Azithromycin (hydrate)_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Azithromycin (hydrate) perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Azithromycin (hydrate)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDLIM5 PDZ and LIM domain 5 0.103455
PM20D1 peptidase M20 domain containing 1 0.10199
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0936892
COL8A1 collagen, type VIII, alpha 1 0.0905112
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0843797
GRAMD1B GRAM domain containing 1B 0.0748319
COL5A2 collagen, type V, alpha 2 0.0681566
GDA guanine deaminase 0.0666022
NAMPT nicotinamide phosphoribosyltransferase 0.0656076
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0639372
ESYT2 extended synaptotagmin-like protein 2 0.0565989
ZEB2 zinc finger E-box binding homeobox 2 0.0549986
KYNU kynureninase 0.054643
SH3KBP1 SH3-domain kinase binding protein 1 0.0498134
EZR ezrin 0.0487556
RAB3B RAB3B, member RAS oncogene family 0.0484639
CXCL8 chemokine (C-X-C motif) ligand 8 0.0475438
DGKD diacylglycerol kinase, delta 130kDa 0.0465771
MFF mitochondrial fission factor 0.0451147
NEK7 NIMA-related kinase 7 0.0448102
CENPF centromere protein F, 350/400kDa 0.0444164
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0439336
IGFBP3 insulin-like growth factor binding protein 3 0.0434917
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0432577
RPS6 ribosomal protein S6 0.0430606
RPS2 ribosomal protein S2 0.0427641
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.042177
CD109 CD109 molecule 0.0417803
VMP1 vacuole membrane protein 1 0.0408211
BZW1 basic leucine zipper and W2 domains 1 0.0404784
KTN1 kinectin 1 (kinesin receptor) 0.0402614
MSN moesin 0.0388617
ELL2 elongation factor, RNA polymerase II, 2 0.0384105
TXNRD1 thioredoxin reductase 1 0.0378606
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0374541
RGS2 regulator of G-protein signaling 2 0.0373948
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0372292
MYOF myoferlin 0.0370366
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0367191
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0364535
RPS12 ribosomal protein S12 0.0363822
WWTR1 WW domain containing transcription regulator 1 0.0362355
PRRC2C proline-rich coiled-coil 2C 0.0359315
ITPRID2 ITPR interacting domain containing 2 0.0356811
TOP2A topoisomerase (DNA) II alpha 170kDa 0.034892
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0345531
TMX4 thioredoxin-related transmembrane protein 4 0.0338553
MKI67 marker of proliferation Ki-67 0.0327193
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0322504
ZBTB38 zinc finger and BTB domain containing 38 0.0320494
CLU clusterin 0.031961
BCAR3 breast cancer anti-estrogen resistance 3 0.0318855
SET SET nuclear proto-oncogene 0.0317247
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0312646
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0312187
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0307568
TGFBR1 transforming growth factor, beta receptor 1 0.0302843
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0301031
FMNL2 formin-like 2 0.0296293
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.029625
ERRFI1 ERBB receptor feedback inhibitor 1 0.0294282
INHBA inhibin, beta A 0.0288229
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0283854
FNDC3A fibronectin type III domain containing 3A 0.0283492
GOLGA4 golgin A4 0.0271874
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0270812
ENO1 enolase 1, (alpha) 0.0264652
TXNIP thioredoxin interacting protein 0.0257994
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0256974
SLF1 SMC5-SMC6 complex localization factor 1 0.0254188
ARHGAP29 Rho GTPase activating protein 29 0.0250341
TPM3 tropomyosin 3 0.0248428
MAP7 microtubule-associated protein 7 0.0247026
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0246776
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0245833
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0243324
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0241704
NTN4 netrin 4 0.024003
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0236005
BDNF brain-derived neurotrophic factor 0.0234604
NFX1 nuclear transcription factor, X-box binding 1 0.0234389
CCDC68 coiled-coil domain containing 68 0.0232808
RTN4 reticulon 4 0.0227746
NRG1 neuregulin 1 0.022732
CSNK1A1 casein kinase 1, alpha 1 0.0223332
OXSR1 oxidative stress responsive 1 0.0218866
NT5C2 5'-nucleotidase, cytosolic II 0.0218823
BMERB1 bMERB domain containing 1 0.021857
DISP1 dispatched homolog 1 (Drosophila) 0.0217411
EIF4B eukaryotic translation initiation factor 4B 0.0216233
P3H2 prolyl 3-hydroxylase 2 0.0214592
FTH1 ferritin, heavy polypeptide 1 0.0213804
AGFG1 ArfGAP with FG repeats 1 0.0213636
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0213044
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0211627
PDIA3 protein disulfide isomerase family A, member 3 0.0211526
GPRIN3 GPRIN family member 3 0.0209081
PCBP2 poly(rC) binding protein 2 0.0208288
ESM1 endothelial cell-specific molecule 1 0.0205199
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.020503

decreased expression

Symbol Name Standardized Value
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.188265
PDE4D phosphodiesterase 4D, cAMP-specific -0.144847
PDE10A phosphodiesterase 10A -0.139597
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.136083
CDH13 cadherin 13 -0.131137
NALF1 NALCN channel auxiliary factor 1 -0.11573
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.112803
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.104638
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0897614
ADGRD1 adhesion G protein-coupled receptor D1 -0.0821167
TMSB10 thymosin beta 10 -0.0794242
SMYD3 SET and MYND domain containing 3 -0.0778538
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0723455
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0684876
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.068381
AUTS2 autism susceptibility candidate 2 -0.0672784
PCBP3 poly(rC) binding protein 3 -0.0641294
MAML3 mastermind-like 3 (Drosophila) -0.0604692
RPS24 ribosomal protein S24 -0.059564
EFNA5 ephrin-A5 -0.0594992
TPT1 tumor protein, translationally-controlled 1 -0.055057
NCKAP5 NCK-associated protein 5 -0.0548209
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0528953
PTMA prothymosin, alpha -0.048516
RPL35A ribosomal protein L35a -0.0483017
WARS1 tryptophanyl-tRNA synthetase 1 -0.0472447
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0463425
SMOC1 SPARC related modular calcium binding 1 -0.0461347
SLC38A2 solute carrier family 38, member 2 -0.0461034
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0451399
FN1 fibronectin 1 -0.0440226
PSD3 pleckstrin and Sec7 domain containing 3 -0.0431439
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0429887
INTS6 integrator complex subunit 6 -0.0421333
VCL vinculin -0.0420004
HLA-B major histocompatibility complex, class I, B -0.0417817
PBX1 pre-B-cell leukemia homeobox 1 -0.0408694
PTPRM protein tyrosine phosphatase, receptor type, M -0.0395987
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0386565
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0381356
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0374811
SOX6 SRY (sex determining region Y)-box 6 -0.0372134
RAD51B RAD51 paralog B -0.0361472
DENND1A DENN/MADD domain containing 1A -0.0352939
HDAC4 histone deacetylase 4 -0.0332088
TTC28 tetratricopeptide repeat domain 28 -0.0323849
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.032328
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0322804
FNDC3B fibronectin type III domain containing 3B -0.031127
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0310937
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0310161
GRB10 growth factor receptor-bound protein 10 -0.030427
IGF1R insulin-like growth factor 1 receptor -0.0304041
WSB1 WD repeat and SOCS box containing 1 -0.0299673
LIMCH1 LIM and calponin homology domains 1 -0.0299274
AEBP2 AE binding protein 2 -0.0287967
MARCHF1 membrane associated ring-CH-type finger 1 -0.0281485
THSD4 thrombospondin, type I, domain containing 4 -0.0277356
IARS1 isoleucyl-tRNA synthetase 1 -0.0273025
EXOC4 exocyst complex component 4 -0.0272737
NDRG1 N-myc downstream regulated 1 -0.0265706
FLNA filamin A, alpha -0.0262463
LAMA5 laminin, alpha 5 -0.0252937
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0252267
RPL31 ribosomal protein L31 -0.025085
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -0.0250625
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0247596
GLRX glutaredoxin (thioltransferase) -0.0247063
PAPPA2 pappalysin 2 -0.0245812
TBC1D22A TBC1 domain family, member 22A -0.0242125
RTN1 reticulon 1 -0.0241878
BABAM2 BRISC and BRCA1 A complex member 2 -0.0239452
SOD2 superoxide dismutase 2, mitochondrial -0.0236118
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0233346
CADM2 cell adhesion molecule 2 -0.0228814
ACTG1 actin gamma 1 -0.0227762
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.022755
SPDYA speedy/RINGO cell cycle regulator family member A -0.0224885
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0224875
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -0.0222843
TBXT T-box transcription factor T -0.0222133
RPL34 ribosomal protein L34 -0.022196
GPC6 glypican 6 -0.022098
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0219845
RPL13A ribosomal protein L13a -0.0219172
RPS13 ribosomal protein S13 -0.0218648
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon -0.0212476
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0210318
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0209823
BCAS3 breast carcinoma amplified sequence 3 -0.0204493
HDLBP high density lipoprotein binding protein -0.0203608
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0199583
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0197153
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0193563
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0192247
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0191275
FNIP1 folliculin interacting protein 1 -0.0189485
ADGRB3 adhesion G protein-coupled receptor B3 -0.0188321
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0187346
GOLGA3 golgin A3 -0.018572