Azilsartan Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/135415867
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Genes

197 proteins with high or low expression in Azilsartan relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
COL11A1 collagen, type XI, alpha 1 2.15
SPC24 SPC24, NDC80 kinetochore complex component 0.75
DUOX1 dual oxidase 1 0.65
EXO1 exonuclease 1 0.63
CCNF cyclin F 0.6
TIPE1 TNF alpha induced protein 8 like 1 0.57
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 0.57
MPHOSPH9 M-phase phosphoprotein 9 0.55
RRM2 ribonucleotide reductase M2 0.55
ERVMER34-1 endogenous retrovirus group MER34, member 1 0.54
TTLL4 tubulin tyrosine ligase-like family member 4 0.54
DES desmin 0.53
RPL37 ribosomal protein L37 0.52
MED29 mediator complex subunit 29 0.51
SCARA3 scavenger receptor class A, member 3 0.5
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) 0.48
TOX2 TOX high mobility group box family member 2 0.48
ZNF664 zinc finger protein 664 0.46
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) 0.44
CDCA7 cell division cycle associated 7 0.44
CDC25B cell division cycle 25B 0.44
KATNBL1 katanin p80 subunit B-like 1 0.43
PCLAF PCNA clamp associated factor 0.43
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.42
ZMYND19 zinc finger, MYND-type containing 19 0.42
RAD51AP1 RAD51 associated protein 1 0.41
DTNA dystrobrevin, alpha 0.41
ATG4D autophagy related 4D, cysteine peptidase 0.4
RMI2 RecQ mediated genome instability 2 0.4
IVNS1ABP influenza virus NS1A binding protein 0.4
ZNF567 zinc finger protein 567 0.4
FOXO1 forkhead box O1 0.39
PTMA prothymosin, alpha 0.39
TWSG1 twisted gastrulation BMP signaling modulator 1 0.39
TRAK2 trafficking protein, kinesin binding 2 0.39
H3C1 H3 clustered histone 1 0.39
DIAPH3 diaphanous-related formin 3 0.38
ESCO2 establishment of sister chromatid cohesion N-acetyltransferase 2 0.38
RARG retinoic acid receptor, gamma 0.38
MUTYH mutY homolog 0.38
FBXO5 F-box protein 5 0.38
LSM10 LSM10, U7 small nuclear RNA associated 0.37
SSNA1 Sjogren syndrome nuclear autoantigen 1 0.37
INAVA innate immunity activator 0.37
NFE2L3 nuclear factor, erythroid 2-like 3 0.37
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans) 0.37
FURIN furin (paired basic amino acid cleaving enzyme) 0.37
KMT5A lysine methyltransferase 5A 0.37
NTN1 netrin 1 0.37
ZNF587 zinc finger protein 587 0.36
PXMP4 peroxisomal membrane protein 4, 24kDa 0.36
ZNF136 zinc finger protein 136 0.36
OBI1 ORC ubiquitin ligase 1 0.36
ZNF267 zinc finger protein 267 0.36
GPATCH3 G patch domain containing 3 0.36
C9ORF40 chromosome 9 open reading frame 40 0.36
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) 0.36
MXRA7 matrix-remodelling associated 7 0.36
HELLS helicase, lymphoid-specific 0.35
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.35
SYTL3 synaptotagmin-like 3 0.35
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 0.35
CCDC77 coiled-coil domain containing 77 0.35
KIF1B kinesin family member 1B 0.35
WDR90 WD repeat domain 90 0.35
DPY30 dpy-30 homolog (C. elegans) 0.35
CENPM centromere protein M 0.35
SPC25 SPC25, NDC80 kinetochore complex component 0.34
TPGS2 tubulin polyglutamylase complex subunit 2 0.34
EVL Enah/Vasp-like 0.34
UBE2R2 ubiquitin-conjugating enzyme E2R 2 0.34
NFE2L1 nuclear factor, erythroid 2-like 1 0.34
SIK2 salt-inducible kinase 2 0.34
CDC26 cell division cycle 26 0.34
DONSON downstream neighbor of SON 0.33
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 0.33
HAUS4 HAUS augmin-like complex, subunit 4 0.33
RNF8 ring finger protein 8, E3 ubiquitin protein ligase 0.33
PEMT phosphatidylethanolamine N-methyltransferase 0.33
ESYT2 extended synaptotagmin-like protein 2 0.33
GINS4 GINS complex subunit 4 (Sld5 homolog) 0.33
KIAA0586 KIAA0586 0.33
CIZ1 CDKN1A interacting zinc finger protein 1 0.32
VASN vasorin 0.32
NDC80 NDC80 kinetochore complex component 0.32
ATAD5 ATPase family, AAA domain containing 5 0.32
CDCA7L cell division cycle associated 7-like 0.32
BRCA1 breast cancer 1, early onset 0.32
HAUS1 HAUS augmin-like complex, subunit 1 0.31
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.31
RPLP1 ribosomal protein, large, P1 0.31
MRFAP1 Morf4 family associated protein 1 0.31
RPL26 ribosomal protein L26 0.31
BORA bora, aurora kinase A activator 0.31
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) 0.31
ZNF689 zinc finger protein 689 0.31
HSBP1 heat shock factor binding protein 1 0.31

low expression

Symbol Name Standardized Value
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -0.94
ELOVL6 ELOVL fatty acid elongase 6 -0.79
NGFR nerve growth factor receptor -0.71
TP53 tumor protein p53 -0.7
RAB24 RAB24, member RAS oncogene family -0.68
FGFBP1 fibroblast growth factor binding protein 1 -0.66
SCNN1A sodium channel, non voltage gated 1 alpha subunit -0.63
RNF7 ring finger protein 7 -0.6
MAGEF1 melanoma antigen family F1 -0.57
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 -0.56
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.55
C18ORF32 chromosome 18 open reading frame 32 -0.55
PRG4 proteoglycan 4 -0.55
TSKU tsukushi, small leucine rich proteoglycan -0.55
CBR1 carbonyl reductase 1 -0.54
HSH2D hematopoietic SH2 domain containing -0.52
SAP30L SAP30-like -0.51
PHLDA3 pleckstrin homology-like domain, family A, member 3 -0.5
RABAC1 Rab acceptor 1 (prenylated) -0.5
HID1 HID1 domain containing -0.5
TACSTD2 tumor-associated calcium signal transducer 2 -0.49
NRBF2 nuclear receptor binding factor 2 -0.49
LRP10 low density lipoprotein receptor-related protein 10 -0.48
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.45
APOE apolipoprotein E -0.45
RNF115 ring finger protein 115 -0.45
ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit -0.45
CLSTN3 calsyntenin 3 -0.44
FN1 fibronectin 1 -0.42
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.42
UBTD1 ubiquitin domain containing 1 -0.42
MSMO1 methylsterol monooxygenase 1 -0.41
ZBTB38 zinc finger and BTB domain containing 38 -0.41
GSTA1 glutathione S-transferase alpha 1 -0.41
F10 coagulation factor X -0.4
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.4
IQCE IQ motif containing E -0.4
F2 coagulation factor II (thrombin) -0.39
HMOX1 heme oxygenase 1 -0.39
GSTM4 glutathione S-transferase mu 4 -0.39
ATE1 arginyltransferase 1 -0.39
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila) -0.39
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.39
EPN3 epsin 3 -0.39
ADGRG1 adhesion G protein-coupled receptor G1 -0.38
TIMP3 TIMP metallopeptidase inhibitor 3 -0.38
HBA1 hemoglobin, alpha 1 -0.38
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 -0.38
TDG thymine-DNA glycosylase -0.37
F5 coagulation factor V (proaccelerin, labile factor) -0.37
FAN1 FANCD2/FANCI-associated nuclease 1 -0.36
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 -0.36
KDM5B lysine (K)-specific demethylase 5B -0.35
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.35
FRRS1 ferric-chelate reductase 1 -0.35
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 -0.34
VTN vitronectin -0.34
UGDH UDP-glucose 6-dehydrogenase -0.34
GGT1 gamma-glutamyltransferase 1 -0.34
GDF15 growth differentiation factor 15 -0.34
ZNF865 zinc finger protein 865 -0.34
SLC38A9 solute carrier family 38, member 9 -0.34
FAT1 FAT atypical cadherin 1 -0.34
CYB561 cytochrome b561 -0.33
SYTL2 synaptotagmin-like 2 -0.33
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.33
CCNG1 cyclin G1 -0.32
NIN ninein (GSK3B interacting protein) -0.32
LANCL3 LanC lantibiotic synthetase component C-like 3 (bacterial) -0.32
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -0.32
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) -0.32
YAF2 YY1 associated factor 2 -0.32
SUCO SUN domain containing ossification factor -0.31
ZMAT3 zinc finger, matrin-type 3 -0.31
SYVN1 synovial apoptosis inhibitor 1, synoviolin -0.31
ENDOV endonuclease V -0.31
MYDGF myeloid-derived growth factor -0.31
NMRK1 nicotinamide riboside kinase 1 -0.31
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 -0.3
CLN3 ceroid-lipofuscinosis, neuronal 3 -0.3
DCBLD1 discoidin, CUB and LCCL domain containing 1 -0.3
CILP2 cartilage intermediate layer protein 2 -0.3
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.29
ZNF525 zinc finger protein 525 -0.29
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -0.29
DEDD death effector domain containing -0.29
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 -0.29
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 -0.29
NCOA4 nuclear receptor coactivator 4 -0.29
TTC31 tetratricopeptide repeat domain 31 -0.29
DMTF1 cyclin D binding myb-like transcription factor 1 -0.29
PRMT2 protein arginine methyltransferase 2 -0.29
DDR1 discoidin domain receptor tyrosine kinase 1 -0.29
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.28
AMACR alpha-methylacyl-CoA racemase -0.28
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -0.28
KDM4B lysine (K)-specific demethylase 4B -0.28
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11 -0.28
LYSMD1 LysM, putative peptidoglycan-binding, domain containing 1 -0.28
IREB2 iron-responsive element binding protein 2 -0.28