| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Auranofin perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Auranofin_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.155361 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0928614 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0855816 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0835846 |
| RAB1A | RAB1A, member RAS oncogene family | 0.0832361 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0830269 |
| PTMA | prothymosin, alpha | 0.0801021 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0790233 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0761903 |
| DSTN | destrin (actin depolymerizing factor) | 0.0726485 |
| MYO1E | myosin IE | 0.0725329 |
| KRT8 | keratin 8, type II | 0.0717798 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0695499 |
| FOXO3 | forkhead box O3 | 0.0693165 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0678482 |
| EGFR | epidermal growth factor receptor | 0.0676967 |
| RPL19 | ribosomal protein L19 | 0.0672795 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0661061 |
| JMJD1C | jumonji domain containing 1C | 0.063631 |
| SPAG9 | sperm associated antigen 9 | 0.0607715 |
| SCFD1 | sec1 family domain containing 1 | 0.0594051 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.059163 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0575724 |
| SMAD3 | SMAD family member 3 | 0.0569887 |
| ARHGAP12 | Rho GTPase activating protein 12 | 0.0567833 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0565168 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.055028 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | 0.0548976 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0548077 |
| SFTPA2 | surfactant protein A2 | 0.0542358 |
| FOXJ3 | forkhead box J3 | 0.0541194 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0540366 |
| ITGA6 | integrin, alpha 6 | 0.0529854 |
| PATJ | PATJ crumbs cell polarity complex component | 0.0523634 |
| PNN | pinin, desmosome associated protein | 0.0518668 |
| PGK1 | phosphoglycerate kinase 1 | 0.0516914 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0513973 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0513888 |
| EZR | ezrin | 0.0510604 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0508472 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0502929 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.050285 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0502825 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0501785 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0501673 |
| SET | SET nuclear proto-oncogene | 0.0494733 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0493662 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0485738 |
| EGR1 | early growth response 1 | 0.0484452 |
| RPS3 | ribosomal protein S3 | 0.0484328 |
| RNF145 | ring finger protein 145 | 0.0479442 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0473276 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0471841 |
| RPLP0 | ribosomal protein, large, P0 | 0.0459369 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.045432 |
| RPL11 | ribosomal protein L11 | 0.0445954 |
| ACTN4 | actinin, alpha 4 | 0.0436631 |
| LAMC2 | laminin, gamma 2 | 0.0433389 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0427689 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0424477 |
| FMN1 | formin 1 | 0.0421137 |
| NEK7 | NIMA-related kinase 7 | 0.0418521 |
| MYO10 | myosin X | 0.0416608 |
| CAMTA1 | calmodulin binding transcription activator 1 | 0.0407105 |
| LDHA | lactate dehydrogenase A | 0.0404993 |
| PKM | pyruvate kinase, muscle | 0.0402114 |
| MT2A | metallothionein 2A | 0.040021 |
| RPS12 | ribosomal protein S12 | 0.0399511 |
| SQSTM1 | sequestosome 1 | 0.039434 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.039225 |
| FAM107B | family with sequence similarity 107, member B | 0.0383308 |
| HMGB1 | high mobility group box 1 | 0.0381272 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0378957 |
| FAT1 | FAT atypical cadherin 1 | 0.0377145 |
| FTL | ferritin, light polypeptide | 0.0375027 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0371515 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.0371107 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0366371 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0365268 |
| RPL15 | ribosomal protein L15 | 0.036421 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0362686 |
| H3-3B | H3.3 histone B | 0.0357079 |
| ATXN1 | ataxin 1 | 0.0356996 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | 0.0356712 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0354517 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0353247 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0353001 |
| MCL1 | myeloid cell leukemia 1 | 0.0351151 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0349894 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0346293 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0337862 |
| KDM5B | lysine (K)-specific demethylase 5B | 0.0336524 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0332735 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.032589 |
| RPL28 | ribosomal protein L28 | 0.0321494 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0317964 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0311682 |
| SLMAP | sarcolemma associated protein | 0.0307885 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0300095 |
| UBXN7 | UBX domain protein 7 | 0.029972 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | -0.187162 |
| EFNA5 | ephrin-A5 | -0.172611 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.16293 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.123992 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.118018 |
| EXT1 | exostosin glycosyltransferase 1 | -0.111662 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.109902 |
| FN1 | fibronectin 1 | -0.10903 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.108369 |
| ASPH | aspartate beta-hydroxylase | -0.0949628 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0901196 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0871525 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0858331 |
| SMYD3 | SET and MYND domain containing 3 | -0.0819114 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0797879 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0796087 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0793453 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0788337 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0773969 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0771036 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0691095 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0681737 |
| COL5A2 | collagen, type V, alpha 2 | -0.065937 |
| MYOF | myoferlin | -0.0652822 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0630889 |
| ACTG1 | actin gamma 1 | -0.0623231 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0621376 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0604091 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0600727 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.057755 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.057684 |
| GPC6 | glypican 6 | -0.0571555 |
| CDYL | chromodomain protein, Y-like | -0.056118 |
| FLNB | filamin B, beta | -0.0555582 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.055258 |
| RORA | RAR-related orphan receptor A | -0.054845 |
| ETNK1 | ethanolamine kinase 1 | -0.0538722 |
| OSMR | oncostatin M receptor | -0.0523845 |
| FOXP1 | forkhead box P1 | -0.0522448 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0520318 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.05138 |
| VCL | vinculin | -0.0506302 |
| MTSS1 | metastasis suppressor 1 | -0.0506129 |
| VGF | VGF nerve growth factor inducible | -0.0505578 |
| YEATS2 | YEATS domain containing 2 | -0.0504668 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0499823 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0498981 |
| DST | dystonin | -0.0493475 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0493073 |
| VMP1 | vacuole membrane protein 1 | -0.0488234 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0485657 |
| PRRC2B | proline-rich coiled-coil 2B | -0.0475985 |
| AOPEP | aminopeptidase O (putative) | -0.0469057 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0451912 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0448169 |
| ZNF609 | zinc finger protein 609 | -0.0447221 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -0.0433505 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0433459 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.04322 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0430957 |
| OSBPL3 | oxysterol binding protein-like 3 | -0.0423605 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.042001 |
| DENND1A | DENN/MADD domain containing 1A | -0.0416651 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0408171 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0401936 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0397405 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0396977 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0386693 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.038367 |
| PRKCA | protein kinase C, alpha | -0.0382032 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0379171 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0369695 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.036682 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0360165 |
| SEC24D | SEC24 family member D | -0.0358013 |
| THOC2 | THO complex 2 | -0.0345883 |
| CALU | calumenin | -0.0344836 |
| YBX1 | Y box binding protein 1 | -0.0342515 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0336456 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0336292 |
| HELZ | helicase with zinc finger | -0.0334771 |
| DTNA | dystrobrevin, alpha | -0.0331603 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.0329584 |
| SUMF1 | sulfatase modifying factor 1 | -0.03214 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0320095 |
| HIP1 | huntingtin interacting protein 1 | -0.0320042 |
| XPO1 | exportin 1 | -0.0316032 |
| RHOA | ras homolog family member A | -0.0307457 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0306455 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0299377 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0296053 |
| PHIP | pleckstrin homology domain interacting protein | -0.0295116 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0292404 |
| FAM13B | family with sequence similarity 13, member B | -0.0289937 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.028895 |
| PTGES2 | prostaglandin E synthase 2 | -0.0285866 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0282649 |
| POTEF | POTE ankyrin domain family, member F | -0.0274812 |
| RPS8 | ribosomal protein S8 | -0.0274333 |
| COG5 | component of oligomeric golgi complex 5 | -0.0272721 |
