Azithromycin (hydrate)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Azithromycin (hydrate) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Azithromycin (hydrate)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.19098
PTPRD protein tyrosine phosphatase, receptor type, D 0.0861052
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0665941
FNBP1 formin binding protein 1 0.064779
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0597739
TLE4 transducin-like enhancer of split 4 0.0589308
VMP1 vacuole membrane protein 1 0.0571172
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0552531
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0542929
PLPP1 phospholipid phosphatase 1 0.0535588
PLAT plasminogen activator, tissue 0.0486663
SOS1 son of sevenless homolog 1 (Drosophila) 0.0457838
FAM13A family with sequence similarity 13, member A 0.0441549
MEF2A myocyte enhancer factor 2A 0.0432069
GLCCI1 glucocorticoid induced 1 0.0361002
FNDC3B fibronectin type III domain containing 3B 0.035723
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0306706
HILPDA hypoxia inducible lipid droplet-associated 0.0283294
ZFC3H1 zinc finger, C3H1-type containing 0.0272776
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0272476
TPST1 tyrosylprotein sulfotransferase 1 0.026681
KLHL13 kelch-like family member 13 0.0265989
ITPRID2 ITPR interacting domain containing 2 0.0261423
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0255447
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0243672
RAB30 RAB30, member RAS oncogene family 0.0241625
MTUS1 microtubule associated tumor suppressor 1 0.0241579
DST dystonin 0.0239033
VGLL4 vestigial-like family member 4 0.0238646
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0237923
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0232227
PLSCR1 phospholipid scramblase 1 0.0231364
RPS2 ribosomal protein S2 0.0231093
EPAS1 endothelial PAS domain protein 1 0.0226913
B2M beta-2-microglobulin 0.022245
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0222416
HAS2 hyaluronan synthase 2 0.0221279
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0218873
RIGI RNA sensor RIG-I 0.0218175
ELL2 elongation factor, RNA polymerase II, 2 0.0216806
SETD2 SET domain containing 2 0.0214277
KIF5B kinesin family member 5B 0.0214194
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0212406
PELI1 pellino E3 ubiquitin protein ligase 1 0.0211004
PIBF1 progesterone immunomodulatory binding factor 1 0.0206489
BTG1 B-cell translocation gene 1, anti-proliferative 0.0204968
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0203684
NFE2L2 nuclear factor, erythroid 2-like 2 0.0203426
PACS1 phosphofurin acidic cluster sorting protein 1 0.0201064
IFI16 interferon, gamma-inducible protein 16 0.0199944
STC1 stanniocalcin 1 0.0199682
ADGRL2 adhesion G protein-coupled receptor L2 0.0199392
TOP2B topoisomerase (DNA) II beta 180kDa 0.0197245
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0197186
BCAS3 breast carcinoma amplified sequence 3 0.0196516
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0195884
IGFBP3 insulin-like growth factor binding protein 3 0.0195832
TPR translocated promoter region, nuclear basket protein 0.0190736
RORA RAR-related orphan receptor A 0.0188948
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0188866
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0187695
MEIS2 Meis homeobox 2 0.0186549
FNIP1 folliculin interacting protein 1 0.0186478
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0186259
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0181175
SLK STE20-like kinase 0.0179194
ITPKB inositol-trisphosphate 3-kinase B 0.017751
PCBP3 poly(rC) binding protein 3 0.0177086
RAI14 retinoic acid induced 14 0.0176569
SERINC1 serine incorporator 1 0.0174351
KDM5B lysine (K)-specific demethylase 5B 0.0172872
JMJD1C jumonji domain containing 1C 0.0170137
ATG10 autophagy related 10 0.0169541
MED13 mediator complex subunit 13 0.0169216
TIMP3 TIMP metallopeptidase inhibitor 3 0.0168128
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0167604
MX1 MX dynamin-like GTPase 1 0.0166218
PHF3 PHD finger protein 3 0.0166189
ANTXR1 anthrax toxin receptor 1 0.0165107
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0164435
ZFP36 ZFP36 ring finger protein 0.016419
EHBP1 EH domain binding protein 1 0.0163738
LNPK lunapark, ER junction formation factor 0.0163642
NRIP1 nuclear receptor interacting protein 1 0.0162971
SSH1 slingshot protein phosphatase 1 0.0161469
FNDC3A fibronectin type III domain containing 3A 0.0160438
ZNF292 zinc finger protein 292 0.0160014
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0160005
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0159872
RYBP RING1 and YY1 binding protein 0.0159713
HMGB2 high mobility group box 2 0.0159696
TNRC6B trinucleotide repeat containing 6B 0.0159648
NFE2L1 nuclear factor, erythroid 2-like 1 0.0159512
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0158882
SNAP25 synaptosomal-associated protein, 25kDa 0.0158447
WDR70 WD repeat domain 70 0.0158125
WAPL WAPL cohesin release factor 0.0157967
PHACTR2 phosphatase and actin regulator 2 0.0156574
HEXIM1 hexamethylene bis-acetamide inducible 1 0.0155894
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0155868

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.440635
NALF1 NALCN channel auxiliary factor 1 -0.13108
NRG1 neuregulin 1 -0.0987503
PTMA prothymosin, alpha -0.0763135
PRKCA protein kinase C, alpha -0.0740445
LSAMP limbic system-associated membrane protein -0.0724899
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.064154
DTNA dystrobrevin, alpha -0.0620392
TMSB10 thymosin beta 10 -0.0595322
MSI2 musashi RNA-binding protein 2 -0.0553243
VIM vimentin -0.0543946
RPL35A ribosomal protein L35a -0.0533545
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0527807
EXT1 exostosin glycosyltransferase 1 -0.0511862
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0499483
FRMD4A FERM domain containing 4A -0.0477971
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0458677
LPIN1 lipin 1 -0.0441123
FTL ferritin, light polypeptide -0.0436166
RPS19 ribosomal protein S19 -0.0434575
RPL23 ribosomal protein L23 -0.043431
NDRG1 N-myc downstream regulated 1 -0.0430088
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0421659
TRIB2 tribbles pseudokinase 2 -0.0421568
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0415195
THSD4 thrombospondin, type I, domain containing 4 -0.0415166
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0402569
DPH6 diphthamine biosynthesis 6 -0.0396455
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0388155
MAML2 mastermind-like 2 (Drosophila) -0.0382188
MBNL2 muscleblind-like splicing regulator 2 -0.0381586
BBX bobby sox homolog (Drosophila) -0.037422
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0369595
ZNF804A zinc finger protein 804A -0.0358742
PKM pyruvate kinase, muscle -0.0358427
ACTG1 actin gamma 1 -0.0349234
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0347031
RPL31 ribosomal protein L31 -0.0337883
VCL vinculin -0.0335148
SLC38A2 solute carrier family 38, member 2 -0.0333292
CTBP2 C-terminal binding protein 2 -0.0331942
FMNL2 formin-like 2 -0.0329882
TPT1 tumor protein, translationally-controlled 1 -0.0328906
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0325949
IGF2 insulin-like growth factor 2 -0.0325686
PTPRM protein tyrosine phosphatase, receptor type, M -0.0324836
ZFAND3 zinc finger, AN1-type domain 3 -0.0321002
RPLP1 ribosomal protein, large, P1 -0.0318041
RPL19 ribosomal protein L19 -0.0311907
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0308546
UNC5C unc-5 homolog C (C. elegans) -0.0307518
CADM2 cell adhesion molecule 2 -0.0305084
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0298256
AK1 adenylate kinase 1 -0.0295486
DACH2 dachshund family transcription factor 2 -0.0295409
RPS6 ribosomal protein S6 -0.029514
EFNA5 ephrin-A5 -0.029513
NREP neuronal regeneration related protein -0.0294897
FMN1 formin 1 -0.0292007
RPL37A ribosomal protein L37a -0.0289571
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0289002
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0285162
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0281223
RPL34 ribosomal protein L34 -0.0279329
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.027699
NF1 neurofibromin 1 -0.0274842
DDR2 discoidin domain receptor tyrosine kinase 2 -0.0271435
KMT2C lysine (K)-specific methyltransferase 2C -0.0268873
SRRM2 serine/arginine repetitive matrix 2 -0.0266927
RPTOR regulatory associated protein of MTOR, complex 1 -0.0264489
SAMD4A sterile alpha motif domain containing 4A -0.0246432
COL1A1 collagen, type I, alpha 1 -0.0243072
CADM1 cell adhesion molecule 1 -0.0241855
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.024175
NPAS3 neuronal PAS domain protein 3 -0.024145
IGF1R insulin-like growth factor 1 receptor -0.0241118
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0240096
PCBP2 poly(rC) binding protein 2 -0.023989
HELZ helicase with zinc finger -0.0239189
SLC39A11 solute carrier family 39, member 11 -0.0239184
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.023906
MACF1 microtubule-actin crosslinking factor 1 -0.0237629
NCAM2 neural cell adhesion molecule 2 -0.0237079
CEMIP cell migration inducing protein, hyaluronan binding -0.023486
LOC112694756 uncharaterized LOC112694756 -0.0234357
COL6A1 collagen, type VI, alpha 1 -0.023433
RPS25 ribosomal protein S25 -0.0233349
RPS14 ribosomal protein S14 -0.0232677
LIMCH1 LIM and calponin homology domains 1 -0.0232046
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0230036
RPS21 ribosomal protein S21 -0.0228033
CNTN4 contactin 4 -0.0225492
SYT1 synaptotagmin I -0.0222617
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0222244
PCDH9 protocadherin 9 -0.0221888
PIAS2 protein inhibitor of activated STAT, 2 -0.0221099
AKAP13 A kinase (PRKA) anchor protein 13 -0.0220876
GMDS GDP-mannose 4,6-dehydratase -0.0219961
SPAG9 sperm associated antigen 9 -0.0219462
CBX3 chromobox homolog 3 -0.0219004