Axon guidance Gene Set

Dataset Reactome Pathways
Category structural or functional annotations
Type pathway
Description The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. (Gene Ontology, GO_0007411)
External Link http://www.reactome.org/PathwayBrowser/#/R-HSA-422475
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Genes

327 proteins participating in the Axon guidance pathway from the Reactome Pathways dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ABLIM1 actin binding LIM protein 1
ABLIM2 actin binding LIM protein family, member 2
ABLIM3 actin binding LIM protein family, member 3
ACTB actin, beta
ACTG1 actin gamma 1
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ADAM10 ADAM metallopeptidase domain 10
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AGRN agrin
ALCAM activated leukocyte cell adhesion molecule
ANK1 ankyrin 1, erythrocytic
ANK2 ankyrin 2, neuronal
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP2M1 adaptor-related protein complex 2, mu 1 subunit
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
APH1A APH1A gamma secretase subunit
APH1B APH1B gamma secretase subunit
ARHGAP35 Rho GTPase activating protein 35
ARHGAP39 Rho GTPase activating protein 39
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ARTN artemin
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit
CACNA1G calcium channel, voltage-dependent, T type, alpha 1G subunit
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit
CACNB1 calcium channel, voltage-dependent, beta 1 subunit
CACNB2 calcium channel, voltage-dependent, beta 2 subunit
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CACNB4 calcium channel, voltage-dependent, beta 4 subunit
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CD24 CD24 molecule
CD72 CD72 molecule
CDC42 cell division cycle 42
CDK1 cyclin-dependent kinase 1
CDK5 cyclin-dependent kinase 5
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CFL1 cofilin 1 (non-muscle)
CHL1 cell adhesion molecule L1-like
CLASP1 cytoplasmic linker associated protein 1
CLASP2 cytoplasmic linker associated protein 2
CLTA clathrin, light chain A
CLTB clathrin, light chain B
CLTC clathrin, heavy chain (Hc)
CLTCL1 clathrin, heavy chain-like 1
CNTN1 contactin 1
CNTN2 contactin 2 (axonal)
CNTN6 contactin 6
CNTNAP1 contactin associated protein 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A4 collagen, type IV, alpha 4
COL4A5 collagen, type IV, alpha 5
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL6A3 collagen, type VI, alpha 3
COL6A5 collagen, type VI, alpha 5
COL6A6 collagen, type VI, alpha 6
COL9A1 collagen, type IX, alpha 1
COL9A2 collagen, type IX, alpha 2
COL9A3 collagen, type IX, alpha 3
CREB1 cAMP responsive element binding protein 1
CRMP1 collapsin response mediator protein 1
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2A2 casein kinase 2, alpha prime polypeptide
CSNK2B casein kinase 2, beta polypeptide
DCC DCC netrin 1 receptor
DCX doublecortin
DLG1 discs, large homolog 1 (Drosophila)
DLG3 discs, large homolog 3 (Drosophila)
DLG4 discs, large homolog 4 (Drosophila)
DNM1 dynamin 1
DNM2 dynamin 2
DNM3 dynamin 3
DOCK1 dedicator of cytokinesis 1
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
DPYSL4 dihydropyrimidinase-like 4
DPYSL5 dihydropyrimidinase-like 5
EFNA1 ephrin-A1
EFNA2 ephrin-A2
EFNA3 ephrin-A3
EFNA4 ephrin-A4
EFNA5 ephrin-A5
EFNB1 ephrin-B1
EFNB2 ephrin-B2
EFNB3 ephrin-B3
EGFR epidermal growth factor receptor
ENAH enabled homolog (Drosophila)
EPHA1 EPH receptor A1
EPHA10 EPH receptor A10
EPHA2 EPH receptor A2
EPHA3 EPH receptor A3
EPHA4 EPH receptor A4
EPHA5 EPH receptor A5
EPHA6 EPH receptor A6
EPHA7 EPH receptor A7
EPHA8 EPH receptor A8
EPHB1 EPH receptor B1
EPHB2 EPH receptor B2
EPHB3 EPH receptor B3
EPHB4 EPH receptor B4
EPHB6 EPH receptor B6
ERBB2 erb-b2 receptor tyrosine kinase 2
EVL Enah/Vasp-like
EZR ezrin
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FES FES proto-oncogene, tyrosine kinase
FGFR1 fibroblast growth factor receptor 1
FYN FYN proto-oncogene, Src family tyrosine kinase
GDNF glial cell derived neurotrophic factor
GFRA1 GDNF family receptor alpha 1
GFRA2 GDNF family receptor alpha 2
GFRA4 GDNF family receptor alpha 4
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GPC1 glypican 1
GRB2 growth factor receptor-bound protein 2
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GSK3B glycogen synthase kinase 3 beta
HFE2 hemochromatosis type 2 (juvenile)
HRAS Harvey rat sarcoma viral oncogene homolog
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA8 heat shock 70kDa protein 8
IL6 interleukin 6
IL6R interleukin 6 receptor
IL6ST interleukin 6 signal transducer
ITGA1 integrin, alpha 1
ITGA10 integrin, alpha 10
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGA9 integrin, alpha 9
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
ITSN1 intersectin 1 (SH3 domain protein)
JAK1 Janus kinase 1
JAK2 Janus kinase 2
KALRN kalirin, RhoGEF kinase
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KDR kinase insert domain receptor
KIAA1598
KIF4A kinesin family member 4A
KIF4B kinesin family member 4B
KRAS Kirsten rat sarcoma viral oncogene homolog
L1CAM L1 cell adhesion molecule
LAMA1 laminin, alpha 1
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LIMK1 LIM domain kinase 1
LIMK2 LIM domain kinase 2
LYN LYN proto-oncogene, Src family tyrosine kinase
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MET MET proto-oncogene, receptor tyrosine kinase
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MSN moesin
MYH10 myosin, heavy chain 10, non-muscle
MYH11 myosin, heavy chain 11, smooth muscle
MYH14 myosin, heavy chain 14, non-muscle
MYH9 myosin, heavy chain 9, non-muscle
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYL12B myosin, light chain 12B, regulatory
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYL9 myosin, light chain 9, regulatory
MYO10 myosin X
NCAM1 neural cell adhesion molecule 1
NCAN neurocan
NCK1 NCK adaptor protein 1
NCK2 NCK adaptor protein 2
NCSTN nicastrin
NEO1 neogenin 1
NFASC neurofascin
NGEF neuronal guanine nucleotide exchange factor
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NRCAM neuronal cell adhesion molecule
NRP1 neuropilin 1
NRP2 neuropilin 2
NRTN neurturin
NTN1 netrin 1
NTN4 netrin 4
NUMB numb homolog (Drosophila)
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PFN1 profilin 1
PFN2 profilin 2
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PITPNA phosphatidylinositol transfer protein, alpha
PLCG1 phospholipase C, gamma 1
PLXNA1 plexin A1
PLXNA2 plexin A2
PLXNA3 plexin A3
PLXNA4 plexin A4
PLXNB1 plexin B1
PLXNB3 plexin B3
PLXNC1 plexin C1
PLXND1 plexin D1
PRKCQ protein kinase C, theta
PRNP prion protein
PSEN2 presenilin 2
PSENEN presenilin enhancer gamma secretase subunit
PSPN persephin
PTK2 protein tyrosine kinase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRA protein tyrosine phosphatase, receptor type, A
PTPRC protein tyrosine phosphatase, receptor type, C
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RANBP9 RAN binding protein 9
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RDX radixin
RGMA repulsive guidance molecule family member a
RGMB repulsive guidance molecule family member b
RHOA ras homolog family member A
RHOB ras homolog family member B
RHOC ras homolog family member C
RHOG ras homolog family member G
RND1 Rho family GTPase 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
RRAS related RAS viral (r-ras) oncogene homolog
SCN10A sodium channel, voltage gated, type X alpha subunit
SCN11A sodium channel, voltage gated, type XI alpha subunit
SCN1A sodium channel, voltage gated, type I alpha subunit
SCN1B sodium channel, voltage gated, type I beta subunit
SCN2A sodium channel, voltage gated, type II alpha subunit
SCN2B sodium channel, voltage gated, type II beta subunit
SCN3A sodium channel, voltage gated, type III alpha subunit
SCN3B sodium channel, voltage gated, type III beta subunit
SCN4A sodium channel, voltage gated, type IV alpha subunit
SCN4B sodium channel, voltage gated, type IV beta subunit
SCN5A sodium channel, voltage gated, type V alpha subunit
SCN7A sodium channel, voltage gated, type VII alpha subunit
SCN8A sodium channel, voltage gated, type VIII alpha subunit
SCN9A sodium channel, voltage gated, type IX alpha subunit
SDC2 syndecan 2
SDCBP syndecan binding protein (syntenin)
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEMA3E sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SH3GL2 SH3-domain GRB2-like 2
SHB Src homology 2 domain containing adaptor protein B
SIAH1 siah E3 ubiquitin protein ligase 1
SIAH2 siah E3 ubiquitin protein ligase 2
SLIT1 slit homolog 1 (Drosophila)
SLIT2 slit homolog 2 (Drosophila)
SLIT3 slit homolog 3 (Drosophila)
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SPTA1 spectrin, alpha, erythrocytic 1
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTB spectrin, beta, erythrocytic
SPTBN1 spectrin, beta, non-erythrocytic 1
SPTBN2 spectrin, beta, non-erythrocytic 2
SPTBN4 spectrin, beta, non-erythrocytic 4
SPTBN5 spectrin, beta, non-erythrocytic 5
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
TIAM1 T-cell lymphoma invasion and metastasis 1
TLN1 talin 1
TREM2 triggering receptor expressed on myeloid cells 2
TRIO trio Rho guanine nucleotide exchange factor
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TRPC3 transient receptor potential cation channel, subfamily C, member 3
TRPC4 transient receptor potential cation channel, subfamily C, member 4
TRPC5 transient receptor potential cation channel, subfamily C, member 5
TRPC6 transient receptor potential cation channel, subfamily C, member 6
TRPC7 transient receptor potential cation channel, subfamily C, member 7
TYK2 tyrosine kinase 2
TYROBP TYRO protein tyrosine kinase binding protein
UNC5A unc-5 homolog A (C. elegans)
UNC5B unc-5 homolog B (C. elegans)
UNC5C unc-5 homolog C (C. elegans)
UNC5D unc-5 homolog D (C. elegans)
VASP vasodilator-stimulated phosphoprotein
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VEGFA vascular endothelial growth factor A
WASL Wiskott-Aldrich syndrome-like
YES1 YES proto-oncogene 1, Src family tyrosine kinase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta