Azithromycin (hydrate)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Azithromycin (hydrate) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Azithromycin (hydrate)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.37657
RPS6 ribosomal protein S6 0.134
RPS12 ribosomal protein S12 0.103203
RPS2 ribosomal protein S2 0.0810917
MSN moesin 0.0787314
CD44 CD44 molecule (Indian blood group) 0.0732767
TXNIP thioredoxin interacting protein 0.0693481
TPT1 tumor protein, translationally-controlled 1 0.061863
ERRFI1 ERBB receptor feedback inhibitor 1 0.0613323
VMP1 vacuole membrane protein 1 0.0520919
RPS8 ribosomal protein S8 0.0502169
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0500302
NAP1L1 nucleosome assembly protein 1-like 1 0.0491044
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0478382
ALCAM activated leukocyte cell adhesion molecule 0.0451926
RPL21 ribosomal protein L21 0.0438117
MCL1 myeloid cell leukemia 1 0.0415696
RIGI RNA sensor RIG-I 0.0362876
RPL37A ribosomal protein L37a 0.0360599
RPS3 ribosomal protein S3 0.0353933
RND3 Rho family GTPase 3 0.0348249
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0347419
ITGA6 integrin, alpha 6 0.0339788
EXT1 exostosin glycosyltransferase 1 0.0334804
EGR1 early growth response 1 0.0333838
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0308447
CALD1 caldesmon 1 0.0306934
RPS17 ribosomal protein S17 0.02983
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0297284
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0295566
RPS7 ribosomal protein S7 0.0295308
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0295071
BCAR3 breast cancer anti-estrogen resistance 3 0.0289158
HAS2 hyaluronan synthase 2 0.0285128
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0283728
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0282657
RTN4 reticulon 4 0.0279999
TPM3 tropomyosin 3 0.0279485
MKI67 marker of proliferation Ki-67 0.0266744
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0266738
KTN1 kinectin 1 (kinesin receptor) 0.0264357
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0263476
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0260762
H1-2 H1.2 linker histone, cluster member 0.0257787
KLF6 Kruppel-like factor 6 0.0257376
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0253025
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0250175
STAT1 signal transducer and activator of transcription 1, 91kDa 0.023477
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0229768
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0228302
FOXD1 forkhead box D1 0.0228089
SET SET nuclear proto-oncogene 0.0227953
LAMB1 laminin, beta 1 0.0227947
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0223355
CSNK1A1 casein kinase 1, alpha 1 0.0222421
FOSL1 FOS-like antigen 1 0.0214339
BPTF bromodomain PHD finger transcription factor 0.0214035
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0212334
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0212253
BTG1 B-cell translocation gene 1, anti-proliferative 0.0211323
NFE2L1 nuclear factor, erythroid 2-like 1 0.0210214
H1-4 H1.4 linker histone, cluster member 0.0209604
LIMA1 LIM domain and actin binding 1 0.0208909
JUN jun proto-oncogene 0.0208531
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0207393
RACK1 receptor for activated C kinase 1 0.0202862
PBX3 pre-B-cell leukemia homeobox 3 0.0198449
CSTB cystatin B (stefin B) 0.0194974
KISS1 KiSS-1 metastasis-suppressor 0.0178177
SDCCAG8 serologically defined colon cancer antigen 8 0.0177078
DENR density-regulated protein 0.0175555
LOC102724023 ES1 protein homolog, mitochondrial 0.0173774
RPL26 ribosomal protein L26 0.0173519
RPS27A ribosomal protein S27a 0.0171705
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.016926
DOCK5 dedicator of cytokinesis 5 0.0169056
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0167591
EFNB2 ephrin-B2 0.0165502
SORCS2 sortilin-related VPS10 domain containing receptor 2 0.0164446
TMEM87A transmembrane protein 87A 0.0161106
EIF5B eukaryotic translation initiation factor 5B 0.0161075
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0160445
RPL9 ribosomal protein L9 0.01603
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0160066
IGFBP3 insulin-like growth factor binding protein 3 0.0158991
TM4SF19 transmembrane 4 L six family member 19 0.0158469
RPS14 ribosomal protein S14 0.0158263
PA2G4 proliferation-associated 2G4, 38kDa 0.0157987
KDM2A lysine (K)-specific demethylase 2A 0.0157623
RPS25 ribosomal protein S25 0.0157269
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0154418
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0154394
LIMS1 LIM and senescent cell antigen-like domains 1 0.0149393
RPS29 ribosomal protein S29 0.0147451
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0146229
PNN pinin, desmosome associated protein 0.0145487
RAD51B RAD51 paralog B 0.0142682
PDLIM5 PDZ and LIM domain 5 0.0142071
NARS1 asparaginyl-tRNA synthetase 1 0.0140907
SYAP1 synapse associated protein 1 0.0140297

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.130576
LSAMP limbic system-associated membrane protein -0.12454
GPC6 glypican 6 -0.119308
PHACTR1 phosphatase and actin regulator 1 -0.112673
TMSB10 thymosin beta 10 -0.110109
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0994386
DTNA dystrobrevin, alpha -0.0993402
PRKG1 protein kinase, cGMP-dependent, type I -0.0925653
FTL ferritin, light polypeptide -0.0861318
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0836903
AHNAK AHNAK nucleoprotein -0.0814999
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0806352
PKM pyruvate kinase, muscle -0.0784296
PTPRG protein tyrosine phosphatase, receptor type, G -0.0748867
LOC112694756 uncharaterized LOC112694756 -0.0704446
CDH13 cadherin 13 -0.0676491
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0645278
MMP12 matrix metallopeptidase 12 -0.0617148
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0575086
EFNA5 ephrin-A5 -0.0573041
RUNX1 runt-related transcription factor 1 -0.0560596
KIAA1217 KIAA1217 -0.0523541
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0523466
CTSB cathepsin B -0.0521053
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0519013
ADAM9 ADAM metallopeptidase domain 9 -0.0511302
ZNF804A zinc finger protein 804A -0.0502138
CFAP251 cilia and flagella associated protein 251 -0.0501768
NTM neurotrimin -0.0501286
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0499943
KDM3A lysine (K)-specific demethylase 3A -0.0494468
CD109 CD109 molecule -0.0494118
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0487533
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0469739
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0460872
PTCHD4 patched domain containing 4 -0.0456334
FLNA filamin A, alpha -0.0444761
ASPH aspartate beta-hydroxylase -0.0441734
WDR45B WD repeat domain 45B -0.0439731
RPL35A ribosomal protein L35a -0.0437443
MSR1 macrophage scavenger receptor 1 -0.0433063
RAD21 RAD21 homolog (S. pombe) -0.0429242
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0413916
APP amyloid beta (A4) precursor protein -0.0411409
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0410958
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 -0.0407787
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0396133
ACTG1 actin gamma 1 -0.0393146
SAMD3 sterile alpha motif domain containing 3 -0.0388458
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0384988
CANX calnexin -0.0384464
ANXA2 annexin A2 -0.0377873
LMAN1 lectin, mannose-binding, 1 -0.0375863
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0367729
LIMCH1 LIM and calponin homology domains 1 -0.0367222
PTK2 protein tyrosine kinase 2 -0.0359416
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0340043
PGK1 phosphoglycerate kinase 1 -0.0338188
AEBP2 AE binding protein 2 -0.0336637
EEF2 eukaryotic translation elongation factor 2 -0.0335218
RPL4 ribosomal protein L4 -0.0333599
GLS2 glutaminase 2 (liver, mitochondrial) -0.0333242
TLE4 transducin-like enhancer of split 4 -0.0333084
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0313955
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0310621
DGKI diacylglycerol kinase, iota -0.0309749
NF1 neurofibromin 1 -0.0307347
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0306075
LDHA lactate dehydrogenase A -0.0305557
NRP2 neuropilin 2 -0.0305239
RASA3 RAS p21 protein activator 3 -0.0298036
KDM4C lysine (K)-specific demethylase 4C -0.0293799
PRKCE protein kinase C, epsilon -0.0292971
ZFAND3 zinc finger, AN1-type domain 3 -0.0292156
CDK14 cyclin-dependent kinase 14 -0.0289429
PHIP pleckstrin homology domain interacting protein -0.0282684
DSCAM Down syndrome cell adhesion molecule -0.0280626
RPL32 ribosomal protein L32 -0.027768
HOOK2 hook microtubule-tethering protein 2 -0.0277095
KPNB1 karyopherin (importin) beta 1 -0.0272619
MARCHF6 membrane associated ring-CH-type finger 6 -0.0271112
TRPS1 trichorhinophalangeal syndrome I -0.026803
GNAS GNAS complex locus -0.0267715
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0267174
RPL13A ribosomal protein L13a -0.0266669
RPL19 ribosomal protein L19 -0.0261313
RBMS1 RNA binding motif, single stranded interacting protein 1 -0.0259992
KIAA1549L KIAA1549-like -0.0257081
C2CD2 C2 calcium-dependent domain containing 2 -0.0255725
PHF3 PHD finger protein 3 -0.0254623
DPYD dihydropyrimidine dehydrogenase -0.0253146
EIF1 eukaryotic translation initiation factor 1 -0.0249993
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0248126
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0247074
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0246866
PARD3 par-3 family cell polarity regulator -0.0246789
NBAS neuroblastoma amplified sequence -0.0244671
METTL15 methyltransferase like 15 -0.0243964
BIRC6 baculoviral IAP repeat containing 6 -0.0242742
INTS6 integrator complex subunit 6 -0.024247