Auranofin_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Auranofin perturbation in SNU-423 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Auranofin_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.181717
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.116117
VIM vimentin 0.104756
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.101081
HSPH1 heat shock 105kDa/110kDa protein 1 0.0672631
HSPA1A heat shock 70kDa protein 1A 0.0650457
AKAP12 A kinase (PRKA) anchor protein 12 0.0586647
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0559019
PLIN2 perilipin 2 0.0499763
FTL ferritin, light polypeptide 0.0485262
VEGFA vascular endothelial growth factor A 0.0472777
ATP13A3 ATPase type 13A3 0.0465891
B2M beta-2-microglobulin 0.0464908
SFTPA2 surfactant protein A2 0.0462681
HLA-A major histocompatibility complex, class I, A 0.0431638
ADM adrenomedullin 0.0428165
GOLGA4 golgin A4 0.0425527
GARS1 glycyl-tRNA synthetase 1 0.0418845
FTH1 ferritin, heavy polypeptide 1 0.0412649
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0411893
PCBP2 poly(rC) binding protein 2 0.0409497
ZFP36L1 ZFP36 ring finger protein-like 1 0.0395153
RPS6 ribosomal protein S6 0.0375858
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0368753
NAMPT nicotinamide phosphoribosyltransferase 0.036496
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0353349
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0347572
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0345546
MXI1 MAX interactor 1, dimerization protein 0.0337404
HELZ helicase with zinc finger 0.0334873
EEF2 eukaryotic translation elongation factor 2 0.0308623
ZNF292 zinc finger protein 292 0.0298835
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0297439
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0288689
UBA6 ubiquitin-like modifier activating enzyme 6 0.028774
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0285279
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0284658
RPS12 ribosomal protein S12 0.0284129
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0281011
CADM1 cell adhesion molecule 1 0.0276129
LCORL ligand dependent nuclear receptor corepressor-like 0.0267458
NAP1L1 nucleosome assembly protein 1-like 1 0.0264607
RAB7A RAB7A, member RAS oncogene family 0.0263097
PTMA prothymosin, alpha 0.026269
MSN moesin 0.026201
UGCG UDP-glucose ceramide glucosyltransferase 0.026176
CALR calreticulin 0.0260403
RND3 Rho family GTPase 3 0.0252348
ESYT2 extended synaptotagmin-like protein 2 0.0250185
MATR3 matrin 3 0.0248118
HSPA1B heat shock 70kDa protein 1B 0.0247979
BASP1 brain abundant, membrane attached signal protein 1 0.0246783
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0236136
HILPDA hypoxia inducible lipid droplet-associated 0.0236
POTEF POTE ankyrin domain family, member F 0.0234729
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.023428
EIF1 eukaryotic translation initiation factor 1 0.0232886
LDHA lactate dehydrogenase A 0.0230765
BCLAF1 BCL2-associated transcription factor 1 0.0227605
FMNL2 formin-like 2 0.0222282
APLP2 amyloid beta (A4) precursor-like protein 2 0.0219787
RAB6A RAB6A, member RAS oncogene family 0.0219053
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0218074
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0214809
RAI1 retinoic acid induced 1 0.0209238
MORF4L2 mortality factor 4 like 2 0.0207199
UBE2H ubiquitin-conjugating enzyme E2H 0.0206745
PGK1 phosphoglycerate kinase 1 0.0206691
CD109 CD109 molecule 0.0206513
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0203532
HMOX1 heme oxygenase 1 0.0202787
DSTN destrin (actin depolymerizing factor) 0.0196729
RPL23 ribosomal protein L23 0.0196453
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0195238
WDFY1 WD repeat and FYVE domain containing 1 0.0193592
INSIG1 insulin induced gene 1 0.0193013
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0186515
SEC24A SEC24 family member A 0.0186109
NGLY1 N-glycanase 1 0.0185353
TSC22D2 TSC22 domain family, member 2 0.0184303
KDM2A lysine (K)-specific demethylase 2A 0.0183157
BAG3 BCL2-associated athanogene 3 0.0180869
ELL2 elongation factor, RNA polymerase II, 2 0.0180354
SNX3 sorting nexin 3 0.0179412
DDIT4 DNA-damage-inducible transcript 4 0.0177818
KTN1 kinectin 1 (kinesin receptor) 0.017493
STAG2 stromal antigen 2 0.0174537
STC1 stanniocalcin 1 0.0174074
PKM pyruvate kinase, muscle 0.0173796
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0173766
INSIG2 insulin induced gene 2 0.0173757
TTC3 tetratricopeptide repeat domain 3 0.0171221
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0170901
RACK1 receptor for activated C kinase 1 0.0170737
MMP12 matrix metallopeptidase 12 0.0169358
YBX1 Y box binding protein 1 0.0169038
EPS8 epidermal growth factor receptor pathway substrate 8 0.0165085
CREBRF CREB3 regulatory factor 0.0164177
PDIA6 protein disulfide isomerase family A, member 6 0.015983
RNF145 ring finger protein 145 0.0158179

decreased expression

Symbol Name Standardized Value
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.132574
BICC1 BicC family RNA binding protein 1 -0.109769
GLIS3 GLIS family zinc finger 3 -0.0952533
VCL vinculin -0.0848133
EXT1 exostosin glycosyltransferase 1 -0.0832545
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0583791
SMAD3 SMAD family member 3 -0.0566408
COL6A3 collagen, type VI, alpha 3 -0.0457104
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0456884
FRMD4A FERM domain containing 4A -0.0443594
NABP1 nucleic acid binding protein 1 -0.0364925
RNF213 ring finger protein 213 -0.0364763
KYNU kynureninase -0.0362674
AHNAK AHNAK nucleoprotein -0.0362577
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0359457
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0356455
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0343794
RIGI RNA sensor RIG-I -0.0343346
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0333895
FNDC3B fibronectin type III domain containing 3B -0.0322878
GPC6 glypican 6 -0.0321619
SLC38A2 solute carrier family 38, member 2 -0.032137
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0318379
EHBP1 EH domain binding protein 1 -0.0317162
TNS3 tensin 3 -0.0312882
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0311297
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0310357
ATXN1 ataxin 1 -0.0303483
THBS1 thrombospondin 1 -0.0299827
ZNFX1 zinc finger, NFX1-type containing 1 -0.0281471
NCOA7 nuclear receptor coactivator 7 -0.0281347
OSMR oncostatin M receptor -0.028087
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0277919
FAM20C family with sequence similarity 20, member C -0.0268013
DST dystonin -0.0265893
IFI16 interferon, gamma-inducible protein 16 -0.0258763
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.025355
ZBTB38 zinc finger and BTB domain containing 38 -0.0249942
SMYD3 SET and MYND domain containing 3 -0.0249852
HMGA2 high mobility group AT-hook 2 -0.0249229
ZBTB20 zinc finger and BTB domain containing 20 -0.0247299
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0243448
CD44 CD44 molecule (Indian blood group) -0.0243161
NAV1 neuron navigator 1 -0.0241408
SVIL supervillin -0.0241099
TMSB10 thymosin beta 10 -0.0240747
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0240248
PDE10A phosphodiesterase 10A -0.0239918
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0234338
HDAC8 histone deacetylase 8 -0.0229166
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0228718
KLF12 Kruppel-like factor 12 -0.0225996
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0225431
PLPP6 phospholipid phosphatase 6 -0.0223552
MAML2 mastermind-like 2 (Drosophila) -0.0221443
VMP1 vacuole membrane protein 1 -0.021766
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0217122
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0215124
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0212058
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0210582
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.020568
PTPRK protein tyrosine phosphatase, receptor type, K -0.0200266
PMP22 peripheral myelin protein 22 -0.0200179
FRMD5 FERM domain containing 5 -0.0194287
DCBLD1 discoidin, CUB and LCCL domain containing 1 -0.0192282
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0189913
METTL15 methyltransferase like 15 -0.0185738
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0182458
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0181615
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0181455
MX1 MX dynamin-like GTPase 1 -0.0180733
SPIDR scaffolding protein involved in DNA repair -0.0180635
TNNC1 troponin C type 1 (slow) -0.0180025
FBXL7 F-box and leucine-rich repeat protein 7 -0.0179647
HDAC9 histone deacetylase 9 -0.0179602
PALLD palladin, cytoskeletal associated protein -0.0179483
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0178202
BPTF bromodomain PHD finger transcription factor -0.0177612
BCAR3 breast cancer anti-estrogen resistance 3 -0.0176179
PLSCR1 phospholipid scramblase 1 -0.017336
SP100 SP100 nuclear antigen -0.0171926
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0171545
XAF1 XIAP associated factor 1 -0.0170265
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0169625
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 -0.0168052
SDC4 syndecan 4 -0.0167935
ANXA2 annexin A2 -0.0166716
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0166037
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0165772
TXNIP thioredoxin interacting protein -0.0165739
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0165663
CD2AP CD2-associated protein -0.0163252
CDK17 cyclin-dependent kinase 17 -0.0163247
SMAD2 SMAD family member 2 -0.0163088
EPAS1 endothelial PAS domain protein 1 -0.01629
LPP LIM domain containing preferred translocation partner in lipoma -0.0162433
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0162295
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0162089
LOC112694756 uncharaterized LOC112694756 -0.0161888
HLA-B major histocompatibility complex, class I, B -0.0161582