Azithromycin (hydrate)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Azithromycin (hydrate) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Azithromycin (hydrate)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.132392
TPT1 tumor protein, translationally-controlled 1 0.106715
TXNIP thioredoxin interacting protein 0.0997719
VMP1 vacuole membrane protein 1 0.0863601
RPS12 ribosomal protein S12 0.0788134
RPS8 ribosomal protein S8 0.0672658
RPS3 ribosomal protein S3 0.0665523
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0630412
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.057821
RACK1 receptor for activated C kinase 1 0.0519146
PCLO piccolo presynaptic cytomatrix protein 0.0482097
RPS6 ribosomal protein S6 0.0481629
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0470278
MT2A metallothionein 2A 0.0459436
RPL37A ribosomal protein L37a 0.0453848
RPS29 ribosomal protein S29 0.0430896
BCAR3 breast cancer anti-estrogen resistance 3 0.0422506
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0418639
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0417693
WWC1 WW and C2 domain containing 1 0.0401232
RPL26 ribosomal protein L26 0.0393312
LAMB3 laminin, beta 3 0.0377158
RPL21 ribosomal protein L21 0.037695
RPS2 ribosomal protein S2 0.0364992
RPS25 ribosomal protein S25 0.035746
SH3KBP1 SH3-domain kinase binding protein 1 0.0357242
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0351842
RPS23 ribosomal protein S23 0.0348115
RPS7 ribosomal protein S7 0.0345841
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0333423
TMF1 TATA element modulatory factor 1 0.0332524
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.032004
AREG amphiregulin 0.0310445
MYO1E myosin IE 0.0300211
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0298546
RPL12 ribosomal protein L12 0.027367
FHIT fragile histidine triad 0.0271686
RPL38 ribosomal protein L38 0.0269989
RPL23 ribosomal protein L23 0.0260442
RPL36A ribosomal protein L36a 0.0256456
AKAP12 A kinase (PRKA) anchor protein 12 0.0256209
BCL2L1 BCL2-like 1 0.0254436
RPL9 ribosomal protein L9 0.0253912
RPLP2 ribosomal protein, large, P2 0.0251557
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.025113
RPS27A ribosomal protein S27a 0.0246891
SMAD3 SMAD family member 3 0.0244788
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.023975
AFDN afadin, adherens junction formation factor 0.0238932
KLF6 Kruppel-like factor 6 0.0237254
RPS27 ribosomal protein S27 0.0236539
DSG2 desmoglein 2 0.0235717
RPL10A ribosomal protein L10a 0.0233431
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0227084
BZW1 basic leucine zipper and W2 domains 1 0.0227075
BPTF bromodomain PHD finger transcription factor 0.02266
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0225849
NACA nascent polypeptide-associated complex alpha subunit 0.0223053
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.022086
EFNA5 ephrin-A5 0.0219744
IL1RAP interleukin 1 receptor accessory protein 0.0219038
EXT1 exostosin glycosyltransferase 1 0.0215976
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0215649
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 0.0214033
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.021297
RPL37 ribosomal protein L37 0.0212405
RPL11 ribosomal protein L11 0.0210527
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0210241
BTBD9 BTB (POZ) domain containing 9 0.0210099
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0205327
WWTR1 WW domain containing transcription regulator 1 0.020119
RPL31 ribosomal protein L31 0.0200807
KIF5B kinesin family member 5B 0.0199017
ANKRD12 ankyrin repeat domain 12 0.0198532
RPS10 ribosomal protein S10 0.0198103
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0197106
RPL27 ribosomal protein L27 0.0196022
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0195343
NRIP1 nuclear receptor interacting protein 1 0.0194822
RPS21 ribosomal protein S21 0.019452
NAP1L1 nucleosome assembly protein 1-like 1 0.0192153
RSL24D1 ribosomal L24 domain containing 1 0.0191805
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0191731
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0191397
ARHGAP5 Rho GTPase activating protein 5 0.0185229
EIF5B eukaryotic translation initiation factor 5B 0.0185099
NFE2L1 nuclear factor, erythroid 2-like 1 0.0183892
SVIL supervillin 0.0182439
PATJ PATJ crumbs cell polarity complex component 0.0180812
SQSTM1 sequestosome 1 0.0178855
DOCK5 dedicator of cytokinesis 5 0.0178139
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0178114
SERINC1 serine incorporator 1 0.017623
H1-4 H1.4 linker histone, cluster member 0.0175848
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0174038
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0172819
GPHN gephyrin 0.0171368
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0169576
RSL1D1 ribosomal L1 domain containing 1 0.016891
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0167876

decreased expression

Symbol Name Standardized Value
MUC4 mucin 4, cell surface associated -0.16483
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.156607
PTMA prothymosin, alpha -0.143764
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.141699
DLG1 discs, large homolog 1 (Drosophila) -0.115255
F3 coagulation factor III (thromboplastin, tissue factor) -0.11481
HMGA1 high mobility group AT-hook 1 -0.114465
RNF213 ring finger protein 213 -0.101174
TMSB4X thymosin beta 4, X-linked -0.100286
FTH1 ferritin, heavy polypeptide 1 -0.0984883
ANXA2 annexin A2 -0.0908464
MUC16 mucin 16, cell surface associated -0.0852581
IGFBP3 insulin-like growth factor binding protein 3 -0.0839847
TMSB10 thymosin beta 10 -0.0830923
EMP1 epithelial membrane protein 1 -0.0823315
POTEF POTE ankyrin domain family, member F -0.077066
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0758815
EZR ezrin -0.075182
MYO6 myosin VI -0.0701406
TMEM123 transmembrane protein 123 -0.0696441
RUNX1 runt-related transcription factor 1 -0.067662
FN1 fibronectin 1 -0.0674179
PKM pyruvate kinase, muscle -0.0639221
CLIP4 CAP-GLY domain containing linker protein family, member 4 -0.062123
HLA-B major histocompatibility complex, class I, B -0.0605641
NDRG1 N-myc downstream regulated 1 -0.0605137
MAML2 mastermind-like 2 (Drosophila) -0.0583401
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0558464
ASPH aspartate beta-hydroxylase -0.0546517
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0546308
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0546141
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0530584
TPM4 tropomyosin 4 -0.0528409
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0520158
LMO7 LIM domain 7 -0.0517013
CCNL1 cyclin L1 -0.0515055
FNDC3B fibronectin type III domain containing 3B -0.0513495
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.050254
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0496914
SULF2 sulfatase 2 -0.0495096
RPL35A ribosomal protein L35a -0.0483738
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0483373
KRT17 keratin 17, type I -0.0481052
MYOF myoferlin -0.0467374
MBNL2 muscleblind-like splicing regulator 2 -0.0464981
ACTN4 actinin, alpha 4 -0.0464429
TSC22D2 TSC22 domain family, member 2 -0.0460759
YBX1 Y box binding protein 1 -0.045957
CD2AP CD2-associated protein -0.0455624
LDHA lactate dehydrogenase A -0.0455547
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0449479
ANLN anillin, actin binding protein -0.0443093
FOSL1 FOS-like antigen 1 -0.0441652
CAV1 caveolin 1, caveolae protein, 22kDa -0.044105
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.043744
LOC112694756 uncharaterized LOC112694756 -0.0436239
LOC102724023 ES1 protein homolog, mitochondrial -0.0427286
PCBP2 poly(rC) binding protein 2 -0.0425563
CANX calnexin -0.0424999
WDR45B WD repeat domain 45B -0.042453
TMOD3 tropomodulin 3 (ubiquitous) -0.0423595
RBM39 RNA binding motif protein 39 -0.0422817
KRT18 keratin 18, type I -0.041496
GNAS GNAS complex locus -0.0414815
KRT7 keratin 7, type II -0.0414034
KRT19 keratin 19, type I -0.0405893
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0403689
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0398459
ARF4 ADP-ribosylation factor 4 -0.0397715
DAPK1 death-associated protein kinase 1 -0.0393561
C3 complement component 3 -0.0393164
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0390181
NAV2 neuron navigator 2 -0.0388583
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0388482
SORBS2 sorbin and SH3 domain containing 2 -0.0384999
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0383497
ANXA1 annexin A1 -0.0381052
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0380854
HLA-A major histocompatibility complex, class I, A -0.0379336
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.037331
PLAU plasminogen activator, urokinase -0.0372001
ZNF207 zinc finger protein 207 -0.0368411
ZNF148 zinc finger protein 148 -0.0362804
CALR calreticulin -0.0361862
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0360112
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0359609
ITGB4 integrin, beta 4 -0.0358357
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0357826
MORF4L2 mortality factor 4 like 2 -0.0357687
NPEPPS aminopeptidase puromycin sensitive -0.0357478
SMC4 structural maintenance of chromosomes 4 -0.0354669
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0353728
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0352778
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0351843
WARS1 tryptophanyl-tRNA synthetase 1 -0.0351045
SPAG9 sperm associated antigen 9 -0.0347156
KDM2A lysine (K)-specific demethylase 2A -0.0341287
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.0339578
AHNAK AHNAK nucleoprotein -0.0336519
ESYT2 extended synaptotagmin-like protein 2 -0.0333544