Azithromycin (hydrate)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Azithromycin (hydrate) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Azithromycin (hydrate)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 0.0916204
RPS12 ribosomal protein S12 0.0793713
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0670644
KTN1 kinectin 1 (kinesin receptor) 0.0568036
RPLP2 ribosomal protein, large, P2 0.0520029
RNF145 ring finger protein 145 0.0459152
PRRC2C proline-rich coiled-coil 2C 0.0428915
RPL21 ribosomal protein L21 0.042791
RPL23 ribosomal protein L23 0.0423053
MT2A metallothionein 2A 0.0413865
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0410751
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0408125
NAP1L1 nucleosome assembly protein 1-like 1 0.0402517
RPL36 ribosomal protein L36 0.0389978
RPS19 ribosomal protein S19 0.0379294
PCBP2 poly(rC) binding protein 2 0.0377122
LOC102724023 ES1 protein homolog, mitochondrial 0.0371657
RPS8 ribosomal protein S8 0.0371531
VMP1 vacuole membrane protein 1 0.0315861
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0298384
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0292715
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0279354
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0267596
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0267079
AKAP12 A kinase (PRKA) anchor protein 12 0.0266865
RPL28 ribosomal protein L28 0.0264874
EIF5B eukaryotic translation initiation factor 5B 0.0260979
NRDC nardilysin convertase 0.0259112
LOC105378220 macrophage receptor MARCO-like 0.0251701
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0250126
WWOX WW domain containing oxidoreductase 0.0244421
RIMKLB ribosomal modification protein rimK-like family member B 0.0244333
PNN pinin, desmosome associated protein 0.0242875
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0241495
RPS29 ribosomal protein S29 0.0241346
PABPN1 poly(A) binding protein, nuclear 1 0.0238546
TXNIP thioredoxin interacting protein 0.022301
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0221593
S100P S100 calcium binding protein P 0.0210764
SON SON DNA binding protein 0.0206627
SRSF11 serine/arginine-rich splicing factor 11 0.0203585
PA2G4 proliferation-associated 2G4, 38kDa 0.0203411
SET SET nuclear proto-oncogene 0.0202238
TSC22D2 TSC22 domain family, member 2 0.0198666
AREG amphiregulin 0.0195741
POTEF POTE ankyrin domain family, member F 0.0195057
PCM1 pericentriolar material 1 0.0194904
RPL5 ribosomal protein L5 0.0194598
KIF5B kinesin family member 5B 0.0191883
RPS14 ribosomal protein S14 0.0186855
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0186732
RPL8 ribosomal protein L8 0.0184874
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0184583
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0184367
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0184269
RPL18 ribosomal protein L18 0.0179953
SFPQ splicing factor proline/glutamine-rich 0.0179204
FBXO11 F-box protein 11 0.0178744
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0177844
COX6C cytochrome c oxidase subunit VIc 0.0177087
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0176084
CLDN4 claudin 4 0.0172715
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0172294
GOLGA4 golgin A4 0.0172225
BRD2 bromodomain containing 2 0.0171724
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0171051
USP8 ubiquitin specific peptidase 8 0.0170817
CSNK1A1 casein kinase 1, alpha 1 0.0170327
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0170173
S100A9 S100 calcium binding protein A9 0.0169361
CD46 CD46 molecule, complement regulatory protein 0.0167195
RPL23A ribosomal protein L23a 0.0167036
SMC4 structural maintenance of chromosomes 4 0.0166279
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0165211
MIDN midnolin 0.0163338
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0162618
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0161927
TMF1 TATA element modulatory factor 1 0.0161445
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0161102
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0160527
POMP proteasome maturation protein 0.0157939
SEC61G Sec61 gamma subunit 0.015748
TPI1 triosephosphate isomerase 1 0.0156841
SOX9 SRY (sex determining region Y)-box 9 0.0155949
TPR translocated promoter region, nuclear basket protein 0.0155246
FN1 fibronectin 1 0.0154742
RBM5 RNA binding motif protein 5 0.0153944
SRRM1 serine/arginine repetitive matrix 1 0.0152861
GOLM2 golgi membrane protein 2 0.015277
BPTF bromodomain PHD finger transcription factor 0.0151589
IFI27 interferon, alpha-inducible protein 27 0.0151555
ZFP36L1 ZFP36 ring finger protein-like 1 0.0149877
DEK DEK proto-oncogene 0.0148868
YBX3 Y box binding protein 3 0.0148735
B2M beta-2-microglobulin 0.0148609
RNF111 ring finger protein 111 0.0145566
ANKRD12 ankyrin repeat domain 12 0.0145093
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.014457
FTL ferritin, light polypeptide 0.014455
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 0.0144142

decreased expression

Symbol Name Standardized Value
ANXA2 annexin A2 -0.153961
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.14631
THSD4 thrombospondin, type I, domain containing 4 -0.135593
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.132437
FLNB filamin B, beta -0.129509
GMDS GDP-mannose 4,6-dehydratase -0.127931
EPS8 epidermal growth factor receptor pathway substrate 8 -0.122087
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.108381
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.106801
LMO7 LIM domain 7 -0.104547
VCL vinculin -0.0956569
TPT1 tumor protein, translationally-controlled 1 -0.0884501
RPL4 ribosomal protein L4 -0.0857113
ACTN4 actinin, alpha 4 -0.0846181
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0797773
F3 coagulation factor III (thromboplastin, tissue factor) -0.0790348
PDE4D phosphodiesterase 4D, cAMP-specific -0.0709894
BACE2 beta-site APP-cleaving enzyme 2 -0.0705819
KRT8 keratin 8, type II -0.0699501
EZR ezrin -0.0681389
PTPRK protein tyrosine phosphatase, receptor type, K -0.0676044
CALB1 calbindin 1, 28kDa -0.0669814
MYO5B myosin VB -0.0636957
LAMB3 laminin, beta 3 -0.0636638
LPP LIM domain containing preferred translocation partner in lipoma -0.0628262
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0600202
TAS2R14 taste receptor, type 2, member 14 -0.0583567
PRELID2 PRELI domain containing 2 -0.0580067
CCSER1 coiled-coil serine-rich protein 1 -0.0576265
TSPAN8 tetraspanin 8 -0.0568569
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0568083
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0567001
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0561334
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0556862
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0547584
AOPEP aminopeptidase O (putative) -0.0547111
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0538795
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0529207
SHROOM3 shroom family member 3 -0.0527112
RPL34 ribosomal protein L34 -0.052148
MPRIP myosin phosphatase Rho interacting protein -0.0520875
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0520619
HDLBP high density lipoprotein binding protein -0.0514052
RPLP0 ribosomal protein, large, P0 -0.0507452
FRMD5 FERM domain containing 5 -0.050027
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type -0.0495409
RIGI RNA sensor RIG-I -0.0493172
RNF213 ring finger protein 213 -0.0481874
ZFAND3 zinc finger, AN1-type domain 3 -0.0472608
LAMA4 laminin, alpha 4 -0.046683
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0465762
AKAP13 A kinase (PRKA) anchor protein 13 -0.0461709
PLAC8 placenta-specific 8 -0.0455804
MSI2 musashi RNA-binding protein 2 -0.0449904
RPS24 ribosomal protein S24 -0.0447387
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0440037
COG5 component of oligomeric golgi complex 5 -0.0439694
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0437209
DENND1A DENN/MADD domain containing 1A -0.0436572
PTPRB protein tyrosine phosphatase, receptor type, B -0.0430959
FNDC3B fibronectin type III domain containing 3B -0.0429709
DSG3 desmoglein 3 -0.0425223
PTPRR protein tyrosine phosphatase, receptor type, R -0.0424038
KLF5 Kruppel-like factor 5 (intestinal) -0.0421901
P3H2 prolyl 3-hydroxylase 2 -0.0421117
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0413661
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1 -0.0411092
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0409133
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0405651
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0404446
SEC31A SEC31 homolog A (S. cerevisiae) -0.0403714
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0395038
OSBPL3 oxysterol binding protein-like 3 -0.0393428
MCU mitochondrial calcium uniporter -0.0390372
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0387193
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0384571
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0383084
LDHA lactate dehydrogenase A -0.0376559
EXOC4 exocyst complex component 4 -0.0376288
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0372537
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0368802
FAT1 FAT atypical cadherin 1 -0.0367436
RAP1B RAP1B, member of RAS oncogene family -0.0358312
FOXO1 forkhead box O1 -0.0354778
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0353354
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0351631
ANXA11 annexin A11 -0.0344496
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0343836
CANX calnexin -0.0341767
INTS6 integrator complex subunit 6 -0.0340483
MON2 MON2 homolog (S. cerevisiae) -0.033927
PRSS3 protease, serine, 3 -0.0339027
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0336933
LOC112694756 uncharaterized LOC112694756 -0.0334992
RIN2 Ras and Rab interactor 2 -0.0334982
NDEL1 nudE neurodevelopment protein 1-like 1 -0.0332661
SVIL supervillin -0.0332553
EEF2 eukaryotic translation elongation factor 2 -0.0332327
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0332274
MED13L mediator complex subunit 13-like -0.0332083