Azithromycin (hydrate)_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Azithromycin (hydrate) perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Azithromycin (hydrate)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.168887
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.149012
MT2A metallothionein 2A 0.138946
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.128887
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.105023
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0859559
TIMP1 TIMP metallopeptidase inhibitor 1 0.0838166
SVIL supervillin 0.0594854
EHBP1 EH domain binding protein 1 0.0578808
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.055412
RPS12 ribosomal protein S12 0.0524436
FOXP1 forkhead box P1 0.0475597
ASPH aspartate beta-hydroxylase 0.0470202
DSPP dentin sialophosphoprotein 0.0460708
BCL2L1 BCL2-like 1 0.0447371
TPT1 tumor protein, translationally-controlled 1 0.0404825
PDLIM5 PDZ and LIM domain 5 0.0393587
ATXN1 ataxin 1 0.0375243
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0363548
FAM107B family with sequence similarity 107, member B 0.0362172
RPL37A ribosomal protein L37a 0.0361464
RPL9 ribosomal protein L9 0.0355688
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0346351
HMGA1 high mobility group AT-hook 1 0.0339726
RAD51B RAD51 paralog B 0.033901
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0337242
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0327327
PAWR PRKC, apoptosis, WT1, regulator 0.031849
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0318184
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0303208
ZBTB20 zinc finger and BTB domain containing 20 0.03025
B2M beta-2-microglobulin 0.0300497
GRB10 growth factor receptor-bound protein 10 0.0297867
BCAR3 breast cancer anti-estrogen resistance 3 0.0296692
FERMT2 fermitin family member 2 0.0292536
ARHGAP9 Rho GTPase activating protein 9 0.0292529
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0283521
MYO1E myosin IE 0.0271622
VCL vinculin 0.0269555
RPS8 ribosomal protein S8 0.026914
FRMD5 FERM domain containing 5 0.0259856
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0258205
RACK1 receptor for activated C kinase 1 0.025295
KYNU kynureninase 0.0249166
ITGAV integrin, alpha V 0.0248983
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0248282
IFI6 interferon, alpha-inducible protein 6 0.0244248
RPS24 ribosomal protein S24 0.024282
ZBTB38 zinc finger and BTB domain containing 38 0.0240698
RASA2 RAS p21 protein activator 2 0.0240433
RPS3 ribosomal protein S3 0.0236678
ENO1 enolase 1, (alpha) 0.0233821
EXT1 exostosin glycosyltransferase 1 0.0225619
GPC6 glypican 6 0.0222094
DST dystonin 0.0220407
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0219976
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.021693
CUL3 cullin 3 0.0214718
DSTN destrin (actin depolymerizing factor) 0.0214079
INTS6 integrator complex subunit 6 0.021251
ITGB5 integrin, beta 5 0.0210317
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0206284
RNASET2 ribonuclease T2 0.0205533
SAMD4A sterile alpha motif domain containing 4A 0.0203969
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0202736
SPRED2 sprouty-related, EVH1 domain containing 2 0.01989
VMP1 vacuole membrane protein 1 0.0196617
RPL23 ribosomal protein L23 0.0196614
S100P S100 calcium binding protein P 0.0195463
TXNIP thioredoxin interacting protein 0.0193873
TMSB10 thymosin beta 10 0.0193812
MBD5 methyl-CpG binding domain protein 5 0.0193042
PALLD palladin, cytoskeletal associated protein 0.0191262
RIGI RNA sensor RIG-I 0.0190373
RAB3B RAB3B, member RAS oncogene family 0.018986
ERN1 endoplasmic reticulum to nucleus signaling 1 0.0184803
ZEB1 zinc finger E-box binding homeobox 1 0.0183554
FERMT1 fermitin family member 1 0.0183443
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0182375
RPS7 ribosomal protein S7 0.0176183
PRRC2C proline-rich coiled-coil 2C 0.0176119
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0174786
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0174278
MACF1 microtubule-actin crosslinking factor 1 0.0174215
BTG1 B-cell translocation gene 1, anti-proliferative 0.0173681
IGFBP1 insulin-like growth factor binding protein 1 0.0173049
RPL21 ribosomal protein L21 0.0173047
TPM1 tropomyosin 1 (alpha) 0.0171749
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0171521
BRD2 bromodomain containing 2 0.016938
PLIN2 perilipin 2 0.0167759
RPS10 ribosomal protein S10 0.0166737
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0164195
BAZ2B bromodomain adjacent to zinc finger domain, 2B 0.0163665
MCL1 myeloid cell leukemia 1 0.0162002
RPL26 ribosomal protein L26 0.0161106
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0160721
ANXA5 annexin A5 0.0157952
RPS2 ribosomal protein S2 0.0157768
ZSWIM5 zinc finger, SWIM-type containing 5 0.0157496

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.323619
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.278076
APOB apolipoprotein B -0.185136
FBF1 Fas (TNFRSF6) binding factor 1 -0.131325
C3 complement component 3 -0.128426
FNDC3B fibronectin type III domain containing 3B -0.119988
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0903649
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0895046
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0866887
EML4 echinoderm microtubule associated protein like 4 -0.0674169
FN1 fibronectin 1 -0.0657078
PEG3 paternally expressed 3 -0.0634178
ELL2 elongation factor, RNA polymerase II, 2 -0.0607993
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0597758
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0589192
LRMDA leucine rich melanocyte differentiation associated -0.0586478
TF transferrin -0.052763
TMEM123 transmembrane protein 123 -0.0522401
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.051415
SOD2 superoxide dismutase 2, mitochondrial -0.0507458
RPS6 ribosomal protein S6 -0.0499181
RBM39 RNA binding motif protein 39 -0.0491489
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0490162
A2M alpha-2-macroglobulin -0.0485429
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0476068
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0465698
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0450668
KDM3A lysine (K)-specific demethylase 3A -0.0416597
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0408545
INSIG2 insulin induced gene 2 -0.040779
GPC3 glypican 3 -0.0401046
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.039957
CP ceruloplasmin (ferroxidase) -0.0396478
WDR45B WD repeat domain 45B -0.0389857
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0386842
TRIM26 tripartite motif containing 26 -0.0383671
TXNRD1 thioredoxin reductase 1 -0.0376335
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0362775
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0359938
CANX calnexin -0.0357928
LYZ lysozyme -0.0357755
AHSG alpha-2-HS-glycoprotein -0.0340984
RAB1A RAB1A, member RAS oncogene family -0.0333886
APOA2 apolipoprotein A-II -0.0332395
CFB complement factor B -0.0326646
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 -0.0324081
SDC4 syndecan 4 -0.0304444
NPR2 natriuretic peptide receptor 2 -0.0292667
MTUS1 microtubule associated tumor suppressor 1 -0.0291768
CPE carboxypeptidase E -0.0286853
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0284634
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0283845
GNAS GNAS complex locus -0.0274969
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0274219
MYH9 myosin, heavy chain 9, non-muscle -0.0272358
CHD6 chromodomain helicase DNA binding protein 6 -0.0267846
PTPRM protein tyrosine phosphatase, receptor type, M -0.02632
RNF213 ring finger protein 213 -0.0261705
MSI2 musashi RNA-binding protein 2 -0.025879
SESTD1 SEC14 and spectrin domains 1 -0.0258392
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0257698
SELENOP selenoprotein P -0.0252951
PEG10 paternally expressed 10 -0.0251975
APOE apolipoprotein E -0.0251446
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0251362
MATR3 matrin 3 -0.0250387
EEF2 eukaryotic translation elongation factor 2 -0.0247363
KDM7A lysine (K)-specific demethylase 7A -0.0247286
PCBP2 poly(rC) binding protein 2 -0.0246866
NPEPPS aminopeptidase puromycin sensitive -0.0244659
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0244654
RPL34 ribosomal protein L34 -0.0243505
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0241497
BHLHE40 basic helix-loop-helix family, member e40 -0.0239847
FTH1 ferritin, heavy polypeptide 1 -0.023934
PDIA3 protein disulfide isomerase family A, member 3 -0.0237031
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0236687
HELZ helicase with zinc finger -0.0236009
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0235428
PTK2 protein tyrosine kinase 2 -0.0235177
HOOK2 hook microtubule-tethering protein 2 -0.0235076
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0233318
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0232885
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0229987
ZNF292 zinc finger protein 292 -0.0227204
CAMTA1 calmodulin binding transcription activator 1 -0.0224848
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0222072
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0221096
MYO1B myosin IB -0.0219427
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0216776
STRN3 striatin, calmodulin binding protein 3 -0.021658
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0215892
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0214887
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.0213327
RPL4 ribosomal protein L4 -0.0213282
H1-0 H1.0 linker histone -0.0212361
USP3 ubiquitin specific peptidase 3 -0.0211089
GLG1 golgi glycoprotein 1 -0.0208812
NCOA7 nuclear receptor coactivator 7 -0.0206986
MAP4 microtubule-associated protein 4 -0.0206945