Axon guidance Gene Set

Dataset WikiPathways Pathways 2024
Category structural or functional annotations
Type pathway
Description The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. (Gene Ontology, GO_0007411)
External Link https://www.wikipathways.org/pathways/WP5289.html
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Genes

72 proteins participating in the Axon guidance pathway from the WikiPathways Pathways 2024 dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABLIM3 actin binding LIM protein family, member 3
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
BMPR1B bone morphogenetic protein receptor, type IB
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase)
BOC BOC cell adhesion associated, oncogene regulated
CDC42 cell division cycle 42
CDK5 cyclin-dependent kinase 5
CFL1 cofilin 1 (non-muscle)
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DCC DCC netrin 1 receptor
DPYSL2 dihydropyrimidinase-like 2
DPYSL5 dihydropyrimidinase-like 5
EFNA1 ephrin-A1
EFNB1 ephrin-B1
ENAH enabled homolog (Drosophila)
EPHA2 EPH receptor A2
EPHB1 EPH receptor B1
FES FES proto-oncogene, tyrosine kinase
FYN FYN proto-oncogene, Src family tyrosine kinase
FZD3 frizzled class receptor 3
GDF7 growth differentiation factor 7
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GSK3B glycogen synthase kinase 3 beta
HRAS Harvey rat sarcoma viral oncogene homolog
ILK integrin-linked kinase
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
L1CAM L1 cell adhesion molecule
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2
LRRC4C leucine rich repeat containing 4C
MAPK1 mitogen-activated protein kinase 1
MET MET proto-oncogene, receptor tyrosine kinase
MYL12B myosin, light chain 12B, regulatory
NCK1 NCK adaptor protein 1
NGEF neuronal guanine nucleotide exchange factor
NRP1 neuropilin 1
NTN3 netrin 3
NTN4 netrin 4
NTNG2 netrin G2
PARD3 par-3 family cell polarity regulator
PARD6A par-6 family cell polarity regulator alpha
PDPK1 3-phosphoinositide dependent protein kinase 1
PLXNA1 plexin A1
PRKCA protein kinase C, alpha
PRKCZ protein kinase C, zeta
PTCH1 patched 1
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGMA repulsive guidance molecule family member a
RHOD ras homolog family member D
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RRAS related RAS viral (r-ras) oncogene homolog
RYK receptor-like tyrosine kinase
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SEMA5B sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
SEMA7A semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
SHH sonic hedgehog
SLIT1 slit homolog 1 (Drosophila)
SLIT2 slit homolog 2 (Drosophila)
SLIT3 slit homolog 3 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
TRPC1 transient receptor potential cation channel, subfamily C, member 1
UNC5D unc-5 homolog D (C. elegans)
WNT4 wingless-type MMTV integration site family, member 4
WNT5A wingless-type MMTV integration site family, member 5A