| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Auranofin perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Auranofin_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.068422 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0488297 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0475472 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0440335 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0424129 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0401972 |
| STC1 | stanniocalcin 1 | 0.0380609 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0374131 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0363244 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.033659 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0330424 |
| MCL1 | myeloid cell leukemia 1 | 0.0328565 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0318697 |
| MT2A | metallothionein 2A | 0.0306272 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0303004 |
| GOLGA4 | golgin A4 | 0.0299921 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0294894 |
| B2M | beta-2-microglobulin | 0.0292935 |
| OGA | O-GlcNAcase | 0.0290272 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0289588 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0280325 |
| SPAG9 | sperm associated antigen 9 | 0.0276016 |
| PTMA | prothymosin, alpha | 0.0268868 |
| COPA | coatomer protein complex, subunit alpha | 0.0268284 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0267864 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0263688 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0263021 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0254818 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.025404 |
| HLA-A | major histocompatibility complex, class I, A | 0.0252609 |
| ATP13A3 | ATPase type 13A3 | 0.0248889 |
| PCBP2 | poly(rC) binding protein 2 | 0.0246826 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0243476 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.023692 |
| NUP58 | nucleoporin 58 | 0.0233339 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0233312 |
| NDRG1 | N-myc downstream regulated 1 | 0.0225424 |
| FAM13A | family with sequence similarity 13, member A | 0.0220502 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0215575 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.021126 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0207903 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0207535 |
| FLNB | filamin B, beta | 0.0205394 |
| HELZ | helicase with zinc finger | 0.0203987 |
| RNF145 | ring finger protein 145 | 0.019893 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0192128 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0183706 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0182753 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0180054 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0175445 |
| ARRDC3 | arrestin domain containing 3 | 0.0174807 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0174245 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0171223 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0170091 |
| DDX3Y | DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked | 0.0169976 |
| TENT5A | terminal nucleotidyltransferase 5A | 0.0164367 |
| WDR43 | WD repeat domain 43 | 0.0162888 |
| SRP54 | signal recognition particle 54kDa | 0.0160642 |
| RIOK3 | RIO kinase 3 | 0.0159923 |
| WDR45B | WD repeat domain 45B | 0.0158321 |
| NGLY1 | N-glycanase 1 | 0.0158305 |
| RTN4 | reticulon 4 | 0.0156674 |
| RAI1 | retinoic acid induced 1 | 0.0155575 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.0154506 |
| ACBD3 | acyl-CoA binding domain containing 3 | 0.0150239 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.014918 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.014812 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0147687 |
| SEC24A | SEC24 family member A | 0.0145831 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0145151 |
| ZNF292 | zinc finger protein 292 | 0.0143994 |
| RPS12 | ribosomal protein S12 | 0.0143413 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0143382 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | 0.0142428 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0142262 |
| AVL9 | AVL9 homolog (S. cerevisiase) | 0.0141849 |
| CDC73 | cell division cycle 73 | 0.014058 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0140521 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0140144 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0139993 |
| EZR | ezrin | 0.0136185 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0136144 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0135912 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0135812 |
| SUCO | SUN domain containing ossification factor | 0.0135227 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0134123 |
| TMF1 | TATA element modulatory factor 1 | 0.0131841 |
| USP37 | ubiquitin specific peptidase 37 | 0.0131752 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0131201 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0130905 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.012985 |
| TGFBR1 | transforming growth factor, beta receptor 1 | 0.0129242 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0128023 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0127694 |
| MSN | moesin | 0.0125527 |
| RPL12 | ribosomal protein L12 | 0.0125325 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0122613 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0121709 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0121328 |
| NBAS | neuroblastoma amplified sequence | 0.0119891 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.439171 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.164704 |
| PDE10A | phosphodiesterase 10A | -0.16138 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.13992 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.132403 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.120362 |
| COL5A2 | collagen, type V, alpha 2 | -0.116677 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.115614 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0991824 |
| ASPH | aspartate beta-hydroxylase | -0.0976926 |
| SMYD3 | SET and MYND domain containing 3 | -0.0919684 |
| CDH13 | cadherin 13 | -0.0889303 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0871226 |
| FN1 | fibronectin 1 | -0.0865141 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0850302 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0845795 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.0707382 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0705128 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0687383 |
| TXNRD1 | thioredoxin reductase 1 | -0.06798 |
| NRCAM | neuronal cell adhesion molecule | -0.0655988 |
| DST | dystonin | -0.0606124 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0581308 |
| EFNA5 | ephrin-A5 | -0.0576804 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0570936 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0550808 |
| GDA | guanine deaminase | -0.0541598 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.053958 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0494668 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0478717 |
| PCBP3 | poly(rC) binding protein 3 | -0.0475392 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0462017 |
| LSAMP | limbic system-associated membrane protein | -0.0447868 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0434749 |
| ANTXR1 | anthrax toxin receptor 1 | -0.0427545 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0408922 |
| PM20D1 | peptidase M20 domain containing 1 | -0.0408604 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0405359 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0391985 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | -0.0383384 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0368992 |
| KIAA0825 | KIAA0825 | -0.0355351 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0352814 |
| CADM2 | cell adhesion molecule 2 | -0.0349019 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0340059 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | -0.0327314 |
| PALLD | palladin, cytoskeletal associated protein | -0.0326524 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0318854 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0315932 |
| GRAMD1B | GRAM domain containing 1B | -0.0305401 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0301644 |
| ATXN1 | ataxin 1 | -0.029048 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0285883 |
| RAD51B | RAD51 paralog B | -0.0284867 |
| NCKAP5 | NCK-associated protein 5 | -0.0277138 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.027617 |
| CTNND2 | catenin (cadherin-associated protein), delta 2 | -0.0275522 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.0274313 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0274146 |
| AUTS2 | autism susceptibility candidate 2 | -0.0272113 |
| TENM3 | teneurin transmembrane protein 3 | -0.0259217 |
| RTN1 | reticulon 1 | -0.0258746 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0257103 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0255234 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | -0.0252417 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0251414 |
| PDE7B | phosphodiesterase 7B | -0.0248416 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0246371 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0245404 |
| MAP1B | microtubule-associated protein 1B | -0.0240389 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0237289 |
| ALPK2 | alpha-kinase 2 | -0.0236444 |
| GLIS3 | GLIS family zinc finger 3 | -0.0235221 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0234515 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0231951 |
| TUSC3 | tumor suppressor candidate 3 | -0.0227011 |
| AOPEP | aminopeptidase O (putative) | -0.0225455 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0222389 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0220673 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0220164 |
| PDE1C | phosphodiesterase 1C, calmodulin-dependent 70kDa | -0.0219207 |
| EXOC4 | exocyst complex component 4 | -0.0216078 |
| KYNU | kynureninase | -0.0215979 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0215269 |
| CREB5 | cAMP responsive element binding protein 5 | -0.0215146 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0212888 |
| PCDH15 | protocadherin-related 15 | -0.0211803 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0209707 |
| SLC44A1 | solute carrier family 44 (choline transporter), member 1 | -0.0208393 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0205516 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0204989 |
| PTGR1 | prostaglandin reductase 1 | -0.020479 |
| TNPO1 | transportin 1 | -0.0201842 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0200596 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | -0.0195593 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0194755 |
| MAP7 | microtubule-associated protein 7 | -0.0192846 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0191915 |
| RANBP17 | RAN binding protein 17 | -0.0190656 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | -0.0189615 |
