Azithromycin (hydrate)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Azithromycin (hydrate) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Azithromycin (hydrate)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.104573
MT2A metallothionein 2A 0.100328
AKAP12 A kinase (PRKA) anchor protein 12 0.0574562
VMP1 vacuole membrane protein 1 0.0553444
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0485082
TPT1 tumor protein, translationally-controlled 1 0.0474725
TXNIP thioredoxin interacting protein 0.047196
RPS12 ribosomal protein S12 0.0432936
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.042392
RPL23 ribosomal protein L23 0.0422179
APOL1 apolipoprotein L, 1 0.0409174
LAMA4 laminin, alpha 4 0.0406891
GOLGB1 golgin B1 0.0394543
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0375893
RPS2 ribosomal protein S2 0.036693
TM4SF1 transmembrane 4 L six family member 1 0.0342602
CSTB cystatin B (stefin B) 0.0341548
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0322978
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0321346
RPL11 ribosomal protein L11 0.0313125
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0301689
DOCK5 dedicator of cytokinesis 5 0.0298087
LCN2 lipocalin 2 0.0293228
CSNK1A1 casein kinase 1, alpha 1 0.0282927
RPS8 ribosomal protein S8 0.0271617
LAMB3 laminin, beta 3 0.0248336
TMF1 TATA element modulatory factor 1 0.0247931
AREG amphiregulin 0.0242896
PHF3 PHD finger protein 3 0.0237735
SMAD3 SMAD family member 3 0.0237454
GOLM2 golgi membrane protein 2 0.0235442
ARHGAP5 Rho GTPase activating protein 5 0.0234598
IFI6 interferon, alpha-inducible protein 6 0.0230504
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0228001
ANGPTL4 angiopoietin-like 4 0.022486
RPL21 ribosomal protein L21 0.0220416
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0218631
RPS3 ribosomal protein S3 0.0216499
NFE2L1 nuclear factor, erythroid 2-like 1 0.0215966
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0214642
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0211027
ERRFI1 ERBB receptor feedback inhibitor 1 0.020867
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0208298
NRIP1 nuclear receptor interacting protein 1 0.0200794
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0199378
KLF6 Kruppel-like factor 6 0.0198413
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0198396
GPATCH2L G patch domain containing 2-like 0.0198284
ANO6 anoctamin 6 0.0197552
RPS7 ribosomal protein S7 0.019729
MCL1 myeloid cell leukemia 1 0.0196588
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0196116
SGMS2 sphingomyelin synthase 2 0.0193963
ADAM28 ADAM metallopeptidase domain 28 0.0193705
BCAR3 breast cancer anti-estrogen resistance 3 0.0190136
WWTR1 WW domain containing transcription regulator 1 0.0189936
SH3KBP1 SH3-domain kinase binding protein 1 0.0189843
ZSWIM6 zinc finger, SWIM-type containing 6 0.0187574
TMEM51 transmembrane protein 51 0.0185315
GOLGA4 golgin A4 0.0181873
BARX2 BARX homeobox 2 0.0181647
SACK1A scaffolding CK1 anchoring protein A 0.0172709
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0171903
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0170489
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0166442
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0166161
BLZF1 basic leucine zipper nuclear factor 1 0.0165686
C15ORF48 chromosome 15 open reading frame 48 0.0164324
RPS25 ribosomal protein S25 0.0157461
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0157284
NAP1L1 nucleosome assembly protein 1-like 1 0.0155827
TMCC3 transmembrane and coiled-coil domain family 3 0.0155651
DUSP5 dual specificity phosphatase 5 0.0153358
SON SON DNA binding protein 0.0152878
DSCAM Down syndrome cell adhesion molecule 0.015172
RPL37A ribosomal protein L37a 0.0150529
RSRP1 arginine/serine-rich protein 1 0.0150242
DUOX2 dual oxidase 2 0.01476
CD58 CD58 molecule 0.0146897
FAM110C family with sequence similarity 110, member C 0.014535
SRSF5 serine/arginine-rich splicing factor 5 0.0144153
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0142709
REST RE1-silencing transcription factor 0.0136232
IFI44L interferon-induced protein 44-like 0.0136203
ERN1 endoplasmic reticulum to nucleus signaling 1 0.013135
ZFP36 ZFP36 ring finger protein 0.0129237
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0128696
MPZL2 myelin protein zero-like 2 0.0128551
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0124548
RPL12 ribosomal protein L12 0.0124184
H1-2 H1.2 linker histone, cluster member 0.0122848
AFDN afadin, adherens junction formation factor 0.0122183
ZC3H12C zinc finger CCCH-type containing 12C 0.0122096
WDR26 WD repeat domain 26 0.0121765
NACA nascent polypeptide-associated complex alpha subunit 0.0120663
BZW1 basic leucine zipper and W2 domains 1 0.0118618
WDPCP WD repeat containing planar cell polarity effector 0.0118371
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0118163
MAPK8 mitogen-activated protein kinase 8 0.0118131
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0117441

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.244568
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.208657
F3 coagulation factor III (thromboplastin, tissue factor) -0.149324
FTH1 ferritin, heavy polypeptide 1 -0.146648
PTMA prothymosin, alpha -0.13917
TMSB4X thymosin beta 4, X-linked -0.109759
MMP7 matrix metallopeptidase 7 -0.107293
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.104841
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.10468
PKM pyruvate kinase, muscle -0.0959281
IGFBP3 insulin-like growth factor binding protein 3 -0.0953991
S100A6 S100 calcium binding protein A6 -0.0904406
CP ceruloplasmin (ferroxidase) -0.088502
POTEF POTE ankyrin domain family, member F -0.0875766
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0841274
ACTG1 actin gamma 1 -0.0806039
PARD3 par-3 family cell polarity regulator -0.078696
MUC4 mucin 4, cell surface associated -0.078185
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0778141
RNF213 ring finger protein 213 -0.0754057
ARHGAP26 Rho GTPase activating protein 26 -0.0730831
VIM vimentin -0.0726987
HLA-A major histocompatibility complex, class I, A -0.0716554
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0698431
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0682893
PGK1 phosphoglycerate kinase 1 -0.0654461
TSC22D2 TSC22 domain family, member 2 -0.0647458
MAML2 mastermind-like 2 (Drosophila) -0.0624048
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0623898
EZR ezrin -0.0620328
ANXA2 annexin A2 -0.0619542
ACTN4 actinin, alpha 4 -0.060038
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0596242
LMO7 LIM domain 7 -0.0590432
HMGA1 high mobility group AT-hook 1 -0.0588563
HLA-B major histocompatibility complex, class I, B -0.0568528
ADAM9 ADAM metallopeptidase domain 9 -0.0561771
LOC112694756 uncharaterized LOC112694756 -0.0561493
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0537691
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0531748
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0527012
RPL35A ribosomal protein L35a -0.0526739
ASPH aspartate beta-hydroxylase -0.0520631
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0512442
KDM5B lysine (K)-specific demethylase 5B -0.0510988
AHNAK AHNAK nucleoprotein -0.0498923
RAB6A RAB6A, member RAS oncogene family -0.0492905
DTNA dystrobrevin, alpha -0.0491736
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0491535
ZFAND3 zinc finger, AN1-type domain 3 -0.0480892
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0479902
CDK6 cyclin-dependent kinase 6 -0.0479872
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0474499
PCDH7 protocadherin 7 -0.047273
FNDC3B fibronectin type III domain containing 3B -0.0468962
APP amyloid beta (A4) precursor protein -0.046793
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0463023
PLAU plasminogen activator, urokinase -0.0459717
RPLP1 ribosomal protein, large, P1 -0.0456829
SPAG9 sperm associated antigen 9 -0.0454287
TPM1 tropomyosin 1 (alpha) -0.0446917
PICALM phosphatidylinositol binding clathrin assembly protein -0.0445822
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0439044
RCOR1 REST corepressor 1 -0.043213
MACF1 microtubule-actin crosslinking factor 1 -0.0430165
TMEM123 transmembrane protein 123 -0.0428685
GRB10 growth factor receptor-bound protein 10 -0.042778
TAPBP TAP binding protein (tapasin) -0.0426603
PRKCA protein kinase C, alpha -0.042501
INSIG1 insulin induced gene 1 -0.0418967
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0411229
IFI27 interferon, alpha-inducible protein 27 -0.0405234
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0400626
FLNB filamin B, beta -0.0396495
UBE2H ubiquitin-conjugating enzyme E2H -0.0393865
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0392576
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0390955
RTN4 reticulon 4 -0.0390746
NCKAP5 NCK-associated protein 5 -0.0385606
TRIO trio Rho guanine nucleotide exchange factor -0.0383961
GNAS GNAS complex locus -0.0382935
STRN3 striatin, calmodulin binding protein 3 -0.0378856
TPM4 tropomyosin 4 -0.0374768
ITGA6 integrin, alpha 6 -0.0374046
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0371415
CCNY cyclin Y -0.0367704
HSPG2 heparan sulfate proteoglycan 2 -0.0362838
DST dystonin -0.0362209
LPP LIM domain containing preferred translocation partner in lipoma -0.0360588
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0355055
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.034406
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0343534
NPEPPS aminopeptidase puromycin sensitive -0.034011
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -0.0339705
ANXA11 annexin A11 -0.0339523
LMNA lamin A/C -0.0338877
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.033741
RASAL2 RAS protein activator like 2 -0.0333121
AFF4 AF4/FMR2 family, member 4 -0.03328
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0332213