Azithromycin (hydrate)_BT-474 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Azithromycin (hydrate) perturbation in BT-474 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Azithromycin (hydrate)_BT-474 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VMP1 vacuole membrane protein 1 0.128527
RPL23 ribosomal protein L23 0.0998026
FBXL20 F-box and leucine-rich repeat protein 20 0.0659836
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0601344
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0577212
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0541093
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0516629
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0501172
FNDC3A fibronectin type III domain containing 3A 0.0493429
SET SET nuclear proto-oncogene 0.0452101
INTS6 integrator complex subunit 6 0.0443477
NCOA3 nuclear receptor coactivator 3 0.0436676
RPS2 ribosomal protein S2 0.0433165
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0429862
SP100 SP100 nuclear antigen 0.0428966
MCL1 myeloid cell leukemia 1 0.0402741
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0392767
PDLIM5 PDZ and LIM domain 5 0.0392183
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0389229
EXT1 exostosin glycosyltransferase 1 0.0378062
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0375365
ZSWIM6 zinc finger, SWIM-type containing 6 0.036902
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0365016
IFI6 interferon, alpha-inducible protein 6 0.0359759
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0357296
KTN1 kinectin 1 (kinesin receptor) 0.0351439
DSPP dentin sialophosphoprotein 0.0348926
ADARB1 adenosine deaminase, RNA-specific, B1 0.0347789
FAM13A family with sequence similarity 13, member A 0.0339658
TPD52 tumor protein D52 0.033219
RAB7A RAB7A, member RAS oncogene family 0.0324545
KDM2A lysine (K)-specific demethylase 2A 0.0323181
RPL19 ribosomal protein L19 0.0314574
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0312825
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0304867
DTNA dystrobrevin, alpha 0.0300702
MED13 mediator complex subunit 13 0.0300244
VCL vinculin 0.0299477
CENPF centromere protein F, 350/400kDa 0.0297875
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.029769
LIMCH1 LIM and calponin homology domains 1 0.0290678
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0290099
NRIP1 nuclear receptor interacting protein 1 0.0288938
VEGFA vascular endothelial growth factor A 0.0287926
FAM168A family with sequence similarity 168, member A 0.0287211
PLSCR1 phospholipid scramblase 1 0.028466
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0272871
DOCK5 dedicator of cytokinesis 5 0.0271407
PRRC2C proline-rich coiled-coil 2C 0.0263804
ANKRD11 ankyrin repeat domain 11 0.0258742
ANKRD12 ankyrin repeat domain 12 0.0256455
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0255968
PFDN4 prefoldin subunit 4 0.0255727
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0253521
RPS12 ribosomal protein S12 0.0253377
ENO1 enolase 1, (alpha) 0.025111
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0250109
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0247438
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0244536
CDK13 cyclin-dependent kinase 13 0.023972
ITCH itchy E3 ubiquitin protein ligase 0.0237136
GRB10 growth factor receptor-bound protein 10 0.0235552
SMC4 structural maintenance of chromosomes 4 0.0232606
NEK7 NIMA-related kinase 7 0.0230128
BBX bobby sox homolog (Drosophila) 0.0224421
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0223319
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.022182
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0221527
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0221315
HSPA8 heat shock 70kDa protein 8 0.0219802
PNN pinin, desmosome associated protein 0.0218277
FBXO11 F-box protein 11 0.0216204
STRN3 striatin, calmodulin binding protein 3 0.021558
WSB1 WD repeat and SOCS box containing 1 0.0215404
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0214752
KMT2E lysine (K)-specific methyltransferase 2E 0.0214135
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0213689
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0212694
PRR11 proline rich 11 0.0209985
NIPBL Nipped-B homolog (Drosophila) 0.0209741
ARID4B AT rich interactive domain 4B (RBP1-like) 0.020774
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0206912
ERBIN erbb2 interacting protein 0.0205871
YAP1 Yes-associated protein 1 0.0205037
RTN3 reticulon 3 0.0204156
AFF1 AF4/FMR2 family, member 1 0.0202894
RAD51B RAD51 paralog B 0.0202794
CSNK1A1 casein kinase 1, alpha 1 0.0202564
SETD5 SET domain containing 5 0.0202291
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0200937
CKAP5 cytoskeleton associated protein 5 0.0198256
SENP6 SUMO1/sentrin specific peptidase 6 0.0198026
RCOR1 REST corepressor 1 0.0196864
GOLGB1 golgin B1 0.0193229
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0192514
ZNF292 zinc finger protein 292 0.0190595
STK4 serine/threonine kinase 4 0.0189554
HELZ helicase with zinc finger 0.0188671
ZNF148 zinc finger protein 148 0.0188361
ANKHD1 ankyrin repeat and KH domain containing 1 0.0187603

decreased expression

Symbol Name Standardized Value
ZMYND8 zinc finger, MYND-type containing 8 -0.188861
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.155219
ACACA acetyl-CoA carboxylase alpha -0.142371
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.11517
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.109068
ERBB2 erb-b2 receptor tyrosine kinase 2 -0.101799
LASP1 LIM and SH3 protein 1 -0.0842674
THSD4 thrombospondin, type I, domain containing 4 -0.0825981
CATSPERB catsper channel auxiliary subunit beta -0.0751943
TRPS1 trichorhinophalangeal syndrome I -0.07161
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0708162
ASPH aspartate beta-hydroxylase -0.0681557
PTMA prothymosin, alpha -0.066788
IGFBP5 insulin-like growth factor binding protein 5 -0.064221
PBX1 pre-B-cell leukemia homeobox 1 -0.062834
CCND1 cyclin D1 -0.061039
RARRES1 retinoic acid receptor responder (tazarotene induced) 1 -0.0568796
FADS2 fatty acid desaturase 2 -0.0563089
TMSB4X thymosin beta 4, X-linked -0.0533245
TMSB10 thymosin beta 10 -0.0490729
TMEM123 transmembrane protein 123 -0.0480448
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0462855
FASN fatty acid synthase -0.0452233
KRT8 keratin 8, type II -0.0439972
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -0.0436969
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0417514
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0414004
AHNAK AHNAK nucleoprotein -0.0403693
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0379086
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.037085
BCAS1 breast carcinoma amplified sequence 1 -0.0370073
SHROOM3 shroom family member 3 -0.0355988
DUSP4 dual specificity phosphatase 4 -0.0351391
IL1RAPL2 interleukin 1 receptor accessory protein-like 2 -0.0351153
YPEL2 yippee-like 2 (Drosophila) -0.0349038
TTC6 tetratricopeptide repeat domain 6 -0.034177
RESF1 retroelement silencing factor 1 -0.0340863
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0340152
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0336227
DNAH14 dynein, axonemal, heavy chain 14 -0.0334832
ELOVL5 ELOVL fatty acid elongase 5 -0.0333057
TRAPPC9 trafficking protein particle complex 9 -0.0328862
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0326177
KRT18 keratin 18, type I -0.0321393
GRB7 growth factor receptor-bound protein 7 -0.0310544
ZNF217 zinc finger protein 217 -0.0299597
TC2N tandem C2 domains, nuclear -0.0298085
KAZN kazrin, periplakin interacting protein -0.0297458
KRT19 keratin 19, type I -0.0293972
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0292876
MSMO1 methylsterol monooxygenase 1 -0.0284931
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0273313
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0272472
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0272344
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0264583
CD164 CD164 molecule, sialomucin -0.02604
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0259269
FTH1 ferritin, heavy polypeptide 1 -0.0258
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 -0.0256933
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -0.0255867
KRT7 keratin 7, type II -0.0247451
NCAM2 neural cell adhesion molecule 2 -0.0245873
FDPS farnesyl diphosphate synthase -0.0244199
ZBTB20 zinc finger and BTB domain containing 20 -0.0238599
OSMR oncostatin M receptor -0.0234759
NCOA7 nuclear receptor coactivator 7 -0.0234611
PTPRK protein tyrosine phosphatase, receptor type, K -0.0232255
TP53INP2 tumor protein p53 inducible nuclear protein 2 -0.0231545
ARHGAP32 Rho GTPase activating protein 32 -0.0231169
PLCB4 phospholipase C, beta 4 -0.0230018
CCNI cyclin I -0.0228621
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0228273
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.0228237
ZFAND3 zinc finger, AN1-type domain 3 -0.0227835
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3 -0.0225045
GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 -0.0223892
NIBAN2 niban apoptosis regulator 2 -0.0223755
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0219215
PGK1 phosphoglycerate kinase 1 -0.0218863
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.021586
ALDH3B2 aldehyde dehydrogenase 3 family, member B2 -0.0214705
ACTN4 actinin, alpha 4 -0.0214626
TNS3 tensin 3 -0.0212926
PKM pyruvate kinase, muscle -0.0206052
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0205981
TENM2 teneurin transmembrane protein 2 -0.0205663
RAB27B RAB27B, member RAS oncogene family -0.0203882
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0203511
MUSK muscle, skeletal, receptor tyrosine kinase -0.0203147
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0203027
UBC ubiquitin C -0.0202843
TAPBP TAP binding protein (tapasin) -0.0202415
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0201955
S100A8 S100 calcium binding protein A8 -0.0199989
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0199372
LOC112694756 uncharaterized LOC112694756 -0.0198671
TMC5 transmembrane channel-like 5 -0.0197696
DLG1 discs, large homolog 1 (Drosophila) -0.0197208
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.0194919
SQLE squalene epoxidase -0.019296