.178225 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.154895 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.132948 |
| MYO1E | myosin IE | -0.118241 |
| ANXA2 | annexin A2 | -0.116423 |
| FN1 | fibronectin 1 | -0.0962686 |
| AHNAK | AHNAK nucleoprotein | -0.0884931 |
| RORA | RAR-related orphan receptor A | -0.0868028 |
| ATOSA | atos homolog A | -0.0866421 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0864365 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0864245 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0863965 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0833301 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0829414 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0797825 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0791328 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0781679 |
| PDE10A | phosphodiesterase 10A | -0.075711 |
| PRELID2 | PRELI domain containing 2 | -0.07298 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0719082 |
| SVIL | supervillin | -0.0664563 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0663908 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0657454 |
| USP53 | ubiquitin specific peptidase 53 | -0.065074 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0644527 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0635921 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0611808 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0611211 |
| VMP1 | vacuole membrane protein 1 | -0.0592325 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0573408 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0559051 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0543219 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0529492 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0522049 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0511689 |
| ZNF217 | zinc finger protein 217 | -0.0508348 |
| GOLGB1 | golgin B1 | -0.0505576 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0501132 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.049467 |
| INTS6 | integrator complex subunit 6 | -0.0491784 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0487104 |
| SETD5 | SET domain containing 5 | -0.0482513 |
| CDCP1 | CUB domain containing protein 1 | -0.0480838 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0478225 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0477966 |
| S100A10 | S100 calcium binding protein A10 | -0.0477174 |
| BPTF | bromodomain PHD finger transcription factor | -0.046978 |
| FNIP1 | folliculin interacting protein 1 | -0.0469559 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0468346 |
| DSCAM | Down syndrome cell adhesion molecule | -0.046346 |
| RAD51B | RAD51 paralog B | -0.0460424 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.045717 |
| FOXO1 | forkhead box O1 | -0.04568 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0456462 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0453123 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0451669 |
| KIAA1217 | KIAA1217 | -0.0446657 |
| GPC6 | glypican 6 | -0.0439988 |
| ENO1 | enolase 1, (alpha) | -0.0437094 |
| TMEM41B | transmembrane protein 41B | -0.043679 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0436138 |
| PRKCA | protein kinase C, alpha | -0.043498 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0424609 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0422267 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0420907 |
| RNF213 | ring finger protein 213 | -0.0420847 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0418928 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.041175 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0409423 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.040823 |
| CDK12 | cyclin-dependent kinase 12 | -0.0406963 |
| RBM47 | RNA binding motif protein 47 | -0.0403922 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0400767 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0393464 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.039188 |
| SMYD3 | SET and MYND domain containing 3 | -0.0387712 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0386476 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0384257 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0381652 |
| MED13L | mediator complex subunit 13-like | -0.0381217 |
| MCL1 | myeloid cell leukemia 1 | -0.037677 |
| DTNA | dystrobrevin, alpha | -0.0376664 |
| GRAMD1B | GRAM domain containing 1B | -0.037665 |
| PTMA | prothymosin, alpha | -0.037624 |
| OSMR | oncostatin M receptor | -0.0375289 |
| ATRN | attractin | -0.0374116 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0373856 |
| CYTH1 | cytohesin 1 | -0.0370748 |
| EXT1 | exostosin glycosyltransferase 1 | -0.037055 |
| AK1 | adenylate kinase 1 | -0.0370154 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.036831 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0365041 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0364433 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0362388 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0355351 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.035428 |
| ABHD17C | abhydrolase domain containing 17C | -0.0352436 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0351083 |
| NBEA | neurobeachin | -0.0350958 |
| NEBL | nebulette | -0.0350476 |
