Azithromycin (hydrate)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Azithromycin (hydrate) perturbation in C32 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Azithromycin (hydrate)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.185971
AKAP12 A kinase (PRKA) anchor protein 12 0.17624
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.143573
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.133498
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.122833
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.106179
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0986771
MT2A metallothionein 2A 0.0972656
ASPH aspartate beta-hydroxylase 0.0904902
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0745061
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0715147
GPC6 glypican 6 0.0704634
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0672779
TPR translocated promoter region, nuclear basket protein 0.0563219
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0544476
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0526081
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0521321
KTN1 kinectin 1 (kinesin receptor) 0.0498067
PDIA4 protein disulfide isomerase family A, member 4 0.0479861
RPS12 ribosomal protein S12 0.0461932
VMP1 vacuole membrane protein 1 0.0446067
SMYD3 SET and MYND domain containing 3 0.0438643
NAMPT nicotinamide phosphoribosyltransferase 0.0432343
TM4SF1 transmembrane 4 L six family member 1 0.0431554
RRBP1 ribosome binding protein 1 0.0428702
PCDH7 protocadherin 7 0.042761
AKAP9 A kinase (PRKA) anchor protein 9 0.042475
GOLGA4 golgin A4 0.0409211
LEF1 lymphoid enhancer-binding factor 1 0.0407761
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0407236
PRELID2 PRELI domain containing 2 0.0392179
GOLGB1 golgin B1 0.0379837
RPS2 ribosomal protein S2 0.0379135
MSN moesin 0.0379088
MACF1 microtubule-actin crosslinking factor 1 0.0376728
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0371232
ATXN1 ataxin 1 0.037031
ZSWIM6 zinc finger, SWIM-type containing 6 0.0368606
TMF1 TATA element modulatory factor 1 0.0345144
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0335699
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0331574
NFE2L1 nuclear factor, erythroid 2-like 1 0.032225
TXNIP thioredoxin interacting protein 0.0320291
RPS8 ribosomal protein S8 0.0313094
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0312275
TPT1 tumor protein, translationally-controlled 1 0.0311447
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0295486
VEGFA vascular endothelial growth factor A 0.0291546
ZFYVE28 zinc finger, FYVE domain containing 28 0.0289352
PHF21A PHD finger protein 21A 0.0287977
DST dystonin 0.0286294
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0285561
RO60 Ro60, Y RNA binding protein 0.0281872
NRIP1 nuclear receptor interacting protein 1 0.0278561
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.027665
WWTR1 WW domain containing transcription regulator 1 0.027378
CANX calnexin 0.0270736
RPS6 ribosomal protein S6 0.0262408
CEMIP2 cell migration inducing hyaluronidase 2 0.0261926
CSNK1A1 casein kinase 1, alpha 1 0.0261111
ERRFI1 ERBB receptor feedback inhibitor 1 0.0260693
TLE4 transducin-like enhancer of split 4 0.0260091
UGP2 UDP-glucose pyrophosphorylase 2 0.0259287
HILPDA hypoxia inducible lipid droplet-associated 0.0258569
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0258328
B2M beta-2-microglobulin 0.0257444
ZNF638 zinc finger protein 638 0.025588
GPHN gephyrin 0.0251503
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0251108
PDIA3 protein disulfide isomerase family A, member 3 0.0250348
EFCAB13 EF-hand calcium binding domain 13 0.0246438
BRD2 bromodomain containing 2 0.0244799
EFNA5 ephrin-A5 0.0244308
PRRC2C proline-rich coiled-coil 2C 0.0243846
DYNLT3 dynein, light chain, Tctex-type 3 0.0241272
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0241124
BTG1 B-cell translocation gene 1, anti-proliferative 0.0240965
ZFP36 ZFP36 ring finger protein 0.023969
ANKRD12 ankyrin repeat domain 12 0.0234991
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0233167
PCLO piccolo presynaptic cytomatrix protein 0.0232624
SQSTM1 sequestosome 1 0.0230222
ABHD17C abhydrolase domain containing 17C 0.022963
FOSL1 FOS-like antigen 1 0.0227901
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0226977
FMNL2 formin-like 2 0.0225424
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0223274
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0223139
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0221663
ANXA5 annexin A5 0.0214075
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0213959
MCL1 myeloid cell leukemia 1 0.0212697
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0209591
MBNL1 muscleblind-like splicing regulator 1 0.0208991
CTNND1 catenin (cadherin-associated protein), delta 1 0.0208891
MYO9B myosin IXB 0.0208296
JMJD1C jumonji domain containing 1C 0.020804
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.0207702
CRYBG3 beta-gamma crystallin domain containing 3 0.0207465
LGALS3 lectin, galactoside-binding, soluble, 3 0.0207369

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.159323
VGF VGF nerve growth factor inducible -0.146936
DCT dopachrome tautomerase -0.117262
HMCN1 hemicentin 1 -0.0917012
NDRG1 N-myc downstream regulated 1 -0.0869353
FN1 fibronectin 1 -0.0859623
FMN1 formin 1 -0.081064
GDF15 growth differentiation factor 15 -0.0795197
TMEM123 transmembrane protein 123 -0.0759666
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0704022
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.066354
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0643808
CDK14 cyclin-dependent kinase 14 -0.0623594
PGK1 phosphoglycerate kinase 1 -0.05924
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0591803
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.057222
TMSB10 thymosin beta 10 -0.0571969
CALD1 caldesmon 1 -0.0561101
PKM pyruvate kinase, muscle -0.0555134
CDC73 cell division cycle 73 -0.0542266
TNNC1 troponin C type 1 (slow) -0.0538205
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0533985
COL19A1 collagen, type XIX, alpha 1 -0.0517334
LOC112694756 uncharaterized LOC112694756 -0.0501817
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0486572
EHBP1 EH domain binding protein 1 -0.0484717
PDE10A phosphodiesterase 10A -0.0480501
RUNX1 runt-related transcription factor 1 -0.0475703
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0457001
C10ORF90 chromosome 10 open reading frame 90 -0.045415
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0448087
SCFD2 sec1 family domain containing 2 -0.0445993
NAV2 neuron navigator 2 -0.0444874
FBXL7 F-box and leucine-rich repeat protein 7 -0.0438249
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0434255
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0419548
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -0.041392
KIRREL1 kirre like nephrin family adhesion molecule 1 -0.0407009
SBF2 SET binding factor 2 -0.0379668
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0378204
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0365992
WDR45B WD repeat domain 45B -0.0365687
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0359662
NPR2 natriuretic peptide receptor 2 -0.0358821
NPAS2 neuronal PAS domain protein 2 -0.0354232
ICAM1 intercellular adhesion molecule 1 -0.034775
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0345046
NAV3 neuron navigator 3 -0.0338227
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0325823
PTCHD4 patched domain containing 4 -0.0322905
NBAS neuroblastoma amplified sequence -0.03228
ANKRD28 ankyrin repeat domain 28 -0.0321979
MMP16 matrix metallopeptidase 16 (membrane-inserted) -0.0320475
MRPS6 mitochondrial ribosomal protein S6 -0.031757
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0313533
PTK2 protein tyrosine kinase 2 -0.0312961
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.030711
PDE4B phosphodiesterase 4B, cAMP-specific -0.0303827
INSIG2 insulin induced gene 2 -0.0302128
GHR growth hormone receptor -0.0300613
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0297562
NRCAM neuronal cell adhesion molecule -0.0297061
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0294149
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0294143
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0293683
JAZF1 JAZF zinc finger 1 -0.0292854
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 -0.0277049
AFF4 AF4/FMR2 family, member 4 -0.0276288
FLNA filamin A, alpha -0.0275928
SOX5 SRY (sex determining region Y)-box 5 -0.0274684
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0274652
CD109 CD109 molecule -0.027422
SRPK2 SRSF protein kinase 2 -0.0271334
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0270437
EBF1 early B-cell factor 1 -0.0269361
BSG basigin (Ok blood group) -0.0269259
OXR1 oxidation resistance 1 -0.026665
UBE3C ubiquitin protein ligase E3C -0.0263212
APP amyloid beta (A4) precursor protein -0.02561
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0253471
TAGLN2 transgelin 2 -0.0250647
RNF213 ring finger protein 213 -0.0250579
ITGB8 integrin, beta 8 -0.0249518
RBM33 RNA binding motif protein 33 -0.0247833
KDM3A lysine (K)-specific demethylase 3A -0.024759
POTEF POTE ankyrin domain family, member F -0.0246036
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0240669
HBP1 HMG-box transcription factor 1 -0.0239836
RNF145 ring finger protein 145 -0.0239477
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0237585
TAC4 tachykinin 4 (hemokinin) -0.0233172
AHCYL2 adenosylhomocysteinase-like 2 -0.0232838
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0232246
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0230431
HELZ helicase with zinc finger -0.0230341
COL1A2 collagen, type I, alpha 2 -0.0228269
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 -0.0227145
FTH1 ferritin, heavy polypeptide 1 -0.0225387
FIP1L1 factor interacting with PAPOLA and CPSF1 -0.0223676
MBNL2 muscleblind-like splicing regulator 2 -0.0220987