Azithromycin (hydrate)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Azithromycin (hydrate) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Azithromycin (hydrate)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.199116
TPT1 tumor protein, translationally-controlled 1 0.092511
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0742026
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0731897
VMP1 vacuole membrane protein 1 0.0702097
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0639221
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0552141
HILPDA hypoxia inducible lipid droplet-associated 0.0527551
CALD1 caldesmon 1 0.048661
RPS12 ribosomal protein S12 0.0478422
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0475388
ASPH aspartate beta-hydroxylase 0.0469509
TIMP3 TIMP metallopeptidase inhibitor 3 0.0445694
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0427788
CD44 CD44 molecule (Indian blood group) 0.0414554
FAM13A family with sequence similarity 13, member A 0.0406453
GOLM2 golgi membrane protein 2 0.0369767
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 0.0369117
MKI67 marker of proliferation Ki-67 0.035978
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0355291
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0351359
DSCAM Down syndrome cell adhesion molecule 0.0348934
RAB1A RAB1A, member RAS oncogene family 0.0345875
PRRC2C proline-rich coiled-coil 2C 0.0341484
PYGL phosphorylase, glycogen, liver 0.0341113
MBNL1 muscleblind-like splicing regulator 1 0.0329217
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0324398
INHBA inhibin, beta A 0.0321576
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0321045
NFE2L1 nuclear factor, erythroid 2-like 1 0.0320305
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0318559
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0314162
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0313527
RIGI RNA sensor RIG-I 0.0300966
WSB1 WD repeat and SOCS box containing 1 0.0299751
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0296874
LOC102724023 ES1 protein homolog, mitochondrial 0.0294925
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0294113
FAM162A family with sequence similarity 162, member A 0.0287017
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0281374
ERRFI1 ERBB receptor feedback inhibitor 1 0.0272321
CLU clusterin 0.0270886
PTPRD protein tyrosine phosphatase, receptor type, D 0.0270212
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0269123
RACK1 receptor for activated C kinase 1 0.0268111
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0265219
RPL11 ribosomal protein L11 0.0260063
ZSWIM6 zinc finger, SWIM-type containing 6 0.0258461
H3-3B H3.3 histone B 0.0258195
RHEB Ras homolog enriched in brain 0.0257522
RPS2 ribosomal protein S2 0.0256274
SMC5 structural maintenance of chromosomes 5 0.0253142
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0244315
HLA-B major histocompatibility complex, class I, B 0.0243014
H1-4 H1.4 linker histone, cluster member 0.0242761
CCNT2 cyclin T2 0.0242185
PHF3 PHD finger protein 3 0.0239231
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0238218
BZW1 basic leucine zipper and W2 domains 1 0.0237501
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0237115
ZNF841 zinc finger protein 841 0.0233705
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0233494
PPIB peptidylprolyl isomerase B (cyclophilin B) 0.0227345
RPL37A ribosomal protein L37a 0.0223867
DOCK5 dedicator of cytokinesis 5 0.0223602
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa 0.0222995
CTNND1 catenin (cadherin-associated protein), delta 1 0.0221875
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0217681
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0216848
PDIA4 protein disulfide isomerase family A, member 4 0.0216152
TM4SF1 transmembrane 4 L six family member 1 0.021578
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0214726
GPBP1 GC-rich promoter binding protein 1 0.021426
ELL2 elongation factor, RNA polymerase II, 2 0.0212027
PRELID2 PRELI domain containing 2 0.0211979
CDC5L cell division cycle 5-like 0.0210648
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0209552
PCBP3 poly(rC) binding protein 3 0.0208799
B2M beta-2-microglobulin 0.0207537
S100A10 S100 calcium binding protein A10 0.0206853
PDIA6 protein disulfide isomerase family A, member 6 0.0206638
BTG1 B-cell translocation gene 1, anti-proliferative 0.0205203
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.0204035
AKAP9 A kinase (PRKA) anchor protein 9 0.0203639
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0200478
SPATS2 spermatogenesis associated, serine-rich 2 0.0200115
HMGA2 high mobility group AT-hook 2 0.0197674
TMEM39A transmembrane protein 39A 0.0196503
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0195684
H1-2 H1.2 linker histone, cluster member 0.0193511
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0193431
SETD5 SET domain containing 5 0.0193116
CEP350 centrosomal protein 350kDa 0.0192719
EIF4B eukaryotic translation initiation factor 4B 0.0191729
RIMS2 regulating synaptic membrane exocytosis 2 0.0191102
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like 0.0190693
RSL1D1 ribosomal L1 domain containing 1 0.0190196
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0190018
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0187808
RAB7A RAB7A, member RAS oncogene family 0.0187651

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.241102
COL6A3 collagen, type VI, alpha 3 -0.185465
TMSB10 thymosin beta 10 -0.135041
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.111065
FN1 fibronectin 1 -0.103082
PKM pyruvate kinase, muscle -0.0976241
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0958892
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0839453
LOC112694756 uncharaterized LOC112694756 -0.080305
RPLP1 ribosomal protein, large, P1 -0.0794136
AHNAK AHNAK nucleoprotein -0.0632324
SBF2 SET binding factor 2 -0.0617197
POTEF POTE ankyrin domain family, member F -0.061697
TPM4 tropomyosin 4 -0.0579181
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0571272
CALR calreticulin -0.0570639
NDRG1 N-myc downstream regulated 1 -0.0569219
RPL35A ribosomal protein L35a -0.0558594
ACTN4 actinin, alpha 4 -0.0548659
TXNRD1 thioredoxin reductase 1 -0.0546598
RNF216 ring finger protein 216 -0.0527296
FNDC3B fibronectin type III domain containing 3B -0.0494127
YBX1 Y box binding protein 1 -0.0468112
FTH1 ferritin, heavy polypeptide 1 -0.0461397
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0449629
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0445975
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0443488
CBX3 chromobox homolog 3 -0.044266
TNS3 tensin 3 -0.0423777
AHR aryl hydrocarbon receptor -0.0418441
NF1 neurofibromin 1 -0.0417477
EEF2 eukaryotic translation elongation factor 2 -0.041741
SDK1 sidekick cell adhesion molecule 1 -0.0412747
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0405479
ZFAND3 zinc finger, AN1-type domain 3 -0.0397864
VIM vimentin -0.0396054
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0395219
RPL19 ribosomal protein L19 -0.0391193
PTMA prothymosin, alpha -0.0389814
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0383583
MAP1B microtubule-associated protein 1B -0.038111
ZBTB20 zinc finger and BTB domain containing 20 -0.0373612
TNNC1 troponin C type 1 (slow) -0.0370175
TRIO trio Rho guanine nucleotide exchange factor -0.036808
CALU calumenin -0.0365796
SYT1 synaptotagmin I -0.0363388
PDE4D phosphodiesterase 4D, cAMP-specific -0.0360685
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0358408
ANKRD11 ankyrin repeat domain 11 -0.0357648
KPNB1 karyopherin (importin) beta 1 -0.0353173
RPL13A ribosomal protein L13a -0.035282
IGFBP5 insulin-like growth factor binding protein 5 -0.0349265
AVL9 AVL9 homolog (S. cerevisiase) -0.0348305
RTN4 reticulon 4 -0.0341385
IGF2 insulin-like growth factor 2 -0.0333798
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0323182
SEPTIN7 septin 7 -0.0321799
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0319831
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.031795
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0317724
IGFBP3 insulin-like growth factor binding protein 3 -0.0317499
ADAM9 ADAM metallopeptidase domain 9 -0.0313802
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0313304
CARD16 caspase recruitment domain family, member 16 -0.0310266
RNF213 ring finger protein 213 -0.0309706
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0309466
RPL28 ribosomal protein L28 -0.0306851
ZMYND8 zinc finger, MYND-type containing 8 -0.0302358
LPP LIM domain containing preferred translocation partner in lipoma -0.0298022
COL5A1 collagen, type V, alpha 1 -0.0297797
POM121C POM121 transmembrane nucleoporin C -0.0294783
PCDHB16 protocadherin beta 16 -0.0289968
LYPD6B LY6/PLAUR domain containing 6B -0.0287341
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0286956
SEC31A SEC31 homolog A (S. cerevisiae) -0.0285447
CKAP4 cytoskeleton-associated protein 4 -0.0279062
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.02772
HDLBP high density lipoprotein binding protein -0.0272619
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0272319
TCF12 transcription factor 12 -0.0271782
LMAN1 lectin, mannose-binding, 1 -0.0271733
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0269805
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0268768
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0268067
TNRC18 trinucleotide repeat containing 18 -0.0264511
RPS19 ribosomal protein S19 -0.0263965
NIBAN2 niban apoptosis regulator 2 -0.0263768
RPS16 ribosomal protein S16 -0.0261131
MAML2 mastermind-like 2 (Drosophila) -0.0258981
DPYD dihydropyrimidine dehydrogenase -0.0258076
USP34 ubiquitin specific peptidase 34 -0.0255649
GNAS GNAS complex locus -0.0255547
TENM3 teneurin transmembrane protein 3 -0.0253754
QSER1 glutamine and serine rich 1 -0.0253746
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0252571
ATP5F1B ATP synthase F1 subunit beta -0.0252553
FLNA filamin A, alpha -0.0252431
WNK1 WNK lysine deficient protein kinase 1 -0.02523
SLC38A2 solute carrier family 38, member 2 -0.0251974
PRR16 proline rich 16 -0.0251945