Auranofin_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Auranofin perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Auranofin_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.149823
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.144037
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.100831
GOLGA4 golgin A4 0.0946308
TXNRD1 thioredoxin reductase 1 0.0920274
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0808163
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0797413
RPS6 ribosomal protein S6 0.0792033
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0736608
ZNF292 zinc finger protein 292 0.0689246
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0649107
NAMPT nicotinamide phosphoribosyltransferase 0.0641348
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0635489
MT2A metallothionein 2A 0.0584734
RTN4 reticulon 4 0.0568248
EIF1 eukaryotic translation initiation factor 1 0.052322
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0511276
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0504469
TXNIP thioredoxin interacting protein 0.0502506
B2M beta-2-microglobulin 0.0501819
TMEM41B transmembrane protein 41B 0.0491576
S100A6 S100 calcium binding protein A6 0.0488714
LDHA lactate dehydrogenase A 0.0475792
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0470435
PKM pyruvate kinase, muscle 0.0467642
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0459372
GARS1 glycyl-tRNA synthetase 1 0.0455083
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0437263
PNISR PNN-interacting serine/arginine-rich protein 0.0434388
EZR ezrin 0.0431504
SQSTM1 sequestosome 1 0.042394
DSCAM Down syndrome cell adhesion molecule 0.0420341
TMSB4X thymosin beta 4, X-linked 0.0417483
EEF2 eukaryotic translation elongation factor 2 0.0415756
KMT2E lysine (K)-specific methyltransferase 2E 0.0410915
KDM3A lysine (K)-specific demethylase 3A 0.0404443
RPS19 ribosomal protein S19 0.0399907
NUP58 nucleoporin 58 0.0398766
NAP1L1 nucleosome assembly protein 1-like 1 0.0397163
PRRC2C proline-rich coiled-coil 2C 0.0396726
RBM39 RNA binding motif protein 39 0.0395485
FLNB filamin B, beta 0.0389022
RPS8 ribosomal protein S8 0.0381603
RNF145 ring finger protein 145 0.0379171
ELOVL5 ELOVL fatty acid elongase 5 0.0373563
FTL ferritin, light polypeptide 0.0373318
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0372335
SMNDC1 survival motor neuron domain containing 1 0.0372206
QKI QKI, KH domain containing, RNA binding 0.0370721
RPL23 ribosomal protein L23 0.0368189
DSTN destrin (actin depolymerizing factor) 0.0365195
RBM25 RNA binding motif protein 25 0.0351392
RPL11 ribosomal protein L11 0.0345598
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0342776
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0342302
ZFAND3 zinc finger, AN1-type domain 3 0.0338975
PGK1 phosphoglycerate kinase 1 0.0338792
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.033291
ACTG1 actin gamma 1 0.0321737
MATR3 matrin 3 0.0320835
RPL12 ribosomal protein L12 0.0319894
RPS3 ribosomal protein S3 0.0314188
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0309029
PFN1 profilin 1 0.0308625
ADAM9 ADAM metallopeptidase domain 9 0.0306957
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0302617
FXR1 fragile X mental retardation, autosomal homolog 1 0.0301967
RPL35A ribosomal protein L35a 0.0301809
RPL37A ribosomal protein L37a 0.0299622
LOC112694756 uncharaterized LOC112694756 0.0296839
TFG TRK-fused gene 0.0295855
CCNL1 cyclin L1 0.029494
ENO2 enolase 2 (gamma, neuronal) 0.029447
POTEF POTE ankyrin domain family, member F 0.0293492
RPLP0 ribosomal protein, large, P0 0.029271
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0291803
RHOA ras homolog family member A 0.0290573
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0289668
CDC73 cell division cycle 73 0.0288164
RAB6A RAB6A, member RAS oncogene family 0.0287378
HMGA1 high mobility group AT-hook 1 0.0281644
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0280688
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0280324
BRWD1 bromodomain and WD repeat domain containing 1 0.0276105
NBAS neuroblastoma amplified sequence 0.0275287
SMC3 structural maintenance of chromosomes 3 0.0272976
RLF rearranged L-myc fusion 0.0272366
SETD5 SET domain containing 5 0.0271864
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0269596
VMP1 vacuole membrane protein 1 0.0268643
ECT2 epithelial cell transforming 2 0.0268172
XPO1 exportin 1 0.0264463
WAC WW domain containing adaptor with coiled-coil 0.0261614
TTC3 tetratricopeptide repeat domain 3 0.0261262
BIRC6 baculoviral IAP repeat containing 6 0.0261197
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0260241
UBA6 ubiquitin-like modifier activating enzyme 6 0.0260149
PCBP2 poly(rC) binding protein 2 0.0259532
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0258029
SEC23A Sec23 homolog A (S. cerevisiae) 0.0252969

decreased expression

Symbol Name Standardized Value
PDE4B phosphodiesterase 4B, cAMP-specific -0.144108
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0986023
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0976311
BMP10 bone morphogenetic protein 10 -0.078809
PDE4D phosphodiesterase 4D, cAMP-specific -0.0703207
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0656931
FOXP1 forkhead box P1 -0.060538
VCL vinculin -0.0543935
GLI3 GLI family zinc finger 3 -0.0516872
SOX6 SRY (sex determining region Y)-box 6 -0.0512423
AHNAK AHNAK nucleoprotein -0.0485955
MYO5C myosin VC -0.0367391
GLI2 GLI family zinc finger 2 -0.0336954
NBEA neurobeachin -0.0314374
PRELID2 PRELI domain containing 2 -0.0297714
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0296126
NPAS2 neuronal PAS domain protein 2 -0.0293603
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0285147
NAV2 neuron navigator 2 -0.0283676
TTC28 tetratricopeptide repeat domain 28 -0.0283368
EGFR epidermal growth factor receptor -0.0274423
BMP2K BMP2 inducible kinase -0.0271374
HDAC9 histone deacetylase 9 -0.0251807
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0247118
DPYD dihydropyrimidine dehydrogenase -0.0244261
CAMKMT calmodulin-lysine N-methyltransferase -0.0243021
INTS6 integrator complex subunit 6 -0.0240037
MKI67 marker of proliferation Ki-67 -0.0237038
EFNA5 ephrin-A5 -0.0227991
DLG1 discs, large homolog 1 (Drosophila) -0.0221424
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0218605
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0217078
PDE7B phosphodiesterase 7B -0.0216166
PDGFC platelet derived growth factor C -0.0213928
DIAPH3 diaphanous-related formin 3 -0.0213858
PRUNE2 prune homolog 2 (Drosophila) -0.0212084
UNC13A unc-13 homolog A (C. elegans) -0.0209764
MACROD2 MACRO domain containing 2 -0.0204872
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0203931
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0200859
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0200167
SDK1 sidekick cell adhesion molecule 1 -0.0199328
ZNF438 zinc finger protein 438 -0.019533
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.019451
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0192518
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0187822
RFC3 replication factor C (activator 1) 3, 38kDa -0.0187383
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0185062
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L -0.0181408
GSE1 Gse1 coiled-coil protein -0.0181238
TAS2R14 taste receptor, type 2, member 14 -0.0180771
AEBP2 AE binding protein 2 -0.0180165
CUX1 cut-like homeobox 1 -0.0179691
TSC22D1 TSC22 domain family, member 1 -0.0178255
FER1L6 fer-1-like family member 6 -0.0175399
FAF1 Fas (TNFRSF6) associated factor 1 -0.0173534
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.017044
CREB5 cAMP responsive element binding protein 5 -0.016552
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0159906
BCOR BCL6 corepressor -0.0157418
ITGA10 integrin, alpha 10 -0.0148534
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0146272
APLF aprataxin and PNKP like factor -0.0139476
TM4SF1 transmembrane 4 L six family member 1 -0.0139422
COMMD10 COMM domain containing 10 -0.0139201
SMC4 structural maintenance of chromosomes 4 -0.013872
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -0.0137903
SCLT1 sodium channel and clathrin linker 1 -0.0136983
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0135715
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0134915
XKR6 XK, Kell blood group complex subunit-related family, member 6 -0.0131947
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0130979
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0129969
HEG1 heart development protein with EGF-like domains 1 -0.0128053
PBX3 pre-B-cell leukemia homeobox 3 -0.0127847
PKP4 plakophilin 4 -0.012686
RAD51B RAD51 paralog B -0.0126601
FHIT fragile histidine triad -0.0124385
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0120324
PHACTR2 phosphatase and actin regulator 2 -0.01201
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0117899
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) -0.0117152
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0116808
TRIOBP TRIO and F-actin binding protein -0.0116075
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.011493
NFIA nuclear factor I/A -0.0113108
ANLN anillin, actin binding protein -0.011216
SH3TC2 SH3 domain and tetratricopeptide repeats 2 -0.0112002
NSD2 nuclear receptor binding SET domain protein 2 -0.0111502
PDE10A phosphodiesterase 10A -0.0111118
EXOC4 exocyst complex component 4 -0.0109744
SEPTIN9 septin 9 -0.0108564
IRS1 insulin receptor substrate 1 -0.010699
RAB27B RAB27B, member RAS oncogene family -0.010676
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0106184
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 -0.01057
CEP112 centrosomal protein 112kDa -0.0105162
HIBCH 3-hydroxyisobutyryl-CoA hydrolase -0.0104831
SORBS2 sorbin and SH3 domain containing 2 -0.0102804
WWOX WW domain containing oxidoreductase -0.0101294