Azithromycin (hydrate)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Azithromycin (hydrate) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Azithromycin (hydrate)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.237262
RPS12 ribosomal protein S12 0.172904
DST dystonin 0.128135
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0950022
TXNIP thioredoxin interacting protein 0.0948585
CAPRIN2 caprin family member 2 0.0920215
PSD3 pleckstrin and Sec7 domain containing 3 0.0887245
ERRFI1 ERBB receptor feedback inhibitor 1 0.0855579
TPT1 tumor protein, translationally-controlled 1 0.0792228
MT1E metallothionein 1E 0.0759259
RPS6 ribosomal protein S6 0.0758299
RPL36 ribosomal protein L36 0.074582
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.068914
WWTR1 WW domain containing transcription regulator 1 0.0621491
TM4SF1 transmembrane 4 L six family member 1 0.0616996
VMP1 vacuole membrane protein 1 0.0609915
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0574118
RPLP2 ribosomal protein, large, P2 0.0568172
RPS3 ribosomal protein S3 0.0527095
SQSTM1 sequestosome 1 0.0521306
RPL26 ribosomal protein L26 0.0517266
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0512231
GOLGA4 golgin A4 0.0506488
BCAR3 breast cancer anti-estrogen resistance 3 0.0482924
RPS2 ribosomal protein S2 0.0472557
RPL37A ribosomal protein L37a 0.0471785
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.04624
VCL vinculin 0.0454452
RPS29 ribosomal protein S29 0.0430225
RPS27 ribosomal protein S27 0.042599
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0409306
SLK STE20-like kinase 0.0406408
RPS8 ribosomal protein S8 0.0398423
ARHGAP5 Rho GTPase activating protein 5 0.038205
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0379395
H1-0 H1.0 linker histone 0.0377049
RPL36A ribosomal protein L36a 0.0371876
RPS7 ribosomal protein S7 0.0358873
RPL35 ribosomal protein L35 0.0345217
PRELID2 PRELI domain containing 2 0.0340014
AKAP9 A kinase (PRKA) anchor protein 9 0.0334614
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.033334
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0332608
OSBPL8 oxysterol binding protein-like 8 0.0328137
AKAP12 A kinase (PRKA) anchor protein 12 0.032156
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0316176
KTN1 kinectin 1 (kinesin receptor) 0.0312894
RPL31 ribosomal protein L31 0.0308134
PDE8A phosphodiesterase 8A 0.0308051
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0299766
HILPDA hypoxia inducible lipid droplet-associated 0.029642
MACF1 microtubule-actin crosslinking factor 1 0.0284581
RPS23 ribosomal protein S23 0.0280768
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0276928
OPTN optineurin 0.0275802
BIRC3 baculoviral IAP repeat containing 3 0.0273418
GOLGB1 golgin B1 0.0268831
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0268649
CEP290 centrosomal protein 290kDa 0.0266737
KLF6 Kruppel-like factor 6 0.0265553
SEC24A SEC24 family member A 0.0264657
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0263622
RPS25 ribosomal protein S25 0.0262506
SYNE2 spectrin repeat containing, nuclear envelope 2 0.026082
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 0.0260325
ESYT2 extended synaptotagmin-like protein 2 0.0260239
DSCAM Down syndrome cell adhesion molecule 0.02557
B2M beta-2-microglobulin 0.0253717
RPL38 ribosomal protein L38 0.0253589
ARL4C ADP-ribosylation factor-like 4C 0.0252375
EREG epiregulin 0.0252316
RPL28 ribosomal protein L28 0.0252052
TMF1 TATA element modulatory factor 1 0.0251901
NFE2L1 nuclear factor, erythroid 2-like 1 0.0247282
MEF2A myocyte enhancer factor 2A 0.0245494
RPS27A ribosomal protein S27a 0.0244356
ANGPTL4 angiopoietin-like 4 0.0244336
RPS10 ribosomal protein S10 0.0239379
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0237627
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0237232
FAM162A family with sequence similarity 162, member A 0.0236791
CSMD3 CUB and Sushi multiple domains 3 0.0234119
SET SET nuclear proto-oncogene 0.023275
KMT2E lysine (K)-specific methyltransferase 2E 0.0232191
LYST lysosomal trafficking regulator 0.0230751
ANKRD12 ankyrin repeat domain 12 0.0230509
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0229734
RAD51B RAD51 paralog B 0.0229525
PLIN2 perilipin 2 0.022769
CXCL8 chemokine (C-X-C motif) ligand 8 0.0224952
TPM3 tropomyosin 3 0.0223971
XRN1 5'-3' exoribonuclease 1 0.0220534
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0217797
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0217357
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0216704
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.02146
CEP350 centrosomal protein 350kDa 0.0214588
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0211685
AREG amphiregulin 0.0208847
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.0206369

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.219692
POTEF POTE ankyrin domain family, member F -0.149152
EEF2 eukaryotic translation elongation factor 2 -0.0978795
TXNRD1 thioredoxin reductase 1 -0.0961822
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0927825
LOC112694756 uncharaterized LOC112694756 -0.0906711
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0879479
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0842865
TMSB10 thymosin beta 10 -0.0842406
CD44 CD44 molecule (Indian blood group) -0.0832832
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0820275
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0768915
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0742517
PTMA prothymosin, alpha -0.0720195
SLC38A2 solute carrier family 38, member 2 -0.0676583
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0674646
TMSB4X thymosin beta 4, X-linked -0.0645407
APP amyloid beta (A4) precursor protein -0.0608065
DLG1 discs, large homolog 1 (Drosophila) -0.0596628
EGR1 early growth response 1 -0.0577858
ACTG1 actin gamma 1 -0.0564109
ANXA1 annexin A1 -0.0526309
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0520961
WARS1 tryptophanyl-tRNA synthetase 1 -0.0510549
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0505916
RNF213 ring finger protein 213 -0.0505493
LDHA lactate dehydrogenase A -0.0484186
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0473998
COL5A2 collagen, type V, alpha 2 -0.0459358
RPL35A ribosomal protein L35a -0.0457346
CFAP299 cilia and flagella associated protein 299 -0.0453045
HMGA1 high mobility group AT-hook 1 -0.0445725
EHBP1 EH domain binding protein 1 -0.0435949
TNS3 tensin 3 -0.0433334
CMIP c-Maf inducing protein -0.043193
PTK2 protein tyrosine kinase 2 -0.0422802
YBX1 Y box binding protein 1 -0.0403291
TGM2 transglutaminase 2 -0.0401137
GSK3B glycogen synthase kinase 3 beta -0.0395188
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0394541
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0393322
PKM pyruvate kinase, muscle -0.0392858
CENPF centromere protein F, 350/400kDa -0.0387619
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0382861
USP34 ubiquitin specific peptidase 34 -0.0377714
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0363575
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0361407
RIGI RNA sensor RIG-I -0.0360844
TAPBP TAP binding protein (tapasin) -0.035721
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0353642
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0349537
NF1 neurofibromin 1 -0.0349209
FTH1 ferritin, heavy polypeptide 1 -0.0348536
OLA1 Obg-like ATPase 1 -0.0346509
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0343374
ACTN4 actinin, alpha 4 -0.0342477
RASAL2 RAS protein activator like 2 -0.0342381
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.034201
RBM25 RNA binding motif protein 25 -0.0341912
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0338417
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0335815
RGS4 regulator of G-protein signaling 4 -0.032957
ZNFX1 zinc finger, NFX1-type containing 1 -0.0326224
BSG basigin (Ok blood group) -0.0325602
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0324933
ZFAND3 zinc finger, AN1-type domain 3 -0.0323396
SP100 SP100 nuclear antigen -0.031773
SPRY4 sprouty homolog 4 (Drosophila) -0.0316394
VDAC1 voltage-dependent anion channel 1 -0.0315112
AHNAK AHNAK nucleoprotein -0.0310656
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0309006
RTN4 reticulon 4 -0.0304261
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0303729
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0302955
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0298706
LMAN1 lectin, mannose-binding, 1 -0.0298379
RAI1 retinoic acid induced 1 -0.0298347
RRM2 ribonucleotide reductase M2 -0.029735
SLC38A1 solute carrier family 38, member 1 -0.0295233
PGK1 phosphoglycerate kinase 1 -0.0289591
ANKRD28 ankyrin repeat domain 28 -0.0286753
AFF4 AF4/FMR2 family, member 4 -0.0285073
TRIO trio Rho guanine nucleotide exchange factor -0.0282861
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0280741
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.0278568
RPLP0 ribosomal protein, large, P0 -0.0278139
DENND1A DENN/MADD domain containing 1A -0.0272131
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0269454
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0268637
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0262599
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0262352
FLNB filamin B, beta -0.0258453
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0256323
FUS FUS RNA binding protein -0.0256129
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0253712
ATP5F1B ATP synthase F1 subunit beta -0.0251306
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0248854
ADGRG6 adhesion G protein-coupled receptor G6 -0.0248619
TUBB4B tubulin, beta 4B class IVb -0.0248185
GNAS GNAS complex locus -0.0247046