Auranofin_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Auranofin perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Auranofin_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TFPI2 tissue factor pathway inhibitor 2 0.13647
AKAP12 A kinase (PRKA) anchor protein 12 0.110059
TXNRD1 thioredoxin reductase 1 0.0943371
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0785771
KTN1 kinectin 1 (kinesin receptor) 0.057017
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0498397
STAT1 signal transducer and activator of transcription 1, 91kDa 0.049489
RTN4 reticulon 4 0.0473555
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0458611
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0438331
MARCHF4 membrane associated ring-CH-type finger 4 0.0437452
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0424853
ELL2 elongation factor, RNA polymerase II, 2 0.0415007
ERRFI1 ERBB receptor feedback inhibitor 1 0.0376022
YBX3 Y box binding protein 3 0.0375492
OGA O-GlcNAcase 0.0349766
TM4SF1 transmembrane 4 L six family member 1 0.034381
RPS12 ribosomal protein S12 0.0338901
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0335675
NFE2L2 nuclear factor, erythroid 2-like 2 0.0331989
NIPBL Nipped-B homolog (Drosophila) 0.0326651
MYPN myopalladin 0.0313259
EIF1 eukaryotic translation initiation factor 1 0.0311266
TMEM41B transmembrane protein 41B 0.0308702
CTTNBP2NL CTTNBP2 N-terminal like 0.030054
YBX1 Y box binding protein 1 0.0299678
MT2A metallothionein 2A 0.029042
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0278155
MATR3 matrin 3 0.0277536
NAMPT nicotinamide phosphoribosyltransferase 0.0274177
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0273981
VCL vinculin 0.0266705
RPL23 ribosomal protein L23 0.0265574
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0260813
RRM2 ribonucleotide reductase M2 0.0259344
RB1CC1 RB1-inducible coiled-coil 1 0.025863
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0255392
RUSC2 RUN and SH3 domain containing 2 0.0250343
RPLP0 ribosomal protein, large, P0 0.0248972
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0248067
KLF6 Kruppel-like factor 6 0.0244712
MYL12B myosin, light chain 12B, regulatory 0.0241308
RPL12 ribosomal protein L12 0.0237341
RAB7A RAB7A, member RAS oncogene family 0.023335
KRT18 keratin 18, type I 0.0230081
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0228676
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0228525
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0228319
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0227285
IMMT inner membrane protein, mitochondrial 0.0222643
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0222514
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0221151
SRSF5 serine/arginine-rich splicing factor 5 0.02178
ADAM17 ADAM metallopeptidase domain 17 0.021578
SERINC1 serine incorporator 1 0.0213286
RPS29 ribosomal protein S29 0.0211437
ADAM9 ADAM metallopeptidase domain 9 0.0210904
B2M beta-2-microglobulin 0.0209965
RPS19 ribosomal protein S19 0.0209134
ZFC3H1 zinc finger, C3H1-type containing 0.0209105
RPL37A ribosomal protein L37a 0.0208803
IPO7 importin 7 0.020477
EZR ezrin 0.0198378
RPS3 ribosomal protein S3 0.0197155
APLP2 amyloid beta (A4) precursor-like protein 2 0.0197129
ANXA5 annexin A5 0.0197004
XPO1 exportin 1 0.0194631
DSCAM Down syndrome cell adhesion molecule 0.0192874
RPLP1 ribosomal protein, large, P1 0.0192291
BZW1 basic leucine zipper and W2 domains 1 0.0189513
EIF3A eukaryotic translation initiation factor 3, subunit A 0.018947
PCBP2 poly(rC) binding protein 2 0.0188502
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0183499
RHOA ras homolog family member A 0.0179927
PPME1 protein phosphatase methylesterase 1 0.0179824
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0178331
RPL38 ribosomal protein L38 0.0177257
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0176658
RNF145 ring finger protein 145 0.0173458
TJP1 tight junction protein 1 0.0173449
RPS27 ribosomal protein S27 0.0173262
CAVIN1 caveolae associated protein 1 0.0171219
GPX4 glutathione peroxidase 4 0.0170076
WDR26 WD repeat domain 26 0.0169345
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0168818
KDM3A lysine (K)-specific demethylase 3A 0.0168735
OSMR oncostatin M receptor 0.0167325
CHD1 chromodomain helicase DNA binding protein 1 0.0165644
TOP2B topoisomerase (DNA) II beta 180kDa 0.0165434
WRN Werner syndrome, RecQ helicase-like 0.0165235
KIF5B kinesin family member 5B 0.0165171
BMAL2 basic helix-loop-helix ARNT like 2 0.0164487
HSPA8 heat shock 70kDa protein 8 0.0163186
LIMA1 LIM domain and actin binding 1 0.0162998
GADD45A growth arrest and DNA-damage-inducible, alpha 0.016272
THOC1 THO complex 1 0.0162686
SQSTM1 sequestosome 1 0.0162334
VMP1 vacuole membrane protein 1 0.0161242
RPL35 ribosomal protein L35 0.0161008
BIRC2 baculoviral IAP repeat containing 2 0.0160761

decreased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B -0.139799
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.130011
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.077154
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0733252
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.07019
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0663871
PDE4D phosphodiesterase 4D, cAMP-specific -0.0653386
EXOC4 exocyst complex component 4 -0.0600096
AFF3 AF4/FMR2 family, member 3 -0.05993
HMGA2 high mobility group AT-hook 2 -0.0567809
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0546099
CANX calnexin -0.0542865
ATXN1 ataxin 1 -0.0475169
THSD4 thrombospondin, type I, domain containing 4 -0.0469733
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0464696
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0440038
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0431461
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0426337
RERE arginine-glutamic acid dipeptide (RE) repeats -0.04163
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0407513
PTK2 protein tyrosine kinase 2 -0.0389603
PYGL phosphorylase, glycogen, liver -0.0385616
PHF21A PHD finger protein 21A -0.0376558
RIMS2 regulating synaptic membrane exocytosis 2 -0.0375566
PATJ PATJ crumbs cell polarity complex component -0.0373221
EGFR epidermal growth factor receptor -0.0372608
DENND5B DENN/MADD domain containing 5B -0.0363023
NF1 neurofibromin 1 -0.0362042
CUX1 cut-like homeobox 1 -0.0354299
THADA thyroid adenoma associated -0.0341628
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0340981
TBC1D5 TBC1 domain family, member 5 -0.0339786
BABAM2 BRISC and BRCA1 A complex member 2 -0.0336705
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0325528
WDR70 WD repeat domain 70 -0.0323488
BPTF bromodomain PHD finger transcription factor -0.0321989
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0316587
EGR1 early growth response 1 -0.0310709
NCOA7 nuclear receptor coactivator 7 -0.03103
EML4 echinoderm microtubule associated protein like 4 -0.0309409
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0307277
SRBD1 S1 RNA binding domain 1 -0.030688
PRH1 proline-rich protein HaeIII subfamily 1 -0.0302509
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0295956
WWOX WW domain containing oxidoreductase -0.0292274
TNRC6B trinucleotide repeat containing 6B -0.0286824
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0281661
MON2 MON2 homolog (S. cerevisiae) -0.0281272
RYR3 ryanodine receptor 3 -0.0280335
RABGAP1L RAB GTPase activating protein 1-like -0.0279484
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.027543
MAP4 microtubule-associated protein 4 -0.0273183
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.027212
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0268862
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0267733
TAS2R14 taste receptor, type 2, member 14 -0.0266903
ZBTB20 zinc finger and BTB domain containing 20 -0.0262338
SBF2 SET binding factor 2 -0.0259311
BICD1 bicaudal D homolog 1 (Drosophila) -0.0251764
PDIA4 protein disulfide isomerase family A, member 4 -0.0251725
WASF2 WAS protein family, member 2 -0.0247516
PRKCE protein kinase C, epsilon -0.024685
SENP6 SUMO1/sentrin specific peptidase 6 -0.0246248
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0245675
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0245497
ZRANB3 zinc finger, RAN-binding domain containing 3 -0.0244274
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0244042
RSF1 remodeling and spacing factor 1 -0.024134
DENND1A DENN/MADD domain containing 1A -0.0241185
CBX5 chromobox homolog 5 -0.0240432
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0238919
BIRC6 baculoviral IAP repeat containing 6 -0.0236407
TPM3 tropomyosin 3 -0.0236146
ZMYM4 zinc finger, MYM-type 4 -0.0235018
AEBP2 AE binding protein 2 -0.0234293
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0232703
SSH2 slingshot protein phosphatase 2 -0.0230724
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0230717
ETV6 ets variant 6 -0.0229545
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0228542
BCAS3 breast carcinoma amplified sequence 3 -0.022618
KDM4B lysine (K)-specific demethylase 4B -0.022487
CAMKMT calmodulin-lysine N-methyltransferase -0.0224242
FNDC3B fibronectin type III domain containing 3B -0.0222904
PHF20 PHD finger protein 20 -0.0219271
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0219128
ZNF609 zinc finger protein 609 -0.0218814
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 -0.0218691
HDAC8 histone deacetylase 8 -0.0218464
PDE10A phosphodiesterase 10A -0.0215618
KIRREL1 kirre like nephrin family adhesion molecule 1 -0.0215053
RHBDD1 rhomboid domain containing 1 -0.0214838
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0212953
R3HDM2 R3H domain containing 2 -0.0212725
DNAH14 dynein, axonemal, heavy chain 14 -0.0211993
ARB2A ARB2 cotranscriptional regulator A -0.0211686
EPAS1 endothelial PAS domain protein 1 -0.0211377
NCOR1 nuclear receptor corepressor 1 -0.0211062
ENO1 enolase 1, (alpha) -0.0210677
DOCK1 dedicator of cytokinesis 1 -0.0210245